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Gerard Hovingh

(Principal Investigator), Prof. MD PhD

 https://orcid.org/0000-0002-8145-1676
20002024

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  • 2016

    Safety and efficacy of LY3015014, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9): a randomized, placebo-controlled Phase 2 study

    Kastelein, J. J. P., Nissen, S. E., Rader, D. J., Hovingh, G. K., Wang, M-D., Shen, T. & Krueger, K. A., 2016, In: European Heart journal. 37, 17, p. 1360-1369

    Research output: Contribution to journal › Article › Academic › peer-review

    68 Citations (Scopus)

  • Sequencing for LIPA mutations in patients with a clinical diagnosis of familial hypercholesterolemia

    Sjouke, B., Defesche, J. C., de Randamie, J. S. E., Wiegman, A., Fouchier, S. W. & Hovingh, G. K., 2016, In: Atherosclerosis. 251, p. 263-265

    Research output: Contribution to journal › Article › Academic › peer-review

    28 Citations (Scopus)

  • Statins in Familial Hypercholesterolemia: Consequences for Coronary Artery Disease and All-Cause Mortality

    Besseling, J., Hovingh, G. K., Huijgen, R., Kastelein, J. J. P. & Hutten, B. A., 2016, In: Journal of the American College of Cardiology. 68, 3, p. 252-260

    Research output: Contribution to journal › Article › Academic › peer-review

    143 Citations (Scopus)

  • Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution

    Patel, A. P., Peloso, G. M., Pirruccello, J. P., Johansen, C. T., Dubé, J. B., Larach, D. B., Ban, M. R., Dallinge-Thie, G. M., Gupta, N., Boehnke, M., Abecasis, G. R., Kastelein, J. J. P., Hovingh, G. K., Hegele, R. A., Rader, D. J. & Kathiresan, S., 2016, In: Atherosclerosis. 250, p. 63-68

    Research output: Contribution to journal › Article › Academic › peer-review

    8 Citations (Scopus)

  • The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

    Ehret, G. B., Ferreira, T., Chasman, D. I., Jackson, A. U., Schmidt, E. M., Johnson, T., Thorleifsson, G., Luan, J., Donnelly, L. A., Kanoni, S., Petersen, A. -K., Pihurl, V., Strawbridge, R. J., Shungin, D., Hughes, M. F., Meirelles, O., Kaakinen, M., Bouatia-Naji, N., Kristiansson, K., Shah, S., & 321 othersKleber, M. E., Guo, X., Lyytikainen, L-P., Fava, C., Eriksson, N., Nolte, I. M., Magnusson, P. K., Salfati, E. L., Rallidis, L. S., Theusch, E., Smith, A. J. P., Folkersen, L., Witkowska, K., Pers, T. H., Joehanes, R., Kim, S. K., Lataniotis, L., Jansen, R., Johnson, A. D., Warren, H., Kim, Y. J., Zhao, W., Wu, Y., Tayo, B. O., Bochud, M., Absher, D., Adair, L. S., Amin, N., Arkingl, D. E., Axelsson, T., Baldassarre, D., Balkau, B., Bandinelli, S., Barnes, M. R., Barroso, I., Bevan, S., Bis, J. C., Bjornsdottir, G., Boehnke, M., Boerwinkle, E., Bonnycastle, L. L., Boomsma, D. I., Bornstein, S. R., Brown, M. J., Burnier, M., Cabrera, C. P., Chambers, J. C., Chang, I-S., Cheng, C-Y., Chines, P. S., Chung, R-H., Collins, F. S., Connell, J. M., Doring, A., Dallongeville, J., Danesh, J., de Faire, U., Delgado, G., Dominiczak, A. F., Doney, A. S. F., Drenos, F., Edkins, S., Eicher, J. D., Elosua, R., Enroth, S., Erdmann, J., Eriksson, P., Esko, T., Evangelou, E., Evans, A., Fai, T., Farra, M., Felixl, J. F., Ferrieres, J., Ferrucci, L., Fornage, M., Forrester, T., Franceschinil, N., Franco, O. H., Franco-Cereceda, A., Fraser, R. M., Ganesh, S. K., Gao, H., Gertow, K., Gianfagna, F., Gigante, B., Giulianini, F., Goe, A., Goodall, A. H., Goodarzi, M., Gorski, M., Grassler, J., Groves, C. J., Gudnason, V., Gyllensten, U., Hallmans, G., Hartikainen, A-L., Hassinen, M., Havulinna, A. S., Hayward, C., Hercberg, S., Herzig, K-H., Hicks, A. A., Hingorani, A. D., Hirschhorn, J. N., Hofmanl, A., Holmen, J., Holmen, O. L., Hottenga, J-J., Howard, P., Hsiung, C. A., Hunt, S. C., Ikram, M. A., Illig, T., Iribarren, C., Jensen, R. A., Kahonen, M., Kang, H. M., Kathiresan, S., Keating, B. J., Khaw, K-T., Kim, Y. K., Kim, E., Kivimaki, M., Klopp, N., Kolovou, G., Komulainen, P., Kooner, J. S., Kosova, G., Krauss, R. M., Kuh, D., Kutalik, Z., Kuusisto, J., Kvaloy, K., Lakka, T. A., Lee, N. R., Lee, I-T., Lee, W-J., Levy, D., Li, X., Liang, K-W., Lin, H., Lin, L., Lindstrom, J., Lobbens, S., Mannisto, S., Muller, G., Muller-Nurasyid, M., Mach, F., Markus, H. S., Marouli, E., McCarthy, M. I., McKenzie, C. A., Meneton, P., Menni, C., Metspalu, A., Mijatovic, V., Moilanen, L., Montasser, M. E., Morris, A. D., Morrison, A. C., Mulas, A., Nagaraja, R., Narisu, N., Nikus, K., O'Donnell, C. J., O'Reilly, P. F., Ong, K. K., Paccaud, F., Palmer, C. D., Parsa, A., Pedersen, N. L., Penninx, B. W., Perola, M., Peters, A., Poulter, N., Pramstaller, P. P., Psaty, B. M., Quertermous, T., Rao, D. C., Rasheed, A., Rayner, N. W., Renstrom, F., Rettig, R., Rice, K. M., Roberts, R., Rose, L. M., Rossouw, J., Samani, N. J., Sanna, S., Saramies, J., Schunkert, H., Sebert, S., Sheu, W. H-H., Shin, Y-A., Sim, X., Smit, J. H., Smith, A. V., Sosa, M. X., Spector, T. D., Stancakova, A., Stanton, A. V., Stirrups, K. E., Stringham, H. M., Sundstrom, J., Swift, A. J., Syvanen, A-C., Tai, E-S., Tanaka, T., Tarasov, K. V., Teumer, A., Thorsteinsdottir, U., Tobin, M. D., Tremoli, E., Uitterlinden, A. G., Uusitupa, M., Vaez, A., Vaidya, D., van Duijn, C. M., van Iperen, E. P. A., Vasan, R. S., Verwoert, G. C., Virtamo, J., Vitart, V., Voight, B. F., Vollenweider, P., Wagner, A., Wain, L. V., Wareham, N. J., Watldns, H., Weder, A. B., Westra, H. J., Wilks, R., Wilsgaard, T., Wilson, J. F., Wong, T. Y., Yang, T-P., Yao, J., Yengo, L., Zhang, W., Zhao, J. H., Zhu, X., Bovet, P., Cooper, R. S., Mohlke, K. L., Saleheen, D., Lee, J-Y., Elliott, P., Gierman, H. J., Willer, C. J., Franke, L., Hovingh, G. K., Taylor, K. D., Dedoussis, G., Sever, P., Wong, A., Lind, L., Assimes, T. L., Njolstad, I., Schwarz, P. E. H., Langenberg, C., Snieder, H., Caulfield, M. J., Melander, E., Laakso, M., Saltevo, J., Rauramaa, R., Tuomilehto, J., Ingelsson, E., Lehtimaki, T., Hveem, K., Palmas, W., Marz, W., Kumar, M., Salomaa, V., Chen, Y-D. I., Rotter, J. I., Froguel, P., Jarvelin, M-R., Lakatta, E. G., Kuulasmaa, K., Franks, P. W., Hamsten, A., Wichmann, H-E., Palmer, C. N. A., Stefansson, K., Ridker, P. M., Loos, R. J. F., Chalcravarti, A., Deloukas, P., Morris, A. P., Newton-Cheh, C., Munroe, P. B., Pihur, V., Lyytikäinen, L-P., Eriksson, N., Arking, D. E., Barroso, I., Döring, A., Fall, T., Farrall, M., Felix, J. F., Franceschini, N., Goel, A., Gräßler, J., Hallmans, G., Hofman, A., Kähönen, M., Kvaløy, K., Lindström, J., Männistö, S., Renström, F., Stančáková, A., Syvänen, A-C., Watkins, H., Njølstad, I., Melander, O., Lehtimäki, T., März, W., Kumari, M. & Chakravarti, A., Oct 2016, In: Nature Genetics. 48, 10, p. 1171-1184

