Research output per year
Research output per year
Personal profile
specialisation
MRI, pathology, neurodegeneration
Research interests
My main research aim is to translate post mortem MRI signatures of neuropathology and neurodegeneration to the clinical setting in order to facilitate a better interpretation of MRI datasets, contributing to a better diagnosis, prognosis and patient stratification.
For this, we set up a standardized pipeline including Alzheimer’s disease and other dementia, Parkinson’s disease, and non-neurological control donors, all undergoing the same 3T in-situ MRI and autopsy protocol with subsequent pathological assessment.
With this approach, my research line is threefold: studying the influence of pathological and neuronal markers on (i) cortical alterations, (ii) specific nuclei and their projections, and (ii) the integrating and segregating brain network.
Education/Academic qualification
PhD, Visualizing and Characterizing Tissue Abnormalities in Multiple Sclerosis, VUmc, Amsterdam, Netherlands
Award Date: 17 Feb 2016
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Normal Aging Brain Collection Amsterdam (NABCA): A comprehensive collection of postmortem high-field imaging, neuropathological and morphometric datasets of non-neurological controls
Jonkman, L. E., Graaf, Y. G., Bulk, M., Kaaij, E., Pouwels, P. J. W., Barkhof, F., Rozemuller, A. J. M., van der Weerd, L., Geurts, J. J. G. & van de Berg, W. D. J., 1 Jan 2019, In: NeuroImage: Clinical. 22, 101698.Research output: Contribution to journal › Article › Academic › peer-review
Open Access13 Citations (Scopus) -
Diffuse Amyloid-β relates to lower structural degree and higher local efficiency in the posterior cingulate cortex: a post-mortem MRI and histology study.
Jonkman, LE., Steenwijk, MD., Galis-de Graaf, Y., Rozemuller, AJM., Geurts, JJG., Barkhof, F. & van de Berg, WDJ., 2020, (Accepted/In press) In: Neurology.Research output: Contribution to journal › Article › Academic › peer-review
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Amyloid-β, p-tau and reactive microglia are pathological correlates of MRI cortical atrophy in Alzheimer's disease
Frigerio, I., Boon, B. D. C., Lin, C-P., Graaf, Y. G-D., Bol, J., Preziosa, P., Twisk, J., Barkhof, F., Hoozemans, J. J. M., Bouwman, F. H., Rozemuller, A. J. M., van de Berg, W. D. J. & Jonkman, L. E., 2021, In: Brain Communications. 3, 4, fcab281.Research output: Contribution to journal › Article › Academic › peer-review
Open Access5 Citations (Scopus) -
Multicenter Evaluation of AI-generated DIR and PSIR for Cortical and Juxtacortical Multiple Sclerosis Lesion Detection
Bouman, P. M., Noteboom, S., Nobrega Santos, F. A., Beck, E. S., Bliault, G., Castellaro, M., Calabrese, M., Chard, D. T., Eichinger, P., Filippi, M., Inglese, M., Lapucci, C., Marciniak, A., Moraal, B., Pinzon, A. M., Mühlau, M., Preziosa, P., Reich, D. S., Rocca, M. A., Schoonheim, M. M., & 6 others, 1 Apr 2023, In: Radiology. 307, 2, e221425.Research output: Contribution to journal › Article › Academic › peer-review
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Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson?s disease dementia
Frigerio, I., Laansma, M. A., Lin, C-P., Hermans, E. J. M., Bouwman, M. M. A., Bol, J. G. J. M., Galis-de Graaf, Y., Hepp, D. H., Rozemuller, A. J. M., Barkhof, F., van de Berg, W. D. J. & Jonkman, L. E., 1 Dec 2023, In: Translational Neurodegeneration. 12, 1, 3.Research output: Contribution to journal › Article › Academic › peer-review
Open Access