Emile van den Akker

Research output

Research output per year 2000 2017 2019 2021 2022 2024

• 58 Article
• 4 Review article
• 1 Comment/Letter to the editor

Research output per year

Research output per year

Search results

• 2024

  GFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation

  Venhuizen, J., van Bergen, M. G. J. M., Bergevoet, S. M., Gilissen, D., Spruijt, C. G., Wingens, L., van den Akker, E., Vermeulen, M., Jansen, J. H., Martens, J. H. A. & van der Reijden, B. A., 1 Dec 2024, In: Communications Biology. 7, 1, 374.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Reduced myeloid commitment and increased uptake by macrophages of stem cell-derived HPS2 neutrophils

  Webbers, S. D., Aarts, C. E., Klein, B., Koops, D., Geissler, J., Tool, A. T., van Bruggen, R., van den Akker, E. & Kuijpers, T. W., 1 Apr 2024, In: Life Science Alliance. 7, 4, e202302263.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• The Gárdos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells

  Petkova-Kirova, P., Murciano, N., Iacono, G., Jansen, J., Simionato, G., Qiao, M., van der Zwaan, C., Rotordam, M. G., John, T., Hertz, L., Hoogendijk, A. J., Becker, N., Wagner, C., von Lindern, M., Egee, S., van den Akker, E. & Kaestner, L., 1 Feb 2024, In: International journal of molecular sciences. 25, 3, 1416.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2023

  A management model in blood, tissue and cell establishments to ensure rapid and sustainable patient access to advanced therapy medicinal products in Europe

  Delgadillo, J., Kerkelä, E., Waters, A., Akker, E. V. D., Lechanteur, C., Baudoux, E., Gardiner, N., De Vos, J. & Vives, J., Dec 2023, In: Cytotherapy. 25, 12, p. 1259-1264 6 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• E-cadherin/β-catenin expression is conserved in human and rat erythropoiesis and marks stress erythropoiesis

  Krimpenfort, R. A., van der Meulen, S. A., Verhagen, H., Driessen, M., Filonova, G., Hoogenboezem, M., van den Akker, E., von Lindern, M. & Nethe, M., 12 Dec 2023, In: Blood advances. 7, 23, p. 7169-7183 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells

  Gallego-Murillo, J. S., Yağcı, N., Pinho, E. M., Wahl, S. A., van den Akker, E. & von Lindern, M., 1 Dec 2023, In: Scientific reports. 13, 1, 6960.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2022

  Circular RNAs exhibit limited evidence for translation, or translation regulation of the mRNA counterpart in terminal hematopoiesis

  Nicolet, B. P., Jansen, S. B. G., Heideveld, E., Ouwehand, W. H., van den Akker, E., von Lindern, M. & Wolkers, M. C., 1 Feb 2022, In: RNA (New York, N.Y.). 28, 2, p. 194-209 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts

  Heshusius, S., Grech, L., Gillemans, N., Brouwer, R. W. W., den Dekker, X. T., van IJcken, W. F. J., Nota, B., Felice, A. E., van Dijk, T. B., von Lindern, M., Borg, J., van den Akker, E. & Philipsen, S., 1 Dec 2022, In: Scientific reports. 12, 1, 336.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  6 Citations (Scopus)

• Expansion and differentiation of ex vivo cultured erythroblasts in scalable stirred bioreactors

  Gallego-Murillo, J. S., Iacono, G., van der Wielen, L. A. M., van den Akker, E., von Lindern, M. & Wahl, S. A., Nov 2022, In: Biotechnology and bioengineering. 119, 11, p. 3096-3116 21 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  7 Citations (Scopus)

• In Vitro Erythropoiesis at Different pO2 Induces Adaptations That Are Independent of Prior Systemic Exposure to Hypoxia

  Simionato, G., Rabe, A., Gallego-Murillo, J. S., van der Zwaan, C., Hoogendijk, A. J., van den Biggelaar, M., Minetti, G., Bogdanova, A., Mairbäurl, H., Wagner, C., Kaestner, L. & van den Akker, E., 1 Apr 2022, In: Cells. 11, 7, 1082.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Optimized Guide RNA Selection Improves Streptococcus pyogenes Cas9 Gene Editing of Human Hematopoietic Stem and Progenitor Cells

  Verhagen, H. J. M. P., Kuijk, C., Rutgers, L., Kokke, A. M., van der Meulen, S. A., van Mierlo, G., Voermans, C. & van den Akker, E., 1 Oct 2022, In: CRISPR Journal. 5, 5, p. 702-716 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  4 Citations (Scopus)

• SYMPHONY consortium: Orchestrating personalized treatment for patients with bleeding disorders

  SYMPHONY consortium, 1 Sept 2022, In: Journal of thrombosis and haemostasis. 20, 9, p. 2001-2011 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)

• The EHA Research Roadmap: Transfusion Medicine

  Stanworth, S. J., Brand, A., Kaveri, S. V., Vrielink, H., Greinacher, A., Domanović, D., von Lindern, M., Allard, S., Bayry, J., Bohonek, M., Buser, A., Claas, F. H. J., Knutson, F., Lozano, M., Olsson, M. L., Pirenne, F., Rebulla, P., So-Osman, C., Tissot, J-D., Toye, A. M., & 3 othersUshiro-Lumb, I., van den Akker, E. & Zeerleder, S., 25 Feb 2022, In: HemaSphere. 6, 2, p. E670

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• Transient receptor potential channel vanilloid type 2 in red cells of cannabis consumer

  Flormann, D., Qiao, M., Murciano, N., Iacono, G., Darras, A., Hof, S., Recktenwald, S. M., Rotordam, M. G., Becker, N., Geisel, J. R., Wagner, C., von Lindern, M., van den Akker, E. & Kaestner, L., May 2022, In: American journal of hematology. 97, 5, p. E180-E183

  Research output: Contribution to journal › Comment/Letter to the editor › Academic

  Open Access
  4 Citations (Scopus)
• 2021

  CD14+ monocytes repress gamma globin expression at early stages of erythropoiesis

  Heshusius, S., Heideveld, E., von Lindern, M. & van den Akker, E., 1 Dec 2021, In: Scientific reports. 11, 1, 1507.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• Generation and characterization of a control and patient-derived human iPSC line containing the Hermansky Pudlak type 2 (HPS2) associated heterozygous compound mutation in AP3B1

  Aarts, C. E. M., Karampini, E., Wüst, T., Webbers, S., Varga, E., Geissler, J., Voorberg, J., von Lindern, M., Bierings, R., van den Akker, E. & Kuijpers, T. W., 1 Jul 2021, In: Stem Cell Research. 54, 102444.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Generation and characterization of a human iPSC line SANi006-A from a Gray Platelet Syndrome patient

  Aarts, C. E. M., Varga, E., Webbers, S., Geissler, J., von Lindern, M., Kuijpers, T. W. & van den Akker, E., 1 Aug 2021, In: Stem Cell Research. 55, 102443.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Generation and characterization of a human iPSC line SANi007-A from a patient with a heterozygous dominant mutation in ELANE

  Aarts, C. E. M., Varga, E., Webbers, S., Geissler, J., von Lindern, M., Kuijpers, T. W. & van den Akker, E., 1 Aug 2021, In: Stem Cell Research. 55, 102440.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• Generation and characterization of a human iPSC line SANi008-A from a Chédiak-Higashi Syndrome patient

  Aarts, C. E. M., Varga, E., Webbers, S., Geissler, J., von Lindern, M., Kuijpers, T. W. & van den Akker, E., 1 Aug 2021, In: Stem Cell Research. 55, 102442.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Hemoglobin switching in mice carrying the Klf1^Nan variant

  Korporaal, A., Gillemans, N., Heshusius, S., Cantú, I., van den Akker, E., van Dijk, T. B., von Lindern, M. & Philipsen, S., Feb 2021, In: Haematologica. 106, 2, p. 464-473 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)

• Mechanical stress induces Ca2+-dependent signal transduction in erythroblasts and modulates erythropoiesis

  Aglialoro, F., Abay, A., Yagci, N., Rab, M. A. E., Kaestner, L., van Wijk, R., von Lindern, M. & van den Akker, E., 2 Jan 2021, In: International journal of molecular sciences. 22, 2, p. 1-15 15 p., 955.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  11 Citations (Scopus)

• Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals

  Eernstman, J., Veldhuisen, B., Ligthart, P., von Lindern, M., van der Schoot, C. E. & van den Akker, E., 1 Dec 2021, In: Scientific reports. 11, 1, 18557.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)

• Rapid, Sensitive, and Specific Severe Acute Respiratory Syndrome Coronavirus 2 Detection: A Multicenter Comparison Between Standard Quantitative Reverse-Transcriptase Polymerase Chain Reaction and CRISPR-Based DETECTR: A Multicenter Comparison between Standard Quantitative Reverse-Transcriptase Polymerase Chain Reaction and CRISPR-Based DETECTR

  Brandsma, E., Verhagen, H. J. M. P., van de Laar, T. J. W., Claas, E. C. J., Cornelissen, M. & van den Akker, E., 15 Jan 2021, In: Journal of infectious diseases. 223, 2, p. 206-213 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  27 Citations (Scopus)

• SMIM1 missense mutations exert their effect on wild type Vel expression late in erythroid differentiation

  van der Rijst, M. V. E., Abay, A., Aglialoro, F., van der Schoot, C. E. & van den Akker, E., Jan 2021, In: Transfusion. 61, 1, p. 236-245 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  3 Citations (Scopus)

• Specific proteome changes in platelets from individuals with GATA1-, GFI1B-, and RUNX1-linked bleeding disorders

  van Bergen, M. G. J. M., Marneth, A. E., Hoogendijk, A. J., van Alphen, F. P. J., van den Akker, E., Laros-van Gorkom, B. A. P., Hoeks, M., Simons, A., de Munnik, S. A., Janssen, J. J. W. M., Martens, J. H. A., Jansen, J. H., Meijer, A. B. & van der Reijden, B. A., 8 Jul 2021, In: Blood. 138, 1, p. 86-90 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  8 Citations (Scopus)

• Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes

  Blom, T., Meinsma, R., di Summa, F., van den Akker, E., van Kuilenburg, A. B. P., Hansen, M. & Tytgat, G. A. M., 2021, In: EJNMMI Research. 11, 1, 81.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity

  Mattebo, A., Sen, T., Jassinskaja, M., Pimková, K., Prieto González-Albo, I., Alattar, A. G., Ramakrishnan, R., Lang, S., Järås, M., Hansson, J., Soneji, S., Singbrant, S., van den Akker, E. & Flygare, J., 5 Aug 2021, In: Scientific reports. 11, 1, p. 15898 15898.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  5 Citations (Scopus)
• 2020

  Identification of a novel DI*02(2558T) allele associated with weakened expression of DI2 antigen

  Wen, J., van den Akker, E., Luo, G., Jia, S., Wei, L., Wang, Z., van der Schoot, C. E. & Ji, Y., Nov 2020, In: Transfusion. 60, 11, p. 2675-2683 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Inside Out Integrin Activation Mediated by PIEZO1 Signaling in Erythroblasts

  Aglialoro, F., Hofsink, N., Hofman, M., Brandhorst, N. & van den Akker, E., 31 Jul 2020, In: Frontiers in physiology. 11, 958.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  30 Citations (Scopus)

• MKL1 deficiency results in a severe neutrophil motility defect due to impaired actin polymerization

  Sprenkeler, E. G. G., Henriet, S. S. V., Tool, A. T. J., Kreft, I. C., van der Bijl, I., Aarts, C. E. M., van Houdt, M., Verkuijlen, P. J. J. H., van Aerde, K., Jaspers, G., van Heijst, A., Koole, W., Gardeitchik, T., Geissler, J., de Boer, M., Tol, S., Bruggeman, C. W., van Alphen, F. P. J., Verhagen, H. J. M. P., van den Akker, E., & 5 othersJanssen, H., van Bruggen, R., van den Berg, T. K., Liem, K. D. & Kuijpers, T. W., 11 Jun 2020, In: Blood. 135, 24, p. 2171-2181 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  27 Citations (Scopus)

• The RNA-binding protein ATXN2 is expressed during megakaryopoiesis and may control timing of gene expression

