Gerard Hovingh

2015

Anacetrapib as lipid-modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE): a randomised, double-blind, placebo-controlled, phase 3 study

Kastelein, J. J. P., Besseling, J., Shah, S., Bergeron, J., Langslet, G., Hovingh, G. K., Al-Saady, N., Koeijvoets, M., Hunter, J., Johnson-Levonas, A. O., Fable, J., Sapre, A. & Mitchel, Y., 2015, In: Lancet. 385, 9983, p. 2153-2161

Research output: Contribution to journal › Article › Academic › peer-review

88 Citations (Scopus)

Analysis of vitamin D levels in patients with and without statin-associated myalgia - a systematic review and meta-analysis of 7 studies with 2420 patients

Michalska-Kasiczak, M., Sahebkar, A., Mikhailidis, D. P., Rysz, J., Muntner, P., Toth, P. P., Jones, S. R., Rizzo, M., Kees Hovingh, G., Farnier, M., Moriarty, P. M., Bittner, V. A., Lip, G. Y. H. & Banach, M., 2015, In: International journal of cardiology. 178, p. 111-116

Research output: Contribution to journal › Article › Academic › peer-review

149 Citations (Scopus)

Annexin A5 haplotypes in familial hypercholesterolemia: lack of association with carotid intima-media thickness and cardiovascular disease risk

Hiddink, L., Dallinga-Thie, G. M., Hovingh, G. K., de Visser, M. C. H., Peer, P. G. M., Stalenhoef, A. F. H. & van Heerde, W. L., 2015, In: Atherosclerosis. 238, 2, p. 195-200

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

ApoA-I mimetics

Stoekenbroek, R. M., Stroes, E. S. & Hovingh, G. K., 2015, In: Handbook of Experimental Pharmacology. 224, p. 631-648

Research output: Contribution to journal › Article › Academic › peer-review

33 Citations (Scopus)

Association Between Familial Hypercholesterolemia and Prevalence of Type 2 Diabetes Mellitus

Besseling, J., Kastelein, J. J. P., Defesche, J. C., Hutten, B. A. & Hovingh, G. K., 2015, In: JAMA. 313, 10, p. 1029-1036

Research output: Contribution to journal › Article › Academic › peer-review

294 Citations (Scopus)

Association of exome sequences with plasma C-reactive protein levels in >9000 participants

Schick, U. M., Auer, P. L., Bis, J. C., Lin, H., Wei, P., Pankratz, N., Lange, L. A., Brody, J., Stitziel, N. O., Kim, D. S., Carlson, C. S., Fornage, M., Haessler, J., Hsu, L., Jackson, R. D., Kooperberg, C., Leal, S. M., Psaty, B. M., Boerwinkle, E., Tracy, R., & 24 othersArdissino, D., Shah, S., Willer, C., Loos, R., Melander, O., McPherson, R., Hovingh, K., Reilly, M., Watkins, H., Girelli, D., Fontanillas, P., Chasman, D. I., Gabriel, S. B., Gibbs, R., Nickerson, D. A., Kathiresan, S., Peters, U., Dupuis, J., Wilson, J. G., Rich, S. S., Morrison, A. C., Benjamin, E. J., Gross, M. D. & Reiner, A. P., 2015, In: Human Molecular Genetics. 24, 2, p. 559-571

Research output: Contribution to journal › Article › Academic › peer-review

33 Citations (Scopus)

A systematic review and meta-analysis of the effect of statins on plasma asymmetric dimethylarginine concentrations

Serban, C., Sahebkar, A., Ursoniu, S., Mikhailidis, D. P., Rizzo, M., Lip, G. Y. H., Kees Hovingh, G., Kastelein, J. J. P., Kalinowski, L., Rysz, J. & Banach, M., 2015, In: Scientific reports. 5, p. 9902

Research output: Contribution to journal › Article › Academic › peer-review

143 Citations (Scopus)

Biological interpretation of genome-wide association studies using predicted gene functions

