Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

Jenny M. Mjösberg; Sara Trifari; Natasha K. Crellin; Charlotte P. Peters; Cornelis M. van Drunen; Berber Piet; Wytske J. Fokkens; Tom Cupedo; Hergen Spits

doi:https://doi.org/10.1038/ni.2104

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

Jenny M. Mjösberg, Sara Trifari, Natasha K. Crellin, Charlotte P. Peters, Cornelis M. van Drunen, Berber Piet, Wytske J. Fokkens, Tom Cupedo, Hergen Spits

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Innate lymphoid cells (ILCs) are emerging as a family of effectors and regulators of innate immunity and tissue remodeling. Interleukin 22 (IL-22)- and IL-17-producing ILCs, which depend on the transcription factor RORγt, express CD127 (IL-7 receptor α-chain) and the natural killer cell marker CD161. Here we describe another lineage-negative CD127(+)CD161(+) ILC population found in humans that expressed the chemoattractant receptor CRTH2. These cells responded in vitro to IL-2 plus IL-25 and IL-33 by producing IL-13. CRTH2(+) ILCs were present in fetal and adult lung and gut. In fetal gut, these cells expressed IL-13 but not IL-17 or IL-22. There was enrichment for CRTH2(+) ILCs in nasal polyps of chronic rhinosinusitis, a typical type 2 inflammatory disease. Our data identify a unique type of human ILC that provides an innate source of T helper type 2 (T(H)2) cytokines

Original language	English
Pages (from-to)	1055-1062
Journal	Nature immunology
Volume	12
Issue number	11
DOIs	https://doi.org/10.1038/ni.2104
Publication status	Published - 2011

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https://doi.org/10.1038/ni.2104

Cite this

@article{988f72dbafba436c8a8aa54308d4575e,

title = "Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161",

abstract = "Innate lymphoid cells (ILCs) are emerging as a family of effectors and regulators of innate immunity and tissue remodeling. Interleukin 22 (IL-22)- and IL-17-producing ILCs, which depend on the transcription factor RORγt, express CD127 (IL-7 receptor α-chain) and the natural killer cell marker CD161. Here we describe another lineage-negative CD127(+)CD161(+) ILC population found in humans that expressed the chemoattractant receptor CRTH2. These cells responded in vitro to IL-2 plus IL-25 and IL-33 by producing IL-13. CRTH2(+) ILCs were present in fetal and adult lung and gut. In fetal gut, these cells expressed IL-13 but not IL-17 or IL-22. There was enrichment for CRTH2(+) ILCs in nasal polyps of chronic rhinosinusitis, a typical type 2 inflammatory disease. Our data identify a unique type of human ILC that provides an innate source of T helper type 2 (T(H)2) cytokines",

author = "Mj{\"o}sberg, {Jenny M.} and Sara Trifari and Crellin, {Natasha K.} and Peters, {Charlotte P.} and {van Drunen}, {Cornelis M.} and Berber Piet and Fokkens, {Wytske J.} and Tom Cupedo and Hergen Spits",

year = "2011",

doi = "https://doi.org/10.1038/ni.2104",

language = "English",

volume = "12",

pages = "1055--1062",

journal = "Nature immunology",

issn = "1529-2908",

publisher = "Nature Publishing Group",

number = "11",

}

TY - JOUR

T1 - Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

AU - Mjösberg, Jenny M.

AU - Trifari, Sara

AU - Crellin, Natasha K.

AU - Peters, Charlotte P.

AU - van Drunen, Cornelis M.

AU - Piet, Berber

AU - Fokkens, Wytske J.

AU - Cupedo, Tom

AU - Spits, Hergen

PY - 2011

Y1 - 2011

N2 - Innate lymphoid cells (ILCs) are emerging as a family of effectors and regulators of innate immunity and tissue remodeling. Interleukin 22 (IL-22)- and IL-17-producing ILCs, which depend on the transcription factor RORγt, express CD127 (IL-7 receptor α-chain) and the natural killer cell marker CD161. Here we describe another lineage-negative CD127(+)CD161(+) ILC population found in humans that expressed the chemoattractant receptor CRTH2. These cells responded in vitro to IL-2 plus IL-25 and IL-33 by producing IL-13. CRTH2(+) ILCs were present in fetal and adult lung and gut. In fetal gut, these cells expressed IL-13 but not IL-17 or IL-22. There was enrichment for CRTH2(+) ILCs in nasal polyps of chronic rhinosinusitis, a typical type 2 inflammatory disease. Our data identify a unique type of human ILC that provides an innate source of T helper type 2 (T(H)2) cytokines

AB - Innate lymphoid cells (ILCs) are emerging as a family of effectors and regulators of innate immunity and tissue remodeling. Interleukin 22 (IL-22)- and IL-17-producing ILCs, which depend on the transcription factor RORγt, express CD127 (IL-7 receptor α-chain) and the natural killer cell marker CD161. Here we describe another lineage-negative CD127(+)CD161(+) ILC population found in humans that expressed the chemoattractant receptor CRTH2. These cells responded in vitro to IL-2 plus IL-25 and IL-33 by producing IL-13. CRTH2(+) ILCs were present in fetal and adult lung and gut. In fetal gut, these cells expressed IL-13 but not IL-17 or IL-22. There was enrichment for CRTH2(+) ILCs in nasal polyps of chronic rhinosinusitis, a typical type 2 inflammatory disease. Our data identify a unique type of human ILC that provides an innate source of T helper type 2 (T(H)2) cytokines

U2 - https://doi.org/10.1038/ni.2104

DO - https://doi.org/10.1038/ni.2104

M3 - Article

C2 - 21909091

SN - 1529-2908

VL - 12

SP - 1055

EP - 1062

JO - Nature immunology

JF - Nature immunology

IS - 11

ER -