  Hansen, M., Zeddies, S., Meinders, M., di Summa, F., Rollmann, E., van Alphen, F. P. J., Hoogendijk, A. J., Moore, K. S., Halbach, M., Gutiérrez, L., van den Biggelaar, M., Thijssen-Timmer, D. C., Auburger, G. W. J., van den Akker, E. & von Lindern, M., Feb 2020, In: International journal of molecular sciences. 21, 3, 967.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  6 Citations (Scopus)
• 2019

  A variant RhAG protein encoded by the RHAG*572A allele causes serological weak D expression while maintaining normal RhCE phenotypes

  Wen, J., Verhagen, O. J. H. M., Jia, S., Liang, Q., Wang, Z., Wei, L., Luo, H., Luo, G., Vidarsson, G., van den Akker, E. A., Ji, Y. & van der Schoot, C. E., 2019, In: Transfusion. 59, 1, p. 405-411 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  7 Citations (Scopus)

• CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1

  Yi, G., Mandoli, A., Jussen, L., Tijchon, E., van Bergen, M. G. J. M., Cordonnier, G., Hansen, M., Kim, B., Nguyen, L. N., Jansen, P. W. T. C., Vermeulen, M., van der Reijden, B., van den Akker, E., Bond, J. & Martens, J. H. A., 2019, In: Blood Cancer Journal. 9, 3, 33.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  5 Citations (Scopus)

• Development of a recombinant anti-Vel immunoglobulin M to identify Vel-negative donors

  van der Rijst, M. V. E., Lissenberg-Thunnissen, S. N., Ligthart, P. C., Visser, R., Jongerius, J. M., Voorn, L., Veldhuisen, B., Vidarsson, G., van den Akker, E. & van der Schoot, C. E., 2019, In: Transfusion. 59, 4, p. 1359-1366 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  6 Citations (Scopus)

• Differential interaction between DARC and SDF-1 on erythrocytes and their precursors

  Klei, T. R. L., Aglialoro, F., Mul, F. P. J., Tol, S., Ligthart, P. C., Seignette, I. M., Geissler, J., van den Akker, E. & van Bruggen, R., 2019, In: Scientific reports. 9, 1, p. 16245 16245.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  5 Citations (Scopus)

• Enhanced Ex Vivo Generation of Erythroid Cells from Human Induced Pluripotent Stem Cells in a Simplified Cell Culture System with Low Cytokine Support

  Bernecker, C., Ackermann, M., Lachmann, N., Rohrhofer, L., Zaehres, H., Araúzo-Bravo, M. J., van den Akker, E., Schlenke, P. & Dorn, I., 2019, In: Stem cells and development. 28, 23, p. 1540-1551 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  41 Citations (Scopus)

• Genetic programming of macrophages generates an in vitro model for the human erythroid island niche

  Lopez-Yrigoyen, M., Yang, C-T., Fidanza, A., Cassetta, L., Taylor, A. H., McCahill, A., Sellink, E., von Lindern, M., van den Akker, E., Mountford, J. C., Pollard, J. W. & Forrester, L. M., 2019, In: Nature communications. 10, 1, 881.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  45 Citations (Scopus)

• Glutaraldehyde - A subtle tool in the investigation of healthy and pathologic red blood cells

  Abay, A., Simionato, G., Chachanidze, R., Bogdanova, A., Hertz, L., Bianchi, P., van den Akker, E., von Lindern, M., Leonetti, M., Minetti, G., Wagner, C. & Kaestner, L., 2019, In: Frontiers in physiology. 10, MAY, 514.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  53 Citations (Scopus)

• Human-induced pluripotent stem cell-derived blood products: state of the art and future directions

  Hansen, M., von Lindern, M., van den Akker, E. & Varga, E., Dec 2019, In: FEBS letters. 593, 23, p. 3288-3303 16 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  38 Citations (Scopus)

• Identification of a novel single-nucleotide mutation in SMIM1 gene that results in low Vel antigen expression

  van der Rijst, M. V. E., Voorn, L., Veldhuisen, B., Jongerius, J. M., van den Akker, E. & van der Schoot, C. E., 2019, In: Transfusion. 59, 10, p. E8-E10

