TY - JOUR
T1 - Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis
AU - Vos, Catharina M. P.
AU - Geurts, Jeroen J. G.
AU - Montagne, Lisette
AU - van Haastert, Elise S.
AU - Bö, Lars
AU - van der Valk, Paul
AU - Barkhof, Frederik
AU - de Vries, Helga E.
PY - 2005
Y1 - 2005
N2 - Postmortem MRI-guided tissue sampling significantly enhances the yield of MS lesions in autopsy material, but so far it is unknown whether abnormalities concur with blood-brain barrier alterations. Here we sampled MS lesions with focal and diffuse abnormalities (diffusely abnormal white matter; DAWM) on MRI; both were coupled to the presence of MS lesions upon neuropathological examination. Extravascular distribution of fibrinogen, indicating BBB disturbance, was observed in so-called (p)reactive lesions that reflect discrete areas of microglial activation without demyelination within an otherwise normal appearing white matter. Leakage became more extensive in active demyelinating MS lesions to chronic inactive lesions. An enlargement of the perivascular (Virchow-Robin) space containing infiltrated leukocytes was associated with both DAWM and focal abnormalities on postmortem MRI. This study shows for the first time that in MS brain changes in the vasculature take place not only in focal lesions but also in DAWM as detected by postmortem MRI. © 2005 Elsevier Inc. All rights reserved.
AB - Postmortem MRI-guided tissue sampling significantly enhances the yield of MS lesions in autopsy material, but so far it is unknown whether abnormalities concur with blood-brain barrier alterations. Here we sampled MS lesions with focal and diffuse abnormalities (diffusely abnormal white matter; DAWM) on MRI; both were coupled to the presence of MS lesions upon neuropathological examination. Extravascular distribution of fibrinogen, indicating BBB disturbance, was observed in so-called (p)reactive lesions that reflect discrete areas of microglial activation without demyelination within an otherwise normal appearing white matter. Leakage became more extensive in active demyelinating MS lesions to chronic inactive lesions. An enlargement of the perivascular (Virchow-Robin) space containing infiltrated leukocytes was associated with both DAWM and focal abnormalities on postmortem MRI. This study shows for the first time that in MS brain changes in the vasculature take place not only in focal lesions but also in DAWM as detected by postmortem MRI. © 2005 Elsevier Inc. All rights reserved.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=27744504478&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/16039866
U2 - https://doi.org/10.1016/j.nbd.2005.06.012
DO - https://doi.org/10.1016/j.nbd.2005.06.012
M3 - Article
C2 - 16039866
SN - 0969-9961
VL - 20
SP - 953
EP - 960
JO - Neurobiology of Disease
JF - Neurobiology of Disease
IS - 3
ER -