TY - JOUR
T1 - Hyperoxia-induced lung injury in acute respiratory distress syndrome
T2 - what is its relative impact?
AU - Lilien, Thijs A.
AU - van Meenen, David M. P.
AU - Schultz, Marcus J.
AU - Bos, Lieuwe D. J.
AU - Bem, Reinout A.
N1 - Funding Information: T. A. Lilien received an Academic Medical Center (AMC) PhD Scholarship (Amsterdam University Medical Center, Graduate School) with Grant No. 24517. Publisher Copyright: Copyright © 2023 the American Physiological Society.
PY - 2023/7/1
Y1 - 2023/7/1
N2 - Over the past decade, the interest in oxygen toxicity has led to various observational studies and randomized clinical trials in critically ill patients, assessing the association with outcomes and the potential benefit of restrictive oxygenation targets. Yet to date, no consensus has been reached regarding the clinical impact of hyperoxia and hyperoxemia. In this perspective article, we explore the experimental and clinical evidence on hyperoxia-induced lung injury (HILI) and assess its relative impact in current critical care practice, specifically in patients who require oxygen therapy due to acute respiratory distress syndrome (ARDS). Here, we suggest that in current clinical practice in the setting of ARDS HILI may actually be of less importance than other ventilator-related factors.
AB - Over the past decade, the interest in oxygen toxicity has led to various observational studies and randomized clinical trials in critically ill patients, assessing the association with outcomes and the potential benefit of restrictive oxygenation targets. Yet to date, no consensus has been reached regarding the clinical impact of hyperoxia and hyperoxemia. In this perspective article, we explore the experimental and clinical evidence on hyperoxia-induced lung injury (HILI) and assess its relative impact in current critical care practice, specifically in patients who require oxygen therapy due to acute respiratory distress syndrome (ARDS). Here, we suggest that in current clinical practice in the setting of ARDS HILI may actually be of less importance than other ventilator-related factors.
KW - acute lung injury
KW - acute respiratory distress syndrome
KW - mechanical ventilation
KW - oxygen therapy
KW - ventilator-induced lung injury
UR - http://www.scopus.com/inward/record.url?scp=85164042267&partnerID=8YFLogxK
U2 - https://doi.org/10.1152/ajplung.00443.2022
DO - https://doi.org/10.1152/ajplung.00443.2022
M3 - Article
C2 - 37129255
SN - 1040-0605
VL - 325
SP - L19-L16
JO - American journal of physiology. Lung cellular and molecular physiology
JF - American journal of physiology. Lung cellular and molecular physiology
IS - 1
ER -