    Research output: Contribution to journal › Article › Academic › peer-review

    303 Citations (Scopus)
  • 2017

    ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels

    Trigueros-Motos, L., van Capelleveen, J. C., Torta, F., Castaño, D., Zhang, L-H., Chai, E. C., Kang, M., Dimova, L. G., Schimmel, A. W. M., Tietjen, I., Radomski, C., Tan, L. J., Thiam, C. H., Narayanaswamy, P., Wu, D. H., Dorninger, F., Yakala, G. K., Barhdadi, A., Angeli, V., Dubé, M-P., & 7 othersBerger, J., Dallinga-Thie, G. M., Tietge, U. J. F., Wenk, M. R., Hayden, M. R., Hovingh, G. K. & Singaraja, R. R., 2017, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 11, p. 2147-2155

    Research output: Contribution to journal › Article › Academic › peer-review

    45 Citations (Scopus)

  • Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study

    van Capelleveen, J. C., Bernelot Moens, S. J., Yang, X., Kastelein, J. J. P., Wareham, N. J., Zwinderman, A. H., Stroes, E. S. G., Witztum, J. L., Hovingh, G. K., Khaw, K-T., Boekholdt, S. M. & Tsimikas, S., 2017, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 6, p. 1206-1212

    Research output: Contribution to journal › Article › Academic › peer-review

    56 Citations (Scopus)

  • Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer-Norfolk Prospective Population Study, the Atherosclerosis Risk in Communities Study, and the Women's Health Study

    van Capelleveen, J. C., Bochem, A. E., Boekholdt, S. M., Mora, S., Hoogeveen, R. C., Ballantyne, C. M., Ridker, P. M., Sun, W., Barter, P. J., Tall, A. R., Zwinderman, A. H., Kastelein, J. J. P., Wareham, N. J., Khaw, K-T. & Hovingh, G. K., 2017, In: Journal of the American Heart Association. 6, 8, e006636.

    Research output: Contribution to journal › Article › Academic › peer-review

    12 Citations (Scopus)

  • Carriers of the PCSK9 R46L Variant Are Characterized by an Antiatherogenic Lipoprotein Profile Assessed by Nuclear Magnetic Resonance Spectroscopy-Brief Report

    Verbeek, R., Boyer, M., Boekholdt, S. M., Hovingh, G. K., Kastelein, J. J. P., Wareham, N., Khaw, K-T. & Arsenault, B. J., 2017, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 1, p. 43-48

    Research output: Contribution to journal › Article › Academic › peer-review

    20 Citations (Scopus)

  • Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals

    Holzinger, E. R., Verma, S. S., Moore, C. B., Hall, M., de, R., Gilbert-Diamond, D., Lanktree, M. B., Pankratz, N., Amuzu, A., Burt, A., Dale, C., Dudek, S., Furlong, C. E., Gaunt, T. R., Kim, D. S., Riess, H., Sivapalaratnam, S., Tragante, V., van Iperen, E. P. A., Brautbar, A., & 32 othersCarrell, D. S., Crosslin, D. R., Jarvik, G. P., Kuivaniemi, H., Kullo, I. J., Larson, E. B., Rasmussen-Torvik, L. J., Tromp, G., Baumert, J., Cruickshanks, K. J., Farrall, M., Hingorani, A. D., Hovingh, G. K., Kleber, M. E., Klein, B. E., Klein, R., Koenig, W., Lange, L. A., Mӓrz, W., North, K. E., Charlotte Onland-Moret, N., Reiner, A. P., Talmud, P. J., van der Schouw, Y. T., Wilson, J. G., Kivimaki, M., Kumari, M., Moore, J. H., Drenos, F., Asselbergs, F. W., Keating, B. J. & Ritchie, M. D., 2017, In: BioData mining. 10, p. 25

    Research output: Contribution to journal › Article › Academic › peer-review

    8 Citations (Scopus)

  • Effects of Supra-Physiological Levothyroxine Dosages on Liver Parameters, Lipids and Lipoproteins in Healthy Volunteers: A Randomized Controlled Crossover Study

    Sjouke, B., Elbers, L. P. B., van Zaane, B., Kastelein, J. J. P., Hovingh, G. K. & Gerdes, V. E. A., 2017, In: Scientific reports. 7, 1, 14174.

    Research output: Contribution to journal › Article › Academic › peer-review

    4 Citations (Scopus)

  • Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 monoclonal antibody alirocumab vs placebo in patients with heterozygous familial hypercholesterolemia

    Kastelein, J. J. P., Hovingh, G. K., Langslet, G., Baccara-Dinet, M. T., Gipe, D. A., Chaudhari, U., Zhao, J., Minini, P. & Farnier, M., 2017, In: Journal of clinical lipidology. 11, 1, p. 195-203

    Research output: Contribution to journal › Article › Academic › peer-review

    54 Citations (Scopus)

  • European Society of Cardiology/European Atherosclerosis Society Task Force consensus statement on proprotein convertase subtilisin/kexin type 9 inhibitors: practical guidance for use in patients at very high cardiovascular risk

    Landmesser, U., Chapman, M. J., Farnier, M., Gencer, B., Gielen, S., Hovingh, G. K., Lüscher, T. F., Sinning, D., Tokgözoglu, L., Wiklund, O., Zamorano, J. L., Pinto, F. J. & Catapano, A. L., 2017, In: European Heart journal. 38, 29, p. 2245-2255

    Research output: Contribution to journal › Article › Academic › peer-review

    129 Citations (Scopus)

  • Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

    AUTHOR GROUP, 2017, In: Molecular psychiatry. 22, 2, p. 192-201

    Research output: Contribution to journal › Article › Academic › peer-review

    49 Citations (Scopus)

  • Extending the use of GWAS data by combining data from different genetic platforms

    van Iperen, E. P. A., Hovingh, G. K., Asselbergs, F. W. & Zwinderman, A. H., 2017, In: PLOS ONE. 12, 2, e0172082.

