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Gerard Hovingh

(Principal Investigator), Prof. MD PhD

 https://orcid.org/0000-0002-8145-1676
20002024

Research activity per year

Search results

  • Novel Therapies Focused on the High-Density Lipoprotein Particle

    van Capelleveen, J. C., Brewer, H. B., Kastelein, J. J. P. & Hovingh, G. K., 2014, In: Circulation Research. 114, 1, p. 193-204

    Research output: Contribution to journal › Review article › Academic › peer-review

    32 Citations (Scopus)

  • ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia

    Kastelein, J. J. P., Ginsberg, H. N., Langslet, G., Hovingh, G. K., Ceska, R., Dufour, R., Blom, D., Civeira, F., Krempf, M., Lorenzato, C., Zhao, J., Pordy, R., Baccara-Dinet, M. T., Gipe, D. A., Geiger, M. J. & Farnier, M., 2015, In: European Heart journal. 36, 43, p. 2996-3003

    Research output: Contribution to journal › Article › Academic › peer-review

    477 Citations (Scopus)

  • Open-label therapy with alirocumab in patients with heterozygous familial hypercholesterolemia: Results from three years of treatment

    Dufour, R., Bergeron, J., Gaudet, D., Weiss, R., Hovingh, G. K., Qing, Z., Yang, F., Andisik, M., Torri, A., Pordy, R. & Gipe, D. A., 2017, In: International journal of cardiology. 228, p. 754-760

    Research output: Contribution to journal › Article › Academic › peer-review

    18 Citations (Scopus)

  • Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

    Vallejo-Vaz, A. J., Marco, M. D., Stevens, C. A. T., Akram, A., Freiberger, T., Hovingh, G. K., Kastelein, J. J. P., Mata, P., Raal, F. J., Santos, R. D., Soran, H., Watts, G. F., Abifadel, M., Aguilar-Salinas, C. A., Al-Khnifsawi, M., Alkindi, F. A., Alnouri, F., Alonso, R., Al-Rasadi, K., Al-Sarraf, A., & 331 othersAshavaid, T. F., Binder, C. J., Bogsrud, M. P., Bourbon, M., Bruckert, E., Chlebus, K., Corral, P., Descamps, O., Durst, R., Ezhov, M., Fras, Z., Genest, J., Groselj, U., Harada-Shiba, M., Kayikcioglu, M., Lalic, K., Lam, C. S. P., Latkovskis, G., Laufs, U., Liberopoulos, E., Lin, J., Maher, V., Majano, N., Marais, A. D., März, W., Mirrakhimov, E., Miserez, A. R., Mitchenko, O., Nawawi, H. M., Nordestgaard, B. R. G., Paragh, G., Petrulioniene, Z., Pojskic, B., Postadzhiyan, A., Reda, A., Reiner, Ž., Sadoh, W. E., Sahebkar, A., Shehab, A., Shek, A. B., Stoll, M., Su, T-C., Subramaniam, T., Susekov, A. V., Symeonides, P., Tilney, M., Tomlinson, B., Truong, T-H., Tselepis, A. D., Tybjærg-Hansen, A., Vázquez-Cárdenas, A., Viigimaa, M., Vohnout, B., Widén, E., Yamashita, S., Banach, M., Gaita, D., Jiang, L., Nilsson, L., Santos, L. E., Schunkert, H., Tokgözoğlu, L., Car, J., Catapano, A. L., Ray, K. K., Akram, A., Car, J., Marco, M. D., Ray, K. K., Stevens, C. A. T., Vallejo-Vaz, A. J., Corral, P., Schreier, L., Watts, G. F., Pang, J., Binder, C. J., Dieplinger, H., Hanauer-Mader, G., Descamps, O., Desutter, J., Langlois, M., Mertens, A., Rietzschel, E., Wallemacq, C., Pojskic, B., Isakovic, D., Dzankovic, A. M., Obralija, J., Pojskic, L., Sisic, I., Stimjanin, E., Torlak, V. A., Santos, R. D., Jannes, C. E., Krieger, J. E., Pereira, A. C., Postadzhiyan, A., Genest, J., Ruel, I., Alonso, R., Asenjo, S., Cuevas, A., Lin, J., Jiang, L., Reiner, Ž., Pećin, I., Symeonides, P., Miltiadous, G., Panayiotou, A. G., Freiberger, T., Vrablik, M., Nordestgaard, B. R. G., Tybjærg-Hansen, A., Benn, M., Reda, A., Viigimaa, M., Heinsar, S., Widén, E., Bruckert, E., Béliard, S., Laufs, U., März, W., Schunkert, H., Gouni-Berthold, I., Hengstenberg, W., Julius, U., Kassner, U., Klose, G., König, C., König, W., Otte, B., Parhofer, K., Schatz, U., Schmidt, N., Steinhagen-Thiessen, E., Vogt, A., Liberopoulos, E., Tselepis, A. D., Antza, C., Athyros, V., Bilianou, E., Boufidou, A., Chrousos, G., Elisaf, M., Garoufi, A., Katsiki, N., Kolovou, G., Kotsis, V., Rallidis, L., Rizos, C., Skalidis, E., Skoumas, I., Tziomalos, K., Tomlinson, B., Paragh, G., Ashavaid, T. F., Shawney, J. P. S., Sahebkar, A., Abbaszadegan, M. R., Aminzadeh, M., Hosseini, S., Mobini, M., Vakili, R., Zaeri, H., Al-Khnifsawi, M., Maher, V., Agar, R., Boran, G., Colwell, N., Crowley, V., Durkin, M., Griffin, D., Kelly, M., Rakovac-Tisdall, A., Durst, R., Bitzur, R., Cohen, H., Eliav, O., Ellis, A., Gavish, D., Harats, D., Henkin, Y., Knobler, H., Leavit, L., Leitersdorf, E., Rubinstein, A., Schurr, D., Shpitzen, S., Szalat, A., Catapano, A. L., Arca, M., Averna, M., Bertolini, S., Calandra, S., Tarugi, P., Harada-Shiba, M., Yamashita, S., Al-Sarraf, A., Mirrakhimov, E., Latkovskis, G., Erglis, A., Gilis, D., Nesterovics, G., Saripo, V., Upena-Roze, A., Abifadel, M., Elbitar, S., Jambart, S. L., Khoury, P. E., Petrulioniene, Z., Gargalskaite, U., Kutkiene, S., Nawawi, H. M., Al-Khateeb, A., An, C. Y., Ismail, Z., Kasim, S., Ibrahim, K. S., Radzi, A. B. M., Kasim, N. A., Nor, N. S. M., Ramli, A. S., Razak, S. A., Muid, S., Rosman, A., Sanusi, A. R., Razman, A. Z., Nazli, S. A., Kek, T. L., Tilney, M., Azzopardi, C., Aguilar Salinas, C. A., Vázquez-Cárdenas, N. A., Galán, G., Magaña-Torres, M. T., Martagon, A., Mehta, R., Hovingh, G. K., Kastelein, J. J. P., Wittekoek, M. E., Sadoh, W. E., Isara, A. R., Obaseki, D. E., Ohenhen, O. A., Bogsrud, M. P., Holven, K. B., Al-Rasadi, K., Santos, L. E., Banach, M., Chlebus, K., Gruchała, M., Baranowska, M., Borowiec-Wolny, J., Gilis-Malinowska, N., Michalska-Grzonkowska, A., Pajkowski, M., Parczewska, A., Romanowska-Kocejko, M., Stróżyk, A., Żarczyńska-Buchowiecka, M., Kleinschmidt, M., Bourbon, M., Alves, A. C., Medeiros, A. M., Alkindi, F. A., Gaita, D., Ezhov, M., Susekov, A. V., Ershova, A., Korneva, V., Kuznetsova, T., Malyshev, P., Meshkov, A., Rozhkova, T., Alnouri, F., Lalic, K., Rajkovic, N., Popovic, L., Lukac, S. S., Stosic, L., Rasulic, I., Lalic, N. M., Subramaniam, T., Lam, C. S. P., Chua, T. S. J., Ting, S. P. L., Vohnout, B., Raslova, K., Fras, Z., Groselj, U., Battelino, T., Cevc, M., Jug, B., Kovac, J., Podkrajsek, K. T., Sustar, U., Trontelj, K. J., Marais, D., Raal, F. J., Mata, P., Isla, L. P. D., Nilsson, L., Miserez, A. R., Martin, F. J., Su, T-C., Charng, M-J., Chen, P-L., Kayikçioglu, M., Tokgözoğlu, L., Mitchenko, O., Shehab, A., Soran, H., Stoll, M., Dell’oca, N., Fernández, G., Ressia, A., Reyes, X., Zelarayan, M., Shek, A. B., Alieva, R. B., Hoshimov, S. U., Kurbanov, R. D., Nizamov, U. I., Majano, N., Lima-Martínez, M. M., Truong, T-H., Nguyen, M-N. T., Do, D-L., Kim, N-T., le, H-A. & le, T-T., 2018, In: Atherosclerosis. 277, p. 234-255

