Marieke Veldkamp


1992 …2023

Research activity per year

Personal profile

Research interests

Research is focused on elucidating the mechanisms underlying cardiac arrhythmias in which the regulation and (mal)function of ion channels, transporters and calcium-handling proteins plays a central role. Insight into arrhythmia mechanisms is achieved by studying electrical activity with the patch-clamp technique in various preparations including: isolated neonatal and adult cardiomyocytes, isolated intracardiac neurons, mammalian cell expression systems etc. Specific projects include:
- The cardiac sodium channel as part of a multi-molecular protein complex
- Differential expression and regulation of the cardiac sodium channels localized to different subcellular micro-domains of the cardiac myocyte
- Biophysical properties of cardiac and neuronal ion channel mutations associated with arrhythmia syndromes
- The role of the cardiac autonomous nervous system in atrial fibrillation: effects of neuropeptides on atrial electrophysiology
- Functional remodeling of intracardiac neurons in heart failure


Cardiac Cellular Electrophysiology

Collaborations and top research areas from the last five years

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