Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study

J. M. Tillema; H.E. Hulst; M. A. Rocca; H. Vrenken; M. D. Steenwijk; D. Damjanovic; C. Enzinger; S. Ropele; G. Tedeschi; A. Gallo; O. Ciccarelli; A. Rovira; X. Montalban; N. de Stefano; M. L. Stromillo; M. Filippi; F. Barkhof

doi:https://doi.org/10.1177/1352458515607650

Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study

J. M. Tillema, H.E. Hulst, M. A. Rocca, H. Vrenken, M. D. Steenwijk, D. Damjanovic, C. Enzinger, S. Ropele, G. Tedeschi, A. Gallo, O. Ciccarelli, A. Rovira, X. Montalban, N. de Stefano, M. L. Stromillo, M. Filippi, F. Barkhof

Research output: Contribution to journal › Article › Academic › peer-review

34 Citations (Scopus)

Abstract

Objectives: The objectives of this paper are to compare in a multicenter setting patterns of regional cortical thickness in patients with relapsing–remitting multiple sclerosis (RRMS) and cognitive impairment (CI) and those cognitively preserved (CP), and explore the relationship between cortical thinning and cognitive performance. Methods: T1-weighted isotropic brain scans were collected at 3T from seven European centers in 60 RRMS patients and 65 healthy controls (HCs). Patients underwent clinical and neuropsychological examinations. Cortical thickness (CTh) measures were calculated using FreeSurfer (failing in four) and both lobar and vertex-based general linear model (GLM) analyses were compared between study groups. Results: Twenty (36%) MS patients were classified as CI. Mean global CTh was smaller in RRMS patients compared to HCs (left 2.43 vs. 2.53 mm, right 2.44 vs. 2.54 mm, p < 0.001). Multivariate GLM regional analysis showed significantly more temporal thinning in CI compared to CP patients. Verbal memory scores correlated to regional cortical thinning in the insula whereas visual memory scores correlated to parietal thinning. Conclusions: This multicenter study showed mild global cortical thinning in RRMS. The extent of thinning is less pronounced than previously reported. Only subtle regional differences between CI and CP patients were observed, some of which related to specific cognitive domains.

Original language	English
Pages (from-to)	901-909
Journal	MULTIPLE SCLEROSIS
Volume	22
Issue number	7
DOIs	https://doi.org/10.1177/1352458515607650
Publication status	Published - Jun 2016

Keywords

MRI
Multiple sclerosis
cognitive impairment
cortical atrophy

Access to Document

https://doi.org/10.1177/1352458515607650

Cite this

Tillema, J. M., Hulst, H. E., Rocca, M. A., Vrenken, H., Steenwijk, M. D., Damjanovic, D., Enzinger, C., Ropele, S., Tedeschi, G., Gallo, A., Ciccarelli, O., Rovira, A., Montalban, X., de Stefano, N., Stromillo, M. L., Filippi, M., & Barkhof, F. (2016). Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study. MULTIPLE SCLEROSIS, 22(7), 901-909. https://doi.org/10.1177/1352458515607650

@article{c7afdcd7485b4a63a0aca0073b6b2f63,

title = "Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study",

abstract = "Objectives: The objectives of this paper are to compare in a multicenter setting patterns of regional cortical thickness in patients with relapsing–remitting multiple sclerosis (RRMS) and cognitive impairment (CI) and those cognitively preserved (CP), and explore the relationship between cortical thinning and cognitive performance. Methods: T1-weighted isotropic brain scans were collected at 3T from seven European centers in 60 RRMS patients and 65 healthy controls (HCs). Patients underwent clinical and neuropsychological examinations. Cortical thickness (CTh) measures were calculated using FreeSurfer (failing in four) and both lobar and vertex-based general linear model (GLM) analyses were compared between study groups. Results: Twenty (36%) MS patients were classified as CI. Mean global CTh was smaller in RRMS patients compared to HCs (left 2.43 vs. 2.53 mm, right 2.44 vs. 2.54 mm, p < 0.001). Multivariate GLM regional analysis showed significantly more temporal thinning in CI compared to CP patients. Verbal memory scores correlated to regional cortical thinning in the insula whereas visual memory scores correlated to parietal thinning. Conclusions: This multicenter study showed mild global cortical thinning in RRMS. The extent of thinning is less pronounced than previously reported. Only subtle regional differences between CI and CP patients were observed, some of which related to specific cognitive domains.",