    Research output: Contribution to journal › Article › Academic › peer-review

    168 Citations (Scopus)

  • Paediatric patients with heterozygous familial hypercholesterolaemia treated with evolocumab for 80 weeks (HAUSER-OLE): a single-arm, multicentre, open-label extension of HAUSER-RCT

    Santos, R. D., Ruzza, A., Hovingh, G. K., Stefanutti, C., Mach, F., Descamps, O. S., Bergeron, J., Wang, B., Bartuli, A., Buonuomo, P. S., Greber-Platzer, S., Luirink, I., Bhatia, A. K., Raal, F. J., Kastelein, J. J. P., Wiegman, A. & Gaudet, D., 1 Oct 2022, In: The Lancet Diabetes and Endocrinology. 10, 10, p. 732-740 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    22 Citations (Scopus)

  • Patients with low HDL-cholesterol caused by mutations in LCAT have increased arterial stiffness

    van den Bogaard, B., Holleboom, A. G., Duivenvoorden, R., Hutten, B. A., Kastelein, J. J. P., Hovingh, G. K., Kuivenhoven, J. A., Stroes, E. S. G. & van den Born, B-J. H., 2012, In: Atherosclerosis. 225, 2, p. 481-485

    Research output: Contribution to journal › Article › Academic › peer-review

    31 Citations (Scopus)

  • PCSK9 as predictor for recurrent cardiovascular disease in familial hypercholesterolemia

    Reeskamp, L. F., R Tromp, T. & Hovingh, G. K., 1 Mar 2021, In: European journal of preventive cardiology. 28, 3, p. 270-271 2 p.

    Research output: Contribution to journal › Editorial › Academic › peer-review

    Open Access
    2 Citations (Scopus)

  • PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study: a mendelian randomisation study

    Schmidt, A. F., Swerdlow, D. I., Holmes, M. V., Patel, R. S., Fairhurst-Hunter, Z., Lyall, D. M., Hartwig, F. P., Horta, B. L., Hyppönen, E., Power, C., Moldovan, M., van Iperen, E., Hovingh, G. K., Demuth, I., Norman, K., Steinhagen-Thiessen, E., Demuth, J., Bertram, L., Liu, T., Coassin, S., & 113 othersWilleit, J., Kiechl, S., Willeit, K., Mason, D., Wright, J., Morris, R., Wanamethee, G., Whincup, P., Ben-Shlomo, Y., McLachlan, S., Price, J. F., Kivimaki, M., Welch, C., Sanchez-Galvez, A., Marques-Vidal, P., Nicolaides, A., Panayiotou, A. G., Onland-Moret, N. C., van der Schouw, Y. T., Matullo, G., Fiorito, G., Guarrera, S., Sacerdote, C., Wareham, N. J., Langenberg, C., Scott, R., Luan, J., Bobak, M., Malyutina, S., Pająk, A., Kubinova, R., Tamosiunas, A., Pikhart, H., Husemoen, L. L. N., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Simonsen, K. S., Cooper, J., Humphries, S. E., Brilliant, M., Kitchner, T., Hakonarson, H., Carrell, D. S., McCarty, C. A., Kirchner, H. L., Larson, E. B., Crosslin, D. R., de Andrade, M., Roden, D. M., Denny, J. C., Carty, C., Hancock, S., Attia, J., Holliday, E., O'Donnell, M., Yusuf, S., Chong, M., Pare, G., van der Harst, P., Said, M. A., Eppinga, R. N., Verweij, N., Snieder, H., Christen, T., Mook-Kanamori, D. O., Gustafsson, S., Lind, L., Ingelsson, E., Pazoki, R., Franco, O., Hofman, A., Uitterlinden, A., Dehghan, A., Teumer, A., Baumeister, S., Dörr, M., Lerch, M. M., Völker, U., Völzke, H., Ward, J., Pell, J. P., Smith, D. J., Meade, T., Maitland-van der Zee, A. H., Baranova, E. V., Young, R., Ford, I., Campbell, A., Padmanabhan, S., Bots, M. L., Grobbee, D. E., Froguel, P., Thuillier, D., Balkau, B., Bonnefond, A., Cariou, B., Smart, M., Bao, Y., Kumari, M., Mahajan, A., Ridker, P. M., Chasman, D. I., Reiner, A. P., Lange, L. A., Ritchie, M. D., Asselbergs, F. W., Casas, J-P., Keating, B. J., Preiss, D., Hingorani, A. D. & Sattar, N., Feb 2017, In: Lancet. Diabetes and endocrinology. 5, 2, p. 97-105 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    278 Citations (Scopus)

  • PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial

    AUTHOR GROUP, 2015, In: Lancet. 385, 9965, p. 331-340

    Research output: Contribution to journal › Article › Academic › peer-review

    636 Citations (Scopus)

  • PCSK9 inhibition with orally administered NNC0385-0434 in hypercholesterolaemia: a randomised, double-blind, placebo-controlled and active-controlled phase 2 trial

    Koren, M. J., Descamps, O., Hata, Y., Hengeveld, E. M., Hovingh, G. K., Ikonomidis, I., Radu Juul Jensen, M. D., Langbakke, I. H., Martens, F. M. A. C., Søndergaard, A. L., Witkowski, A. & Koenig, W., 1 Mar 2024, In: The Lancet Diabetes and Endocrinology. 12, 3, p. 174-183 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    2 Citations (Scopus)

  • PCSK9 inhibitors: Novel therapeutic agents for the treatment of hypercholesterolemia

    Verbeek, R., Stoekenbroek, R. M. & Hovingh, G. K., 2015, In: European journal of pharmacology. 763, Part A, p. 38-47

    Research output: Contribution to journal › Article › Academic › peer-review

    34 Citations (Scopus)

  • PCSK9 inhibitors in clinical practice: Delivering on the promise?

    Stoekenbroek, R. M., Hartgers, M. L., Rutte, R., de Wijer, D. D., Stroes, E. S. G. & Hovingh, G. K., 2018, In: Atherosclerosis. 270, March, p. 205-210

    Research output: Contribution to journal › Article › Academic › peer-review

    41 Citations (Scopus)

  • Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

    AUTHOR GROUP, 2014, In: Nature communications. 5, p. 5068

    Research output: Contribution to journal › Article › Academic › peer-review

    197 Citations (Scopus)

  • Phenotype diversity among patients with homozygous familial hypercholesterolemia: A cohort study

    Raal, F. J., Sjouke, B., Hovingh, G. K. & Isaac, B. F., 2016, In: Atherosclerosis. 248, p. 238-244

    Research output: Contribution to journal › Article › Academic › peer-review

    47 Citations (Scopus)

  • Plasma amyloid-β in patients with Tangier disease

    Shahim, P., Bochem, A. E., Mattsson, N., Lautner, R., Blennow, K., Hovingh, G. K., Motazacker, M. M. & Zetterberg, H., 2013, In: Journal of Alzheimer s disease. 35, 2, p. 307-312

    Research output: Contribution to journal › Article › Academic › peer-review

    3 Citations (Scopus)

  • Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: a prospective case-control analysis nested in the EPIC-Norfolk population study

    Holleboom, A. G., Kuivenhoven, J. A., Vergeer, M., Hovingh, G. K., van Miert, J. N., Wareham, N. J., Kastelein, J. J. P., Khaw, K-T. & Boekholdt, S. M., 2010, In: Journal of Lipid Research. 51, 2, p. 416-421

    Research output: Contribution to journal › Article › Academic › peer-review

    58 Citations (Scopus)

  • Plasma lipoprotein(a) levels in patients with homozygous autosomal dominant hypercholesterolemia

    Sjouke, B., Yahya, R., Tanck, M. W. T., Defesche, J. C., de Graaf, J., Wiegman, A., Kastelein, J. J. P., Mulder, M. T., Hovingh, G. K. & Roeters van Lennep, J. E., 2017, In: Journal of clinical lipidology. 11, 2, p. 507-514

    Research output: Contribution to journal › Article › Academic › peer-review

    18 Citations (Scopus)

  • Polygenic Background Modifies Risk of Coronary Artery Disease Among Individuals With Heterozygous Familial Hypercholesterolemia

    Reeskamp, L. F., Shim, I., Dron, J. S., Ibrahim, S., Tromp, T. R., Fahed, A. C., Patel, A. P., Hutten, B. A., Stroes, E. S. G., Hovingh, G. K. & Khera, A. V., Nov 2023, In: JACC: Advances. 2, 9, 100662.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    1 Citation (Scopus)

  • Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and design of the global EAS Familial Hypercholesterolaemia Studies Collaboration

    Vallejo-Vaz, A. J., Akram, A., Kondapally Seshasai, S. R., Cole, D., Watts, G. F., Hovingh, G. K., Kastelein, J. J. P., Mata, P., Raal, F. J., Santos, R. D., Soran, H., Freiberger, T., Abifadel, M., Aguilar-Salinas, C. A., Alnouri, F., Alonso, R., Al-Rasadi, K., Banach, M., Bogsrud, M. P., Bourbon, M., & 52 othersBruckert, E., Car, J., Ceska, R., Corral, P., Descamps, O., Dieplinger, H., Do, C. T., Durst, R., Ezhov, M. V., Fras, Z., Gaita, D., Gaspar, I. M., Genest, J., Harada-Shiba, M., Jiang, L., Kayikcioglu, M., Lam, C. S. P., Latkovskis, G., Laufs, U., Liberopoulos, E., Lin, J., Lin, N., Maher, V., Majano, N., Marais, A. D., März, W., Mirrakhimov, E., Miserez, A. R., Mitchenko, O., Nawawi, H., Nilsson, L., Nordestgaard, B. G., Paragh, G., Petrulioniene, Z., Pojskic, B., Reiner, Ž., Sahebkar, A., Santos, L. E., Schunkert, H., Shehab, A., Slimane, M. N., Stoll, M., Su, T-C., Susekov, A., Tilney, M., Tomlinson, B., Tselepis, A. D., Vohnout, B., Widén, E., Yamashita, S., Catapano, A. L. & Ray, K. K., 2016, In: Atherosclerosis. Supplements. 22, p. 1-32

    Research output: Contribution to journal › Article › Academic › peer-review

    92 Citations (Scopus)

  • Population and assay thresholds for the predictive value of lipoprotein (a) for coronary artery disease: the EPIC-Norfolk Prospective Population Study

    Verbeek, R., Boekholdt, S. M., Stoekenbroek, R. M., Hovingh, G. K., Witztum, J. L., Wareham, N. J., Sandhu, M. S., Khaw, K-T. & Tsimikas, S., 2016, In: Journal of Lipid Research. 57, 4, p. 697-705

    Research output: Contribution to journal › Article › Academic › peer-review

    28 Citations (Scopus)

  • Prevalence and management of familial hypercholesterolaemia in coronary patients: An analysis of EUROASPIRE IV, a study of the European Society of Cardiology

    de Backer, G., Besseling, J., Chapman, J., Hovingh, G. K., Kastelein, J. J. P., Kotseva, K., Ray, K., Reiner, Ž., Wood, D. & de Bacquer, D., 2015, In: Atherosclerosis. 241, 1, p. 169-175

    Research output: Contribution to journal › Article › Academic › peer-review

    131 Citations (Scopus)

  • Prevention of cardiovascular disease in patients with familial hypercholesterolaemia: The role of PCSK9 inhibitors

    Pećin, I., Hartgers, M. L., Hovingh, G. K., Dent, R. & Reiner, Ž., 2017, In: European journal of preventive cardiology. 24, 13, p. 1383-1401

    Research output: Contribution to journal › Review article › Academic › peer-review

    42 Citations (Scopus)

  • Probleemgeoriënteerd denken in de cardiologie en vasculaire geneeskunde; een praktijkboek voor de opleiding en de kliniek

    Hovingh, G. K. (ed.) & Somsen, G. A. (ed.), 2007, Utrecht: De Tijdstroom. (Probleemgeoriënteerd denken in de Interne Geneeskunde)

    Research output: Book/Report › Book editing › Professional

  • Proprotein convertase subtilisin/kexin type 9 inhibition as the next statin?

