Rage signalling promotes intestinal tumourigenesis

J. Heijmans; N. V. J. A. Büller; E. Hoff; A. A. Dihal; T. van der Poll; M. A. D. van Zoelen; A. Bierhaus; I. Biemond; J. C. H. Hardwick; D. W. Hommes; V. Muncan; G. R. van den Brink

doi:https://doi.org/10.1038/onc.2012.119

Rage signalling promotes intestinal tumourigenesis

J. Heijmans, N. V. J. A. Büller, E. Hoff, A. A. Dihal, T. van der Poll, M. A. D. van Zoelen, A. Bierhaus, I. Biemond, J. C. H. Hardwick, D. W. Hommes, V. Muncan, G. R. van den Brink

Research output: Contribution to journal › Article › Academic › peer-review

49 Citations (Scopus)

Abstract

Development of colon cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns that are derived from either pathogens (PAMPs) or cellular damage (DAMPs). These molecules can promote tumourigenesis by activation of the innate immune system, but the individual contribution of ligands and their receptors remains elusive. The receptor for advanced glycation end products (Rage) is a pattern recognition receptor that binds multiple ligands derived from a damaged cell environment such as Hmgb1 and S100 protein. Here we show that Rage signalling has a critical role in sporadic development of intestinal adenomas, as Apc(Min/+) Rage(-/-) mice are protected against tumourigenesis

Original language	English
Pages (from-to)	1202-1206
Journal	Oncogene
Volume	32
Issue number	9
DOIs	https://doi.org/10.1038/onc.2012.119
Publication status	Published - 2013

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https://doi.org/10.1038/onc.2012.119

Cite this

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title = "Rage signalling promotes intestinal tumourigenesis",

abstract = "Development of colon cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns that are derived from either pathogens (PAMPs) or cellular damage (DAMPs). These molecules can promote tumourigenesis by activation of the innate immune system, but the individual contribution of ligands and their receptors remains elusive. The receptor for advanced glycation end products (Rage) is a pattern recognition receptor that binds multiple ligands derived from a damaged cell environment such as Hmgb1 and S100 protein. Here we show that Rage signalling has a critical role in sporadic development of intestinal adenomas, as Apc(Min/+) Rage(-/-) mice are protected against tumourigenesis",

author = "J. Heijmans and B{\"u}ller, {N. V. J. A.} and E. Hoff and Dihal, {A. A.} and {van der Poll}, T. and {van Zoelen}, {M. A. D.} and A. Bierhaus and I. Biemond and Hardwick, {J. C. H.} and Hommes, {D. W.} and V. Muncan and {van den Brink}, {G. R.}",

year = "2013",

doi = "https://doi.org/10.1038/onc.2012.119",

language = "English",

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T1 - Rage signalling promotes intestinal tumourigenesis

AU - Heijmans, J.

AU - Büller, N. V. J. A.

AU - Hoff, E.

AU - Dihal, A. A.

AU - van der Poll, T.

AU - van Zoelen, M. A. D.

AU - Bierhaus, A.

AU - Biemond, I.

AU - Hardwick, J. C. H.

AU - Hommes, D. W.

AU - Muncan, V.

AU - van den Brink, G. R.

PY - 2013

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AB - Development of colon cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns that are derived from either pathogens (PAMPs) or cellular damage (DAMPs). These molecules can promote tumourigenesis by activation of the innate immune system, but the individual contribution of ligands and their receptors remains elusive. The receptor for advanced glycation end products (Rage) is a pattern recognition receptor that binds multiple ligands derived from a damaged cell environment such as Hmgb1 and S100 protein. Here we show that Rage signalling has a critical role in sporadic development of intestinal adenomas, as Apc(Min/+) Rage(-/-) mice are protected against tumourigenesis

U2 - https://doi.org/10.1038/onc.2012.119

DO - https://doi.org/10.1038/onc.2012.119

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