TY - JOUR
T1 - Dectin-1 deficiency does not affect atherosclerosis development in mice
AU - Szilagyi, Katka
AU - Gijbels, Marion J. J.
AU - van der Velden, Saskia
AU - Heinsbroek, Sigrid E. M.
AU - Kraal, Georg
AU - de Winther, Menno P. J.
AU - van den Berg, Timo K.
PY - 2015
Y1 - 2015
N2 - Recent data suggest the involvement of dectin-1 in atherosclerosis through regulation of local reactive oxygen species production. The aim of the current study was to assess the effect of dectin-1 deficiency on atherosclerotic plaque development. Using immunohistochemistry dectin-1 expression was observed on foamy macrophages in atherosclerotic lesions in mice. Following lethal irradiation LDLR(-/-) mice were reconstituted with bone marrow from either wild type or dectin-1(-/-) mice. After recovery, mice were fed a high fat diet for 9 weeks and atherosclerotic lesions were analyzed. Overall, we found no significant differences in plaque size or severity between the groups. Also no differences were observed in granulocyte or macrophage composition of the plaques or in the ability to produce reactive oxygen species by macrophages from both groups. Dectin-1 is dispensable for the development of atherosclerotic lesions in mice
AB - Recent data suggest the involvement of dectin-1 in atherosclerosis through regulation of local reactive oxygen species production. The aim of the current study was to assess the effect of dectin-1 deficiency on atherosclerotic plaque development. Using immunohistochemistry dectin-1 expression was observed on foamy macrophages in atherosclerotic lesions in mice. Following lethal irradiation LDLR(-/-) mice were reconstituted with bone marrow from either wild type or dectin-1(-/-) mice. After recovery, mice were fed a high fat diet for 9 weeks and atherosclerotic lesions were analyzed. Overall, we found no significant differences in plaque size or severity between the groups. Also no differences were observed in granulocyte or macrophage composition of the plaques or in the ability to produce reactive oxygen species by macrophages from both groups. Dectin-1 is dispensable for the development of atherosclerotic lesions in mice
U2 - https://doi.org/10.1016/j.atherosclerosis.2015.02.005
DO - https://doi.org/10.1016/j.atherosclerosis.2015.02.005
M3 - Article
C2 - 25682030
SN - 0021-9150
VL - 239
SP - 318
EP - 321
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -