Projects per year
Personal profile
Research interests
I use head-mounted miniaturized microscopes combined with chronically implanted microendoscopes to image calcium signaling in vivo in striatal output neurons and midbrain dopamine neurons of freely-behaving rats to visualize how motivational behavior is encoded in the brain, specifically the shift from goal-directed to habitual behavior. In addition, I use this technique to image cellular activity in genetically engineered mice that show compulsive-like behaviors to understand the neuronal mechanisms of compulsivity that could potentially lead to a better understanding of psychiatric disorders such as addiction, OCD, and trichotillomania.
specialisation
Network
Projects
- 2 Active
-
Willuhn I.: The neurocircuitry of compulsive behavior
van den Boom, B., Derksen, M., Ehmer, I., van Elzelingen, W., Goedhoop, J., Willuhn, I., Arbab, T., Faust, R. & Burgeno, L.
31/03/2015 → …
Project: Research
-
Denys D.A.J.P.: Deep Brain Stimulation and Obsessive-Compulsive Disorders
Denys, D., Derks, E., Figee, M., Roelfsema, P., Vulink, N., Willuhn, I., Bais, M., Bangel, K., van Bennekom, M., Bergfeld, I., Blom, R., van den Boom, B., Cerrone, K., Derksen, M., van Diepen, R., ten Doesschate, F., Domen, A., Ehmer, I., van Elzelingen, W., Goedhoop, J., Goldschmidt, T., de Haan, M., Jager, I., Kasanmoentalib, A., Kuipers, L., van Leeuwen, W., Levar, N., Liebrand, L., Molenaar, C., Ooms, P., Oudijn, M., Polak, R., van der Pol, M., Scheepens, D., Schroder, A., Smolders, R., van der Straten, A., Strous, J., Turbyne, C., van Westen, M., Zantvoord, J., Turner, R., van der Linden, M., Matilla, T. & Schippers, R.
1/07/2011 → …
Project: Research
-
Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error
Goedhoop, J. N., van den Boom, B. J. G., Robke, R., Veen, F., Fellinger, L., van Elzelingen, W., Arbab, T. & Willuhn, I., 11 Nov 2022, In: eLife. 11, e82711.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
Invasive and Non-invasive Neurostimulation for OCD
Bergfeld, I. O., Dijkstra, E., Graat, I., de Koning, P., van den Boom, B. J. G., Arbab, T., Vulink, N., Denys, D., Willuhn, I. & Mocking, R. J. T., 2021, Current Topics in Behavioral Neurosciences. Springer Science and Business Media Deutschland GmbH, Vol. 49. p. 399-436 38 p. (Current Topics in Behavioral Neurosciences; vol. 49).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review
14 Citations (Scopus) -
NINscope, a versatile miniscope for multi-region circuit investigations
de Groot, A., van den Boom, B. J., van Genderen, R. M., Coppens, J., van Veldhuijzen, J., Bos, J., Hoedemaker, H., Negrello, M., Willuhn, I., de Zeeuw, C. I. & Hoogland, T. M., Jan 2020, In: eLife. 9, e49987.Research output: Contribution to journal › Article › Academic › peer-review
Open Access58 Citations (Scopus) -
Behavioral flexibility in a mouse model for obsessive-compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants: Impaired Pavlovian reversal learning in SAPAP3 mutants
van den Boom, B. J. G., Mooij, A. H., Misevičiūtė, I., Denys, D. & Willuhn, I., 2019, In: Genes, brain, and behavior. 18, 4, p. e12557 e12557.Research output: Contribution to journal › Article › Academic › peer-review
Open Access20 Citations (Scopus) -
Differential Effects of Deep Brain Stimulation of the Internal Capsule and the Striatum on Excessive Grooming in Sapap3 Mutant Mice
Pinhal, C. M., van den Boom, B. J. G., Santana-Kragelund, F., Fellinger, L., Bech, P., Hamelink, R., Feng, G., Willuhn, I., Feenstra, M. G. P. & Denys, D., 2018, In: Biological Psychiatry. 84, 12, p. 917-925Research output: Contribution to journal › Article › Academic › peer-review
26 Citations (Scopus)