    Rakipovski, G. N., Hovingh, G. K. & Nyberg, M., 1 Dec 2020, In: Current opinion in lipidology. 31, 6, p. 340-346 7 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    4 Citations (Scopus)

  • Proprotein Convertase Subtilisin Kexin Type 9 Inhibition for Autosomal Recessive Hypercholesterolemia-Brief Report

    Thedrez, A., Sjouke, B., Passard, M., Prampart-Fauvet, S., Guédon, A., Croyal, M., Dallinga-Thie, G., Peter, J., Blom, D., Ciccarese, M., Cefalù, A. B., Pisciotta, L., Santos, R. D., Averna, M., Raal, F., Pintus, P., Cossu, M., Hovingh, K. & Lambert, G., 2016, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 8, p. 1647-1650

    Research output: Contribution to journal › Article › Academic › peer-review

    20 Citations (Scopus)

  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

    Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T., & 380 othersFeitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Boeing, H., Hammerschlag, A. R., Polderman, T. J., Boerwinkle, E., Böger, C. A., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Brumat, M., Burt, A. A., Butterworth, A. S., Campbell, P. T., Cappellani, S., Carey, D. J., Catamo, E., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. I., Chowdhury, R., Christensen, C., Chu, A. Y., Cocca, M., Collins, F. S., Cook, J. P., Corley, J., Corominas Galbany, J., Cox, A. J., Crosslin, D. S., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, P. I. W., Groot, M. C. H., Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., Heijer, M., Hollander, A. I., Ruijter, H. M., Dennis, J. G., Denny, J. C., Angelantonio, E., Drenos, F., Du, M., Dubé, M-P., Dunning, A. M., Easton, D. F., Edwards, T. L., Ellinghaus, D., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A-E., Farooqi, I. S., Faul, J. D., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franco, O. H., Franke, A., Franks, P. W., Friedrich, N., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, A. P., Gordon-Larsen, P., Gorski, M., Grabe, H-J., Grant, S. F. A., Grarup, N., Griffiths, H. L., Grove, M. L., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Have, C. T., Hayward, C., He, L., Heard-Costa, N. L., Heath, A. C., Heid, I. M., Helgeland, Ø., Hernesniemi, J., Hewitt, A. W., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hu, Y., Huang, P. L., Huffman, J. E., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J-H., Jarvik, G. P., Jensen, G. B., Jia, Y., Johansson, S., Jørgensen, M. E., Jørgensen, T., Jukema, J. W., Kahali, B., Kahn, R. S., Kähönen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, L. A., Kim, E., Kitajima, H., Komulainen, P., Kooner, J. S., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T. A., Lamparter, D., Lange, E. M., Lange, L. A., Langenberg, C., Larson, E. B., Lee, N. R., Lehtimäki, T., Lewis, C. E., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K-H., Lin, L-A., Lin, X., Lind, L., Lindström, J., Linneberg, A., Liu, C-T., Liu, D. J., Liu, Y., Lo, K. S., Lophatananon, A., Lotery, A. J., Loukola, A., Luan, J., Lubitz, S. A., Lyytikäinen, L-P., Männistö, S., Marenne, G., Mazul, A. L., McCarthy, M. I., McKean-Cowdin, R., Medland, S. E., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, K. L., Moilanen, L., Moitry, M., Montgomery, G. W., Mook-Kanamori, D. O., Moore, C., Mori, T. A., Morris, A. D., Morris, A. P., Müller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Narisu, N., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njølstad, P. R., Nordestgaard, B. G., Nyholt, D. R., O'Connel, J. R., O'Donoghue, M. L., Olde Loohuis, L. M., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Pers, T. H., Person, T. N., Peters, A., Petersen, E. R. B., Peyser, P. A., Pirie, A., Polasek, O., Puolijoki, H., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Renström, F., Rheinberger, M., Ridker, P. M., Rioux, J. D., Rivas, M. A., Roberts, D. J., Robertson, N. R., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sapkota, Y., Sattar, N., Schoen, R. E., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S. H., Sheu, W. H-H., Sim, X., Slater, A. J., Small, K. S., Smith, A. V., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stefansson, K., Steinthorsdottir, V., Stirrups, K. E., Strauch, K., Stringham, H. M., Stumvoll, M., Sun, L., Surendran, P., Swift, A. J., Tada, H., Tansey, K. E., Tardif, J-C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, B. H., Tönjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Uusitupa, M., Laan, S. W., Duijn, C. M., Leeuwen, N., van Setten, J., Vanhala, M., Varbo, A., Varga, T. V., Varma, R., Velez Edwards, D. R., Vermeulen, S. H., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, T. F., Völker, U., Vuckovic, D., Wagenknecht, L. E., Walker, M., Wallentin, L., Wang, F., Wang, C. A., Wang, S., Wang, Y., Ware, E. B., Wareham, N. J., Warren, H. R., Waterworth, D. M., Wessel, J., White, H. D., Willer, C. J., Wilson, J. G., Witte, D. R., Wood, A. R., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zhou, W., Zondervan, K. T., Rotter, J. I., Pospisilik, J. A., Rivadeneira, F., Borecki, I. B., Deloukas, P., Frayling, T. M., Lettre, G., North, K. E., Lindgren, C. M., Hirschhorn, J. N. & Loos, R. J. F., Jan 2018, In: Nature Genetics. 50, 1, p. 26-41 22 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    237 Citations (Scopus)

  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (vol 50, pg 26, 2018)