    Research output: Contribution to journal › Article › Academic › peer-review

    5 Citations (Scopus)

  • Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk

    CARDIoGRAM Consortium, CARDIoGRAMPlusC4D Consortium, Wellcome Trust Case Control Consortium & MuTHER Consortium, 1 Aug 2017, In: PLOS ONE. 12, 8, e0182999.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    4 Citations (Scopus)

  • GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia

    Hu, X., Dallinga-Thie, G. M., Hovingh, G. K., Chang, S. Y., Sandoval, N. P., Dang, T. L. P., Fukamachi, I., Miyashita, K., Nakajima, K., Murakami, M., Fong, L. G., Ploug, M., Young, S. G. & Beigneux, A. P., 2017, In: Journal of clinical lipidology. 11, 4, p. 964-971

    Research output: Contribution to journal › Article › Academic › peer-review

    25 Citations (Scopus)

  • Homozygous familial hypercholesterolaemia: light at the end of the tunnel

    Stoekenbroek, R. M., Kees Hovingh, G. & Kastelein, J. J. P., 2017, In: European Heart journal. 39, 14, p. 1169-1171

    Research output: Contribution to journal › Article › Academic › peer-review

    4 Citations (Scopus)

  • Ideal cardiovascular health influences cardiovascular disease risk associated with high lipoprotein(a) levels and genotype: The EPIC-Norfolk prospective population study

    Perrot, N., Verbeek, R., Sandhu, M., Boekholdt, S. M., Hovingh, G. K., Wareham, N. J., Khaw, K-T. & Arsenault, B. J., 2017, In: Atherosclerosis. 256, p. 47-52

    Research output: Contribution to journal › Article › Academic › peer-review

    61 Citations (Scopus)

  • Identification and Management of Statin-Associated Symptoms in Clinical Practice: Extension of a Clinician Survey to 12 Further Countries

    Rosenson, R. S., Gandra, S. R., McKendrick, J., Dent, R., Wieffer, H., Cheng, L-I., Catapano, A. L., Oh, P., Kees Hovingh, G. & Stroes, E. S., 2017, In: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. 31, 2, p. 187-195

    Research output: Contribution to journal › Article › Academic › peer-review

    17 Citations (Scopus)

  • Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

    EPIC-CVD Consortium, Takeuchi, F., Tan, S. P., van der Most, P. J., van Vliet-Ostaptchouk, J. V., Wong, A., Yengo, L., Zhao, W., Goel, A., Martinez Larrad, M. T., Radke, D., Salo, P., Tanaka, T., van Iperen, E. P. A., Abecasis, G., Afaq, S., Alizadeh, B. Z., Bertoni, A. G., Bonnefond, A., Bottcher, Y., & 145 othersBottinger, E. P., Campbell, H., Carlson, O. D., Chen, C-H., Cho, Y. S., Garvey, W. T., Gieger, C., Goodarzi, M. O., Grallert, H., Hamsten, A., Hartman, C. A., Herder, C., Hsiung, C. A., Huang, J., Igase, M., Isono, M., Katsuya, T., Khor, C-C., Kiess, W., Kohara, K., Kovacs, P., Lee, J., Lee, W-J., Lehne, B., Li, H., Liu, J., Lobbens, S., Luan, J., Lyssenko, V., Meitinger, T., Miki, T., Miljkovic, I., Moon, S., Mulas, A., Muller, G., Muller-Nurasyid, M., Nagaraja, R., Nauck, M., Pankow, J. S., Polasek, O., Prokopenko, I., Ramos, P. S., Rasmussen-Torvik, L., Rathmann, W., Rich, S. S., Robertson, N. R., Roden, M., Roussel, R., Rudan, I., Scott, R. A., Scott, W. R., Sennblad, B., Siscovick, D. S., Strauch, K., Sun, L., Swertz, M., Tajuddin, S. M., Taylor, K. D., teo, Y-Y., Tham, Y. C., Tonjes, A., Wareham, N. J., Wilsgaard, T., Hingorani, A. D., Egan, J., Ferrucci, L., Hovingh, G. K., Jula, A., Kivimaki, M., Kumari, M., Njolstad, I., Palmer, C. N. A., Serrano Rios, M., Stumvoll, M., Watkins, H., Aung, T., Bluher, M., Boehnke, M., Bornstein, S. R., Chambers, J. C., Chasman, D. I., Chen, Y-D. I., Cheng, C-Y., Cucca, F., Deloukas, P., Evans, M. K., Fornage, M., Friedlander, Y., Froguel, P., Groop, L., Gross, M. D., Harris, T. B., Hayward, C., Heng, C-K., Ingelsson, E., Kato, N., Kim, B-J., Koh, W-P., Kooner, J. S., Korner, A., Kuh, D., Kuusisto, J., Laakso, M., Lin, X., Liu, Y., Loos, R. J. F., Magnusson, P. K. E., Marz, W., McCarthy, M. I., Oldehinkel, A. J., Ong, K. K., Pedersen, N. L., Pereira, M. A., Peters, A., Ridker, P. M., Sabanayagam, C., Sale, M., Saleheen, D., Saltevo, J., Schwarz, P. E., Sheu, W. H. H., Snieder, H., Spector, T. D., Tabara, Y., Tuomilehto, J., Wilson, J. G., Wilson, J. F., Wolffenbuttel, B. H. R., Wong, T. Y., Wu, J-Y., Yuan, J-M., Zonderman, A. B., Soranzo, N., Guo, X., Roberts, D. J., Florez, J. C., Sladek, R., Dupuis, J., Morris, A. P., Tai, E. -S., Selvin, E., Rotter, J. I., Langenberg, C., Barroso, I. & Meigs, J. B., Sept 2017, In: PLoS medicine. 14, 9, p. e1002383 e1002383.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    274 Citations (Scopus)

  • Long-term safety, tolerability, and efficacy of evolocumab in patients with heterozygous familial hypercholesterolemia

    Hovingh, G. K., Raal, F. J., Dent, R., Stefanutti, C., Descamps, O., Masana, L., Lira, A., Bridges, I., Coll, B. & Sullivan, D., 2017, In: Journal of clinical lipidology. 11, 6, p. 1448-1457

    Research output: Contribution to journal › Article › Academic › peer-review

    47 Citations (Scopus)

  • Long-term treatment with evolocumab added to conventional drug therapy, with or without apheresis, in patients with homozygous familial hypercholesterolaemia: an interim subset analysis of the open-label TAUSSIG study

    Raal, F. J., Hovingh, G. K., Blom, D., Santos, R. D., Harada-Shiba, M., Bruckert, E., Couture, P., Soran, H., Watts, G. F., Kurtz, C., Honarpour, N., Tang, L., Kasichayanula, S., Wasserman, S. M. & Stein, E. A., 2017, In: Lancet. Diabetes and endocrinology. 5, 4, p. 280-290

    Research output: Contribution to journal › Article › Academic › peer-review

    195 Citations (Scopus)

  • Managing the challenging homozygous familial hypercholesterolemia patient: Academic insights and practical approaches for a severe dyslipidemia, a National Lipid Association Masters Summit

    Hovingh, G. K., Goldberg, A. C. & Moriarty, P. M., 2017, In: Journal of clinical lipidology. 11, 3, p. 602-616

    Research output: Contribution to journal › Article › Academic › peer-review

    16 Citations (Scopus)

  • Open-label therapy with alirocumab in patients with heterozygous familial hypercholesterolemia: Results from three years of treatment

    Dufour, R., Bergeron, J., Gaudet, D., Weiss, R., Hovingh, G. K., Qing, Z., Yang, F., Andisik, M., Torri, A., Pordy, R. & Gipe, D. A., 2017, In: International journal of cardiology. 228, p. 754-760

    Research output: Contribution to journal › Article › Academic › peer-review

    18 Citations (Scopus)

  • PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study: a mendelian randomisation study

