Combination antiretroviral therapy failure and HIV super-infection

Daniela Bezemer; Ard van Sighem; Frank de Wolf; Marion Cornelissen; Antoinette C. van der Kuyl; Suzanne Jurriaans; Lia van der Hoek; Maria Prins; Roel A. Coutinho; Vladimir V. Lukashov

doi:https://doi.org/10.1097/QAD.0b013e3282f37489

Combination antiretroviral therapy failure and HIV super-infection

Daniela Bezemer, Ard van Sighem, Frank de Wolf, Marion Cornelissen, Antoinette C. van der Kuyl, Suzanne Jurriaans, Lia van der Hoek, Maria Prins, Roel A. Coutinho, Vladimir V. Lukashov

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

In addition to development or selection of resistance, failure to continuously suppress HIV-1 production while still using initially effective combination antiretroviral therapy (cART) may result from super-infection with a drug-resistant strain. Both transmission of drug resistant HIV and super-infection have been demonstrated. We analysed HIV pol genes obtained before start of initially successful cART and during failure while still on cART in 101 patients. Difference in precART and cART failure sequences were explained by evolution and not by super-infection

Original language	English
Pages (from-to)	309-311
Journal	AIDS (London, England)
Volume	22
Issue number	2
DOIs	https://doi.org/10.1097/QAD.0b013e3282f37489
Publication status	Published - 2008

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https://doi.org/10.1097/QAD.0b013e3282f37489

Cite this

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title = "Combination antiretroviral therapy failure and HIV super-infection",

abstract = "In addition to development or selection of resistance, failure to continuously suppress HIV-1 production while still using initially effective combination antiretroviral therapy (cART) may result from super-infection with a drug-resistant strain. Both transmission of drug resistant HIV and super-infection have been demonstrated. We analysed HIV pol genes obtained before start of initially successful cART and during failure while still on cART in 101 patients. Difference in precART and cART failure sequences were explained by evolution and not by super-infection",

author = "Daniela Bezemer and {van Sighem}, Ard and {de Wolf}, Frank and Marion Cornelissen and {van der Kuyl}, {Antoinette C.} and Suzanne Jurriaans and {van der Hoek}, Lia and Maria Prins and Coutinho, {Roel A.} and Lukashov, {Vladimir V.}",

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T1 - Combination antiretroviral therapy failure and HIV super-infection

AU - Bezemer, Daniela

AU - van Sighem, Ard

AU - de Wolf, Frank

AU - Cornelissen, Marion

AU - van der Kuyl, Antoinette C.

AU - Jurriaans, Suzanne

AU - van der Hoek, Lia

AU - Prins, Maria

AU - Coutinho, Roel A.

AU - Lukashov, Vladimir V.

PY - 2008

Y1 - 2008

N2 - In addition to development or selection of resistance, failure to continuously suppress HIV-1 production while still using initially effective combination antiretroviral therapy (cART) may result from super-infection with a drug-resistant strain. Both transmission of drug resistant HIV and super-infection have been demonstrated. We analysed HIV pol genes obtained before start of initially successful cART and during failure while still on cART in 101 patients. Difference in precART and cART failure sequences were explained by evolution and not by super-infection

AB - In addition to development or selection of resistance, failure to continuously suppress HIV-1 production while still using initially effective combination antiretroviral therapy (cART) may result from super-infection with a drug-resistant strain. Both transmission of drug resistant HIV and super-infection have been demonstrated. We analysed HIV pol genes obtained before start of initially successful cART and during failure while still on cART in 101 patients. Difference in precART and cART failure sequences were explained by evolution and not by super-infection

U2 - https://doi.org/10.1097/QAD.0b013e3282f37489

DO - https://doi.org/10.1097/QAD.0b013e3282f37489

M3 - Article

C2 - 18097235

SN - 0269-9370

VL - 22

SP - 309

EP - 311

JO - AIDS (London, England)

JF - AIDS (London, England)

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ER -