    Turcot, V., Lu, Y., Highland, HM., Schurmann, C., Justice, AE., Fine, RS., Bradfield, JP., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, AE., Karaderi, T., Lempradl, A., Locke, AE., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, KL., Alfred, T., & 381 othersFeitosa, MF., Masca, NGD., Manning, AK., Medina-Gomez, C., Mudgal, P., Ng, MCY., Reiner, AP., Vedantam, S., Willems, SM., Winkler, TW., Abecasis, G., Aben, KK., Alam, DS., Alharthi, SE., Allison, M., Amouyel, P., Asselbergs, FW., Auer, PL., Balkau, B., Bang, LE., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, LF., Bluher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Boger, CA., Bork-Jensen, J., Bots, ML., Bottinger, EP., Bowden, DW., Brandslund, I., Breen, G., Brilliant, MH., Broer, L., Brumat, M., Burt, AA., Butterworth, AS., Campbell, PT., Cappellani, S., Carey, DJ., Catamo, E., Caulfield, MJ., Chambers, JC., Chasman, DI., Chen, Y-DI., Chowdhury, R., Christensen, C., Chu, AY., Cocca, M., Collins, FS., Cook, JP., Corley, J., Galbany, JC., Cox, AJ., Crosslin, DS., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, PIW., Groot, MCH., Mutsert, R., Deary, IJ., Dedoussis, G., Demerath, EW., Heijer, M., Hollander, AI., Ruijter, HM., Dennis, JG., Denny, JC., Di Angelantonio, E., Drenos, F., Du, M., Dube, M-P., Dunning, AM., Easton, DF., Edwards, TL., Ellinghaus, D., Ellinor, PT., Elliott, P., Evangelou, E., Farmaki, A-E., Farooqi, IS., Faul, JD., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, JC., Ford, I., Fornage, M., Franco, OH., Franke, A., Franks, PW., Friedrich, N., Frikke-Schmidt, R., Galesloot, TE., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, AP., Gordon-Larsen, P., Gorski, M., Grabe, H-J., Grant, SFA., Grarup, N., Griffiths, HL., Grove, ML., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, AR., Hansen, T., Harris, KM., Harris, TB., Hattersley, AT., Have, CT., Hayward, C., He, L., Heard-Costa, NL., Heath, AC., Heid, IM., Helgeland, O., Hernesniemi, J., Hewitt, AW., Holmen, OL., Hovingh, GK., Howson, JMM., Hu, Y., Huang, PL., Huffman, JE., Ikram, MA., Ingelsson, E., Jackson, AU., Jansson, J-H., Jarvik, GP., Jensen, GB., Jia, Y., Johansson, S., Jorgensen, ME., Jorgensen, T., Jukema, JW., Kahali, B., Kahn, RS., Kahonen, M., Kamstrup, PR., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, SLR., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, LA., Kim, E., Kitajima, H., Komulainen, P., Kooner, JS., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, TA., Lamparter, D., Lange, EM., Lange, LA., Langenberg, C., Larson, EB., Lee, NR., Lehtimaki, T., Lewis, CE., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K-H., Lin, L-A., Lin, X., Lind, L., Lindstrom, J., Linneberg, A., Liu, C-T., Liu, DJ., Liu, Y., Lo, KS., Lophatananon, A., Lotery, AJ., Loukola, A., Luan, J., Lubitz, SA., Lyytikainen, L-P., Mannisto, S., Marenne, G., Mazul, AL., McCarthy, MI., McKean-Cowdin, R., Medland, SE., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, KL., Moilanen, L., Moitry, M., Montgomery, GW., Mook-Kanamori, DO., Moore, C., Mori, TA., Morris, AD., Morris, AP., Mueller-Nurasyid, M., Munroe, PB., Nalls, MA., Narisu, N., Nelson, CP., Neville, M., Nielsen, SF., Nikus, K., Njolstad, PR., Nordestgaard, BG., Nyholt, DR., O'Connel, JR., O'Donoghue, ML., Loohuis, LMO., Ophoff, RA., Owen, KR., Packard, CJ., Padmanabhan, S., Palmer, CNA., Palmer, ND., Pasterkamp, G., Patel, AP., Pattie, A., Pedersen, O., Peissig, PL., Peloso, GM., Pennell, CE., Perola, M., Perry, JA., Perry, JRB., Pers, TH., Person, TN., Peters, A., Petersen, ERB., Peyser, PA., Pirie, A., Polasek, O., Polderman, TJ., Puolijoki, H., Raitakari, OT., Rasheed, A., Rauramaa, R., Reilly, DF., Renstrom, F., Rheinberger, M., Ridker, PM., Rioux, JD., Rivas, MA., Roberts, DJ., Robertson, NR., Robino, A., Rolandsson, O., Rudan, I., Ruth, KS., Saleheen, D., Salomaa, V., Samani, NJ., Sapkota, Y., Sattar, N., Schoen, RE., Schreiner, PJ., Schulze, MB., Scott, RA., Segura-Lepe, MP., Shah, SH., Sheu, WH-H., Sim, X., Slater, AJ., Small, KS., Smith, AV., Southam, L., Spector, TD., Speliotes, EK., Starr, JM., Stefansson, K., Steinthorsdottir, V., Stirrups, KE., Strauch, K., Stringham, HM., Stumvoll, M., Sun, L., Surendran, P., Swift, AJ., Tada, H., Tansey, KE., Tardif, J-C., Taylor, KD., Teumer, A., Thompson, DJ., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, BH., Tonjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, JP., Uher, R., Uitterlinden, AG., Uusitupa, M., Laan, SW., Duijn, CM., Leeuwen, N., van Setten, J., Vanhala, M., Varbo, A., Varga, TV., Varma, R., Edwards, DRV., Vermeulen, SH., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, TF., Volker, U., Vuckovic, D., Wagenknecht, LE., Walker, M., Wallentin, L., Wang, F., Wang, CA., Wang, S., Wang, Y., Ware, EB., Wareham, NJ., Warren, HR., Waterworth, DM., Wessel, J., White, HD., Willer, CJ., Wilson, JG., Witte, DR., Wood, AR., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, LM., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, JH., Zhao, W., Zhou, W., Zondervan, KT., Consortium, GG., Rotter, JI., Pospisilik, JA., Rivadeneira, F., Borecki, IB., Deloukas, P., Frayling, TM., Lettre, G., North, KE., Lindgren, CM., Hirschhorn, JN. & Loos, RJF., 16 Mar 2018, In: Nature Genetics. 50, 5, p. 766-767 2 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (vol 50, pg 765, 2017)

