Comorbid amyloid-β pathology affects clinical and imaging features in VCD

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INTRODUCTION: To date, the clinical relevance of comorbid amyloid-β (Aβ) pathology in patients with vascular cognitive disorders (VCD) is largely unknown.

METHODS: We included 218 VCD patients with available cerebrospinal fluid Aβ42 levels. Patients were divided into Aβ+ mild-VCD (n = 84), Aβ- mild-VCD (n = 68), Aβ+ major-VCD (n = 31), and Aβ- major-VCD (n = 35). We measured depression with the Geriatric Depression Scale, cognition with a neuropsychological test battery and derived white matter hyperintensities (WMH) and gray matter atrophy from MRI.

RESULTS: Aβ- patients showed more depressive symptoms than Aβ+. In the major-VCD group, Aβ- patients performed worse on attention (P = .02) and executive functioning (P = .008) than Aβ+. We found no cognitive differences in patients with mild VCD. In the mild-VCD group, Aβ- patients had more WMH than Aβ+ patients, whereas conversely, in the major-VCD group, Aβ+ patients had more WMH. Atrophy patterns did not differ between Aβ+ and Aβ- VCD group.

DISCUSSION: Comorbid Aβ pathology affects the manifestation of VCD, but effects differ by severity of VCD.

Original languageEnglish
Pages (from-to)354-364
Number of pages11
JournalAlzheimers & Dementia
Issue number2
Early online date27 Nov 2019
Publication statusPublished - 1 Feb 2020


  • Amyloid-β
  • Cognition
  • Gray matter atrophy
  • MRI
  • Vascular cognitive disorders
  • Vascular dementia
  • White matter hyperintensities

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