    Schmidt, A. F., Swerdlow, D. I., Holmes, M. V., Patel, R. S., Fairhurst-Hunter, Z., Lyall, D. M., Hartwig, F. P., Horta, B. L., Hyppönen, E., Power, C., Moldovan, M., van Iperen, E., Hovingh, G. K., Demuth, I., Norman, K., Steinhagen-Thiessen, E., Demuth, J., Bertram, L., Liu, T., Coassin, S., & 113 othersWilleit, J., Kiechl, S., Willeit, K., Mason, D., Wright, J., Morris, R., Wanamethee, G., Whincup, P., Ben-Shlomo, Y., McLachlan, S., Price, J. F., Kivimaki, M., Welch, C., Sanchez-Galvez, A., Marques-Vidal, P., Nicolaides, A., Panayiotou, A. G., Onland-Moret, N. C., van der Schouw, Y. T., Matullo, G., Fiorito, G., Guarrera, S., Sacerdote, C., Wareham, N. J., Langenberg, C., Scott, R., Luan, J., Bobak, M., Malyutina, S., Pająk, A., Kubinova, R., Tamosiunas, A., Pikhart, H., Husemoen, L. L. N., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Simonsen, K. S., Cooper, J., Humphries, S. E., Brilliant, M., Kitchner, T., Hakonarson, H., Carrell, D. S., McCarty, C. A., Kirchner, H. L., Larson, E. B., Crosslin, D. R., de Andrade, M., Roden, D. M., Denny, J. C., Carty, C., Hancock, S., Attia, J., Holliday, E., O'Donnell, M., Yusuf, S., Chong, M., Pare, G., van der Harst, P., Said, M. A., Eppinga, R. N., Verweij, N., Snieder, H., Christen, T., Mook-Kanamori, D. O., Gustafsson, S., Lind, L., Ingelsson, E., Pazoki, R., Franco, O., Hofman, A., Uitterlinden, A., Dehghan, A., Teumer, A., Baumeister, S., Dörr, M., Lerch, M. M., Völker, U., Völzke, H., Ward, J., Pell, J. P., Smith, D. J., Meade, T., Maitland-van der Zee, A. H., Baranova, E. V., Young, R., Ford, I., Campbell, A., Padmanabhan, S., Bots, M. L., Grobbee, D. E., Froguel, P., Thuillier, D., Balkau, B., Bonnefond, A., Cariou, B., Smart, M., Bao, Y., Kumari, M., Mahajan, A., Ridker, P. M., Chasman, D. I., Reiner, A. P., Lange, L. A., Ritchie, M. D., Asselbergs, F. W., Casas, J-P., Keating, B. J., Preiss, D., Hingorani, A. D. & Sattar, N., Feb 2017, In: Lancet. Diabetes and endocrinology. 5, 2, p. 97-105 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    278 Citations (Scopus)

  • Plasma lipoprotein(a) levels in patients with homozygous autosomal dominant hypercholesterolemia

    Sjouke, B., Yahya, R., Tanck, M. W. T., Defesche, J. C., de Graaf, J., Wiegman, A., Kastelein, J. J. P., Mulder, M. T., Hovingh, G. K. & Roeters van Lennep, J. E., 2017, In: Journal of clinical lipidology. 11, 2, p. 507-514

    Research output: Contribution to journal › Article › Academic › peer-review

    18 Citations (Scopus)

  • Rare and low-frequency coding variants alter human adult height

    EPIC-InterAct Consortium, Böger, C. A., Bonnycastle, L. L., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Burt, A. A., Butterworth, A. S., Carey, D. J., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y-D. I., Chowdhury, R., Christensen, C., & 299 othersChu, A. Y., Cocca, M., Collins, F. S., Cook, J. P., Corley, J., Galbany, J. C., Cox, A. J., Cuellar-Partida, G., Danesh, J., Davies, G., de Bakker, P. I. W., de Borst, G. J., de Denus, S., de Groot, M. C. H., de Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., den Hollander, A. I., Dennis, J. G., Di Angelantonio, E., Drenos, F., Du, M., Dunning, A. M., Easton, D. F., Ebeling, T., Edwards, T. L., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A-E., Faul, J. D., Feitosa, M. F., Feng, S., Ferrannini, E., Ferrario, M. M., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franks, P. W., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Giedraitis, V., Giri, A., Girotto, G., Gordon, S. D., Gordon-Larsen, P., Gorski, M., Grarup, N., Grove, M. L., Gudnason, V., Gustafsson, S., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Hayward, C., He, L., Heid, I. M., Heikkilä, K., Helgeland, Ø., Hernesniemi, J., Hewitt, A. W., Hocking, L. J., Hollensted, M., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hoyng, C. B., Huang, P. L., Hveem, K., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J-H., Jarvik, G. P., Jensen, G. B., Jhun, M. A., Jia, Y., Jiang, X., Johansson, S., Jørgensen, M. E., Jørgensen, T., Jousilahti, P., Jukema, J. W., Kahali, B., Kahn, R. S., Kähönen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kee, F., Keeman, R., Kiemeney, L. A., Kitajima, H., Kluivers, K. B., Kocher, T., Komulainen, P., Kontto, J., Kooner, J. S., Kooperberg, C., Kovacs, P., Kriebel, J., Kuivaniemi, H., Küry, S., Kuusisto, J., La Bianca, M., Laakso, M., Lakka, T. A., Lange, E. M., Lange, L. A., Langefeld, C. D., Langenberg, C., Larson, E. B., Lee, I. -T., Lehtimäki, T., Lewis, C. E., Li-Gao, R., Lin, H., Lin, L-A., Lin, X., Lind, L., Lindström, J., Linneberg, A., Liu, Y., Liu, Y., Lophatananon, A., Luan, J., Lubitz, S. A., Lyytikäinen, L-P., Mackey, D. A., Madden, P. A. F., Manning, A. K., Männistö, S., Marenne, G., Marten, J., Martin, N. G., Mazul, A. L., Meidtner, K., Metspalu, A., Mitchell, P., Mohlke, K. L., Mook-Kanamori, D. O., Morgan, A., Morris, A. D., Morris, A. P., Müller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Nauck, M., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njølstad, P. R., Nordestgaard, B. G., Ntalla, I., O'Connel, J. R., Oksa, H., Loohuis, L. M. O., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Person, T. N., Pirie, A., Polasek, O., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Reiner, A. P., Renström, F., Ridker, P. M., Rioux, J. D., Robertson, N., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sandow, K., Sapkota, Y., Sattar, N., Schmidt, M. K., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S., Sim, X., Sivapalaratnam, S., Small, K. S., Smith, A. V., Smith, J. A., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Steinthorsdottir, V., Stringham, H. M., Stumvoll, M., Surendran, P., 't Hart, L. M., Tansey, K. E., Tardif, J-C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorsteinsdottir, U., Thuesen, B. H., Tönjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Ulivi, S., van der Laan, S. W., van der Leij, A. R., van Duijn, C. M., van Setten, J., Varbo, A., Varga, T. V., Varma, R., Edwards, D. R. V., Vermeulen, S. H., Vestergaard, H., Vitart, V., Vogt, T. F., Vozzi, D., Walker, M., Wang, F., Wang, C. A., Wang, S., Wang, Y., Wareham, N. J., Warren, H. R., Wessel, J., Willems, S. M., Wilson, J. G., Witte, D. R., Woods, M. O., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zheng, H., Zhou, W., Rotter, J. I., Boehnke, M., Kathiresan, S., McCarthy, M. I., Willer, C. J., Stefansson, K., Borecki, I. B., Liu, D. J., North, K. E., Heard-Costa, N. L., Pers, T. H., Lindgren, C. M., Oxvig, C., Kutalik, Z., Rivadeneira, F., Loos, R. J. F., Frayling, T. M., Hirschhorn, J. N., Deloukas, P. & Lettre, G., 9 Feb 2017, In: NATURE. 542, 7640, p. 186-190 5 p.