AUTHOR GROUP, 2015, In: Nature communications. 6, p. 5890

Research output: Contribution to journal › Article › Academic › peer-review

513 Citations (Scopus)

Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial

Hovingh, G. K., Kastelein, J. J. P., van Deventer, S. J. H., Round, P., Ford, J., Saleheen, D., Rader, D. J., Brewer, H. B. & Barter, P. J., 2015, In: Lancet. 386, 9992, p. 452-460

Research output: Contribution to journal › Article › Academic › peer-review

165 Citations (Scopus)

Clinical Features of Lysosomal Acid Lipase Deficiency

Burton, B. K., Deegan, P. B., Enns, G. M., Guardamagna, O., Horslen, S., Hovingh, G. K., Lobritto, S. J., Malinova, V., McLin, V. A., Raiman, J., Di Rocco, M., Santra, S., Sharma, R., Sykut-Cegielska, J., Whitley, C. B., Eckert, S., Valayannopoulos, V. & Quinn, A. G., 2015, In: Journal of pediatric gastroenterology and nutrition. 61, 6, p. 619-625

Research output: Contribution to journal › Article › Academic › peer-review

91 Citations (Scopus)

Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA

Kootte, R. S., Smits, L. P., van der Valk, F. M., Dasseux, J-L., Keyserling, C. H., Barbaras, R., Paolini, J. F., Santos, R. D., van Dijk, T. H., Dallinga-van Thie, G. M., Nederveen, A. J., Mulder, W. J. M., Hovingh, G. K., Kastelein, J. J. P., Groen, A. K. & Stroes, E. S., 2015, In: Journal of Lipid Research. 56, 3, p. 703-712

Research output: Contribution to journal › Article › Academic › peer-review

71 Citations (Scopus)

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

AUTHOR GROUP, 2015, In: NATURE. 518, 7537, p. 102-+

Research output: Contribution to journal › Article › Academic › peer-review

534 Citations (Scopus)

Exome sequencing in suspected monogenic dyslipidemias

Stitziel, N. O., Peloso, G. M., Abifadel, M., Cefalu, A. B., Fouchier, S., Motazacker, M. M., Tada, H., Larach, D. B., Awan, Z., Haller, J. F., Pullinger, C. R., Varret, M., Rabès, J-P., Noto, D., Tarugi, P., Kawashiri, M-A., Nohara, A., Yamagishi, M., Risman, M., deo, R., & 20 othersRuel, I., Shendure, J., Nickerson, D. A., Wilson, J. G., Rich, S. S., Gupta, N., Farlow, D. N., Neale, B. M., Daly, M. J., Kane, J. P., Freeman, M. W., Genest, J., Rader, D. J., Mabuchi, H., Kastelein, J. J. P., Hovingh, G. K., Averna, M. R., Gabriel, S., Boileau, C. & Kathiresan, S., 2015, In: Circulation. Cardiovascular genetics. 8, 2, p. 343-350

Research output: Contribution to journal › Article › Academic › peer-review

42 Citations (Scopus)

Familial hypercholesterolaemia: A global call to arms

Vallejo-Vaz, A. J., Kondapally Seshasai, S. R., Cole, D., Hovingh, G. K., Kastelein, J. J. P., Mata, P., Raal, F. J., Santos, R. D., Soran, H., Watts, G. F., Abifadel, M., Aguilar-Salinas, C. A., Akram, A., Alnouri, F., Alonso, R., Al-Rasadi, K., Banach, M., Bogsrud, M. P., Bourbon, M., Bruckert, E., & 27 othersCar, J., Corral, P., Descamps, O., Dieplinger, H., Durst, R., Freiberger, T., Gaspar, I. M., Genest, J., Harada-Shiba, M., Jiang, L., Kayikcioglu, M., Lam, C. S. P., Latkovskis, G., Laufs, U., Liberopoulos, E., Nilsson, L., Nordestgaard, B. G., O'Donoghue, J. M., Sahebkar, A., Schunkert, H., Shehab, A., Stoll, M., Su, T-C., Susekov, A., Widén, E., Catapano, A. L. & Ray, K. K., 2015, In: Atherosclerosis. 243, 1, p. 257-259

