An IL-8 gene promoter polymorphism is associated with the risk of the development of AIDS-related Kaposi's sarcoma: a case-control study

Antoinette C. van der Kuyl; Abeltje M. Polstra; Gerrit Jan Weverling; Fokla Zorgdrager; Remco van den Burg; Marion Cornelissen

doi:https://doi.org/10.1097/00002030-200405210-00016

An IL-8 gene promoter polymorphism is associated with the risk of the development of AIDS-related Kaposi's sarcoma: a case-control study

Antoinette C. van der Kuyl, Abeltje M. Polstra, Gerrit Jan Weverling, Fokla Zorgdrager, Remco van den Burg, Marion Cornelissen

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

In a case-control study, we studied the effect of a single nucleotide polymorphism in the IL-8 promoter on the risk of the development of AIDS-related Kaposi's sarcoma (KS). KS developed in 46% of individuals with the TT genotype and in 66% of AA/AT genotypes (P = 0.038). Patients with the TT genotype were rarely affected with visceral KS (7% versus 36%; P = 0.06), which suggests that carriers of the TT genotype are protected from (severe) KS development

Original language	English
Pages (from-to)	1206-1208
Journal	AIDS (London, England)
Volume	18
Issue number	8
DOIs	https://doi.org/10.1097/00002030-200405210-00016
Publication status	Published - 2004

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https://doi.org/10.1097/00002030-200405210-00016

Cite this

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title = "An IL-8 gene promoter polymorphism is associated with the risk of the development of AIDS-related Kaposi's sarcoma: a case-control study",

abstract = "In a case-control study, we studied the effect of a single nucleotide polymorphism in the IL-8 promoter on the risk of the development of AIDS-related Kaposi's sarcoma (KS). KS developed in 46% of individuals with the TT genotype and in 66% of AA/AT genotypes (P = 0.038). Patients with the TT genotype were rarely affected with visceral KS (7% versus 36%; P = 0.06), which suggests that carriers of the TT genotype are protected from (severe) KS development",

author = "{van der Kuyl}, {Antoinette C.} and Polstra, {Abeltje M.} and Weverling, {Gerrit Jan} and Fokla Zorgdrager and {van den Burg}, Remco and Marion Cornelissen",

year = "2004",

doi = "https://doi.org/10.1097/00002030-200405210-00016",

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AU - van der Kuyl, Antoinette C.

AU - Polstra, Abeltje M.

AU - Weverling, Gerrit Jan

AU - Zorgdrager, Fokla

AU - van den Burg, Remco

AU - Cornelissen, Marion

PY - 2004

Y1 - 2004

N2 - In a case-control study, we studied the effect of a single nucleotide polymorphism in the IL-8 promoter on the risk of the development of AIDS-related Kaposi's sarcoma (KS). KS developed in 46% of individuals with the TT genotype and in 66% of AA/AT genotypes (P = 0.038). Patients with the TT genotype were rarely affected with visceral KS (7% versus 36%; P = 0.06), which suggests that carriers of the TT genotype are protected from (severe) KS development

AB - In a case-control study, we studied the effect of a single nucleotide polymorphism in the IL-8 promoter on the risk of the development of AIDS-related Kaposi's sarcoma (KS). KS developed in 46% of individuals with the TT genotype and in 66% of AA/AT genotypes (P = 0.038). Patients with the TT genotype were rarely affected with visceral KS (7% versus 36%; P = 0.06), which suggests that carriers of the TT genotype are protected from (severe) KS development

U2 - https://doi.org/10.1097/00002030-200405210-00016

DO - https://doi.org/10.1097/00002030-200405210-00016

M3 - Article

C2 - 15166538

SN - 0269-9370

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JO - AIDS (London, England)

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