TY - JOUR
T1 - Prevalence of group B streptococcal colonization in the healthy non-pregnant population: a systematic review and meta-analysis
AU - van Kassel, Merel N.
AU - Janssen, Sanne W. C. M.
AU - Kofman, Sanne
AU - Brouwer, Matthijs C.
AU - van de Beek, Diederik
AU - Bijlsma, Merijn W.
N1 - Funding Information: Funding was received from the Netherlands Organization for Health Research and Development (ZonMw; NWO-Vidi-Grant (grant number 917.17.308 ) to MCB; NWO-Vici-Grant (grant number 918.19.627 ) to DvdB); and the Academic Medical Centerer (AMC Innovative Impulse Grant) and Steun Emma Foundation Grant to MWB. Publisher Copyright: © 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/7
Y1 - 2021/7
N2 - Background: Colonization and transmission precede invasive group B streptococcal (GBS) disease. Data on GBS colonization prevalence, detection methods and risk factors for carriage are relevant for vaccine development and to understand GBS pathogenesis. Objectives: To evaluate GBS colonization prevalence after the first week of life in the healthy non-pregnant population. Data sources: Pubmed/Medline, Embase, Latin American and Caribbean Health Sciences Literature, World Health Organization Library Information System, and Scopus. Search performed 12 January 2021 with search terms related to ‘GBS’ and ‘colonization, epidemiology, prevalence or screening’ without restrictions. Study eligibility criteria: All studies that reported prevalence of GBS colonization (any site) in the healthy population. Participants: All individuals (>6 days of age), with no indication of pregnancy, invasive disease or severe underlying immunological co-morbidities. Methods: Logit transformation and a random effects model (DerSimonian and Laird) were used to pool colonization estimates. Subgroup analysis and meta-regression on a priori determined subgroups were performed. Results: We included 98 studies with 43 112 participants. Our search identified 9309 studies of which 8831 were excluded based on title and abstract and 380 after reading the full text. Colonization rates varied considerably between studies (I2 = 97%), which could be partly explained by differences in culture methods (R2 = 27%), culture sites (R2 = 24%), continent (R2 = 10%) and participant's age (R2 = 6%). Higher prevalence was found with selective culture methods (19%, 95% CI 16%–23% versus non-selective methods 8%, 95% CI 6%–9%; p < 0.0001). Colonization rates were highest in rectum (19%, 95% CI 15%–24%), vagina (14%, 95% CI 12%–17%) and urethra (9%, 95% CI 5%–18%). In participants with negative rectal cultures, 7% (95% CI 5%–9%) had GBS cultured from another niche. Colonization prevalence was lower in children (6 months to 16 years; 3%, 95% CI 2%–5%) compared with adults (16%, 95% CI 14%–20%; p < 0.0001). Using selective culture methods in adults resulted in a prevalence of 26% (95% CI 19%–33%) rectal, 21% (95% CI 17%–25%) vaginal and 9% (95% CI 6%–14%) urethral colonization. Conclusion: The rectum is the most common body site colonized by GBS. The best approach to screen for any GBS colonization is to screen multiple body sites using selective culture methods.
AB - Background: Colonization and transmission precede invasive group B streptococcal (GBS) disease. Data on GBS colonization prevalence, detection methods and risk factors for carriage are relevant for vaccine development and to understand GBS pathogenesis. Objectives: To evaluate GBS colonization prevalence after the first week of life in the healthy non-pregnant population. Data sources: Pubmed/Medline, Embase, Latin American and Caribbean Health Sciences Literature, World Health Organization Library Information System, and Scopus. Search performed 12 January 2021 with search terms related to ‘GBS’ and ‘colonization, epidemiology, prevalence or screening’ without restrictions. Study eligibility criteria: All studies that reported prevalence of GBS colonization (any site) in the healthy population. Participants: All individuals (>6 days of age), with no indication of pregnancy, invasive disease or severe underlying immunological co-morbidities. Methods: Logit transformation and a random effects model (DerSimonian and Laird) were used to pool colonization estimates. Subgroup analysis and meta-regression on a priori determined subgroups were performed. Results: We included 98 studies with 43 112 participants. Our search identified 9309 studies of which 8831 were excluded based on title and abstract and 380 after reading the full text. Colonization rates varied considerably between studies (I2 = 97%), which could be partly explained by differences in culture methods (R2 = 27%), culture sites (R2 = 24%), continent (R2 = 10%) and participant's age (R2 = 6%). Higher prevalence was found with selective culture methods (19%, 95% CI 16%–23% versus non-selective methods 8%, 95% CI 6%–9%; p < 0.0001). Colonization rates were highest in rectum (19%, 95% CI 15%–24%), vagina (14%, 95% CI 12%–17%) and urethra (9%, 95% CI 5%–18%). In participants with negative rectal cultures, 7% (95% CI 5%–9%) had GBS cultured from another niche. Colonization prevalence was lower in children (6 months to 16 years; 3%, 95% CI 2%–5%) compared with adults (16%, 95% CI 14%–20%; p < 0.0001). Using selective culture methods in adults resulted in a prevalence of 26% (95% CI 19%–33%) rectal, 21% (95% CI 17%–25%) vaginal and 9% (95% CI 6%–14%) urethral colonization. Conclusion: The rectum is the most common body site colonized by GBS. The best approach to screen for any GBS colonization is to screen multiple body sites using selective culture methods.
KW - Carriage
KW - Colonization
KW - Group B streptococcus
KW - Non-pregnant healthy population
KW - Population
KW - Prevalence
KW - Serotype
KW - Streptococcus agalactiae
UR - http://www.scopus.com/inward/record.url?scp=85105117556&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.cmi.2021.03.024
DO - https://doi.org/10.1016/j.cmi.2021.03.024
M3 - Review article
C2 - 33813109
SN - 1198-743X
VL - 27
SP - 968
EP - 980
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
IS - 7
ER -