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    Open Access
    414 Citations (Scopus)

  • Selection of individuals for genetic testing for familial hypercholesterolaemia: development and external validation of a prediction model for the presence of a mutation causing familial hypercholesterolaemia

    Besseling, J., Reitsma, J. B., Gaudet, D., Brisson, D., Kastelein, J. J. P., Hovingh, G. K. & Hutten, B. A., 2017, In: European Heart journal. 38, 8, p. 565-573

    Research output: Contribution to journal › Article › Academic › peer-review

    46 Citations (Scopus)

  • Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease

    Webb, T. R., Erdmann, J., Stirrups, K. E., Stitziel, N. O., Masca, N. G. D., Jansen, H., Kanoni, S., Nelson, C. P., Ferrario, P. G., König, I. R., Eicher, J. D., Johnson, A. D., Hamby, S. E., Betsholtz, C., Ruusalepp, A., Franzén, O., Schadt, E. E., Björkegren, J. L. M., Weeke, P. E., Auer, P. L., & 114 othersSchick, U. M., Lu, Y., Zhang, H., Dube, M-P., Goel, A., Farrall, M., Peloso, G. M., Won, H-H., Do, R., van Iperen, E., Kruppa, J., Mahajan, A., Scott, R. A., Willenborg, C., Braund, P. S., van Capelleveen, J. C., Doney, A. S. F., Donnelly, L. A., Asselta, R., Merlini, P. A., Duga, S., Marziliano, N., Denny, J. C., Shaffer, C., El-Mokhtari, N. E., Franke, A., Heilmann, S., Hengstenberg, C., Hoffmann, P., Holmen, O. L., Hveem, K., Jansson, J-H., Jöckel, K-H., Kessler, T., Kriebel, J., Laugwitz, K. L., Marouli, E., Martinelli, N., McCarthy, M. I., van Zuydam, N. R., Meisinger, C., Esko, T., Mihailov, E., Escher, S. A., Alver, M., Moebus, S., Morris, A. D., Virtamo, J., Nikpay, M., Olivieri, O., Provost, S., AlQarawi, A., Robertson, N. R., Akinsansya, K. O., Reilly, D. F., Vogt, T. F., Yin, W., Asselbergs, F. W., Kooperberg, C., Jackson, R. D., Stahl, E., Müller-Nurasyid, M., Strauch, K., Varga, T. V., Waldenberger, M., Zeng, L., Chowdhury, R., Salomaa, V., Ford, I., Jukema, J. W., Amouyel, P., Kontto, J., Nordestgaard, B. G., Ferrières, J., Saleheen, D., Sattar, N., Surendran, P., Wagner, A., Young, R., Howson, J. M. M., Butterworth, A. S., Danesh, J., Ardissino, D., Bottinger, E. P., Erbel, R., Franks, P. W., Girelli, D., Hall, A. S., Hovingh, G. K., Kastrati, A., Lieb, W., Meitinger, T., Kraus, W. E., Shah, S. H., McPherson, R., Orho-Melander, M., Melander, O., Metspalu, A., Palmer, C. N. A., Peters, A., Rader, D. J., Reilly, M. P., Loos, R. J. F., Reiner, A. P., Roden, D. M., Tardif, J-C., Thompson, J. R., Wareham, N. J., Watkins, H., Willer, C. J., Samani, N. J., Schunkert, H., Deloukas, P. & Kathiresan, S., 2017, In: Journal of the American College of Cardiology. 69, 7, p. 823-836

    Research output: Contribution to journal › Article › Academic › peer-review

    188 Citations (Scopus)

  • The effect of lomitapide on cardiovascular outcome measures in homozygous familial hypercholesterolemia: A modelling analysis

    Leipold, R., Raal, F., Ishak, J., Hovingh, K. & Phillips, H., 2017, In: European journal of preventive cardiology. 24, 17, p. 1843-1850

    Research output: Contribution to journal › Article › Academic › peer-review

    29 Citations (Scopus)
  • 2018

    2017 Update of ESC/EAS Task Force on practical clinical guidance for proprotein convertase subtilisin/kexin type 9 inhibition in patients with atherosclerotic cardiovascular disease or in familial hypercholesterolaemia

    Landmesser, U., Chapman, M. J., Stock, J. K., Amarenco, P., Belch, J. J. F., Borén, J., Farnier, M., Ference, B. A., Gielen, S., Graham, I., Grobbee, D. E., Hovingh, G. K., Lüscher, T. F., Piepoli, M. F., Ray, K. K., Stroes, E. S., Wiklund, O., Windecker, S., Zamorano, J. L., Pinto, F., & 3 othersTokgözoglu, L., Bax, J. J. & Catapano, A. L., 2018, In: European Heart journal. 39, 14, p. 1131–1143

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    179 Citations (Scopus)

  • Achieved LDL cholesterol levels in patients with heterozygous familial hypercholesterolemia: A model that explores the efficacy of conventional and novel lipid-lowering therapy

    Hartgers, M. L., Besseling, J., Stroes, E. S., Wittekoek, J., Rutten, J. H. W., de Graaf, J., Visseren, F. L. J., Imholz, B. P. M., Roeters van Lennep, J. E., Huijgen, R., Kastelein, J. J. P. & Hovingh, G. K., 2018, In: Journal of clinical lipidology. 12, 4, p. 972-980.e1

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    16 Citations (Scopus)

  • A Deep Intronic Variant in LDLR in Familial Hypercholesterolemia

    Reeskamp, L. F., Hartgers, M. L., Peter, J., Dallinga-Thie, G. M., Zuurbier, L., Defesche, J. C., Grefhorst, A. & Hovingh, G. K., 1 Dec 2018, In: Circulation. Genomic and precision medicine. 11, 12, p. e002385

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    Open Access
    22 Citations (Scopus)

  • Alirocumab dosing patterns during 40 months of open-label treatment in patients with heterozygous familial hypercholesterolemia

    Hovingh, G. K., Guyton, J. R., Langslet, G., Dufour, R., Baccara-Dinet, M. T., Din-Bell, C., Manvelian, G. & Farnier, M., 2018, In: Journal of clinical lipidology. 12, 6, p. 1463-1470

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    Open Access
    2 Citations (Scopus)

  • Assessment of the 1% of Patients with Consistent < 15% Reduction in Low-Density Lipoprotein Cholesterol: Pooled Analysis of 10 Phase 3 ODYSSEY Alirocumab Trials

    Bays, H. E., Rosenson, R. S., Baccara-Dinet, M. T., Louie, M. J., Thompson, D. & Hovingh, G. K., 2018, In: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. 32, 2, p. 175-180

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    Open Access
    22 Citations (Scopus)

  • Cardiovascular disease risk associated with elevated lipoprotein(a) attenuates at low low-density lipoprotein cholesterol levels in a primary prevention setting

    Verbeek, R., Hoogeveen, R. M., Langsted, A., Stiekema, L. C. A., Verweij, S. L., Hovingh, G. K., Wareham, N. J., Khaw, K-T., Boekholdt, S. M., Nordestgaard, B. G. & Stroes, E. S. G., 2018, In: European Heart journal. 39, 27, p. 2589-2596 8 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    90 Citations (Scopus)

  • Complete and Partial Lecithin:Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis

    Oldoni, F., Baldassarre, D., Castelnuovo, S., Ossoli, A., Amato, M., van Capelleveen, J., Hovingh, G. K., de Groot, E., Bochem, A., Simonelli, S., Barbieri, S., Veglia, F., Franceschini, G., Kuivenhoven, J. A., Holleboom, A. G. & Calabresi, L., 2018, In: Circulation. 138, 10, p. 1000-1007

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    51 Citations (Scopus)

  • Effect of atorvastatin, cholesterol ester transfer protein inhibition, and diabetes mellitus on circulating proprotein subtilisin kexin type 9 and lipoprotein(a) levels in patients at high cardiovascular risk

    Arsenault, B. J., Petrides, F., Tabet, F., Bao, W., Hovingh, G. K., Boekholdt, S. M., Ramin-Mangata, S., Meilhac, O., DeMicco, D., Rye, K-A., Waters, D. D., Kastelein, J. J. P., Barter, P. & Lambert, G., 2018, In: Journal of clinical lipidology. 12, 1, p. 130-136

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    40 Citations (Scopus)

  • Efficacy and Safety of Pitavastatin in Children and Adolescents with Familial Hypercholesterolemia in Japan and Europe

    Harada-Shiba, M., Kastelein, J. J. P., Hovingh, G. K., Ray, K. K., Ohtake, A., Arisaka, O., Ohta, T., Okada, T., Suganami, H. & Wiegman, A., 2018, In: Journal of atherosclerosis and thrombosis. 25, 5, p. 422-429

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    15 Citations (Scopus)

  • Ethnic differences in plasma lipid levels in a large multiethnic cohort: The HELIUS study

    Gazzola, K., Snijder, M. B., Hovingh, G. K., Stroes, E. S. G., Peters, R. J. G. & van den Born, B-J. H., 2018, In: Journal of clinical lipidology. 12, 5, p. 1217-1224.e1

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    13 Citations (Scopus)

  • Genetics of familial hypercholesterolemia: a tool for development of novel lipid lowering pharmaceuticals?