Research output: Contribution to journal › Article › Academic › peer-review

148 Citations (Scopus)

Genetically Determined Height and Coronary Artery Disease

AUTHOR GROUP, 2015, In: New England journal of medicine. 372, 17, p. 1608-1618

Research output: Contribution to journal › Article › Academic › peer-review

186 Citations (Scopus)

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

AUTHOR GROUP, 2015, In: Nature Genetics. 47, 12, p. 1415-+

Research output: Contribution to journal › Article › Academic › peer-review

302 Citations (Scopus)

Genetic studies of body mass index yield new insights for obesity biology

AUTHOR GROUP, Maegi, R., Kanoni, S., Kleber, M. E., Kristiansson, K., Lim, U., Lotay, V., Mangino, M., Leach, I. M., Medina-Gomez, C., Medland, S. E., Nalls, M. A., Palmer, C. D., Pasko, D., Pechlivanis, S., Peters, MJ., Prokopenko, I., Shungin, D., Stancakova, A., Strawbridge, R. J., & 414 othersSung, Y. J., Teumer, A., Trompet, S., van der Laan, S. W., van Settee, J., Van Vliet-Ostaptchouk, J. V., Wang, Z., Yengo, L., Zhang, W., Isaacs, A., Albrecht, E., Arnlov, J., Arscott, G. M., Attwood, A. P., Bandinelli, S., Barrett, A., Bas, I. N., Bellis, C., Bennett, A. J., Berne, C., Blagieva, R., Blueher, M., Bohringer, S., Bonnycastle, L. L., Boettcher, Y., Boyd, H. A., Bruinenberg, M., Caspersen, I. H., Chen, Y. I., Clarke, R., Daw, E. W., de Craen, A. J. M., Delgado, G., Dimitriou, M., Doney, A. S. F., Eklund, N., Estrada, K., Eury, E., Folkersen, L., Fraser, R. M., Garcia, M. E., Geller, F., Giedraitis, V., Gigante, B., Go, A. S., Golay, A., Goodall, A. H., Gordon, S. D., Gorski, M., Grabe, H., Grallert, H., Grammer, T. B., Graessler, J., Gronberg, H., Groves, C. J., Gusto, G., Haessler, J., Hall, P., Haller, T., Hallmans, G., Hartman, C. A., Hassinen, M., Hayward, C., Heard-Costa, N. L., Helmer, Q., Hengstenberg, C., Holmen, O., Hottenga, J. J., James, A. L., Jeff, J. M., Johansson, A., Jolley, J., Juliusdottir, T., Kinnunen, L., Koenig, W., Koskenvuo, M., Kratzer, W., Laitinen, J., Lamina, C., Leander, K., Lee, N. R., Lichtner, P., Lind, L., Lindstrom, J., Lo, K. S., Lobbens, S., Lorbeer, R., Lu, Y., Mach, F., Magnusson, P. K. E., Mahajan, A., McArdle, W. L., McLachlan, S., Menni, C., Merger, S., Mihailov, E., Milani, L., Moayyeri, A., Monda, K. L., Morken, M. A., Mulas, A., Mueller, G., Mueller-Nurasyid, M., Musk, A. W., Nagaraja, R., Noethen, M. M., Nolte, I. M., Pilz, S., Rayner, N. W., Renstrom, F., Rettig, R., Ried, J. S., Ripke, S., Robertson, N. R., Rose, L. M., Sanna, S., Scharnagl, H., Scholtens, S., Schumacher, F. R., Scott, W. R., Seufferlein, T., Shi, J., Smith, A. V., Smolonska, J., Stanton, A. V., Steinthorsdottir, V., Stirrups, K., Stringham, H. M., Sundstrom, J., Swertz, M. A., Swift, A. J., Syvanen, A., Tan, S., Tayo, B. O., Thorand, B., Thorleifsson, G., Tyrer, J. P., Uh, H., Vandenput, L., Verhulst, F. C., Vermeulen, S. H., Verweij, N., Vonk, J. M., Waite, L. L., Warren, H. R., Waterworth, D., Weedon, M. N., Wilkens, L. R., Willenborg, C., Wilsgaard, T., Wojczynski, M. K., Wong, A., Wrightl, A. F., Zhang, Q., Brennan, E. P., Choi, M., Dastani, Z., Drong, A. W., Eriksson, P., Franco-Cereceda, A., Gadin, J. R., Gharavi, A. G., Goddard, M. E., Handsaker, R. E., Huang, J., Karpe, F., Kathiresan, S., Keildson, S., Kiryluk, K., Kubo, M., Lee, J., Liang, L., Lifton, R. P., Ma, B., McCarroll, S. A., McKnight, A. J., Min, J. L., Moffatt, M. F., Montgomery, G. W., Murabito, J. M., Nicholson, G., Nyholt, DR., Okada, Y., Perry, J. R. B., Dorajoo, R., Reinmaa, E., Salem, R. M., Sandholm, N., Scott, R. A., Stolk, L., Takahashi, A., Tanaka, T., van 