    Turcot, V., Lu, Y., Highland, HM., Schurmann, C., Justice, AE., Fine, RS., Bradfield, JP., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, AE., Karaderi, T., Lempradl, A., Locke, AE., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, KL., Alfred, T., & 380 othersFeitosa, MF., Masca, NGD., Manning, AK., Medina-Gomez, C., Mudgal, P., Ng, MCY., Reiner, AP., Vedantam, S., Willems, SM., Winkler, TW., Abecasis, G., Aben, KK., Alam, DS., Alharthi, SE., Allison, M., Amouyel, P., Asselbergs, FW., Auer, PL., Balkau, B., Bang, LE., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, LF., Bluher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Boger, CA., Bork-Jensen, J., Bots, ML., Bottinger, EP., Bowden, DW., Brandslund, I., Breen, G., Brilliant, MH., Broer, L., Brumat, M., Burt, AA., Butterworth, AS., Campbell, PT., Cappellani, S., Carey, DJ., Catamo, E., Caulfield, MJ., Chambers, JC., Chasman, DI., Chen, Y-DI., Chowdhury, R., Christensen, C., Chu, AY., Cocca, M., Collins, FS., Cook, JP., Corley, J., Galbany, JC., Cox, AJ., Crosslin, DS., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, PIW., Groot, MCH., Mutsert, R., Deary, IJ., Dedoussis, G., Demerath, EW., Heijer, M., Hollander, AI., Ruijter, HM., Dennis, JG., Denny, JC., Angelantonio, E., Drenos, F., Du, M., Dube, M-P., Dunning, AM., Easton, DF., Edwards, TL., Ellinghaus, D., Ellinor, PT., Elliott, P., Evangelou, E., Farmaki, A-E., Farooqi, IS., Faul, JD., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, JC., Ford, I., Fornage, M., Franco, OH., Franke, A., Franks, PW., Friedrich, N., Frikke-Schmidt, R., Galesloot, TE., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, AP., Gordon-Larsen, P., Gorski, M., Grabe, H-J., Grant, SFA., Grarup, N., Griffiths, HL., Grove, ML., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, AR., Hansen, T., Harris, KM., Harris, TB., Hattersley, AT., Have, CT., Hayward, C., He, L., Heard-Costa, NL., Heath, AC., Heid, IM., Helgeland, O., Hernesniemi, J., Hewitt, AW., Holmen, OL., Hovingh, GK., Howson, JMM., Hu, Y., Huang, PL., Huffman, JE., Ikram, MA., Ingelsson, E., Jackson, AU., Jansson, J-H., Jarvik, GP., Jensen, GB., Jia, Y., Johansson, S., Jorgensen, ME., Jorgensen, T., Jukema, JW., Kahali, B., Kahn, RS., Kahonen, M., Kamstrup, PR., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, SLR., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, LA., Kim, E., Kitajima, H., Komulainen, P., Kooner, JS., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, TA., Lamparter, D., Lange, EM., Lange, LA., Langenberg, C., Larson, EB., Lee, NR., Lehtimaki, T., Lewis, CE., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K-H., Lin, L-A., Lin, X., Lind, L., Lindstrom, J., Linneberg, A., Liu, C-T., Liu, DJ., Liu, Y., Lo, KS., Lophatananon, A., Lotery, AJ., Loukola, A., Luan, J., Lubitz, SA., Lyytikainen, L-P., Mannisto, S., Marenne, G., Mazul, AL., McCarthy, MI., McKean-Cowdin, R., Medland, SE., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, KL., Moilanen, L., Moitry, M., Montgomery, GW., Mook-Kanamori, DO., Moore, C., Mori, TA., Morris, AD., Morris, AP., Mueller-Nurasyid, M., Munroe, PB., Nalls, MA., Narisu, N., Nelson, CP., Neville, M., Nielsen, SF., Nikus, K., Njolstad, PR., Nordestgaard, BG., Nyholt, DR., O'Connel, JR., O'Donoghue, ML., Loohuis, LMO., Ophoff, RA., Owen, KR., Packard, CJ., Padmanabhan, S., Palmer, CNA., Palmer, ND., Pasterkamp, G., Patel, AP., Pattie, A., Pedersen, O., Peissig, PL., Peloso, GM., Pennell, CE., Perola, M., Perry, JA., Perry, JRB., Pers, TH., Person, TN., Peters, A., Petersen, ERB., Peyser, PA., Pirie, A., Polasek, O., Polderman, TJ., Puolijoki, H., Raitakari, OT., Rasheed, A., Rauramaa, R., Reilly, DF., Renstrom, F., Rheinberger, M., Ridker, PM., Rioux, JD., Rivas, MA., Roberts, DJ., Robertson, NR., Robino, A., Rolandsson, O., Rudan, I., Ruth, KS., Saleheen, D., Salomaa, V., Samani, NJ., Sapkota, Y., Sattar, N., Schoen, RE., Schreiner, PJ., Schulze, MB., Scott, RA., Segura-Lepe, MP., Shah, SH., Sheu, WH-H., Sim, X., Slater, AJ., Small, KS., Smith, AV., Southam, L., Spector, TD., Speliotes, EK., Starr, JM., Stefansson, K., Steinthorsdottir, V., Stirrups, KE., Strauch, K., Stringham, HM., Stumvoll, M., Sun, L., Surendran, P., Swift, AJ., Tada, H., Tansey, KE., Tardif, J-C., Taylor, KD., Teumer, A., Thompson, DJ., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, BH., Tonjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, JP., Uher, R., Uitterlinden, AG., Uusitupa, M., Laan, SW., Duijn, CM., Leeuwen, N., van Setten, J., Vanhala, M., Varbo, A., Varga, TV., Varma, R., Edwards, DRV., Vermeulen, SH., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, TF., Volker, U., Vuckovic, D., Wagenknecht, LE., Walker, M., Wallentin, L., Wang, F., Wang, CA., Wang, S., Wang, Y., Ware, EB., Wareham, NJ., Warren, HR., Waterworth, DM., Wessel, J., White, HD., Willer, CJ., Wilson, JG., Witte, DR., Wood, AR., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, LM., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, JH., Zhao, W., Zhou, W., Zondervan, KT., Rotter, JI., Pospisilik, JA., Rivadeneira, F., Borecki, IB., Deloukas, P., Frayling, TM., Lettre, G., North, KE., Lindgren, CM., Hirschhorn, JN. & Loos, RJF., 16 Mar 2018, In: Nature Genetics. 50, 5, p. 765-766 2 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

    CHD Exome+ Consortium, 1 Mar 2019, In: Nature Genetics. 51, 3, p. 452–469 18 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    71 Citations (Scopus)

  • Proteinuria in early childhood due to familial LCAT deficiency caused by loss of a disulfide bond in lecithin:cholesterol acyl transferase

    Holleboom, A. G., Kuivenhoven, J. A., van Olden, C. C., Peter, J., Schimmel, A. W., Levels, J. H., Valentijn, R. M., Vos, P., Defesche, J. C., Kastelein, J. J. P., Hovingh, G. K., Stroes, E. S. G. & Hollak, C. E. M., 2011, In: Atherosclerosis. 216, 1, p. 161-165

    Research output: Contribution to journal › Article › Academic › peer-review

    25 Citations (Scopus)

  • Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x)

    CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators & Understanding Society Scientific Group, Jul 2019, In: Nature Genetics. 51, 7, p. 1191-1192 2 p.

    Research output: Contribution to journal › Erratum/Corrigendum › Academic

    Open Access
    5 Citations (Scopus)

  • Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (Nature Communications, (2021), 12, 1, (24), 10.1038/s41467-020-19366-9): Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (Nature Communications, (2021), 12, 1, (24), 10.1038/s41467-020-19366-9)

    Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), 1 Dec 2021, In: Nature communications. 12, 1, 995.