    Volta, A., Hovingh, G. K. & Grefhorst, A., 2018, In: Current opinion in lipidology. 29, 2, p. 80-86

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    5 Citations (Scopus)

  • Inhibiting PCSK9 — biology beyond LDL control

    Stoekenbroek, R. M., Lambert, G., Cariou, B. & Hovingh, G. K., 2018, In: Nature reviews. Endocrinology. 15, 1, p. 52-62

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    96 Citations (Scopus)

  • Long-term safety and efficacy of alirocumab in patients with heterozygous familial hypercholesterolemia: An open-label extension of the ODYSSEY program

    Farnier, M., Hovingh, G. K., Langslet, G., Dufour, R., Baccara-Dinet, M. T., Din-Bell, C., Manvelian, G. & Guyton, J. R., 2018, In: Atherosclerosis. 278, p. 307-314

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    45 Citations (Scopus)

  • Naturally occurring variants in LRP1 (Low-Density lipoprotein receptor-related protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans

    Oldoni, F., van Capelleveen, J. C., Dalila, N., Wolters, J. C., Heeren, J., Sinke, R. J., Hui, D. Y., Dallinga-Thie, G. M., Frikke-Schmidt, R., Hovingh, K. G., van de Sluis, B., Tybjærg-Hansen, A. & Kuivenhoven, J. A., 2018, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 7, p. 1440-1453

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    13 Citations (Scopus)

  • Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

    Vallejo-Vaz, A. J., Marco, M. D., Stevens, C. A. T., Akram, A., Freiberger, T., Hovingh, G. K., Kastelein, J. J. P., Mata, P., Raal, F. J., Santos, R. D., Soran, H., Watts, G. F., Abifadel, M., Aguilar-Salinas, C. A., Al-Khnifsawi, M., Alkindi, F. A., Alnouri, F., Alonso, R., Al-Rasadi, K., Al-Sarraf, A., & 331 othersAshavaid, T. F., Binder, C. J., Bogsrud, M. P., Bourbon, M., Bruckert, E., Chlebus, K., Corral, P., Descamps, O., Durst, R., Ezhov, M., Fras, Z., Genest, J., Groselj, U., Harada-Shiba, M., Kayikcioglu, M., Lalic, K., Lam, C. S. P., Latkovskis, G., Laufs, U., Liberopoulos, E., Lin, J., Maher, V., Majano, N., Marais, A. D., März, W., Mirrakhimov, E., Miserez, A. R., Mitchenko, O., Nawawi, H. M., Nordestgaard, B. R. G., Paragh, G., Petrulioniene, Z., Pojskic, B., Postadzhiyan, A., Reda, A., Reiner, Ž., Sadoh, W. E., Sahebkar, A., Shehab, A., Shek, A. B., Stoll, M., Su, T-C., Subramaniam, T., Susekov, A. V., Symeonides, P., Tilney, M., Tomlinson, B., Truong, T-H., Tselepis, A. D., Tybjærg-Hansen, A., Vázquez-Cárdenas, A., Viigimaa, M., Vohnout, B., Widén, E., Yamashita, S., Banach, M., Gaita, D., Jiang, L., Nilsson, L., Santos, L. E., Schunkert, H., Tokgözoğlu, L., Car, J., Catapano, A. L., Ray, K. K., Akram, A., Car, J., Marco, M. D., Ray, K. K., Stevens, C. A. T., Vallejo-Vaz, A. J., Corral, P., Schreier, L., Watts, G. F., Pang, J., Binder, C. J., Dieplinger, H., Hanauer-Mader, G., Descamps, O., Desutter, J., Langlois, M., Mertens, A., Rietzschel, E., Wallemacq, C., Pojskic, B., Isakovic, D., Dzankovic, A. M., Obralija, J., Pojskic, L., Sisic, I., Stimjanin, E., Torlak, V. A., Santos, R. D., Jannes, C. E., Krieger, J. E., Pereira, A. C., Postadzhiyan, A., Genest, J., Ruel, I., Alonso, R., Asenjo, S., Cuevas, A., Lin, J., Jiang, L., Reiner, Ž., Pećin, I., Symeonides, P., Miltiadous, G., Panayiotou, A. G., Freiberger, T., Vrablik, M., Nordestgaard, B. R. G., Tybjærg-Hansen, A., Benn, M., Reda, A., Viigimaa, M., Heinsar, S., Widén, E., Bruckert, E., Béliard, S., Laufs, U., März, W., Schunkert, H., Gouni-Berthold, I., Hengstenberg, W., Julius, U., Kassner, U., Klose, G., König, C., König, W., Otte, B., Parhofer, K., Schatz, U., Schmidt, N., Steinhagen-Thiessen, E., Vogt, A., Liberopoulos, E., Tselepis, A. D., Antza, C., Athyros, V., Bilianou, E., Boufidou, A., Chrousos, G., Elisaf, M., Garoufi, A., Katsiki, N., Kolovou, G., Kotsis, V., Rallidis, L., Rizos, C., Skalidis, E., Skoumas, I., Tziomalos, K., Tomlinson, B., Paragh, G., Ashavaid, T. F., Shawney, J. P. S., Sahebkar, A., Abbaszadegan, M. R., Aminzadeh, M., Hosseini, S., Mobini, M., Vakili, R., Zaeri, H., Al-Khnifsawi, M., Maher, V., Agar, R., Boran, G., Colwell, N., Crowley, V., Durkin, M., Griffin, D., Kelly, M., Rakovac-Tisdall, A., Durst, R., Bitzur, R., Cohen, H., Eliav, O., Ellis, A., Gavish, D., Harats, D., Henkin, Y., Knobler, H., Leavit, L., Leitersdorf, E., Rubinstein, A., Schurr, D., Shpitzen, S., Szalat, A., Catapano, A. L., Arca, M., Averna, M., Bertolini, S., Calandra, S., Tarugi, P., Harada-Shiba, M., Yamashita, S., Al-Sarraf, A., Mirrakhimov, E., Latkovskis, G., Erglis, A., Gilis, D., Nesterovics, G., Saripo, V., Upena-Roze, A., Abifadel, M., Elbitar, S., Jambart, S. L., Khoury, P. E., Petrulioniene, Z., Gargalskaite, U., Kutkiene, S., Nawawi, H. M., Al-Khateeb, A., An, C. Y., Ismail, Z., Kasim, S., Ibrahim, K. S., Radzi, A. B. M., Kasim, N. A., Nor, N. S. M., Ramli, A. S., Razak, S. A., Muid, S., Rosman, A., Sanusi, A. R., Razman, A. Z., Nazli, S. A., Kek, T. L., Tilney, M., Azzopardi, C., Aguilar Salinas, C. A., Vázquez-Cárdenas, N. A., Galán, G., Magaña-Torres, M. T., Martagon, A., Mehta, R., Hovingh, G. K., Kastelein, J. J. P., Wittekoek, M. E., Sadoh, W. E., Isara, A. R., Obaseki, D. E., Ohenhen, O. A., Bogsrud, M. P., Holven, K. B., Al-Rasadi, K., Santos, L. E., Banach, M., Chlebus, K., Gruchała, M., Baranowska, M., Borowiec-Wolny, J., Gilis-Malinowska, N., Michalska-Grzonkowska, A., Pajkowski, M., Parczewska, A., Romanowska-Kocejko, M., Stróżyk, A., Żarczyńska-Buchowiecka, M., Kleinschmidt, M., Bourbon, M., Alves, A. C., Medeiros, A. M., Alkindi, F. A., Gaita, D., Ezhov, M., Susekov, A. V., Ershova, A., Korneva, V., Kuznetsova, T., Malyshev, P., Meshkov, A., Rozhkova, T., Alnouri, F., Lalic, K., Rajkovic, N., Popovic, L., Lukac, S. S., Stosic, L., Rasulic, I., Lalic, N. M., Subramaniam, T., Lam, C. S. P., Chua, T. S. J., Ting, S. P. L., Vohnout, B., Raslova, K., Fras, Z., Groselj, U., Battelino, T., Cevc, M., Jug, B., Kovac, J., Podkrajsek, K. T., Sustar, U., Trontelj, K. J., Marais, D., Raal, F. J., Mata, P., Isla, L. P. D., Nilsson, L., Miserez, A. R., Martin, F. J., Su, T-C., Charng, M-J., Chen, P-L., Kayikçioglu, M., Tokgözoğlu, L., Mitchenko, O., Shehab, A., Soran, H., Stoll, M., Dell’oca, N., Fernández, G., Ressia, A., Reyes, X., Zelarayan, M., Shek, A. B., Alieva, R. B., Hoshimov, S. U., Kurbanov, R. D., Nizamov, U. I., Majano, N., Lima-Martínez, M. M., Truong, T-H., Nguyen, M-N. T., Do, D-L., Kim, N-T., le, H-A. & le, T-T., 2018, In: Atherosclerosis. 277, p. 234-255

