Innate lymphoid cells in inflammatory bowel diseases

C. P. Peters; J. M. Mjösberg; J. H. Bernink; H. Spits

doi:https://doi.org/10.1016/j.imlet.2015.10.004

Innate lymphoid cells in inflammatory bowel diseases

C. P. Peters, J. M. Mjösberg, J. H. Bernink, H. Spits

Research output: Contribution to journal › Review article › Academic › peer-review

55 Citations (Scopus)

Abstract

It is generally believed that inflammatory bowel diseases (IBD) are caused by an aberrant immune response to environmental triggers in genetically susceptible individuals. The exact contribution of the adaptive and innate immune system has not been elucidated. However, recent advances in treatments targeting key inflammatory mediators such as tumour necrosis factor highlight the crucial role of the innate immune system in IBD. Innate lymphoid cells (ILCs) have recently been identified to play an important role in immune mediated inflammatory diseases. In this review we recapitulate the current knowledge on ILCs in IBD

Original language	English
Pages (from-to)	124-131
Journal	Immunology letters
Volume	172
DOIs	https://doi.org/10.1016/j.imlet.2015.10.004
Publication status	Published - 2016

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https://doi.org/10.1016/j.imlet.2015.10.004

Cite this

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title = "Innate lymphoid cells in inflammatory bowel diseases",

abstract = "It is generally believed that inflammatory bowel diseases (IBD) are caused by an aberrant immune response to environmental triggers in genetically susceptible individuals. The exact contribution of the adaptive and innate immune system has not been elucidated. However, recent advances in treatments targeting key inflammatory mediators such as tumour necrosis factor highlight the crucial role of the innate immune system in IBD. Innate lymphoid cells (ILCs) have recently been identified to play an important role in immune mediated inflammatory diseases. In this review we recapitulate the current knowledge on ILCs in IBD",

author = "Peters, {C. P.} and Mj{\"o}sberg, {J. M.} and Bernink, {J. H.} and H. Spits",

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AU - Mjösberg, J. M.

AU - Bernink, J. H.

AU - Spits, H.

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AB - It is generally believed that inflammatory bowel diseases (IBD) are caused by an aberrant immune response to environmental triggers in genetically susceptible individuals. The exact contribution of the adaptive and innate immune system has not been elucidated. However, recent advances in treatments targeting key inflammatory mediators such as tumour necrosis factor highlight the crucial role of the innate immune system in IBD. Innate lymphoid cells (ILCs) have recently been identified to play an important role in immune mediated inflammatory diseases. In this review we recapitulate the current knowledge on ILCs in IBD

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DO - https://doi.org/10.1016/j.imlet.2015.10.004

M3 - Review article

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VL - 172

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JO - Immunology letters

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