TY - JOUR
T1 - Expression of adhesion molecules on peripheral lymphocytes predicts future lesion development in MS
AU - Eikelenboom, M.J.
AU - Killestein, J.
AU - Izeboud, T
AU - Kalkers, N.F.
AU - Baars, P.A.
AU - van Lier, RA
AU - Barkhof, F.
AU - Uitdehaag, B.M.J.
AU - Polman, C.H.
AU - van Lier, Rene A. W.
PY - 2005
Y1 - 2005
N2 - The expression of adhesion molecules (alpha4beta1-integrin, LFA-1, ICAM-1) on T cells, measured by flow cytometry, was compared in different subtypes of multiple sclerosis (MS) and related to future lesion development as seen as delta T1 and T2 lesion load per year on magnetic resonance imaging (MRI). LFA-1 and alpha4beta1-integrin showed higher expression on CD4 and CD8 T lymphocytes in the secondary progressive compared to the relapsing-remitting (CD4: p <0.01, p=ns, p <0.05; CD8: p <0.001, p <0.001, p <0.001, respectively) and primary progressive MS phase (CD4: p <0.001, p <0.01, p <0.05; CD8: p <0.01, p <0.01, p <0.001, respectively). The adhesion molecule expression of alpha4- (r=0.31; p <0.05) and beta1-integrin (r=0.38; p <0.01) on CD4+ cells and of LFA-1beta on both CD4+ and CD8+ (r=0.28, p <0.05) and r=0.29; p <0.05, respectively) cells was significantly related to increase in T2 lesion load. Our study provides further evidence for the involvement of integrins in lesion development, shown as T2 lesions on MRI in MS
AB - The expression of adhesion molecules (alpha4beta1-integrin, LFA-1, ICAM-1) on T cells, measured by flow cytometry, was compared in different subtypes of multiple sclerosis (MS) and related to future lesion development as seen as delta T1 and T2 lesion load per year on magnetic resonance imaging (MRI). LFA-1 and alpha4beta1-integrin showed higher expression on CD4 and CD8 T lymphocytes in the secondary progressive compared to the relapsing-remitting (CD4: p <0.01, p=ns, p <0.05; CD8: p <0.001, p <0.001, p <0.001, respectively) and primary progressive MS phase (CD4: p <0.001, p <0.01, p <0.05; CD8: p <0.01, p <0.01, p <0.001, respectively). The adhesion molecule expression of alpha4- (r=0.31; p <0.05) and beta1-integrin (r=0.38; p <0.01) on CD4+ cells and of LFA-1beta on both CD4+ and CD8+ (r=0.28, p <0.05) and r=0.29; p <0.05, respectively) cells was significantly related to increase in T2 lesion load. Our study provides further evidence for the involvement of integrins in lesion development, shown as T2 lesions on MRI in MS
U2 - https://doi.org/10.1016/j.jneuroim.2004.09.005
DO - https://doi.org/10.1016/j.jneuroim.2004.09.005
M3 - Article
C2 - 15589057
SN - 0165-5728
VL - 158
SP - 222
EP - 230
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -