TY - JOUR
T1 - Dementia prevention in memory clinics
T2 - recommendations from the European task force for brain health services
AU - Frisoni, Giovanni B.
AU - Altomare, Daniele
AU - Ribaldi, Federica
AU - Villain, Nicolas
AU - Brayne, Carol
AU - Mukadam, Naaheed
AU - Abramowicz, Marc
AU - Barkhof, Frederik
AU - Berthier, Marcelo
AU - Bieler-Aeschlimann, Melanie
AU - Blennow, Kaj
AU - Brioschi Guevara, Andrea
AU - Carrera, Emmanuel
AU - Chételat, Gaël
AU - Csajka, Chantal
AU - Demonet, Jean-François
AU - Dodich, Alessandra
AU - Garibotto, Valentina
AU - Georges, Jean
AU - Hurst, Samia
AU - Jessen, Frank
AU - Kivipelto, Miia
AU - Llewellyn, David J.
AU - McWhirter, Laura
AU - Milne, Richard
AU - Minguillón, Carolina
AU - Miniussi, Carlo
AU - Molinuevo, José Luis
AU - Nilsson, Peter M.
AU - Noyce, Alastair
AU - Ranson, Janice M.
AU - Grau-Rivera, Oriol
AU - Schott, Jonathan M.
AU - Solomon, Alina
AU - Stephen, Ruth
AU - van der Flier, Wiesje
AU - van Duijn, Cornelia
AU - Vellas, Bruno
AU - Visser, Leonie N. C.
AU - Cummings, Jeffrey L.
AU - Scheltens, Philip
AU - Ritchie, Craig
AU - Dubois, Bruno
N1 - Funding Information: The workshop of June 15-16 2020 was funded in part by the Swiss National Science Foundation (SNSF) under grant agreement IZSEZ0_193593 . The SNSF had no role in the development of the concepts and ideas illustrated in the present manuscript nor in its writing and in the decision to submit the paper for publication. None of the coauthors received any compensation related to the workshop or the writing of the scientific manuscripts that ensued, including the present one. All authors had full access to the data in the study, and they accept responsibility to submit for publication. Publisher Copyright: © 2022 The Author(s)
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence supports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk factors including brain pathology, and risk stratification, (ii) risk communication with ad-hoc protocols, (iii) risk reduction with multi-domain interventions, and (iv) cognitive enhancement with cognitive and physical training. A roadmap is proposed for concept validation and ensuing clinical deployment.
AB - Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence supports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk factors including brain pathology, and risk stratification, (ii) risk communication with ad-hoc protocols, (iii) risk reduction with multi-domain interventions, and (iv) cognitive enhancement with cognitive and physical training. A roadmap is proposed for concept validation and ensuing clinical deployment.
KW - Cognitive enhancement
KW - Dementia
KW - Memory clinic
KW - Prevention
KW - Risk assessment
KW - Risk communication
KW - Risk reduction
UR - http://www.scopus.com/inward/record.url?scp=85148701592&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.lanepe.2022.100576
DO - https://doi.org/10.1016/j.lanepe.2022.100576
M3 - Review article
C2 - 36895446
SN - 2666-7762
VL - 26
JO - The Lancet Regional Health - Europe
JF - The Lancet Regional Health - Europe
M1 - 100576
ER -