't Hooft, F. M., Vinkhuyzen, A. A. E., Westra, H., Zheng, W., Zondervan, K. T., Heath, A. C., Arveiler, D., Bakker, S. J. L., Beilby, J., Bergman, R. N., Blangero, J., Bovet, P., Campbell, H., Caulfield, M. J., Cesana, G., Chakravarti, A., Chasman, D. I., Chines, P. S., Collins, F. S., Crawford, D. C., Cupples, L. A., Cusi, D., Danesh, J., de Faire, U., den Ruijter, H. M., Dominiczak, A. F., Erbel, R., Erdmann, J., Eriksson, J. G., Farrall, M., Felix, S. B., Ferrannini, E., Ferrieres, J., Ford, I., Forouhi, N. G., Forrester, T., Franco, O. H., Gansevoort, R. T., Gejman, P. V., Gieger, C., Gottesman, O., Gudnason, V., Gyllensten, U., Hall, A. S., Harris, T. B., Hattersley, A. T., Hicks, A. A., Hindorff, L. A., Hingorani, A. D., Hofman, A., Homuth, G., Humphries, S. E., Hunt, S. C., Hypponen, E., Illig, T., Jacobs, K. B., Jarvelin, M., Joeckel, K., Johansen, B., Jousilahti, P., Jukema, J. W., Jula, A. M., Kaprio, J., Keinanen-Kiukaanniemi, S. M., Kiemeney, L. A., Knekt, P., Kooner, J. S., Kooperberg, C., Kovacs, P., Kraja, A. T., Kumari, M., Kuusisto, J., Lakka, T. A., Langenberg, C., Le Marchand, L., Lehtimaki, T., Lyssenko, V., Mannisto, S., Marette, A., Matise, T. C., McKenzie, C. A., McKnight, B., Moll, F. L., Morris, A. D., Morris, A. P., Murray, J. C., Nelis, M., Ohlsson, C., Oldehinkel, A. J., Ong, K. K., Madden, P. A. F., Pasterkamp, G., Peden, J. F., Peters, A., Postma, D. S., Pramstaller, P. P., Price, J. F., Qi, L., Raitakari, O. T., Rankinen, T., Rao, D. C., Rice, T. K., Ridker, P. M., Rioux, J. D., Ritchie, M. D., Rudan, I., Salomaa, V., Samani, N. J., Saramines, J., Sarzynski, M. A., Schunkert, H., Schwarz, P. E. H., Sever, P., Shuldiner, A. R., Sinisalo, J., Stolk, R. P., Strauch, K., Toenjes, A., Tregouet, D., Tremblay, A., Tremoli, E., Virtamo, J., Vohl, M., Voelker, U., Waeber, G., Willemsen, G., Witteman, J. C., Zillikens, M. C., Adair, L. S., Amouyel, P., Asselbergs, F. W., Assimes, T. L., Bochud, M., Boehm, B. O., Boerwinkle, E., Bornstein, S. R., Bottinger, E. P., Bouchard, C., Cauchi, S., Chambers, J. C., Chanock, S. J., Cooper, R. S., de Bakker, P. I. W., Dedoussis, G., Ferrucci, L., Franks, P. W., Froguel, P., Groop, L. C., Haiman, C. A., Hamsten, A., Hui, J., Hunter, D. J., Hveem, K., Kaplan, R. C., Kivimaki, M., Kuh, D., Laakso, M., Liu, Y., Martin, N. G., Maerz, W., Melbve, M., Metspalu, A., Moebus, S., Munroe, P. B., Njolstad, I., Oostra, B. A., Palmer, C. N. A., Pedersen, N. L., Perola, M., Perusse, L., Peters, U., Power, C., Quertermous, T., Rauramaa, R., Rivadeneira, F., Saaristo, T. E., Saleheen, D., Sattar, N., Schadt, E. E., Schlessinger, D., Slagboom, P. E., Snieder, H., Spector, T. D., Thorsteinsdottir, U. R., Stumvoll, M., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., van der Harst, P., Walker, M., Wallaschofski, H., Wareham, N. J., Watkins, H., Weir, D. R., Wichmann, H., Wilson, J. F., Zanen, P., Borecki, I. B., Deloukas, P., Fox, C. S., Heid, I. M., O'Connell, J. R., Strachan, D. P., Stefansson, K., van Duijri, C. M., Abecasis, G. R., Franke, L., Frayling, T. M., McCarthy, M. I., Visscher, P. M., Scherag, A., Willer, C. J., Boehnke, M., Mohlke, K. L., Lindgren, C. M., Beckmann, J. S., Barroso, I., North, K. E., Ingelsson, E., Hirschhorn, J. N., Loos, R. J. F. & Speliotes, E. K., 2015, In: NATURE. 518, 7538, p. 197-U401

