Cerebral perfusion in the predementia stages of Alzheimer's disease

Maja A. A. Binnewijzend; Marije R. Benedictus; Joost P. A. Kuijer; Wiesje M. van der Flier; Charlotte E. Teunissen; Niels D. Prins; Mike P. Wattjes; Bart N. M. van Berckel; Philip Scheltens; Frederik Barkhof

doi:https://doi.org/10.1007/s00330-015-3834-9

Cerebral perfusion in the predementia stages of Alzheimer's disease

Maja A. A. Binnewijzend, Marije R. Benedictus, Joost P. A. Kuijer, Wiesje M. van der Flier, Charlotte E. Teunissen, Niels D. Prins, Mike P. Wattjes, Bart N. M. van Berckel, Philip Scheltens, Frederik Barkhof

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Abstract

Objectives To investigate arterial spin-labelling (ASL) cerebral blood flow (CBF) changes in predementia stages of Alzheimer’s disease (AD). Methods Data were obtained from 177 patients with subjective complaints, mild cognitive impairment and AD from the Amsterdam Dementia Cohort. AD stages were based on diagnosis and cerebrospinal fluid biomarkers amyloid-β (Aβ) and total-tau (tau). General-linear-models were used to assess relationships between AD stages and total and regional CBF, correcting for age and sex. Results Decreasing CBF was related to more advanced AD stages in all supratentorial regions (p for trend < 0.05). Post-hoc testing revealed that CBF was lower in AD compared to controls and stage-1 predementia patients (i.e. abnormal Aβ and normal tau) in temporal and parietal regions, and compared to stage-2 predementia patients (i.e. abnormal Aβ and tau) in temporal regions. CBF values of stage-2 predementia patients were numerically in between those of stage-1 predementia patients and AD. Conclusion The continuing decrease of CBF along the continuum of AD indicates the potential of ASL-CBF as a measure for disease progression.

Original language	English
Pages (from-to)	506-514
Journal	European Radiology
Volume	26
Issue number	2
DOIs	https://doi.org/10.1007/s00330-015-3834-9
Publication status	Published - Feb 2016

Keywords

Alzheimer's disease
Arterial spin-labelling MRI
Cerebral blood flow/cerebral perfusion
Disease progression
Prodromal AD

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https://doi.org/10.1007/s00330-015-3834-9

Cite this

@article{d126ebe7d57f478e970f57cc870bbfcd,

title = "Cerebral perfusion in the predementia stages of Alzheimer's disease",

abstract = "Objectives To investigate arterial spin-labelling (ASL) cerebral blood flow (CBF) changes in predementia stages of Alzheimer{\textquoteright}s disease (AD). Methods Data were obtained from 177 patients with subjective complaints, mild cognitive impairment and AD from the Amsterdam Dementia Cohort. AD stages were based on diagnosis and cerebrospinal fluid biomarkers amyloid-β (Aβ) and total-tau (tau). General-linear-models were used to assess relationships between AD stages and total and regional CBF, correcting for age and sex. Results Decreasing CBF was related to more advanced AD stages in all supratentorial regions (p for trend < 0.05). Post-hoc testing revealed that CBF was lower in AD compared to controls and stage-1 predementia patients (i.e. abnormal Aβ and normal tau) in temporal and parietal regions, and compared to stage-2 predementia patients (i.e. abnormal Aβ and tau) in temporal regions. CBF values of stage-2 predementia patients were numerically in between those of stage-1 predementia patients and AD. Conclusion The continuing decrease of CBF along the continuum of AD indicates the potential of ASL-CBF as a measure for disease progression.",

keywords = "Alzheimer's disease, Arterial spin-labelling MRI, Cerebral blood flow/cerebral perfusion, Disease progression, Prodromal AD",

author = "Binnewijzend, {Maja A. A.} and Benedictus, {Marije R.} and Kuijer, {Joost P. A.} and {van der Flier}, {Wiesje M.} and Teunissen, {Charlotte E.} and Prins, {Niels D.} and Wattjes, {Mike P.} and {van Berckel}, {Bart N. M.} and Philip Scheltens and Frederik Barkhof",

year = "2016",

month = feb,

doi = "https://doi.org/10.1007/s00330-015-3834-9",

language = "English",

volume = "26",

pages = "506--514",

journal = "European Radiology",

issn = "0938-7994",

publisher = "Springer Verlag",

number = "2",

}

TY - JOUR

T1 - Cerebral perfusion in the predementia stages of Alzheimer's disease

AU - Binnewijzend, Maja A. A.

AU - Benedictus, Marije R.

AU - Kuijer, Joost P. A.

AU - van der Flier, Wiesje M.

AU - Teunissen, Charlotte E.

AU - Prins, Niels D.

AU - Wattjes, Mike P.

AU - van Berckel, Bart N. M.

AU - Scheltens, Philip

AU - Barkhof, Frederik

PY - 2016/2

Y1 - 2016/2

N2 - Objectives To investigate arterial spin-labelling (ASL) cerebral blood flow (CBF) changes in predementia stages of Alzheimer’s disease (AD). Methods Data were obtained from 177 patients with subjective complaints, mild cognitive impairment and AD from the Amsterdam Dementia Cohort. AD stages were based on diagnosis and cerebrospinal fluid biomarkers amyloid-β (Aβ) and total-tau (tau). General-linear-models were used to assess relationships between AD stages and total and regional CBF, correcting for age and sex. Results Decreasing CBF was related to more advanced AD stages in all supratentorial regions (p for trend < 0.05). Post-hoc testing revealed that CBF was lower in AD compared to controls and stage-1 predementia patients (i.e. abnormal Aβ and normal tau) in temporal and parietal regions, and compared to stage-2 predementia patients (i.e. abnormal Aβ and tau) in temporal regions. CBF values of stage-2 predementia patients were numerically in between those of stage-1 predementia patients and AD. Conclusion The continuing decrease of CBF along the continuum of AD indicates the potential of ASL-CBF as a measure for disease progression.

AB - Objectives To investigate arterial spin-labelling (ASL) cerebral blood flow (CBF) changes in predementia stages of Alzheimer’s disease (AD). Methods Data were obtained from 177 patients with subjective complaints, mild cognitive impairment and AD from the Amsterdam Dementia Cohort. AD stages were based on diagnosis and cerebrospinal fluid biomarkers amyloid-β (Aβ) and total-tau (tau). General-linear-models were used to assess relationships between AD stages and total and regional CBF, correcting for age and sex. Results Decreasing CBF was related to more advanced AD stages in all supratentorial regions (p for trend < 0.05). Post-hoc testing revealed that CBF was lower in AD compared to controls and stage-1 predementia patients (i.e. abnormal Aβ and normal tau) in temporal and parietal regions, and compared to stage-2 predementia patients (i.e. abnormal Aβ and tau) in temporal regions. CBF values of stage-2 predementia patients were numerically in between those of stage-1 predementia patients and AD. Conclusion The continuing decrease of CBF along the continuum of AD indicates the potential of ASL-CBF as a measure for disease progression.

KW - Alzheimer's disease

KW - Arterial spin-labelling MRI

KW - Cerebral blood flow/cerebral perfusion

KW - Disease progression

KW - Prodromal AD

U2 - https://doi.org/10.1007/s00330-015-3834-9

DO - https://doi.org/10.1007/s00330-015-3834-9

M3 - Article

C2 - 26040647

SN - 0938-7994

VL - 26

SP - 506

EP - 514

JO - European Radiology

JF - European Radiology

IS - 2

ER -