    Research output: Contribution to journal › Article › Academic › peer-review

    168 Citations (Scopus)

  • PCSK9 inhibitors in clinical practice: Delivering on the promise?

    Stoekenbroek, R. M., Hartgers, M. L., Rutte, R., de Wijer, D. D., Stroes, E. S. G. & Hovingh, G. K., 2018, In: Atherosclerosis. 270, March, p. 205-210

    Research output: Contribution to journal › Article › Academic › peer-review

    41 Citations (Scopus)

  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

    Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T., & 380 othersFeitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Boeing, H., Hammerschlag, A. R., Polderman, T. J., Boerwinkle, E., Böger, C. A., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Brumat, M., Burt, A. A., Butterworth, A. S., Campbell, P. T., Cappellani, S., Carey, D. J., Catamo, E., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. I., Chowdhury, R., Christensen, C., Chu, A. Y., Cocca, M., Collins, F. S., Cook, J. P., Corley, J., Corominas Galbany, J., Cox, A. J., Crosslin, D. S., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, P. I. W., Groot, M. C. H., Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., Heijer, M., Hollander, A. I., Ruijter, H. M., Dennis, J. G., Denny, J. C., Angelantonio, E., Drenos, F., Du, M., Dubé, M-P., Dunning, A. M., Easton, D. F., Edwards, T. L., Ellinghaus, D., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A-E., Farooqi, I. S., Faul, J. D., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franco, O. H., Franke, A., Franks, P. W., Friedrich, N., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, A. P., Gordon-Larsen, P., Gorski, M., Grabe, H-J., Grant, S. F. A., Grarup, N., Griffiths, H. L., Grove, M. L., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Have, C. T., Hayward, C., He, L., Heard-Costa, N. L., Heath, A. C., Heid, I. M., Helgeland, Ø., Hernesniemi, J., Hewitt, A. W., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hu, Y., Huang, P. L., Huffman, J. E., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J-H., Jarvik, G. P., Jensen, G. B., Jia, Y., Johansson, S., Jørgensen, M. E., Jørgensen, T., Jukema, J. W., Kahali, B., Kahn, R. S., Kähönen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, L. A., Kim, E., Kitajima, H., Komulainen, P., Kooner, J. S., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T. A., Lamparter, D., Lange, E. M., Lange, L. A., Langenberg, C., Larson, E. B., Lee, N. R., Lehtimäki, T., Lewis, C. E., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K-H., Lin, L-A., Lin, X., Lind, L., Lindström, J., Linneberg, A., Liu, C-T., Liu, D. J., Liu, Y., Lo, K. S., Lophatananon, A., Lotery, A. J., Loukola, A., Luan, J., Lubitz, S. A., Lyytikäinen, L-P., Männistö, S., Marenne, G., Mazul, A. L., McCarthy, M. I., McKean-Cowdin, R., Medland, S. E., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, K. L., Moilanen, L., Moitry, M., Montgomery, G. W., Mook-Kanamori, D. O., Moore, C., Mori, T. A., Morris, A. D., Morris, A. P., Müller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Narisu, N., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njølstad, P. R., Nordestgaard, B. G., Nyholt, D. R., O'Connel, J. R., O'Donoghue, M. L., Olde Loohuis, L. M., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Pers, T. H., Person, T. N., Peters, A., Petersen, E. R. B., Peyser, P. A., Pirie, A., Polasek, O., Puolijoki, H., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Renström, F., Rheinberger, M., Ridker, P. M., Rioux, J. D., Rivas, M. A., Roberts, D. J., Robertson, N. R., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sapkota, Y., Sattar, N., Schoen, R. E., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S. H., Sheu, W. H-H., Sim, X., Slater, A. J., Small, K. S., Smith, A. V., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stefansson, K., Steinthorsdottir, V., Stirrups, K. E., Strauch, K., Stringham, H. M., Stumvoll, M., Sun, L., Surendran, P., Swift, A. J., Tada, H., Tansey, K. E., Tardif, J-C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, B. H., Tönjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Uusitupa, M., Laan, S. W., Duijn, C. M., Leeuwen, N., van Setten, J., Vanhala, M., Varbo, A., Varga, T. V., Varma, R., Velez Edwards, D. R., Vermeulen, S. H., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, T. F., Völker, U., Vuckovic, D., Wagenknecht, L. E., Walker, M., Wallentin, L., Wang, F., Wang, C. A., Wang, S., Wang, Y., Ware, E. B., Wareham, N. J., Warren, H. R., Waterworth, D. M., Wessel, J., White, H. D., Willer, C. J., Wilson, J. G., Witte, D. R., Wood, A. R., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zhou, W., Zondervan, K. T., Rotter, J. I., Pospisilik, J. A., Rivadeneira, F., Borecki, I. B., Deloukas, P., Frayling, T. M., Lettre, G., North, K. E., Lindgren, C. M., Hirschhorn, J. N. & Loos, R. J. F., Jan 2018, In: Nature Genetics. 50, 1, p. 26-41 22 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    237 Citations (Scopus)

  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (vol 50, pg 26, 2018)

