TY - JOUR
T1 - The effect of amyloid pathology and glucose metabolism on cortical volume loss over time in Alzheimer's disease
AU - Adriaanse, Sofie M.
AU - van Dijk, Koene R. A.
AU - Ossenkoppele, Rik
AU - Reuter, Martin
AU - Tolboom, Nelleke
AU - Zwan, Marissa D.
AU - Yaqub, Maqsood
AU - Boellaard, Ronald
AU - Windhorst, Albert D.
AU - van der Flier, Wiesje M.
AU - Scheltens, Philip
AU - Lammertsma, Adriaan A.
AU - Barkhof, Frederik
AU - van Berckel, Bart N. M.
PY - 2014
Y1 - 2014
N2 - Purpose The present multimodal neuroimaging study examined whether amyloid pathology and glucose metabolism are related to cortical volume loss over time in Alzheimer's disease (AD) patients and healthy elderly controls. Methods Structural MRI scans of eleven AD patients and ten controls were available at baseline and follow-up (mean interval 2.5 years). Change in brain structure over time was defined as percent change of cortical volume within seven a-priori defined regions that typically show the strongest structural loss in AD. In addition, two PET scans were performed at baseline: [C-11] PIB to assess amyloid-beta plaque load and [18F]FDG to assess glucose metabolism. [11C] PIB binding and [18F]FDG uptake were measured in the precuneus, a region in which both amyloid deposition and glucose hypometabolism occur early in the course of AD. Results While amyloid-beta plaque load at baseline was not related to cortical volume loss over time in either group, glucose metabolism within the group of AD patients was significantly related to volume loss over time (rho=0.56, p <0.05). Conclusion The present study shows that in a group of AD patients amyloid-beta plaque load as measured by [11C] PIB behaves as a trait marker (i.e., all AD patients showed elevated levels of amyloid, not related to subsequent disease course), whilst hypometabolism as measured by [18F] FDG changed over time indicating that it could serve as a state marker that is predictive of neurodegeneration
AB - Purpose The present multimodal neuroimaging study examined whether amyloid pathology and glucose metabolism are related to cortical volume loss over time in Alzheimer's disease (AD) patients and healthy elderly controls. Methods Structural MRI scans of eleven AD patients and ten controls were available at baseline and follow-up (mean interval 2.5 years). Change in brain structure over time was defined as percent change of cortical volume within seven a-priori defined regions that typically show the strongest structural loss in AD. In addition, two PET scans were performed at baseline: [C-11] PIB to assess amyloid-beta plaque load and [18F]FDG to assess glucose metabolism. [11C] PIB binding and [18F]FDG uptake were measured in the precuneus, a region in which both amyloid deposition and glucose hypometabolism occur early in the course of AD. Results While amyloid-beta plaque load at baseline was not related to cortical volume loss over time in either group, glucose metabolism within the group of AD patients was significantly related to volume loss over time (rho=0.56, p <0.05). Conclusion The present study shows that in a group of AD patients amyloid-beta plaque load as measured by [11C] PIB behaves as a trait marker (i.e., all AD patients showed elevated levels of amyloid, not related to subsequent disease course), whilst hypometabolism as measured by [18F] FDG changed over time indicating that it could serve as a state marker that is predictive of neurodegeneration
U2 - https://doi.org/10.1007/s00259-014-2704-z
DO - https://doi.org/10.1007/s00259-014-2704-z
M3 - Article
C2 - 24615466
SN - 1619-7070
VL - 41
SP - 1190
EP - 1198
JO - European journal of nuclear medicine and molecular imaging
JF - European journal of nuclear medicine and molecular imaging
IS - 6
ER -