Projects per year
Personal profile
Specialisation
Wilma van de Berg is senior translational and cellular neuroscientist, principal investigator and associate professor at dept. Anatomy and Neurosciences, head of the research section Clinical Neuroanatomy and Biobanking (CNAB), member of executive board of Advanced Optical Microscopy Core (www.ao2m.amsterdam) and lecturer in clinical neuroanatomy, neuropathology of movement disorders and clinical and translational neurosciences, Amsterdam UMC. She is an expert in human neuroanatomy, morphometry and 3D imaging (quantitaive MRI-to-pathology), and structural and cellular biology. She is founder and director of the Normal Aging Brain Bank (www.nabca.eu), which collects advanced postmortem MRI and high-quality brain tissue of non-demented elderly for stimulating translational research in neurosciences.
Research interests
Her research over the years has focused on unravelling cellular mechanisms underpinning selective vulnerability, protein aggregation, clinical heterogeneity and disease progression in Parkinson’s disease and related neurodegenerative disorders. The knowledge on neuroanatomy, neuropathology, cellular disease mechanisms and human brain morphology in aging and disease is utilized to define novel MRI and biofluid biomarkers for improving early diagnosis and prediction of cognitive decline in Parkinson’s disease. She has gained experience in conducting clinical studies (e.g. PROGRESS-PD) in which Parkinson patients and age-matched controls were followed for eight years and identification of biofluid markers for disease progression in PD. She currently co-leads the longitudinal cohort ‘Profiling Parkinson’s’(ProPARK) and works closely together with clinical and industrie partners to identify molecular subtypes in Parkinson's disease. She is also partner in a large EU consortium, named NEUROCOV, which aims to unravel wich cell types are susceptible to SARS-CoV-2 infection and how damage occurs and what makes individualss vulnerable or resistant to such complications.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Cellular Neuroscience and Pediatrics, Maastricht University
Award Date: 12 Jun 2003
Master, Biological Health Sciences, Maastricht University, Maastricht, Netherlands
1 Sep 1993 → 30 Sep 2030
Award Date: 30 Sep 1998
External positions
President of Dutch Parkinson Scientists Association, Dutch Parkinson Scientists
1 Apr 2021 → 1 Apr 2024
Executive Board Parkinsonalliance Netherlands, Parkinsonalliance Netherlands
26 Mar 2021 → 26 Mar 2025
Keywords
- QD Chemistry
- Biochemistry
- RB Pathology
- morphometry
- QM Human anatomy
- MRI
- cellular imaging
- RZ Other systems of medicine
- Neurology
- Molecular Biology
- molecular diagnostics
Network
Projects
- 1 Active
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ADAPT-PD: Dysfunctional adaptive immune responses drive the disease progression of Parkinson’s disease.
van de Berg, W., Berendse, H. & Rozemuller, A.
1/10/2021 → 30/09/2023
Project: Research
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Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies
Moors, T. E., Mona, D., Luehe, S., Duran-Pacheco, G., Spycher, L., Mundigl, O., Kaluza, K., Huber, S., Hug, M. N., Kremer, T., Ritter, M., Dziadek, S., Dernick, G., van de Berg, W. D. J. & Britschgi, M., 3 Jun 2022, In: Acta neuropathologica communications. 10, 1, 82.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy
Moors, T. E., Maat, C. A., Niedieker, D., Mona, D., Petersen, D., Timmermans-Huisman, E., Kole, J., El-Mashtoly, S. F., Spycher, L., Zago, W., Barbour, R., Mundigl, O., Kaluza, K., Huber, S., Hug, M. N., Kremer, T., Ritter, M., Dziadek, S., Geurts, J. J. G., Gerwert, K., & 2 others , Sep 2021, In: Acta Neuropathologica. 142, 3, p. 423-448 26 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access25 Citations (Scopus) -
Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes
Shahmoradian, S. H., Lewis, A. J., Genoud, C., Hench, J. R., Moors, T. E., Navarro, P. P., Castaño-Díez, D., Schweighauser, G., Graff-Meyer, A., Goldie, K. N., Sütterlin, R., Huisman, E., Ingrassia, A., Gier, Y. D., Rozemuller, A. J. M., Wang, J., Paepe, A. D., Erny, J., Staempfli, A., Hoernschemeyer, J., & 13 others , 2019, In: Nature neuroscience. 22, 7, p. 1099-1109Research output: Contribution to journal › Article › Academic › peer-review
401 Citations (Scopus) -
Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series
Geut, H., Hepp, D. H., Foncke, E., Berendse, H. W., Rozemuller, J. M., Huitinga, I. & van de Berg, W. D. J., 26 Mar 2020, In: Acta neuropathologica communications. 8, 1, p. 39 1 p., 39.Research output: Contribution to journal › Article › Academic › peer-review
Open Access19 Citations (Scopus) -
CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinson's Disease
Oosterveld, L. P., Kuiper, T. I., Majbour, N. K., Verberk, I. M. W., van Dijk, K. D., Twisk, J. W. R., El-Agnaf, O. M., Teunissen, C. E., Weinstein, H. C., Klein, M., Berendse, H. W. & van de Berg, W. D. J., 2 Nov 2020, In: International journal of molecular sciences. 21, 22, p. 1-12 12 p., 8519.Research output: Contribution to journal › Article › Academic › peer-review
6 Citations (Scopus)
Prizes
Press/Media
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VUmc persbericht
DH Hepp, Wilma van de Berg & MM Schoonheim
28/11/2017
1 Media contribution
Press/Media: Public Engagement Activities
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