Astrid van der Sar

Research output

Research output per year 2005 2008 2009 2011 2012 2014 2015 2018 2021

• 39 Article

Research output per year

Research output per year

Search results

• 2021

  IL-1R1-Dependent Signals Improve Control of Cytosolic Virulent Mycobacteria In Vivo

  van der Niet, S., van Zon, M., de Punder, K., Grootemaat, A., Rutten, S., Moorlag, S. J. C. F. M., Houben, D., van der Sar, A. M., Bitter, W., Brosch, R., Hernandez Pando, R., Pena, M. T., Peters, P. J., Reits, E. A., Mayer-Barber, K. D. & van der Wel, N. N., 5 May 2021, In: mSphere. 6, 3, p. 1-17 17 p., e00153-21.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)
• 2020

  Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development

  Van Wijk, R. C., van der Sar, A. M., Krekels, E. H. J., Verboom, T., Spaink, H. P., Simonsson, U. S. H. & van der Graaf, P. H., Nov 2020, In: Clinical and Translational Science. 13, 6, p. 1060-1064 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)
• 2019

  CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity

  Majolée, J., Pronk, M. C. A., Jim, K. K., van Bezu, J. S. M., van der Sar, A. M., Hordijk, P. L. & Kovačević, I., 1 Dec 2019, In: Scientific reports. 9, 1, 8131.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  16 Citations (Scopus)

• Type VII Secretion Substrates of Pathogenic Mycobacteria Are Processed by a Surface Protease

  Burggraaf, M. J., Speer, A., Meijers, A. S., Ummels, R., van der Sar, A. M., Korotkov, K. V., Bitter, W. & Kuijl, C., 29 Oct 2019, In: MBio. 10, 5, p. 1-14 14 p., e01951-19.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  19 Citations (Scopus)
• 2018

  A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5

  van Leeuwen, L. M., Evans, R. J., Jim, K. K., Verboom, T., Fang, X., Bojarczuk, A., Malicki, J., Johnston, S. A. & van der Sar, A. M., 2018, In: Biology open. 7, 2, bio030494.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  43 Citations (Scopus)

• EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF

  Phan, T. H., van Leeuwen, L. M., Kuijl, C., Ummels, R., van Stempvoort, G., Rubio-Canalejas, A., Piersma, S. R., Jiménez, C. R., van der Sar, A. M., Houben, E. N. G. & Bitter, W., 13 Aug 2018, In: PLoS pathogens. 14, 8, p. 1-26 26 p., e1007247.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  29 Citations (Scopus)

• Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria

  Sommer, R., Neres, J., Piton, J., Dhar, N., van der Sar, A., Mukherjee, R., Laroche, T., Dyson, P. J., McKinney, J. D., Bitter, W., Makarov, V. & Cole, S. T., 16 Nov 2018, In: ACS Chemical Biology. 13, 11, p. 3184-3192 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  14 Citations (Scopus)

• Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry

  Bruinen, A. L., Fisher, G. L., Balez, R., van der Sar, A. M., Ooi, L. & Heeren, R. M. A., 2018, In: Journal of the American Society for Mass Spectrometry. 29, 8, p. 1571-1581

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  18 Citations (Scopus)

• Mycobacteria employ two different mechanisms to cross the blood–brain barrier

  van Leeuwen, L. M., Boot, M., Kuijl, C., Picavet, D. I., van Stempvoort, G., van der Pol, S. M. A., de Vries, H. E., van der Wel, N. N., van der Kuip, M., van Furth, A. M., van der Sar, A. M. & Bitter, W., 1 Sept 2018, In: Cellular microbiology. 20, 9, p. e12858 e12858.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  40 Citations (Scopus)
• 2016

  Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model

  Jim, K. K., Engelen-Lee, J., van der Sar, A. M., Bitter, W., Brouwer, M. C., van der Ende, A., Veening, J. W., van de Beek, D. & Vandenbroucke-Grauls, C. M. J. E., 19 Aug 2016, In: Journal of neuroinflammation. 13, 1, p. 1-13 13 p., 188.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  35 Citations (Scopus)

• Prophylactic administration of chicken cathelicidin-2 boosts zebrafish embryonic innate immunity

  Schneider, V. A. F., van Dijk, A., van der Sar, A. M., Kraaij, M. D., Veldhuizen, E. J. A. & Haagsman, H. P., Jul 2016, In: Developmental & Comparative Immunology. 60, p. 108-114

  Research output: Contribution to journal › Article › Academic › peer-review
  10 Citations (Scopus)
• 2015

  Animal models of tuberculosis: Zebrafish

  van Leeuwen, L. M., van der Sar, A. M. & Bitter, W., 2015, In: Cold Spring Harbor perspectives in medicine. 5, 3, a018580.