keywords = "MRI, Multiple sclerosis, cognitive impairment, cortical atrophy",

author = "Tillema, {J. M.} and H.E. Hulst and Rocca, {M. A.} and H. Vrenken and Steenwijk, {M. D.} and D. Damjanovic and C. Enzinger and S. Ropele and G. Tedeschi and A. Gallo and O. Ciccarelli and A. Rovira and X. Montalban and {de Stefano}, N. and Stromillo, {M. L.} and M. Filippi and F. Barkhof",

year = "2016",

month = jun,

doi = "https://doi.org/10.1177/1352458515607650",

language = "English",

volume = "22",

pages = "901--909",

journal = "MULTIPLE SCLEROSIS",

issn = "1352-4585",

publisher = "SAGE Publications Ltd",

number = "7",

}

Tillema, JM, Hulst, HE, Rocca, MA, Vrenken, H , Steenwijk, MD, Damjanovic, D, Enzinger, C, Ropele, S, Tedeschi, G, Gallo, A, Ciccarelli, O, Rovira, A, Montalban, X, de Stefano, N, Stromillo, ML, Filippi, M & Barkhof, F 2016, 'Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study', MULTIPLE SCLEROSIS, vol. 22, no. 7, pp. 901-909. https://doi.org/10.1177/1352458515607650

TY - JOUR

T1 - Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study

AU - Tillema, J. M.

AU - Hulst, H.E.

AU - Rocca, M. A.

AU - Vrenken, H.

AU - Steenwijk, M. D.

AU - Damjanovic, D.

AU - Enzinger, C.

AU - Ropele, S.

AU - Tedeschi, G.

AU - Gallo, A.

AU - Ciccarelli, O.

AU - Rovira, A.

AU - Montalban, X.

AU - de Stefano, N.

AU - Stromillo, M. L.

AU - Filippi, M.

AU - Barkhof, F.

PY - 2016/6

Y1 - 2016/6

N2 - Objectives: The objectives of this paper are to compare in a multicenter setting patterns of regional cortical thickness in patients with relapsing–remitting multiple sclerosis (RRMS) and cognitive impairment (CI) and those cognitively preserved (CP), and explore the relationship between cortical thinning and cognitive performance. Methods: T1-weighted isotropic brain scans were collected at 3T from seven European centers in 60 RRMS patients and 65 healthy controls (HCs). Patients underwent clinical and neuropsychological examinations. Cortical thickness (CTh) measures were calculated using FreeSurfer (failing in four) and both lobar and vertex-based general linear model (GLM) analyses were compared between study groups. Results: Twenty (36%) MS patients were classified as CI. Mean global CTh was smaller in RRMS patients compared to HCs (left 2.43 vs. 2.53 mm, right 2.44 vs. 2.54 mm, p < 0.001). Multivariate GLM regional analysis showed significantly more temporal thinning in CI compared to CP patients. Verbal memory scores correlated to regional cortical thinning in the insula whereas visual memory scores correlated to parietal thinning. Conclusions: This multicenter study showed mild global cortical thinning in RRMS. The extent of thinning is less pronounced than previously reported. Only subtle regional differences between CI and CP patients were observed, some of which related to specific cognitive domains.

AB - Objectives: The objectives of this paper are to compare in a multicenter setting patterns of regional cortical thickness in patients with relapsing–remitting multiple sclerosis (RRMS) and cognitive impairment (CI) and those cognitively preserved (CP), and explore the relationship between cortical thinning and cognitive performance. Methods: T1-weighted isotropic brain scans were collected at 3T from seven European centers in 60 RRMS patients and 65 healthy controls (HCs). Patients underwent clinical and neuropsychological examinations. Cortical thickness (CTh) measures were calculated using FreeSurfer (failing in four) and both lobar and vertex-based general linear model (GLM) analyses were compared between study groups. Results: Twenty (36%) MS patients were classified as CI. Mean global CTh was smaller in RRMS patients compared to HCs (left 2.43 vs. 2.53 mm, right 2.44 vs. 2.54 mm, p < 0.001). Multivariate GLM regional analysis showed significantly more temporal thinning in CI compared to CP patients. Verbal memory scores correlated to regional cortical thinning in the insula whereas visual memory scores correlated to parietal thinning. Conclusions: This multicenter study showed mild global cortical thinning in RRMS. The extent of thinning is less pronounced than previously reported. Only subtle regional differences between CI and CP patients were observed, some of which related to specific cognitive domains.

KW - MRI

KW - Multiple sclerosis

KW - cognitive impairment

KW - cortical atrophy

U2 - https://doi.org/10.1177/1352458515607650

DO - https://doi.org/10.1177/1352458515607650

M3 - Article

C2 - 26432859

SN - 1352-4585

VL - 22

SP - 901

EP - 909

JO - MULTIPLE SCLEROSIS

JF - MULTIPLE SCLEROSIS

IS - 7

ER -