TY - JOUR
T1 - Validation of a Dutch Risk Score Predicting Poor Outcome in Adults with Bacterial Meningitis in Vietnam and Malawi
AU - Schut, Ewout S.
AU - Brouwer, Matthijs C.
AU - Scarborough, Matthew
AU - Mai, Nguyen Thi Hoang
AU - Thwaites, Guy E.
AU - Farrar, Jeremy J.
AU - Reitsma, Johannes B.
AU - van de Beek, Diederik
PY - 2012
Y1 - 2012
N2 - We have previously developed and validated a prognostic model to predict the risk for unfavorable outcome in Dutch adults with bacterial meningitis. The aim of the current study was to validate this model in adults with bacterial meningitis from two developing countries, Vietnam and Malawi. Demographic and clinical characteristics of Vietnamese (n = 426), Malawian patients (n = 465) differed substantially from those of Dutch patients (n = 696). The Dutch model underestimated the risk of poor outcome in both Malawi and Vietnam. The discrimination of the original model (c-statistic [c] 0.84; 95% confidence interval 0.81 to 0.86) fell considerably when re-estimated in the Vietnam cohort (c = 0.70) or in the Malawian cohort (c = 0.68). Our validation study shows that new prognostic models have to be developed for these countries in a sufficiently large series of unselected patients
AB - We have previously developed and validated a prognostic model to predict the risk for unfavorable outcome in Dutch adults with bacterial meningitis. The aim of the current study was to validate this model in adults with bacterial meningitis from two developing countries, Vietnam and Malawi. Demographic and clinical characteristics of Vietnamese (n = 426), Malawian patients (n = 465) differed substantially from those of Dutch patients (n = 696). The Dutch model underestimated the risk of poor outcome in both Malawi and Vietnam. The discrimination of the original model (c-statistic [c] 0.84; 95% confidence interval 0.81 to 0.86) fell considerably when re-estimated in the Vietnam cohort (c = 0.70) or in the Malawian cohort (c = 0.68). Our validation study shows that new prognostic models have to be developed for these countries in a sufficiently large series of unselected patients
U2 - https://doi.org/10.1371/journal.pone.0034311
DO - https://doi.org/10.1371/journal.pone.0034311
M3 - Article
C2 - 22470555
SN - 1932-6203
VL - 7
SP - e34311
JO - PLOS ONE
JF - PLOS ONE
IS - 3
ER -