Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder

Hamdi Mbarek; Yuri Milaneschi; Jouke-Jan Hottenga; Lannie Ligthart; Eco J C de Geus; Erik A Ehli; Gonneke Willemsen; Gareth E Davies; Jan H Smit; Dorret I Boomsma; Brenda W J H Penninx

doi:10.1017/thg.2017.30

Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder

Hamdi Mbarek, Yuri Milaneschi, Jouke-Jan Hottenga, Lannie Ligthart, Eco J C de Geus, Erik A Ehli, Gonneke Willemsen, Gareth E Davies, Jan H Smit, Dorret I Boomsma, Brenda W J H Penninx

Research output: Contribution to journal › Article › Academic › peer-review

23 Citations (Scopus)

Abstract

In 2009, the first genome-wide association study (GWAS) for major depressive disorder (MDD) highlighted an association with PCLO locus on chromosome 7, although not reaching genome-wide significance level. In the present study, we revisited the original GWAS after increasing the overall sample size and the number of interrogated SNPs. In an analysis comparing 1,942 cases with lifetime diagnosis of MDD and 4,565 controls, PCLO showed a genome-wide significant association with MDD at SNP (rs2715157, p = 2.91 × 10-8) and gene-based (p = 1.48 × 10-7) level. Our results confirm the potential role of the PCLO gene in MDD, which is worth further replication and functional studies.

Original language	English
Pages (from-to)	267-270
Number of pages	4
Journal	Twin research and human genetics
Volume	20
Issue number	4
Early online date	25 May 2017
DOIs	https://doi.org/10.1017/thg.2017.30
Publication status	Published - 1 Aug 2017

Keywords

Journal Article
PCLO
genetics
genome-wide association study
major depressive disorder

Cohort Studies

Netherlands Twin Register (NTR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://research.vu.nl/ws/files/299849838/Genome-wide-significance-for-pclo-as-a-gene-for-major-depressive-disorder.pdfLicence: Article 25fa Dutch Copyright Act

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title = "Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder",

abstract = "In 2009, the first genome-wide association study (GWAS) for major depressive disorder (MDD) highlighted an association with PCLO locus on chromosome 7, although not reaching genome-wide significance level. In the present study, we revisited the original GWAS after increasing the overall sample size and the number of interrogated SNPs. In an analysis comparing 1,942 cases with lifetime diagnosis of MDD and 4,565 controls, PCLO showed a genome-wide significant association with MDD at SNP (rs2715157, p = 2.91 × 10-8) and gene-based (p = 1.48 × 10-7) level. Our results confirm the potential role of the PCLO gene in MDD, which is worth further replication and functional studies.",

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AU - Milaneschi, Yuri

AU - Hottenga, Jouke-Jan

AU - Ligthart, Lannie

AU - de Geus, Eco J C

AU - Ehli, Erik A

AU - Willemsen, Gonneke

AU - Davies, Gareth E

AU - Smit, Jan H

AU - Boomsma, Dorret I

AU - Penninx, Brenda W J H

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N2 - In 2009, the first genome-wide association study (GWAS) for major depressive disorder (MDD) highlighted an association with PCLO locus on chromosome 7, although not reaching genome-wide significance level. In the present study, we revisited the original GWAS after increasing the overall sample size and the number of interrogated SNPs. In an analysis comparing 1,942 cases with lifetime diagnosis of MDD and 4,565 controls, PCLO showed a genome-wide significant association with MDD at SNP (rs2715157, p = 2.91 × 10-8) and gene-based (p = 1.48 × 10-7) level. Our results confirm the potential role of the PCLO gene in MDD, which is worth further replication and functional studies.

AB - In 2009, the first genome-wide association study (GWAS) for major depressive disorder (MDD) highlighted an association with PCLO locus on chromosome 7, although not reaching genome-wide significance level. In the present study, we revisited the original GWAS after increasing the overall sample size and the number of interrogated SNPs. In an analysis comparing 1,942 cases with lifetime diagnosis of MDD and 4,565 controls, PCLO showed a genome-wide significant association with MDD at SNP (rs2715157, p = 2.91 × 10-8) and gene-based (p = 1.48 × 10-7) level. Our results confirm the potential role of the PCLO gene in MDD, which is worth further replication and functional studies.

KW - Journal Article

KW - PCLO

KW - genetics

KW - genome-wide association study

KW - major depressive disorder

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Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder

Abstract

Keywords

Cohort Studies

UN SDGs

Access to Document

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