    Research output: Contribution to journal › Erratum/Corrigendum › Academic › peer-review

    Open Access
    5 Citations (Scopus)

  • Quality control and conduct of genome-wide association meta-analyses

    AUTHOR GROUP, Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Willemsen, G., Penninx, B. W. J. H. & Smit, J. H., 2014, In: Nature protocols. 9, 5, p. 1192-1212 21 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    293 Citations (Scopus)

  • Quality of life and coping in Dutch homozygous familial hypercholesterolemia patients: A qualitative study

    Mulder, J. W. C. M., Kranenburg, L. W., Treling, W. J., Hovingh, G. K., Rutten, J. H. W., Busschbach, J. J. & Roeters van Lennep, J. E., May 2022, In: Atherosclerosis. 348, p. 75-81 7 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    5 Citations (Scopus)

  • Rare and low-frequency coding variants alter human adult height

    EPIC-InterAct Consortium, Böger, C. A., Bonnycastle, L. L., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Burt, A. A., Butterworth, A. S., Carey, D. J., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y-D. I., Chowdhury, R., Christensen, C., & 299 othersChu, A. Y., Cocca, M., Collins, F. S., Cook, J. P., Corley, J., Galbany, J. C., Cox, A. J., Cuellar-Partida, G., Danesh, J., Davies, G., de Bakker, P. I. W., de Borst, G. J., de Denus, S., de Groot, M. C. H., de Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., den Hollander, A. I., Dennis, J. G., Di Angelantonio, E., Drenos, F., Du, M., Dunning, A. M., Easton, D. F., Ebeling, T., Edwards, T. L., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A-E., Faul, J. D., Feitosa, M. F., Feng, S., Ferrannini, E., Ferrario, M. M., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franks, P. W., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Giedraitis, V., Giri, A., Girotto, G., Gordon, S. D., Gordon-Larsen, P., Gorski, M., Grarup, N., Grove, M. L., Gudnason, V., Gustafsson, S., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Hayward, C., He, L., Heid, I. M., Heikkilä, K., Helgeland, Ø., Hernesniemi, J., Hewitt, A. W., Hocking, L. J., Hollensted, M., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hoyng, C. B., Huang, P. L., Hveem, K., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J-H., Jarvik, G. P., Jensen, G. B., Jhun, M. A., Jia, Y., Jiang, X., Johansson, S., Jørgensen, M. E., Jørgensen, T., Jousilahti, P., Jukema, J. W., Kahali, B., Kahn, R. S., Kähönen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kee, F., Keeman, R., Kiemeney, L. A., Kitajima, H., Kluivers, K. B., Kocher, T., Komulainen, P., Kontto, J., Kooner, J. S., Kooperberg, C., Kovacs, P., Kriebel, J., Kuivaniemi, H., Küry, S., Kuusisto, J., La Bianca, M., Laakso, M., Lakka, T. A., Lange, E. M., Lange, L. A., Langefeld, C. D., Langenberg, C., Larson, E. B., Lee, I. -T., Lehtimäki, T., Lewis, C. E., Li-Gao, R., Lin, H., Lin, L-A., Lin, X., Lind, L., Lindström, J., Linneberg, A., Liu, Y., Liu, Y., Lophatananon, A., Luan, J., Lubitz, S. A., Lyytikäinen, L-P., Mackey, D. A., Madden, P. A. F., Manning, A. K., Männistö, S., Marenne, G., Marten, J., Martin, N. G., Mazul, A. L., Meidtner, K., Metspalu, A., Mitchell, P., Mohlke, K. L., Mook-Kanamori, D. O., Morgan, A., Morris, A. D., Morris, A. P., Müller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Nauck, M., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njølstad, P. R., Nordestgaard, B. G., Ntalla, I., O'Connel, J. R., Oksa, H., Loohuis, L. M. O., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Person, T. N., Pirie, A., Polasek, O., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Reiner, A. P., Renström, F., Ridker, P. M., Rioux, J. D., Robertson, N., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sandow, K., Sapkota, Y., Sattar, N., Schmidt, M. K., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S., Sim, X., Sivapalaratnam, S., Small, K. S., Smith, A. V., Smith, J. A., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Steinthorsdottir, V., Stringham, H. M., Stumvoll, M., Surendran, P., 't Hart, L. M., Tansey, K. E., Tardif, J-C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorsteinsdottir, U., Thuesen, B. H., Tönjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Ulivi, S., van der Laan, S. W., van der Leij, A. R., van Duijn, C. M., van Setten, J., Varbo, A., Varga, T. V., Varma, R., Edwards, D. R. V., Vermeulen, S. H., Vestergaard, H., Vitart, V., Vogt, T. F., Vozzi, D., Walker, M., Wang, F., Wang, C. A., Wang, S., Wang, Y., Wareham, N. J., Warren, H. R., Wessel, J., Willems, S. M., Wilson, J. G., Witte, D. R., Woods, M. O., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zheng, H., Zhou, W., Rotter, J. I., Boehnke, M., Kathiresan, S., McCarthy, M. I., Willer, C. J., Stefansson, K., Borecki, I. B., Liu, D. J., North, K. E., Heard-Costa, N. L., Pers, T. H., Lindgren, C. M., Oxvig, C., Kutalik, Z., Rivadeneira, F., Loos, R. J. F., Frayling, T. M., Hirschhorn, J. N., Deloukas, P. & Lettre, G., 9 Feb 2017, In: NATURE. 542, 7640, p. 186-190 5 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    414 Citations (Scopus)

  • Rare dyslipidaemias, from phenotype to genotype to management: a European Atherosclerosis Society task force consensus statement

    Hegele, R. A., Borén, J., Ginsberg, H. N., Arca, M., Averna, M., Binder, C. J., Calabresi, L., Chapman, M. J., Cuchel, M., von Eckardstein, A., Frikke-Schmidt, R., Gaudet, D., Hovingh, G. K., Kronenberg, F., Lütjohann, D., Parhofer, K. G., Raal, F. J., Ray, K. K., Remaley, A. T., Stock, J. K., & 3 othersStroes, E. S., Tokgözoğlu, L. & Catapano, A. L., Jan 2020, In: Lancet. Diabetes and endocrinology. 8, 1, p. 50-67 18 p.

    Research output: Contribution to journal › Review article › Academic › peer-review

    Open Access
    112 Citations (Scopus)

  • Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

    AUTHOR GROUP, Craen, A. J. M., Rader, D. J., Willemsen, G. & Boomsma, D. I., 2016, In: Science. 351, 6278, p. 1166-1171

    Research output: Contribution to journal › Article › Academic › peer-review

    425 Citations (Scopus)

  • Recent failures in antiatherosclerotic drug development: examples from the thyroxin receptor agonist, the secretory phospholipase A2 antagonist, and the acyl coenzyme A: cholesterol acyltransferase inhibitor programs

    Stoekenbroek, R. M., Kastelein, J. J. P. & Hovingh, G. K., 2013, In: Current opinion in lipidology. 24, 6, p. 459-466

    Research output: Contribution to journal › Review article › Academic › peer-review

    6 Citations (Scopus)

  • Recognition and Treatment of Homozygous Familial Hypercholesterolemia by Primary Care Physicians: a Survey from the National Lipid Association

    Hemphill, L., Goldberg, A., Hovingh, K., Cohen, J. & Karalis, D. G., 1 Jul 2020, In: Journal of General Internal Medicine. 35, 7, p. 2225-2227 3 p.

