TY - JOUR
T1 - Direct comparison of [11C] choline and [18F] FET PET to detect glioma infiltration: a diagnostic accuracy study in eight patients
T2 - a diagnostic accuracy study in eight patients
AU - Verburg, Niels
AU - Koopman, Thomas
AU - Yaqub, Maqsood
AU - Hoekstra, Otto S.
AU - Lammertsma, Adriaan A.
AU - Schwarte, Lothar A.
AU - Barkhof, Frederik
AU - Pouwels, Petra J. W.
AU - Heimans, Jan J.
AU - Reijneveld, Jaap C.
AU - Rozemuller, Annemieke J. M.
AU - Vandertop, William P.
AU - Wesseling, Pieter
AU - Boellaard, Ronald
AU - de Witt Hamer, Philip C.
PY - 2019/6/28
Y1 - 2019/6/28
N2 - Background: Positron emission tomography (PET) is increasingly used to guide local treatment in glioma. The purpose of this study was a direct comparison of two potential tracers for detecting glioma infiltration, O-(2-[18F]-fluoroethyl)-l-tyrosine ([18F] FET) and [11C] choline. Methods: Eight consecutive patients with newly diagnosed diffuse glioma underwent dynamic [11C] choline and [18F] FET PET scans. Preceding craniotomy, multiple stereotactic biopsies were obtained from regions inside and outside PET abnormalities. Biopsies were assessed independently for tumour presence by two neuropathologists. Imaging measurements were derived at the biopsy locations from 10 to 40 min [11C] choline and 20–40, 40–60 and 60–90 min [18F] FET intervals, as standardized uptake value (SUV) and tumour-to-brain ratio (TBR). Diagnostic accuracies of both tracers were compared using receiver operating characteristic analysis and generalized linear mixed modelling with consensus histopathological assessment as reference. Results: Of the 74 biopsies, 54 (73%) contained tumour. [11C] choline SUV and [18F] FET SUV and TBR at all intervals were higher in tumour than in normal samples. For [18F] FET, the diagnostic accuracy of TBR was higher than that of SUV for intervals 40–60 min (area under the curve: 0.88 versus 0.81, p = 0.026) and 60–90 min (0.90 versus 0.81, p = 0.047). The diagnostic accuracy of [18F] FET TBR 60–90 min was higher than that of [11C] choline SUV 20–40 min (0.87 versus 0.67, p = 0.005). Conclusions: [18F] FET was more accurate than [11C] choline for detecting glioma infiltration. Highest accuracy was found for [18F] FET TBR for the interval 60–90 min post-injection.
AB - Background: Positron emission tomography (PET) is increasingly used to guide local treatment in glioma. The purpose of this study was a direct comparison of two potential tracers for detecting glioma infiltration, O-(2-[18F]-fluoroethyl)-l-tyrosine ([18F] FET) and [11C] choline. Methods: Eight consecutive patients with newly diagnosed diffuse glioma underwent dynamic [11C] choline and [18F] FET PET scans. Preceding craniotomy, multiple stereotactic biopsies were obtained from regions inside and outside PET abnormalities. Biopsies were assessed independently for tumour presence by two neuropathologists. Imaging measurements were derived at the biopsy locations from 10 to 40 min [11C] choline and 20–40, 40–60 and 60–90 min [18F] FET intervals, as standardized uptake value (SUV) and tumour-to-brain ratio (TBR). Diagnostic accuracies of both tracers were compared using receiver operating characteristic analysis and generalized linear mixed modelling with consensus histopathological assessment as reference. Results: Of the 74 biopsies, 54 (73%) contained tumour. [11C] choline SUV and [18F] FET SUV and TBR at all intervals were higher in tumour than in normal samples. For [18F] FET, the diagnostic accuracy of TBR was higher than that of SUV for intervals 40–60 min (area under the curve: 0.88 versus 0.81, p = 0.026) and 60–90 min (0.90 versus 0.81, p = 0.047). The diagnostic accuracy of [18F] FET TBR 60–90 min was higher than that of [11C] choline SUV 20–40 min (0.87 versus 0.67, p = 0.005). Conclusions: [18F] FET was more accurate than [11C] choline for detecting glioma infiltration. Highest accuracy was found for [18F] FET TBR for the interval 60–90 min post-injection.
KW - Biopsy
KW - Diagnostic accuracy
KW - Glioma
KW - [ C] choline
KW - [ F] FET
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85068119232&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31254208
UR - http://www.scopus.com/inward/record.url?scp=85068119232&partnerID=8YFLogxK
U2 - https://doi.org/10.1186/s13550-019-0523-8
DO - https://doi.org/10.1186/s13550-019-0523-8
M3 - Article
C2 - 31254208
SN - 2191-219X
VL - 9
SP - 57
JO - EJNMMI Research
JF - EJNMMI Research
IS - 1
M1 - 57
ER -