Research output per year
Research output per year
Personal profile
Specialisation
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Research interests
My research focuses on the investigation of the bidirectional interaction between tumor cells and the bone marrow (BM) microenvironment. My studies have resulted in the development of (3D) co-culture systems and unique murine xenograft models that allow us to study the pathogenesis of hematological tumors, novel therapeutic interventions, and mechanisms of microenvironment-induced resistance.
Keywords
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
- multiple myeloma
- cancer-induced bone disease
- mesenchymal stromal cells
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma
Groen, R. W. J., Noort, W. A., Raymakers, R. A., Prins, H-J., Aalders, L., Hofhuis, F. M., Moerer, P., van Velzen, J. F., Bloem, A. C., van Kessel, B., Rozemuller, H., van Binsbergen, E., Buijs, A., Yuan, H., de Bruijn, J. D., de Weers, M., Parren, P. W. H. I., Schuringa, J. J., Lokhorst, H. M., Mutis, T., & 1 others, 19 Jul 2012, In: Blood. 120, 3, p. e9-e16Research output: Contribution to journal › Article › Academic › peer-review
96 Citations (Scopus) -
CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia
Naik, J., Themeli, M., de Jong-Korlaar, R., Ruiter, R. W. J., Poddighe, P. J., Yuan, H., de Bruijn, J. D., Ossenkoppele, G. J., Zweegman, S., Smit, L., Mutis, T., Martens, A. C. M., van de Donk, N. W. C. J. & Groen, R. W. J., 28 Feb 2019, In: Haematologica. 104, 3, p. e100-e103Research output: Contribution to journal › Letter › Academic › peer-review
Open Access60 Citations (Scopus) -
Establishing human leukemia xenograft mouse models by implanting human bone marrow-like scaffold-based niches
Antonelli, A., Noort, W. A., Jaques, J., de Boer, B., de Jong-Korlaar, R., Brouwers-Vos, A. Z., Lubbers-Aalders, L., van Velzen, J. F., Bloem, A. C., Yuan, H., de Bruijn, J. D., Ossenkoppele, G. J., Martens, A. C. M., Vellenga, E., Groen, R. W. J. & Schuringa, J. J., 22 Dec 2016, In: Blood. 128, 25, p. 2949-2959 11 p.Research output: Contribution to journal › Article › Academic › peer-review
54 Citations (Scopus) -
Bone marrow mesenchymal stromal cells can render multiple myeloma cells resistant to cytotoxic machinery of CAR T cells through inhibition of apoptosis
Holthof, L. C., van der Schans, J. J., Katsarou, A., Poels, R., Gelderloos, A. T., Drent, E., van Hal-van Veen, S. E., Li, F., Zweegman, S., van de Donk, N. W. C. J., Themeli, M., Groen, R. W. J. & Mutis, T., 1 Jul 2021, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 27, 13, p. 3793-3803 11 p.Research output: Contribution to journal › Article › Academic › peer-review
13 Citations (Scopus) -
Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence
Katsarou, A., Sjöstrand, M., Naik, J., Mansilla-Soto, J., Kefala, D., Kladis, G., Nianias, A., Ruiter, R., Poels, R., Sarkar, I., Patankar, Y. R., Merino, E., Reijmers, R. M., Frerichs, K. A., Yuan, H., de Bruijn, J., Stroopinsky, D., Avigan, D., van de Donk, N. W. C. J., Zweegman, S., & 4 others, 8 Dec 2021, In: Science Translational Medicine. 13, 623, p. eabh1962Research output: Contribution to journal › Article › Academic › peer-review
13 Citations (Scopus)