Projects per year
Personal profile
Research interests
Currently, I am working on neuroimaging for (ischemic) stroke at the Department of Biomedical Engineering and Physics. As a collaborator on the STAIRS (Stroke treatment decision support by Artificial Intelligence for analysis of MR images) project, my aim is to accelerate magnetic resonance imaging (MRI) and to simultaneously enable detection of stroke in the acute setting with aid of deep learning. In our group, we will develop an efficient way to combine different MRI modalities (e.g., diffusion-weighted MRI (dMRI), and fluid-attenuated inversion recovery (FLAIR)) into a useful tool for clinical decision making.
Previously, I investigated deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) and treatment-resistant depression (TRD) at the Department of Psychiatry. My focus was on finding the optimal target structures in white matter with dMRI (treatment optimization) and imaging-based prediction of individual treatment outcome (improved patient selection). In collaboration with the neurosurgeons, we updated the DBS targeting strategies for psychiatric DBS to include information on individual white matter structures.
My other interests include high-resolution and high-field (7T) dMRI and their application in research or in the clinic.
specialisation
Network
Projects
- 2 Active
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van Wingen G.A.: Neuroimaging in Psychiatry
van Leeuwen, W., Liebrand, L., Scheepens, D., van der Straten, A., Zhutovsky, P., van Wingen, G., Thomas, R., Bruin, W., Eijsker, N., El-Gazzar, A., Fridgeirsson, E., Liu, S., Meijs, H., Prentice, A., Votterl, H., Yucel, D., Zhutovsky, P. & van de Mortel, L.
15/11/2020 → …
Project: Research
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Denys D.A.J.P.: Deep Brain Stimulation and Obsessive-Compulsive Disorders
Denys, D., Derks, E., Figee, M., Roelfsema, P., Vulink, N., Willuhn, I., Bais, M., Bangel, K., van Bennekom, M., Bergfeld, I., Blom, R., van den Boom, B., Cerrone, K., Derksen, M., van Diepen, R., ten Doesschate, F., Domen, A., Ehmer, I., van Elzelingen, W., Goedhoop, J., Goldschmidt, T., de Haan, M., Jager, I., Kasanmoentalib, A., Kuipers, L., van Leeuwen, W., Levar, N., Liebrand, L., Molenaar, C., Ooms, P., Oudijn, M., Polak, R., van der Pol, M., Scheepens, D., Schroder, A., Smolders, R., van der Straten, A., Strous, J., Turbyne, C., van Westen, M., Zantvoord, J., Turner, R., van der Linden, M., Matilla, T. & Schippers, R.
1/07/2011 → …
Project: Research
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On the right track: Using neuroimaging to improve deep brain stimulation outcomes in psychiatry
Liebrand, L. C., 2023, 141 p.Research output: PhD Thesis › Phd-Thesis - Research and graduation internal
Open Access -
A high-resolution multi-shell 3T diffusion magnetic resonance imaging dataset as part of the Amsterdam Ultra-high field adult lifespan database (AHEAD)
Keuken, M. C., Liebrand, L. C., Bazin, P. L., Alkemade, A., van Berendonk, N., Groot, J. M., Isherwood, S. J. S., Kemp, S., Lute, N., Mulder, M. J., Trutti, A. C., Caan, M. W. A. & Forstmann, B. U., Jun 2022, In: Data in brief. 42, 9 p., 108086.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Tractography-based versus anatomical landmark-based targeting in vALIC deep brain stimulation for refractory obsessive-compulsive disorder
Graat, I., Mocking, R. J. T., Liebrand, L. C., van den Munckhof, P., Bot, M., Schuurman, P. R., Bergfeld, I. O., van Wingen, G. & Denys, D., Dec 2022, In: Molecular psychiatry. 27, 12, p. 5206-5212 7 p.Research output: Contribution to journal › Article › Academic › peer-review
3 Citations (Scopus) -
Utilizing 7-Tesla Subthalamic Nucleus Connectivity in Deep Brain Stimulation for Parkinson Disease
Mathiopoulou, V., Rijks, N., Caan, M. W. A., Liebrand, L. C., Ferreira, F., de Bie, R. M. A., van den Munckhof, P., Schuurman, P. R. & Bot, M., 2022, (E-pub ahead of print) In: Neuromodulation.Research output: Contribution to journal › Article › Academic › peer-review
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Deep brain stimulation response in obsessive–compulsive disorder is associated with preoperative nucleus accumbens volume
Liebrand, L. C., Zhutovsky, P., Tolmeijer, E. K., Graat, I., Vulink, N., de Koning, P., Figee, M., Schuurman, P. R., van den Munckhof, P., Caan, M. W. A., Denys, D. & van Wingen, G. A., 1 Jan 2021, In: NeuroImage: Clinical. 30, 102640.Research output: Contribution to journal › Article › Academic › peer-review
Open Access4 Citations (Scopus)