TY - JOUR
T1 - Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis
AU - Simon, Shira
AU - Nauta, Ilse M.
AU - Hillebrand, Arjan
AU - Schoonheim, Menno M.
AU - Uitdehaag, Bernard M. J.
AU - van Dam, Maureen
AU - Hulst, Hanneke E.
AU - Klein, Martin
AU - Stam, Cornelis J.
AU - de Jong, Brigit A.
AU - Strijbis, Eva M. M.
N1 - Funding Information: The authors thank the psychologists of the Amsterdam UMC, Department of Medical Psychology, and the EEG/MEG technicians of the Amsterdam UMC, Department of Clinical Neurophysiology and MEG Center, for the data acquisition. The authors also thank all patients for their participation. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Dutch MS Research Foundation, grant #15-911. Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Dutch MS Research Foundation, grant #15-911. Publisher Copyright: © The Author(s), 2023.
PY - 2023/7
Y1 - 2023/7
N2 - Background: Suboptimal performance during neuropsychological testing frequently occurs in multiple sclerosis (MS), leading to unreliable cognitive outcomes. Neurophysiological alterations correlate with MS-related cognitive impairment, but studies have not yet considered performance validity. Objectives: To investigate neurophysiological markers of cognitive impairment in MS, while explicitly addressing performance validity. Methods: Magnetoencephalography recordings, neuropsychological assessments, and performance validity testing were obtained from 90 MS outpatients with cognitive complaints. Spectral and resting-state functional connectivity (rsFC) properties were compared between cognitively impaired (CI), cognitively preserved (CP), and suboptimally performing (SUB) patients using regression models and permutation testing. Results: CI had higher power in low-frequency bands and lower power in high bands compared to CP, indicating neuronal slowing. CI also showed lower beta power compared to SUB. Overall power spectra visually differed between CI and CP, and SUB showed overlap with both groups. CI had lower rsFC than CP and SUB patients. CP and SUB patients showed no differences. Conclusion: Neuronal slowing and altered rsFC can be considered cognitive markers in MS. Patients who performed suboptimally showed resemblance with patients with and without cognitive impairments, and although their overall neurophysiological profile was more similar to patients without impairments, it suggests heterogeneity regarding their pathophysiology.
AB - Background: Suboptimal performance during neuropsychological testing frequently occurs in multiple sclerosis (MS), leading to unreliable cognitive outcomes. Neurophysiological alterations correlate with MS-related cognitive impairment, but studies have not yet considered performance validity. Objectives: To investigate neurophysiological markers of cognitive impairment in MS, while explicitly addressing performance validity. Methods: Magnetoencephalography recordings, neuropsychological assessments, and performance validity testing were obtained from 90 MS outpatients with cognitive complaints. Spectral and resting-state functional connectivity (rsFC) properties were compared between cognitively impaired (CI), cognitively preserved (CP), and suboptimally performing (SUB) patients using regression models and permutation testing. Results: CI had higher power in low-frequency bands and lower power in high bands compared to CP, indicating neuronal slowing. CI also showed lower beta power compared to SUB. Overall power spectra visually differed between CI and CP, and SUB showed overlap with both groups. CI had lower rsFC than CP and SUB patients. CP and SUB patients showed no differences. Conclusion: Neuronal slowing and altered rsFC can be considered cognitive markers in MS. Patients who performed suboptimally showed resemblance with patients with and without cognitive impairments, and although their overall neurophysiological profile was more similar to patients without impairments, it suggests heterogeneity regarding their pathophysiology.
KW - Multiple sclerosis
KW - cognitive impairment
KW - functional connectivity
KW - oscillatory activity
KW - performance validity
UR - http://www.scopus.com/inward/record.url?scp=85160801965&partnerID=8YFLogxK
U2 - https://doi.org/10.1177/13524585231159817
DO - https://doi.org/10.1177/13524585231159817
M3 - Article
C2 - 36964707
SN - 1352-4585
VL - 29
SP - 1001
EP - 1011
JO - MULTIPLE SCLEROSIS JOURNAL
JF - MULTIPLE SCLEROSIS JOURNAL
IS - 8
ER -