A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense

Henrike Veninga, Robert M. Hoek, Alex F. de Vos, Alex M. de Bruin, Feng-Qi An, Tom van der Poll, René A. W. van Lier, M. Edward Medof, Jörg Hamann

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13 Citations (Scopus)


In addition to its complement-regulating activity, CD55 is a ligand of the adhesion class G protein-coupled receptor CD97; however, the relevance of this interaction has remained elusive. We previously showed that mice lacking a functional CD97 gene have increased numbers of granulocytes. Here, we demonstrate that CD55-deficient mice display a comparable phenotype with about two-fold more circulating granulocytes in the blood stream, the marginated pool, and the spleen. This granulocytosis was independent of increased complement activity. Augmented numbers of Gr-1-positive cells in cell cycle in the bone marrow indicated a higher granulopoietic activity in mice lacking either CD55 or CD97. Concomitant with the increase in blood granulocyte numbers, Cd55⁻/⁻ mice challenged with the respiratory pathogen Streptococcus pneumoniae developed less bacteremia and died later after infection. Collectively, these data suggest that complement-independent interaction of CD55 with CD97 is functionally relevant and involved in granulocyte homeostasis and host defense
Original languageEnglish
Article numbere24431
Pages (from-to)e24431
Issue number10
Publication statusPublished - 2011

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