TY - JOUR
T1 - Microbiota-neuroimmune cross talk in stress-induced visceral hypersensitivity of the bowel
AU - van Thiel, Isabelle A. M.
AU - de Jonge, Wouter J.
AU - Chiu, Isaac M.
AU - van den Wijngaard, Rene M.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Visceral hypersensitivity of the lower gastrointestinal tract, defined as an increased response to colorectal distension, frequently prompts episodes of debilitating abdominal pain in irritable bowel syndrome (IBS). Although the pathophysiology of IBS is not yet fully elucidated, it is well known that stress is a major risk factor for development and acts as a trigger of pain sensation. Stress modulates both immune responses as well as the gut microbiota and vice versa. Additionally, either microbes themselves or through involvement of the immune system, activate or sensitize afferent nociceptors. In this paper, we review current knowledge on the influence of stress along the gut-brain-microbiota axis and exemplify relevant neuroimmune cross talk mechanisms in visceral hypersensitivity, working toward understanding how gut microbiota-neuroimmune cross talk contributes to visceral pain sensation in IBS patients.
AB - Visceral hypersensitivity of the lower gastrointestinal tract, defined as an increased response to colorectal distension, frequently prompts episodes of debilitating abdominal pain in irritable bowel syndrome (IBS). Although the pathophysiology of IBS is not yet fully elucidated, it is well known that stress is a major risk factor for development and acts as a trigger of pain sensation. Stress modulates both immune responses as well as the gut microbiota and vice versa. Additionally, either microbes themselves or through involvement of the immune system, activate or sensitize afferent nociceptors. In this paper, we review current knowledge on the influence of stress along the gut-brain-microbiota axis and exemplify relevant neuroimmune cross talk mechanisms in visceral hypersensitivity, working toward understanding how gut microbiota-neuroimmune cross talk contributes to visceral pain sensation in IBS patients.
KW - Brain-gut-microbiota
KW - Irritable bowel syndrome
KW - Microbiome
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=85085630583&partnerID=8YFLogxK
U2 - https://doi.org/10.1152/ajpgi.00196.2019
DO - https://doi.org/10.1152/ajpgi.00196.2019
M3 - Article
C2 - 32308040
SN - 0193-1857
VL - 318
SP - G1034-G1041
JO - American journal of physiology. Gastrointestinal and liver physiology
JF - American journal of physiology. Gastrointestinal and liver physiology
IS - 6
ER -