TY - JOUR
T1 - Irreversible electroporation: state of the art
AU - Wagstaff, Peter G. K.
AU - Buijs, Mara
AU - van den Bos, Willemien
AU - de Bruin, Daniel M.
AU - Zondervan, Patricia J.
AU - de La Rosette, Jean J. M. C. H.
AU - Laguna Pes, M. Pilar
PY - 2016
Y1 - 2016
N2 - The field of focal ablative therapy for the treatment of cancer is characterized by abundance of thermal ablative techniques that provide a minimally invasive treatment option in selected tumors. However, the unselective destruction inflicted by thermal ablation modalities cats result in damage to vital structures its the vicinity- of the tumor. Furthermore, the efficacy of thermal ablation intensity can be impaired due to thermal sink caused by large blood vessels in the proximity of the tumor. Irreversible electroporation (IRE) is a novel ablation modality based on the principle of electroporation or electropenneabilization, in which electric pulses are used to create nanoscale defects in the cell membrane. In theory, IRE has the potential of overcoming the aforementioned limitations of thermal ablation techniques. This review provides a description of the principle of IRE, combined with an overview of in vivo research performed to date in the liver, pancreas, kidney, and prostate
AB - The field of focal ablative therapy for the treatment of cancer is characterized by abundance of thermal ablative techniques that provide a minimally invasive treatment option in selected tumors. However, the unselective destruction inflicted by thermal ablation modalities cats result in damage to vital structures its the vicinity- of the tumor. Furthermore, the efficacy of thermal ablation intensity can be impaired due to thermal sink caused by large blood vessels in the proximity of the tumor. Irreversible electroporation (IRE) is a novel ablation modality based on the principle of electroporation or electropenneabilization, in which electric pulses are used to create nanoscale defects in the cell membrane. In theory, IRE has the potential of overcoming the aforementioned limitations of thermal ablation techniques. This review provides a description of the principle of IRE, combined with an overview of in vivo research performed to date in the liver, pancreas, kidney, and prostate
U2 - https://doi.org/10.2147/OTT.586086
DO - https://doi.org/10.2147/OTT.586086
M3 - Review article
C2 - 27217767
SN - 1178-6930
VL - 9
SP - 2437
EP - 2446
JO - OncoTargets and Therapy
JF - OncoTargets and Therapy
ER -