  Research output: Contribution to journal › Article › Academic › peer-review
  42 Citations (Scopus)

• First Demonstration of Antigen Induced Cytokine Expression by CD4-1(+) Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio)

  Yoon, S., Mitra, S., Wyse, C., Alnabulsi, A., Zou, J., Weerdenburg, E. M., van der Sar, A. M., Wang, D. F., Secombes, C. J. & Bird, S., 2015, In: PLOS ONE. 10, 6, e0126378.

  Research output: Contribution to journal › Article › Academic › peer-review
  70 Citations (Scopus)

• Genome-wide transposon mutagenesis indicates that Mycobacterium marinum customizes its virulence mechanisms for survival and replication in different hosts.

  Weerdenburg, E. M., Abdallah, A., Rangkuti, F., Abd El Ghany, M., Otto, T. D., Adroub, S. A., Molenaar, D., Ummels, R., Ter Veen, K., van Stempvoort, G., van der Sar, A. M., Ali, S., Langridge, G. C., Thomson, N. R., Pain, A. & Bitter, W., 2015, In: Infection and immunity. 83, p. 1778-1788 5.

  Research output: Contribution to journal › Article › Academic › peer-review
  50 Citations (Scopus)

• The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection

  Torraca, V., Cui, C., Boland, R., Bebelman, J. P., van der Sar, A. M., Smit, M. J., Siderius, M., Spaink, H. P. & Meijer, A. H., 2015, In: Disease Models and Mechanisms. 8, 3, p. 253-269

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  102 Citations (Scopus)
• 2014

  Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector.

  van der Woude, A. D., Stoop, E. J. M., Stiess, M., Wang, Q., Ummels, R., van Stempvoort, G., Piersma, S. R., Cascioferro, A., Jimenez, C. R., Houben, E. N. G., Luirink, J., Pieters, J., van der Sar, A. M. & Bitter, W., 2014, In: Cellular microbiology. 16, 2, p. 280-295

  Research output: Contribution to journal › Article › Academic › peer-review
  47 Citations (Scopus)

• Assessing pseudomonas virulence with nonmammalian host: zebrafish

  Llamas, M. A. & van der Sar, A. M., 2014, In: Methods in Molecular Biology. 1149, p. 709-721

  Research output: Contribution to journal › Article › Academic › peer-review
  10 Citations (Scopus)

• Modeling tuberculous meningitis in zebrafish using Mycobacterium marinum.

  van Leeuwen, L. M., van der Kuip, M., Youssef, S. A., de Bruin, A., Bitter, W., van Furth, A. M. & van der Sar, A. M., 2014, In: Disease Models and Mechanisms. 7, 9, p. 1111-1122

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  36 Citations (Scopus)

• Towards a new combination therapy for tuberculosis with next generation benzothiazinones

  Makarov, V., Lechartier, B., Zhang, M., Neres, J., van der Sar, A. M., Raadsen, S. A., Hartkoorn, R. C., Ryabova, O. B., Vocat, A., Decosterd, L. A., Widmer, N., Buclin, T., Bitter, W., Andries, K., Pojer, F., Dyson, P. J. & Cole, S. T., 2014, In: EMBO molecular medicine. 6, 3, p. 372-383

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  320 Citations (Scopus)
• 2013

  Galectin-4 Reduces Migration and Metastasis Formation of Pancreatic Cancer Cells

  Da Silva Aresta Belo, A. I., van der Sar, A. M., Tefsen, B. & van Die, I., 2013, In: PLOS ONE. 8, 6, e65957.

  Research output: Contribution to journal › Article › Academic › peer-review
  50 Citations (Scopus)

• Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity

  Stoop, E. J. M., Mishra, A. K., Driessen, N. N., van Stempvoort, G., Bouchier, P., Verboom, T., van Leeuwen, L. M., Sparrius, M., Raadsen, S. A., van Zon, M., van der Wel, N. N., Besra, G. S., Geurtsen, J. J. G., Bitter, W., Appelmelk, B. J. & van der Sar, A. M., 2013, In: Cellular microbiology. 15, 12, p. 2093-2108

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  28 Citations (Scopus)
• 2012

  Are bacterial lysozyme inhibitors important in bacteria-host interactions?

