TY - JOUR
T1 - Tissue-resident memory T cells at the center of immunity to solid tumors
AU - Amsen, Derk
AU - van Gisbergen, Klaas P. J. M.
AU - Hombrink, Pleun
AU - van Lier, Rene A. W.
PY - 2018
Y1 - 2018
N2 - Immune responses in tissues are constrained by the physiological properties of the tissue involved. Tissue-resident memory T cells (TRM cells) are a recently discovered lineage of T cells specialized for life and function within tissues. Emerging evidence has shown that TRM cells have a special role in the control of solid tumors. A high frequency of TRM cells in tumors correlates with favorable disease progression in patients with cancer, and studies of mice have shown that TRM cells are necessary for optimal immunological control of solid tumors. Here we describe what defines TRM cells as a separate lineage and how these cells are generated. Furthermore, we discuss the properties that allow TRM cells to operate in normal and transformed tissues, as well as implications for the treatment of patients with cancer.
AB - Immune responses in tissues are constrained by the physiological properties of the tissue involved. Tissue-resident memory T cells (TRM cells) are a recently discovered lineage of T cells specialized for life and function within tissues. Emerging evidence has shown that TRM cells have a special role in the control of solid tumors. A high frequency of TRM cells in tumors correlates with favorable disease progression in patients with cancer, and studies of mice have shown that TRM cells are necessary for optimal immunological control of solid tumors. Here we describe what defines TRM cells as a separate lineage and how these cells are generated. Furthermore, we discuss the properties that allow TRM cells to operate in normal and transformed tissues, as well as implications for the treatment of patients with cancer.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047110508&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29777219
U2 - https://doi.org/10.1038/s41590-018-0114-2
DO - https://doi.org/10.1038/s41590-018-0114-2
M3 - Review article
C2 - 29777219
SN - 1529-2908
VL - 19
SP - 538
EP - 546
JO - Nature immunology
JF - Nature immunology
IS - 6
ER -