TY - JOUR
T1 - Power in GWAS: lifting the curse of the clinical cut-off
AU - van der Sluis, S.
AU - Posthuma, D.
AU - Nivard, M.G.
AU - Verhage, M.
AU - Dolan, C.V.
PY - 2013
Y1 - 2013
N2 - Although genome-wide association studies (GWAS), in general, facilitated important discovery of new biological knowledge about diseases,1, 2, 3 identified variants for psychiatric disorders explain little variation, and insight into the role of genes in highly heritable psychiatric traits remains poor.4, 5 Low statistical power is seen as the main reason for the failure to locate more variants, and has resulted in a call for larger samples. Our present study, however, shows that better use of (available) phenotypic information can also increase power considerably.
AB - Although genome-wide association studies (GWAS), in general, facilitated important discovery of new biological knowledge about diseases,1, 2, 3 identified variants for psychiatric disorders explain little variation, and insight into the role of genes in highly heritable psychiatric traits remains poor.4, 5 Low statistical power is seen as the main reason for the failure to locate more variants, and has resulted in a call for larger samples. Our present study, however, shows that better use of (available) phenotypic information can also increase power considerably.
U2 - https://doi.org/10.1038/mp.2012.65
DO - https://doi.org/10.1038/mp.2012.65
M3 - Article
C2 - 22614290
SN - 1359-4184
VL - 18
SP - 2
EP - 3
JO - Molecular psychiatry
JF - Molecular psychiatry
IS - 1
ER -