Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions

R. Ossenkoppele; W.M. van der Flier; S.C.J. Verfaillie; H. Vrenken; A. Versteeg; R.A. van Schijndel; S.A. Sikkes; J. Twisk; S.M. Adriaanse; M.D. Zwan; R. Boellaard; A.D. Windhorst; F. Barkhof; P. Scheltens; A.A. Lammertsma; B.N.M. van Berckel

doi:https://doi.org/10.1212/WNL.0000000000000432

Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions

R. Ossenkoppele, W.M. van der Flier, S.C.J. Verfaillie, H. Vrenken, A. Versteeg, R.A. van Schijndel, S.A. Sikkes, J. Twisk, S.M. Adriaanse, M.D. Zwan, R. Boellaard, A.D. Windhorst, F. Barkhof, P. Scheltens, A.A. Lammertsma, B.N.M. van Berckel

Research output: Contribution to journal › Article › Academic › peer-review

49 Citations (Scopus)

Abstract

Objective: To assess how amyloid deposition, glucose hypometabolism, and cerebral atrophy affect neuropsychological performance in patients with Alzheimer disease (AD) dementia, patients with mild cognitive impairment (MCI), and controls over time. Methods: A total of 41 patients with AD dementia, 28 patients with MCI, and 19 controls underwent [

Original language	English
Pages (from-to)	1768-1775
Journal	Neurology
Volume	82
Issue number	20
DOIs	https://doi.org/10.1212/WNL.0000000000000432
Publication status	Published - 2014

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Cite this

Ossenkoppele, R., van der Flier, W. M., Verfaillie, S. C. J., Vrenken, H., Versteeg, A., van Schijndel, R. A., Sikkes, S. A., Twisk, J., Adriaanse, S. M., Zwan, M. D., Boellaard, R., Windhorst, A. D., Barkhof, F., Scheltens, P., Lammertsma, A. A., & van Berckel, B. N. M. (2014). Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions. Neurology, 82(20), 1768-1775. https://doi.org/10.1212/WNL.0000000000000432

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Ossenkoppele, R , van der Flier, WM, Verfaillie, SCJ, Vrenken, H, Versteeg, A, van Schijndel, RA , Sikkes, SA , Twisk, J, Adriaanse, SM, Zwan, MD , Boellaard, R , Windhorst, AD , Barkhof, F , Scheltens, P , Lammertsma, AA & van Berckel, BNM 2014, 'Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions', Neurology, vol. 82, no. 20, pp. 1768-1775. https://doi.org/10.1212/WNL.0000000000000432

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AU - Ossenkoppele, R.

AU - van der Flier, W.M.

AU - Verfaillie, S.C.J.

AU - Vrenken, H.

AU - Versteeg, A.

AU - van Schijndel, R.A.

AU - Sikkes, S.A.

AU - Twisk, J.

AU - Adriaanse, S.M.

AU - Zwan, M.D.

AU - Boellaard, R.

AU - Windhorst, A.D.

AU - Barkhof, F.

AU - Scheltens, P.

AU - Lammertsma, A.A.

AU - van Berckel, B.N.M.

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AB - Objective: To assess how amyloid deposition, glucose hypometabolism, and cerebral atrophy affect neuropsychological performance in patients with Alzheimer disease (AD) dementia, patients with mild cognitive impairment (MCI), and controls over time. Methods: A total of 41 patients with AD dementia, 28 patients with MCI, and 19 controls underwent [

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