Health-related physical fitness in patients with multiple myeloma or lymphoma recently treated with autologous stem cell transplantation

Saskia Persoon, Marie José Kersten, Laurien M. Buffart, Griet Vander Slagmolen, Joke W. Baars, Otto Visser, Annelies Manenschijn, Frans Nollet, Mai J.M. Chinapaw

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)


Objectives We aimed to examine health-related physical fitness and its demographic and clinical correlates in patients recently treated with autologous stem cell transplantation. Design Cross-sectional study. Methods In 109 patients (multiple myeloma: n = 58, lymphoma: n = 51, median age: 55, range: 19–67 years) maximal exercise testing was conducted to assess cardiorespiratory fitness (VO2peak). Upper and lower extremity muscle strength were assessed with hand grip- and fixed dynamometry and body composition with whole body DXA scans. In addition, we assessed the patients’ demographic and clinical characteristics and examined whether they were associated with health-related physical fitness. Results VO2peak was 21.7 (5.5) mL/min/kg, 26% below reference values. Muscle strength was also reduced when compared with reference values (upper extremity: 90%, lower extremity: 80%) and 73% of our population was classified as overweight or obese. Being female and being older were significantly associated with a lower cardiorespiratory fitness (gender: β = −2.7, 95%CI = −4.6;−0.7 mL/min/kg; age: β = −0.2, 95%CI = −0.3;−0.1 mL/min/kg), upper (gender: β = −17.7, 95%CI = −20.1;−15.3 kg; age: β = −0.2, 95%CI = −0.3;−0.1 kg) and lower (gender: β = −58.3, 95%CI = −73.5;− 43.0 Nm; age: β = −1.7, 95%CI = −2.4;−1.1 Nm) extremity muscle strength. Patients who were non-smoking (β = −5.3, 95%CI = −8.7;−1.9), women (β = 7.2, 95%CI = 4.8;9.6) and diagnosed with multiple myeloma (β = 4.6, 95%CI = 2.2;6.9) had a higher percentage body fat. Conclusions The physical fitness deficits in this population indicate the need for targeted interventions. Trial registration Netherlands Trial Register - NTR2341

Original languageEnglish
Pages (from-to)116-122
Number of pages7
JournalJournal of Science and Medicine in Sport
Issue number2
Early online date2016
Publication statusPublished - 1 Feb 2017


  • Body composition
  • Exercise tolerance
  • Hematology
  • Muscle strength

Cite this