    Research output: Contribution to journal › Comment/Letter to the editor › Academic

    Open Access
    4 Citations (Scopus)

  • Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia

    Harchaoui, K. E., Franssen, R., Hovingh, G. K., Bisoendial, R. J., Stellaard, F., Kuipers, F., Kastelein, J. J. P., Kuivenhoven, J. A., Stroes, E. S. G. & Groen, A. K., 2009, In: Atherosclerosis. 207, 2, p. 614-616

    Research output: Contribution to journal › Article › Academic › peer-review

    11 Citations (Scopus)

  • Reducing the Clinical and Public Health Burden of Familial Hypercholesterolemia: A Global Call to Action

    Wilemon, K. A., Patel, J., Aguilar-Salinas, C., Ahmed, C. D., Alkhnifsawi, M., Almahmeed, W., Alonso, R., Al-Rasadi, K., Badimon, L., Bernal, L. M., Bogsrud, M. P., Braun, L. T., Brunham, L., Catapano, A. L., Čillíková, K., Corral, P., Cuevas, R., Defesche, J. C., Descamps, O. S., de Ferranti, S., & 69 othersEiselé, J-L., Elikir, G., Folco, E., Freiberger, T., Fuggetta, F., Gaspar, I. M., Gesztes, Á. G., Grošelj, U., Hamilton-Craig, I., Hanauer-Mader, G., Harada-Shiba, M., Hastings, G., Hovingh, G. K., Izar, M. C., Jamison, A., Karlsson, G. N., Kayikçioǧlu, M., Koob, S., Koseki, M., Lane, S., Lima-Martinez, M. M., López, G., Martinez, T. L., Marais, D., Marion, L., Mata, P., Maurina, I., Maxwell, D., Mehta, R., Mensah, G. A., Miserez, A. R., Neely, D., Nicholls, S. J., Nohara, A., Nordestgaard, B. R. G., Ose, L., Pallidis, A., Pang, J., Payne, J., Peterson, A. L., Popescu, M. P., Puri, R., Ray, K. K., Reda, A., Sampietro, T., Santos, R. D., Schalkers, I., Schreier, L., Shapiro, M. D., Sijbrands, E., Soffer, D., Stefanutti, C., Stoll, M., Sy, R. G., Tamayo, M. L., Tilney, M. K., Tokgözoǧlu, L., Tomlinson, B., Vallejo-Vaz, A. J., Vazquez-Cárdenas, A., de Luca, P. V., Wald, D. S., Watts, G. F., Wenger, N. K., Wolf, M., Wood, D., Zegerius, A., Gaziano, T. A. & Gidding, S. S., Feb 2020, In: JAMA Cardiology. 5, 2, p. 217-229 13 p.

    Research output: Contribution to journal › Review article › Academic › peer-review

    170 Citations (Scopus)

  • Regional Variations in Alirocumab Dosing Patterns in Patients with Heterozygous Familial Hypercholesterolemia During an Open-Label Extension Study

    Langslet, G., Hovingh, G. K., Guyton, J. R., Baccara-Dinet, M. T., Letierce, A., Manvelian, G. & Farnier, M., 1 Aug 2020, In: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. 34, 4, p. 515-523 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    2 Citations (Scopus)

  • Relationship of lipoprotein-associated apolipoprotein C-III with lipid variables and coronary artery disease risk: The EPIC-Norfolk prospective population study

    van Capelleveen, J. C., Lee, S-R., Verbeek, R., Kastelein, J. J. P., Wareham, N. J., Stroes, E. S. G., Hovingh, G. K., Khaw, K-T., Boekholdt, S. M., Witztum, J. L. & Tsimikas, S., 2018, In: Journal of clinical lipidology. 12, 6, p. 1493-1501.e11

    Research output: Contribution to journal › Article › Academic › peer-review

    7 Citations (Scopus)

  • Reply: statin-induced low low-density lipoprotein cholesterol level: is lower better?

    Boekholdt, S. M., Hovingh, G. K., Waters, D. D., Grundy, S. M. & Kastelein, J. J. P., 2015, In: Journal of the American College of Cardiology. 65, 1, p. 109

    Research output: Contribution to journal › Comment/Letter to the editor › Academic

  • Resmetirom (MGL-3196) in Patients With Heterozygous Familial Hypercholesterolemia

    Hovingh, G. K., Klausen, I. C., Heggen, E., McCarty, K., Zhou, R., Isaac, B. F., Taub, R., Langslet, G. & Kastelein, J. J. P., 29 Mar 2022, In: Journal of the American College of Cardiology. 79, 12, p. 1220-1222 3 p.

    Research output: Contribution to journal › Comment/Letter to the editor › Academic

    6 Citations (Scopus)

  • Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein

    Bisoendial, R. J., Hovingh, G. K., Levels, J. H. M., Lerch, P. G., Andresen, I., Hayden, M. R., Kastelein, J. J. P. & Stroes, E. S. G., 2003, In: Circulation. 107, 23, p. 2944-2948

    Research output: Contribution to journal › Article › Academic › peer-review

    284 Citations (Scopus)

  • Retrospective analysis of cohort database: Phenotypic variability in a large dataset of patients confirmed to have homozygous familial hypercholesterolemia

    Raal, F. J., Sjouke, B., Hovingh, G. K. & Isaac, B. F., 2016, In: Data in brief. 7, p. 1458-1462

    Research output: Contribution to journal › Article › Academic › peer-review

    1 Citation (Scopus)

  • Role of CETP inhibitors in the treatment of dyslipidemia

    van der Steeg, W. A., Kuivenhoven, J. A., Klerkx, A. H., Boekholdt, S. M., Hovingh, G. K. & Kastelein, J. J. P., 2004, In: Current opinion in lipidology. 15, 6, p. 631-636

    Research output: Contribution to journal › Review article › Academic › peer-review

    54 Citations (Scopus)

  • Safety and efficacy of granulocyte colony-stimulating factor in kidney and liver transplant recipients

    Turgeon, N., Hovingh, G. K., Fishman, J. A., Basgoz, N., Tolkoff-Rubin, N. E., Doran, M., Cosimi, A. B. & Rubin, R. H., 2000, In: Transplant infectious disease. 2, 1, p. 15-21

    Research output: Contribution to journal › Article › Academic › peer-review

    48 Citations (Scopus)

  • Safety and efficacy of LY3015014, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9): a randomized, placebo-controlled Phase 2 study

    Kastelein, J. J. P., Nissen, S. E., Rader, D. J., Hovingh, G. K., Wang, M-D., Shen, T. & Krueger, K. A., 2016, In: European Heart journal. 37, 17, p. 1360-1369

    Research output: Contribution to journal › Article › Academic › peer-review

    68 Citations (Scopus)