Amyloid and its association with default network integrity in Alzheimer's disease

S.M. Adriaanse; E.J. Sanz-Arigita; M.A.A. Binnewijzend; R. Ossenkoppele; N. Tolboom; D.M.E. van Assema; A.M. Wink; R. Boellaard; M.M. Yaqub; A.D. Windhorst; W.M. van der Flier; P. Scheltens; A.A. Lammertsma; S.A.R.B. Rombouts; F. Barkhof; B.N.M. van Berckel

doi:https://doi.org/10.1002/hbm.22213

Amyloid and its association with default network integrity in Alzheimer's disease

S.M. Adriaanse, E.J. Sanz-Arigita, M.A.A. Binnewijzend, R. Ossenkoppele, N. Tolboom, D.M.E. van Assema, A.M. Wink, R. Boellaard, M.M. Yaqub, A.D. Windhorst, W.M. van der Flier, P. Scheltens, A.A. Lammertsma, S.A.R.B. Rombouts, F. Barkhof, B.N.M. van Berckel

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Abstract

The purpose of this study was to investigate the association between functional connectivity and beta-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN. Hum Brain Mapp 35:779-791, 2014. (c) 2012 Wiley Periodicals, Inc

Original language	English
Pages (from-to)	779-791
Journal	Human brain mapping
Volume	35
Issue number	3
DOIs	https://doi.org/10.1002/hbm.22213
Publication status	Published - 2014

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Adriaanse, S. M., Sanz-Arigita, E. J., Binnewijzend, M. A. A., Ossenkoppele, R., Tolboom, N., van Assema, D. M. E., Wink, A. M., Boellaard, R., Yaqub, M. M., Windhorst, A. D., van der Flier, W. M., Scheltens, P., Lammertsma, A. A., Rombouts, S. A. R. B., Barkhof, F., & van Berckel, B. N. M. (2014). Amyloid and its association with default network integrity in Alzheimer's disease. Human brain mapping, 35(3), 779-791. https://doi.org/10.1002/hbm.22213

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title = "Amyloid and its association with default network integrity in Alzheimer's disease",

abstract = "The purpose of this study was to investigate the association between functional connectivity and beta-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN. Hum Brain Mapp 35:779-791, 2014. (c) 2012 Wiley Periodicals, Inc",

author = "S.M. Adriaanse and E.J. Sanz-Arigita and M.A.A. Binnewijzend and R. Ossenkoppele and N. Tolboom and {van Assema}, D.M.E. and A.M. Wink and R. Boellaard and M.M. Yaqub and A.D. Windhorst and {van der Flier}, W.M. and P. Scheltens and A.A. Lammertsma and S.A.R.B. Rombouts and F. Barkhof and {van Berckel}, B.N.M.",

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Adriaanse, SM, Sanz-Arigita, EJ, Binnewijzend, MAA, Ossenkoppele, R, Tolboom, N, van Assema, DME, Wink, AM , Boellaard, R , Yaqub, MM , Windhorst, AD , van der Flier, WM , Scheltens, P , Lammertsma, AA, Rombouts, SARB, Barkhof, F & van Berckel, BNM 2014, 'Amyloid and its association with default network integrity in Alzheimer's disease', Human brain mapping, vol. 35, no. 3, pp. 779-791. https://doi.org/10.1002/hbm.22213

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AU - Adriaanse, S.M.

AU - Sanz-Arigita, E.J.

AU - Binnewijzend, M.A.A.

AU - Ossenkoppele, R.

AU - Tolboom, N.

AU - van Assema, D.M.E.

AU - Wink, A.M.

AU - Boellaard, R.

AU - Yaqub, M.M.

AU - Windhorst, A.D.

AU - van der Flier, W.M.

AU - Scheltens, P.

AU - Lammertsma, A.A.

AU - Rombouts, S.A.R.B.

AU - Barkhof, F.

AU - van Berckel, B.N.M.

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