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• Large-scale in vitro production of red blood cells from human peripheral blood mononuclear cells

  Heshusius, S., Heideveld, E., Burger, P., Thiel-Valkhof, M., Sellink, E., Varga, E., Ovchynnikova, E., Visser, A., Martens, J. H. A., von Lindern, M. & van den Akker, E., 2019, In: Blood advances. 3, 21, p. 3337-3350 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  57 Citations (Scopus)

• Molecular mechanisms of bleeding disorderassociated GFI1BQ287* mutation and its affected pathways in megakaryocytes and platelets

  van Oorschot, R., Hansen, M., Koornneef, J. M., Marneth, A. E., Bergevoet, S. M., van Bergen, M. G. J. M., van Alphen, F. P. J., van der Zwaan, C., Martens, J. H. A., Vermeulen, M., Jansen, P. W. T. C., Baltissen, M. P. A., Gorkom, B. A. P. L., Janssen, H., Jansen, J. H., von Lindern, M., Meijer, A. B., van den Akker, E. & van der Reijden, B. A., 2019, In: Haematologica. 104, 7, p. 1460-1472 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  21 Citations (Scopus)
• 2018

  Circular RNA expression in human hematopoietic cells is widespread and cell-type specific

  Nicolet, B. P., Engels, S., Aglialoro, F., van den Akker, E., von Lindern, M. & Wolkers, M. C., 2018, In: Nucleic Acids Research. 46, 16, p. 8168-8180 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  140 Citations (Scopus)

• Csde1 binds transcripts involved in protein homeostasis and controls their expression in an erythroid cell line

  Moore, K. S., Yagci, N., van Alphen, F., Paolini, N. A., Horos, R., Held, N. M., Houtkooper, R. H., van den Akker, E., Meijer, A. B., 't Hoen, P. A. C. & von Lindern, M., 2018, In: Scientific reports. 8, 1, p. 2628

  Research output: Contribution to journal › Article › Academic › peer-review
  18 Citations (Scopus)

• Efficient production of erythroid, megakaryocytic and myeloid cells, using single cell-derived iPSC colony differentiation

  Hansen, M., Varga, E., Aarts, C., Wust, T., Kuijpers, T., von Lindern, M. & van den Akker, E., 2018, In: Stem Cell Research. 29, p. 232-244

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  34 Citations (Scopus)

• Glucocorticoids induce differentiation of monocytes towards macrophages that share functional and phenotypical aspects with erythroblastic island macrophages

  Heideveld, E., Hampton-O'Neil, L. A., Cross, S. J., van Alphen, F. P. J., van den Biggelaar, M., Toye, A. M. & van den Akker, E., 2018, In: Haematologica. 103, 3, p. 395-405 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  51 Citations (Scopus)

• The shape shifting story of reticulocyte maturation

  Ovchynnikova, E., Aglialoro, F., von Lindern, M. & van den Akker, E., 2018, In: Frontiers in physiology. 9, JUL, 829.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  44 Citations (Scopus)
• 2017

  DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism

  Ovchynnikova, E., Aglialoro, F., Bentlage, A. E. H., Vidarsson, G., Salinas, N. D., von Lindern, M., Tolia, N. H. & van den Akker, E., 2017, In: Blood. 130, 12, p. 1441-1444

  Research output: Contribution to journal › Article › Academic › peer-review
  33 Citations (Scopus)

• Digesting the role of bone marrow macrophages on hematopoiesis

  Heideveld, E. & van den Akker, E., 2017, In: Immunobiology. 222, 6, p. 814-822

  Research output: Contribution to journal › Article › Academic › peer-review
  35 Citations (Scopus)

• Generation and characterization of a human iPSC line SANi005-A containing the gray platelet associated heterozygous mutation p.Q287*in GFI1B

  Hansen, M., Varga, E., Wüst, T., Mellink, C., van der Kevie-Kersemaekers, A-M., Marneth, A. E., von Lindern, M., van der Reijden, B. & van den Akker, E., 2017, In: Stem Cell Research. 25, p. 34-37

  Research output: Contribution to journal › Article › Academic › peer-review
  3 Citations (Scopus)