TY - JOUR
T1 - A Perspective on Organoids for Virology Research
AU - Sridhar, Adithya
AU - Simmini, Salvatore
AU - Ribeiro, Carla M. S.
AU - Tapparel, Caroline
AU - Evers, Melvin M.
AU - Pajkrt, Dasja
AU - Wolthers, Katja
PY - 2020/11/23
Y1 - 2020/11/23
N2 - Animal models and cell lines are invaluable for virology research and host-pathogen interaction studies. However, it is increasingly evident that these models are not sufficient to fully understand human viral diseases. With the advent of three-dimensional organotypic cultures, it is now possible to study viral infections in the human context. This perspective explores the potential of these organotypic cultures, also known as organoids, for virology research, antiviral testing, and shaping the virology landscape.
AB - Animal models and cell lines are invaluable for virology research and host-pathogen interaction studies. However, it is increasingly evident that these models are not sufficient to fully understand human viral diseases. With the advent of three-dimensional organotypic cultures, it is now possible to study viral infections in the human context. This perspective explores the potential of these organotypic cultures, also known as organoids, for virology research, antiviral testing, and shaping the virology landscape.
KW - human organoids
KW - standardization
KW - virology
UR - http://www.scopus.com/inward/record.url?scp=85096818817&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/v12111341
DO - https://doi.org/10.3390/v12111341
M3 - Article
C2 - 33238561
SN - 1999-4915
VL - 12
JO - Viruses
JF - Viruses
IS - 11
ER -