TY - JOUR
T1 - Clusterin Levels in Plasma Predict Cognitive Decline and Progression to Alzheimer's Disease
AU - Jongbloed, W.
AU - van Dijk, K.D.
AU - Mulder, S.D.
AU - van de Berg, W.D.J.
AU - Blankenstein, M.A.
AU - van der Flier, W.M.
AU - Veerhuis, R.
PY - 2015
Y1 - 2015
N2 - Background: Increased clusterin levels have been reported in brain, cerebrospinal fluid (CSF), and plasma of Alzheimer's disease (AD) patients. Because changes are also observed in mild cognitive impairment (MCI), a possible relationship between clusterin levels and early neurodegenerative changes in AD was suggested. Objectives: To determine whether clusterin concentrations could 1) serve as a diagnostic marker for AD, 2) predict disease progression in MCI, and 3) correlate with AD-biomarkers. Methods: Clusterin levels in CSF and plasma, as well as AD biomarker levels of Aβ
AB - Background: Increased clusterin levels have been reported in brain, cerebrospinal fluid (CSF), and plasma of Alzheimer's disease (AD) patients. Because changes are also observed in mild cognitive impairment (MCI), a possible relationship between clusterin levels and early neurodegenerative changes in AD was suggested. Objectives: To determine whether clusterin concentrations could 1) serve as a diagnostic marker for AD, 2) predict disease progression in MCI, and 3) correlate with AD-biomarkers. Methods: Clusterin levels in CSF and plasma, as well as AD biomarker levels of Aβ
U2 - https://doi.org/10.3233/JAD-150036
DO - https://doi.org/10.3233/JAD-150036
M3 - Article
C2 - 26402636
SN - 1387-2877
VL - 46
SP - 1103
EP - 1110
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 4
ER -
