Projects per year
Personal profile
Research interests
I use head-mounted miniaturized microscopes combined with chronically implanted microendoscopes to image calcium signaling in vivo in striatal output neurons and midbrain dopamine neurons of freely-behaving rats to visualize how motivational behavior is encoded in the brain, specifically the shift from goal-directed to habitual behavior. In addition, I use this technique to image cellular activity in genetically engineered mice that show compulsive-like behaviors to understand the neuronal mechanisms of compulsivity that could potentially lead to a better understanding of psychiatric disorders such as addiction, OCD, and trichotillomania.
specialisation
Collaborations and top research areas from the last five years
Projects
- 2 Active
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Willuhn I.: The neurocircuitry of compulsive behavior
van den Boom, B., Derksen, M., Ehmer, I., van Elzelingen, W., Goedhoop, J., Willuhn, I., Arbab, T., Faust, R. & Burgeno, L.
31/03/2015 → …
Project: Research
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Denys D.A.J.P.: Deep Brain Stimulation and Obsessive-Compulsive Disorders
Denys, D., Derks, E., Figee, M., Roelfsema, P., Vulink, N., Willuhn, I., Bais, M., Bangel, K., van Bennekom, M., Bergfeld, I., Blom, R., van den Boom, B., Cerrone, K., Derksen, M., van Diepen, R., ten Doesschate, F., Domen, A., Ehmer, I., van Elzelingen, W., Goedhoop, J., Goldschmidt, T., de Haan, M., Jager, I., Kasanmoentalib, A., Kuipers, L., van Leeuwen, W., Levar, N., Liebrand, L., Molenaar, C., Ooms, P., Oudijn, M., Polak, R., van der Pol, M., Scheepens, D., Schroder, A., Smolders, R., van der Straten, A., Strous, J., Turbyne, C., van Westen, M., Zantvoord, J., Turner, R., van der Linden, M., Matilla, T. & Schippers, R.
1/07/2011 → …
Project: Research
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Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model
van den Boom, B. J. G., Elhazaz-Fernandez, A., Rasmussen, P. A., van Beest, E. H., Parthasarathy, A., Denys, D. & Willuhn, I., 1 Dec 2023, In: Nature communications. 14, 1, 5385.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error
Goedhoop, J. N., van den Boom, B. J. G., Robke, R., Veen, F., Fellinger, L., van Elzelingen, W., Arbab, T. & Willuhn, I., 11 Nov 2022, In: eLife. 11, e82711.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
SpecSeg is a versatile toolbox that segments neurons and neurites in chronic calcium imaging datasets based on low-frequency cross-spectral power
de Kraker, L., Seignette, K., Thamizharasu, P., van den Boom, B. J. G., Ferreira Pica, I., Willuhn, I., Levelt, C. N. & Togt, C. V. D., 24 Oct 2022, In: Cell Reports Methods. 2, 10, 100299.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Invasive and Non-invasive Neurostimulation for OCD
Bergfeld, I. O., Dijkstra, E., Graat, I., de Koning, P., van den Boom, B. J. G., Arbab, T., Vulink, N., Denys, D., Willuhn, I. & Mocking, R. J. T., 2021, Current Topics in Behavioral Neurosciences. Springer Science and Business Media Deutschland GmbH, Vol. 49. p. 399-436 38 p. (Current Topics in Behavioral Neurosciences; vol. 49).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review
19 Citations (Scopus) -
NINscope, a versatile miniscope for multi-region circuit investigations
de Groot, A., van den Boom, B. J., van Genderen, R. M., Coppens, J., van Veldhuijzen, J., Bos, J., Hoedemaker, H., Negrello, M., Willuhn, I., de Zeeuw, C. I. & Hoogland, T. M., Jan 2020, In: eLife. 9, e49987.Research output: Contribution to journal › Article › Academic › peer-review
Open Access68 Citations (Scopus)