TY - JOUR
T1 - Lower cerebral blood flow in subjects with Alzheimer's dementia, mild cognitive impairment, and subjective cognitive decline using two-dimensional phase-contrast magnetic resonance imaging
AU - Leijenaar, Jolien F.
AU - van Maurik, Ingrid S.
AU - Kuijer, Joost P.A.
AU - van der Flier, Wiesje M.
AU - Scheltens, Philip
AU - Barkhof, Frederik
AU - Prins, Niels D.
PY - 2017
Y1 - 2017
N2 - Introduction In this cross-sectional study, we aimed to detect differences in cerebral blood flow (CBF) between subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and subjective cognitive decline (SCD), using two-dimensional phase-contrast magnetic resonance imaging. Methods We included 74 AD patients (67 years, 51% female), 36 MCI patients (66 years, 33% female), and 62 patients with SCD (60 years, 32% female) from the Amsterdam Dementia Cohort. Patients with SCD are those who visited the memory clinic with subjective cognitive complaints without objective cognitive impairment. Whole-brain CBF (mL/100 g/min) was calculated using total volume flow measured with two-dimensional phase-contrast magnetic resonance imaging and normalized for brain volume. Results Mean CBF values (SD) were lower in AD compared to SCD (age and sex adjusted 70 ± 26 vs. 82 ± 24 mL/100 g/min, P <.05). Mean CBF values of MCI were comparable to AD. Across clinical groups, lower CBF was associated with lower scores on the Mini–Mental State Examination (age and sex adjusted stβ = 0.19 per mL/100 g/min; P =.02). Discussion Lower whole-brain CBF is seen in AD patients compared to SCD patients and is associated with worse cognitive function.
AB - Introduction In this cross-sectional study, we aimed to detect differences in cerebral blood flow (CBF) between subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and subjective cognitive decline (SCD), using two-dimensional phase-contrast magnetic resonance imaging. Methods We included 74 AD patients (67 years, 51% female), 36 MCI patients (66 years, 33% female), and 62 patients with SCD (60 years, 32% female) from the Amsterdam Dementia Cohort. Patients with SCD are those who visited the memory clinic with subjective cognitive complaints without objective cognitive impairment. Whole-brain CBF (mL/100 g/min) was calculated using total volume flow measured with two-dimensional phase-contrast magnetic resonance imaging and normalized for brain volume. Results Mean CBF values (SD) were lower in AD compared to SCD (age and sex adjusted 70 ± 26 vs. 82 ± 24 mL/100 g/min, P <.05). Mean CBF values of MCI were comparable to AD. Across clinical groups, lower CBF was associated with lower scores on the Mini–Mental State Examination (age and sex adjusted stβ = 0.19 per mL/100 g/min; P =.02). Discussion Lower whole-brain CBF is seen in AD patients compared to SCD patients and is associated with worse cognitive function.
KW - Alzheimer's disease
KW - Cerebral blood flow
KW - Cognition
KW - Neurodegeneration
KW - Two-dimensional phase-contrast MRI
UR - http://www.scopus.com/inward/record.url?scp=85034774030&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.dadm.2017.10.001
DO - https://doi.org/10.1016/j.dadm.2017.10.001
M3 - Article
C2 - 29234724
SN - 2352-8729
VL - 9
SP - 76
EP - 83
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
ER -