Research output per year
Research output per year
Personal profile
Research interests
I am a PhD student in the Autophagy-directed Immunity (ADI) group, led by Dr. Carla Ribeiro.
Autophagy functions as an antiviral defense mechanism by degrading intracellular viral components. In degradative autophagy, HIV-1 components can be targeted for destruction, thus preventing HIV-1 infection and transmission1. Recently, another function for autophagy in secretion has been discovered2. However, the molecular mechanism of secretory autophagy is poorly understood. Notably, secretory autophagy may play important roles in virus-induced inflammation and viral transmission3.
My PhD project aims to define the molecular mechanism of secretory autophagy, and its role in molecular inflammation and viral transmission. Specific objectives are: 1) Elucidate the molecular mechanism of secretory autophagy; 2) Identify inflammatory output released by secretory autophagy; and 3) Investigate the role of secretory autophagy in viral transmission in vitro and ex vivo.
1. Ribeiro CMS, Sarrami-Forooshani R, Setiawan LC, et al. Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets. Nature. 2016;540(7633):448-452. doi:10.1038/nature20567.
2. Kimura T, Jia J, Claude-taupin A, et al. Cellular and molecular mechanism for secretory autophagy. Autophagy. 2017;13(6):1084-1085. doi:10.1080/15548627.2017.1307486.
3. Wu Y, Mettling C, Wu S, Yu C, Perng G. Autophagy-associated dengue vesicles promote viral transmission avoiding antibody neutralization. Nat Publ Gr. 2016;(6):32243. doi:10.1038/srep32243
specialisation
Autophagy-mediated secretion: A novel mechanism of molecular inflammation and viral transmission
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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Autophagy-enhancing ATG16L1 polymorphism is associated with improved clinical outcome and T-cell immunity in chronic HIV-1 infection
Schreurs, R. R. C. E., Koulis, A., Booiman, T., Boeser-Nunnink, B., Cloherty, A. P. M., Rader, A. G., Patel, K. S., Kootstra, N. A. & Ribeiro, C. M. S., 1 Dec 2024, In: Nature communications. 15, 1, 2465.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockade
Cloherty, A. P. M., Rader, A. G., Patel, K. S., Pérez-Vargas, J., Thompson, C. A. H., Ennis, S., Niikura, M., Wildenberg, M. E., Muncan, V., Schreurs, R. R. C. E., Jean, F. & Ribeiro, C. M. S., 1 Dec 2023, In: Emerging Microbes & Infections. 12, 1, p. 2195020 2195020.Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus) -
Deciphering cellular decluttering: The impact of autophagy mechanisms in host-virus immune interactions
Cloherty, A. P. M., 2023, 256 p.Research output: PhD Thesis › Phd-Thesis - Research and graduation internal
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Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19
Ibelings, R., van den Brom, C. E. & the Amsterdam UMC COVID-19 biobank study group, 1 Sept 2023, In: Artery Research. 29, 3, p. 83-93 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection
Amsterdam UMC COVID-19 biobank study group, 1 Aug 2023, In: eBioMedicine. 94, p. 104729 104729.Research output: Contribution to journal › Article › Academic › peer-review
Open Access8 Citations (Scopus)
Datasets
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Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockade
Cloherty, A. (Creator), Rader, A. (Creator), Patel, K. S. (Creator), Pérez-Vargas, J. (Creator), Thompson, C. A. H. (Creator), Ennis, S. (Creator), Niikura, M. (Creator), Wildenberg, M. (Creator), Dijkstra - Muncan, V. (Creator), Schreurs, R. (Creator), Jean, F. (Creator) & Ribeiro, C. (Creator), Taylor & Francis, 2023
DOI: 10.6084/m9.figshare.22323729, https://tandf.figshare.com/articles/dataset/Berbamine_suppresses_intestinal_SARS-CoV-2_infection_via_a_BNIP3-dependent_autophagy_blockade/22323729
Dataset
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Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockade
Cloherty, A. (Creator), Rader, A. (Creator), Patel, K. S. (Creator), Pérez-Vargas, J. (Creator), Thompson, C. A. H. (Creator), Ennis, S. (Creator), Niikura, M. (Creator), Wildenberg, M. (Creator), Dijkstra - Muncan, V. (Creator), Schreurs, R. (Creator), Jean, F. (Creator) & Ribeiro, C. (Creator), Taylor & Francis, 2023
DOI: 10.6084/m9.figshare.22323729.v2, https://tandf.figshare.com/articles/dataset/Berbamine_suppresses_intestinal_SARS-CoV-2_infection_via_a_BNIP3-dependent_autophagy_blockade/22323729/2
Dataset
Press/Media
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Alexandra Cloherty is the FameLab Netherlands Winner 2021
1/06/2021
1 item of Media coverage
Press/Media: Press / Media