TY - JOUR
T1 - Thinner temporal and parietal cortex is related to incident clinical progression to dementia in patients with subjective cognitive decline
AU - Verfaillie, Sander C J
AU - Tijms, Betty
AU - Versteeg, Adriaan
AU - Benedictus, Marije R
AU - Bouwman, Femke H
AU - Scheltens, Philip
AU - Barkhof, Frederik
AU - Vrenken, Hugo
AU - van der Flier, Wiesje M
PY - 2016
Y1 - 2016
N2 - INTRODUCTION: We aimed to investigate if thinner cortex of the Alzheimer's disease (AD)-signature region was related to clinical progression in patients with subjective cognitive decline (SCD).METHODS: We included 302 SCD patients with clinical follow-up (≥1 year) and three-dimensional T1 magnetic resonance imaging. We estimated AD-signature cortical thickness, consisting of nine frontal, parietal, and temporal gyri and hippocampal volume. We used Cox proportional hazard models (hazard ratios and 95% confidence intervals) to evaluate cortical thickness in relation to clinical progression to mild cognitive impairment (MCI) or dementia.RESULTS: After a follow-up of the mean (standard deviation) 3 (2) years, 49 patients (16%) showed clinical progression to MCI (n = 32), AD (n = 9), or non-AD dementia (n = 8). Hippocampal volumes, thinner cortex of the AD-signature (hazard ratio [95% confidence interval], 5 [2-17]) and various AD-signature subcomponents were associated with increased risk of clinical progression. Stratified analyses showed that thinner AD-signature cortex was specifically predictive for clinical progression to dementia but not to MCI.DISCUSSION: In SCD patients, thinner regional cortex is associated with clinical progression to dementia.
AB - INTRODUCTION: We aimed to investigate if thinner cortex of the Alzheimer's disease (AD)-signature region was related to clinical progression in patients with subjective cognitive decline (SCD).METHODS: We included 302 SCD patients with clinical follow-up (≥1 year) and three-dimensional T1 magnetic resonance imaging. We estimated AD-signature cortical thickness, consisting of nine frontal, parietal, and temporal gyri and hippocampal volume. We used Cox proportional hazard models (hazard ratios and 95% confidence intervals) to evaluate cortical thickness in relation to clinical progression to mild cognitive impairment (MCI) or dementia.RESULTS: After a follow-up of the mean (standard deviation) 3 (2) years, 49 patients (16%) showed clinical progression to MCI (n = 32), AD (n = 9), or non-AD dementia (n = 8). Hippocampal volumes, thinner cortex of the AD-signature (hazard ratio [95% confidence interval], 5 [2-17]) and various AD-signature subcomponents were associated with increased risk of clinical progression. Stratified analyses showed that thinner AD-signature cortex was specifically predictive for clinical progression to dementia but not to MCI.DISCUSSION: In SCD patients, thinner regional cortex is associated with clinical progression to dementia.
U2 - https://doi.org/10.1016/j.dadm.2016.10.007
DO - https://doi.org/10.1016/j.dadm.2016.10.007
M3 - Article
C2 - 28054027
VL - 5
SP - 43
EP - 52
JO - Alzheimer's & dementia (Amsterdam, Netherlands)
JF - Alzheimer's & dementia (Amsterdam, Netherlands)
ER -