  Vanderkelen, L., van der Sar, A. M., Goddeeris, B. M. & Michiels, C. W., 2012, In: Communications in agricultural and applied biological sciences. 77, 1, p. 61-65

  Research output: Contribution to journal › Article › Academic › peer-review

• Cyanovirin-N Inhibits Mannose-Dependent Mycobacterium-C-Type Lectin Interactions but Does Not Protect against Murine Tuberculosis

  Driessen, N. N., Boshoff, H. I. M., Maaskant, J. J., Gilissen, S. A. C., Vink, S., van der Sar, A. M., Vandenbroucke-Grauls, C. M. J. E., Bewley, C. A., Appelmelk, B. J. & Geurtsen, J. J. G., 2012, In: Journal of Immunology. 189, 7, p. 3585-3592

  Research output: Contribution to journal › Article › Academic › peer-review
  7 Citations (Scopus)

• ESX-5-deficient Mycobacterium marinum is hypervirulent in adult zebrafish.

  Weerdenburg, E. M., Abdallah, A. M., Mitra, S., de Punder, K., van der Wel, N. N., Bird, S., Appelmelk, B. J., Bitter, W. & van der Sar, A. M., 2012, In: Cellular microbiology. 14, 5, p. 728-739

  Research output: Contribution to journal › Article › Academic › peer-review
  57 Citations (Scopus)

• Infection of zebrafish embryos with intracellular bacterial pathogens

  Benard, E. L., van der Sar, A. M., Ellett, F., Lieschke, G. J., Spaink, H. P. & Meijer, A. H., 2012, In: Journal of Visualized Experiments. 15, 61, e3781.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  172 Citations (Scopus)

• Tubercle bacilli rely on a type VII army for pathogenicity.

  Stoop, E. J. M., Bitter, W. & van der Sar, A. M., 2012, In: Trends in Microbiology. 20, 10, p. 477-484

  Research output: Contribution to journal › Article › Academic › peer-review
  78 Citations (Scopus)

• Unexpected link between lipooligosaccharide biosynthesis and surface protein release in Mycobacterium marinum.

  van der Woude, A. D., Sarkar, D., Bhatt, A., Sparrius, M., Raadsen, S. A., Boon, L., Geurtsen, J. J. G., Houben, E. N. G., Besra, G. S., Bitter, W., van der Sar, A. M. & Luirink, S., 2012, In: Journal of Biological Chemistry. 287, 24, p. 20417-20429

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  39 Citations (Scopus)
• 2011

  Discovery of zebrafish (Danio rerio) interleukin-23 alpha (IL-23 alpha) chain, a subunit important for the formation of IL-23, a cytokine involved in the development of Th17 cells and inflammation

  Holt, A., Mitra, S., van der Sar, A. M., Alnabulsi, A., Secombes, C. J. & Bird, S., 2011, In: Molecular immunology. 48, 8, p. 981-991

  Research output: Contribution to journal › Article › Academic › peer-review
  30 Citations (Scopus)

• Identification of a Glycosyltransferase from Mycobacterium marinum Involved in Addition of a Caryophyllose Moiety in Lipooligosaccharides

  Sarkar, D., Sidhu, M., Singh, A., Chen, J. M., Lammas, D. A., van der Sar, A. M., Besra, G. S. & Bhatt, A., 2011, In: Journal of Bacteriology. 193, 9, p. 2336-2340

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  23 Citations (Scopus)

• Mycobacterial Secretion Systems ESX-1 and ESX-5 Play Distinct Roles in Host Cell Death and Inflammasome Activation

  Abdallah, A. M., Bestebroer, J., Savage, N. D. L., de Punder, K., van Zon, M., Wilson, L., Korbee, C. J., van der Sar, A. M., Ottenhoff, T. H. M., van der Wel, N. N., Bitter, W. & Peters, P. J., 1 Nov 2011, In: Journal of immunology (Baltimore, Md.. 187, 9, p. 4744-4753 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  118 Citations (Scopus)

• Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component

  Stoop, E. J. M., Schipper, T., Huber, S. K. R., Nezhinsky, A. E., Verbeek, F. J., Gurcha, S. S., Besra, G. S., Vandenbroucke-Grauls, C. M. J. E., Bitter, W. & van der Sar, A. M., 2011, In: Disease Models and Mechanisms. 4, 4, p. 526-536

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  90 Citations (Scopus)
• 2009

  A Novel Extracytoplasmic Function (ECF) Sigma Factor Regulates Virulence in Pseudomonas aeruginosa

  Llamas Lorente, M. A., van der Sar, A., Chu, B. C. H., Sparrius, M., Vogel, H. J. & Bitter, W., 2009, In: PLoS pathogens. 5, 9, p. e1000572 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  66 Citations (Scopus)

• Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components

  van der Sar, A. M., Spaink, H. P., Zakrzewska, A., Bitter, W. & Meijer, A. L., 2009, In: Molecular immunology. 46, 11-12, p. 2317-2332

  Research output: Contribution to journal › Article › Academic › peer-review
  95 Citations (Scopus)

• The role of gamma interferon in innate immunity in the zebrafish embryo

  Sieger, D., Stein, C., Neifer, D., van der Sar, A. M. & Leptin, M., 2009, In: Disease Models and Mechanisms. 2, 11-12, p. 571-581

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  111 Citations (Scopus)

• Zebrafish development and regeneration: new tools for biomedical research

  Brittijn, S. A., Duivesteijn, S. J., Belmamoune, M., Bertens, L. F. M., Bitter, W., Bruijn, J. D., Champagne, D. L., Cuppen, E., Flik, G., Vandenbroucke-Grauls, C. M. J. E., Janssen, R. J., Jong, I. M. L., de Kloet, E. R., Kros, A., Meijer, A. H., Metz, J. R., van der Sar, A. M., Schaaf, M. C., Schulte-Merker, S., Spaink, H. P., & 9 othersTak, PP., Verbeek, F. J., Vervoordeldonk, M. J., Vonk, F., Witte, F., Yuan, H. L., Richardson, M. K., Debruijn, J. D. & Schaaf, M. J. M., 2009, In: The international journal of developmental biology. 53, 5-6, p. 835-850

  Research output: Contribution to journal › Article › Academic › peer-review
  136 Citations (Scopus)
• 2008

  Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish

  Meijer, A. H., van der Sar, A. M., Cunha, C., Lamers, G. E., Laplante, M. A., Kikuta, H., Bitter, W., Becker, T. S. & Spaink, H. P., 2008, In: Developmental & Comparative Immunology. 32, 1, p. 36-49

  Research output: Contribution to journal › Article › Academic › peer-review
  111 Citations (Scopus)

• The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction

  Appelmelk, B. J., den Dunnen, J. T., Driessen, N. N., Ummels, R., Pak, M., Nigou, J., Larrouy-Maumus, G., Gurcha, S. S., Movahedzadeh, F., Geurtsen, J., Brown, E. J., Eysink Smeets, M. M., Besra, G. S., Willemsen, P. T., Lowary, T. L., van Kooyk, Y., Maaskant, J. J., Stoker, N. G., van der Ley, P., Puzo, G., & 7 othersVandenbroucke-Grauls, C. M. J. E., Wieland, C. W., van der Poll, T., Geijtenbeek, T. B. H., van der Sar, A. M., Bitter, W. & van Kooijk, Y., 2008, In: Cellular microbiology. 10, 4, p. 930-944

  Research output: Contribution to journal › Article › Academic › peer-review
  99 Citations (Scopus)

• Transmission of Mycobacterium marinum from fish to a very young child

  Doedens, R. A., van der Sar, A. M., Bitter, W. & Scholvinck, E. H., 2008, In: Pediatric Infectious Disease Journal. 27, 1, p. 81-83

  Research output: Contribution to journal › Article › Academic › peer-review
  11 Citations (Scopus)
• 2005

  Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection

  Meijer, A. H., Verbeek, F. J., Salas-Vidal, E., Corredor-Adamez, M., Bussman, J., van der Sar, A., Otto, G. W., Geisler, R. & Spaink, H. P., 2005, In: Molecular immunology. 42, 10, p. 1185-1203

  Research output: Contribution to journal › Article › Academic › peer-review
  128 Citations (Scopus)