    Turcot, V., Lu, Y., Highland, HM., Schurmann, C., Justice, AE., Fine, RS., Bradfield, JP., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, AE., Karaderi, T., Lempradl, A., Locke, AE., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, KL., Alfred, T., & 381 othersFeitosa, MF., Masca, NGD., Manning, AK., Medina-Gomez, C., Mudgal, P., Ng, MCY., Reiner, AP., Vedantam, S., Willems, SM., Winkler, TW., Abecasis, G., Aben, KK., Alam, DS., Alharthi, SE., Allison, M., Amouyel, P., Asselbergs, FW., Auer, PL., Balkau, B., Bang, LE., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, LF., Bluher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Boger, CA., Bork-Jensen, J., Bots, ML., Bottinger, EP., Bowden, DW., Brandslund, I., Breen, G., Brilliant, MH., Broer, L., Brumat, M., Burt, AA., Butterworth, AS., Campbell, PT., Cappellani, S., Carey, DJ., Catamo, E., Caulfield, MJ., Chambers, JC., Chasman, DI., Chen, Y-DI., Chowdhury, R., Christensen, C., Chu, AY., Cocca, M., Collins, FS., Cook, JP., Corley, J., Galbany, JC., Cox, AJ., Crosslin, DS., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, PIW., Groot, MCH., Mutsert, R., Deary, IJ., Dedoussis, G., Demerath, EW., Heijer, M., Hollander, AI., Ruijter, HM., Dennis, JG., Denny, JC., Di Angelantonio, E., Drenos, F., Du, M., Dube, M-P., Dunning, AM., Easton, DF., Edwards, TL., Ellinghaus, D., Ellinor, PT., Elliott, P., Evangelou, E., Farmaki, A-E., Farooqi, IS., Faul, JD., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, JC., Ford, I., Fornage, M., Franco, OH., Franke, A., Franks, PW., Friedrich, N., Frikke-Schmidt, R., Galesloot, TE., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, AP., Gordon-Larsen, P., Gorski, M., Grabe, H-J., Grant, SFA., Grarup, N., Griffiths, HL., Grove, ML., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, AR., Hansen, T., Harris, KM., Harris, TB., Hattersley, AT., Have, CT., Hayward, C., He, L., Heard-Costa, NL., Heath, AC., Heid, IM., Helgeland, O., Hernesniemi, J., Hewitt, AW., Holmen, OL., Hovingh, GK., Howson, JMM., Hu, Y., Huang, PL., Huffman, JE., Ikram, MA., Ingelsson, E., Jackson, AU., Jansson, J-H., Jarvik, GP., Jensen, GB., Jia, Y., Johansson, S., Jorgensen, ME., Jorgensen, T., Jukema, JW., Kahali, B., Kahn, RS., Kahonen, M., Kamstrup, PR., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, SLR., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, LA., Kim, E., Kitajima, H., Komulainen, P., Kooner, JS., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, TA., Lamparter, D., Lange, EM., Lange, LA., Langenberg, C., Larson, EB., Lee, NR., Lehtimaki, T., Lewis, CE., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K-H., Lin, L-A., Lin, X., Lind, L., Lindstrom, J., Linneberg, A., Liu, C-T., Liu, DJ., Liu, Y., Lo, KS., Lophatananon, A., Lotery, AJ., Loukola, A., Luan, J., Lubitz, SA., Lyytikainen, L-P., Mannisto, S., Marenne, G., Mazul, AL., McCarthy, MI., McKean-Cowdin, R., Medland, SE., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, KL., Moilanen, L., Moitry, M., Montgomery, GW., Mook-Kanamori, DO., Moore, C., Mori, TA., Morris, AD., Morris, AP., Mueller-Nurasyid, M., Munroe, PB., Nalls, MA., Narisu, N., Nelson, CP., Neville, M., Nielsen, SF., Nikus, K., Njolstad, PR., Nordestgaard, BG., Nyholt, DR., O'Connel, JR., O'Donoghue, ML., Loohuis, LMO., Ophoff, RA., Owen, KR., Packard, CJ., Padmanabhan, S., Palmer, CNA., Palmer, ND., Pasterkamp, G., Patel, AP., Pattie, A., Pedersen, O., Peissig, PL., Peloso, GM., Pennell, CE., Perola, M., Perry, JA., Perry, JRB., Pers, TH., Person, TN., Peters, A., Petersen, ERB., Peyser, PA., Pirie, A., Polasek, O., Polderman, TJ., Puolijoki, H., Raitakari, OT., Rasheed, A., Rauramaa, R., Reilly, DF., Renstrom, F., Rheinberger, M., Ridker, PM., Rioux, JD., Rivas, MA., Roberts, DJ., Robertson, NR., Robino, A., Rolandsson, O., Rudan, I., Ruth, KS., Saleheen, D., Salomaa, V., Samani, NJ., Sapkota, Y., Sattar, N., Schoen, RE., Schreiner, PJ., Schulze, MB., Scott, RA., Segura-Lepe, MP., Shah, SH., Sheu, WH-H., Sim, X., Slater, AJ., Small, KS., Smith, AV., Southam, L., Spector, TD., Speliotes, EK., Starr, JM., Stefansson, K., Steinthorsdottir, V., Stirrups, KE., Strauch, K., Stringham, HM., Stumvoll, M., Sun, L., Surendran, P., Swift, AJ., Tada, H., Tansey, KE., Tardif, J-C., Taylor, KD., Teumer, A., Thompson, DJ., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, BH., Tonjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, JP., Uher, R., Uitterlinden, AG., Uusitupa, M., Laan, SW., Duijn, CM., Leeuwen, N., van Setten, J., Vanhala, M., Varbo, A., Varga, TV., Varma, R., Edwards, DRV., Vermeulen, SH., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, TF., Volker, U., Vuckovic, D., Wagenknecht, LE., Walker, M., Wallentin, L., Wang, F., Wang, CA., Wang, S., Wang, Y., Ware, EB., Wareham, NJ., Warren, HR., Waterworth, DM., Wessel, J., White, HD., Willer, CJ., Wilson, JG., Witte, DR., Wood, AR., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, LM., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, JH., Zhao, W., Zhou, W., Zondervan, KT., Consortium, GG., Rotter, JI., Pospisilik, JA., Rivadeneira, F., Borecki, IB., Deloukas, P., Frayling, TM., Lettre, G., North, KE., Lindgren, CM., Hirschhorn, JN. & Loos, RJF., 16 Mar 2018, In: Nature Genetics. 50, 5, p. 766-767 2 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (vol 50, pg 765, 2017)

    Turcot, V., Lu, Y., Highland, HM., Schurmann, C., Justice, AE., Fine, RS., Bradfield, JP., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, AE., Karaderi, T., Lempradl, A., Locke, AE., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, KL., Alfred, T., & 380 othersFeitosa, MF., Masca, NGD., Manning, AK., Medina-Gomez, C., Mudgal, P., Ng, MCY., Reiner, AP., Vedantam, S., Willems, SM., Winkler, TW., Abecasis, G., Aben, KK., Alam, DS., Alharthi, SE., Allison, M., Amouyel, P., Asselbergs, FW., Auer, PL., Balkau, B., Bang, LE., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, LF., Bluher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Boger, CA., Bork-Jensen, J., Bots, ML., Bottinger, EP., Bowden, DW., Brandslund, I., Breen, G., Brilliant, MH., Broer, L., Brumat, M., Burt, AA., Butterworth, AS., Campbell, PT., Cappellani, S., Carey, DJ., Catamo, E., Caulfield, MJ., Chambers, JC., Chasman, DI., Chen, Y-DI., Chowdhury, R., Christensen, C., Chu, AY., Cocca, M., Collins, FS., Cook, JP., Corley, J., Galbany, JC., Cox, AJ., Crosslin, DS., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, PIW., Groot, MCH., Mutsert, R., Deary, IJ., Dedoussis, G., Demerath, EW., Heijer, M., Hollander, AI., Ruijter, HM., Dennis, JG., Denny, JC., Angelantonio, E., Drenos, F., Du, M., Dube, M-P., Dunning, AM., Easton, DF., Edwards, TL., Ellinghaus, D., Ellinor, PT., Elliott, P., Evangelou, E., Farmaki, A-E., Farooqi, IS., Faul, JD., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, JC., Ford, I., Fornage, M., Franco, OH., Franke, A., Franks, PW., Friedrich, N., Frikke-Schmidt, R., Galesloot, TE., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, AP., Gordon-Larsen, P., Gorski, M., Grabe, H-J., Grant, SFA., Grarup, N., Griffiths, HL., Grove, ML., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, AR., Hansen, T., Harris, KM., Harris, TB., Hattersley, AT., Have, CT., Hayward, C., He, L., Heard-Costa, NL., 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