TY - JOUR
T1 - Role of mast cells in colorectal cancer development, the jury is still out
AU - Heijmans, J.
AU - Büller, N. V.
AU - Muncan, V.
AU - van den Brink, G. R.
PY - 2012
Y1 - 2012
N2 - The link between inflammation and colorectal cancer development is becoming increasingly clear. It had long been recognized that patients with inflammatory bowel disease are at an increased risk of colon cancer. Evidence from experimental animals now also implicates the innate immune system in the development of sporadically occurring intestinal adenomas, the precursors to colorectal cancer. Here we discuss the interaction between the immune system and the adenoma to carcinoma sequence with a special emphasis on the role of mast cells which may play a key role in adenoma development. This article is part of a Special Issue entitled: Mast cells in inflammation. (C) 2010 Elsevier B.V. All rights reserved
AB - The link between inflammation and colorectal cancer development is becoming increasingly clear. It had long been recognized that patients with inflammatory bowel disease are at an increased risk of colon cancer. Evidence from experimental animals now also implicates the innate immune system in the development of sporadically occurring intestinal adenomas, the precursors to colorectal cancer. Here we discuss the interaction between the immune system and the adenoma to carcinoma sequence with a special emphasis on the role of mast cells which may play a key role in adenoma development. This article is part of a Special Issue entitled: Mast cells in inflammation. (C) 2010 Elsevier B.V. All rights reserved
U2 - https://doi.org/10.1016/j.bbadis.2010.12.001
DO - https://doi.org/10.1016/j.bbadis.2010.12.001
M3 - Review article
C2 - 21146606
SN - 0925-4439
VL - 1822
SP - 9
EP - 13
JO - Biochimica et Biophysica Acta-Molecular Basis of Disease
JF - Biochimica et Biophysica Acta-Molecular Basis of Disease
IS - 1
ER -