Research output: Contribution to journal › Article › Academic › peer-review

3056 Citations (Scopus)

High-dose atorvastatin is superior to moderate-dose simvastatin in preventing peripheral arterial disease

Stoekenbroek, R. M., Boekholdt, S. M., Fayyad, R., Laskey, R., Tikkanen, M. J., Pedersen, T. R. & Hovingh, G. K., 2015, In: Heart (British Cardiac Society). 101, 5, p. 356-362

Research output: Contribution to journal › Article › Academic › peer-review

33 Citations (Scopus)

Homozigot ailevi hiperkolesterolemi: klinisyenlerin taniyi ve klinik yönetimi geliştirmelerine yönelik yeni anlayişlar ve rehberlik. Avrupa Ateroskleroz Derneği'nin Ailevi Hiperkolesterolemi Üzerine Uzlaşi Paneli yazili görüşü

AUTHOR GROUP, 2015, In: Türk Kardiyoloji Derneği arşivi. 43, Suppl. 1, p. 1-14

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype-phenotype relationship, and clinical outcome

Sjouke, B., Kusters, D. M., Kindt, I., Besseling, J., Defesche, J. C., Sijbrands, E. J. G., Roeters van Lennep, J. E., Stalenhoef, A. F. H., Wiegman, A., de Graaf, J., Fouchier, S. W., Kastelein, J. J. P. & Hovingh, G. K., 2015, In: European Heart journal. 36, 9, p. 560-565

Research output: Contribution to journal › Article › Academic › peer-review

362 Citations (Scopus)

Hypercholesterolaemia and hepatosplenomegaly: two manifestations of cholesteryl ester storage disease

Sjouke, B., van der Stappen, J. W. J., Groener, J. E. M., Pepping, A., Wevers, R. A., Gouw, A., Dikkeschei, L. D., Mijnhout, S., Hovingh, G. K. & Alleman, M. A., 2015, In: Netherlands journal of medicine. 73, 3, p. 129-132

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Impact of statin therapy on coronary plaque composition: a systematic review and meta-analysis of virtual histology intravascular ultrasound studies

Banach, M., Serban, C., Sahebkar, A., Mikhailidis, D. P., Ursoniu, S., Ray, K. K., Rysz, J., Toth, P. P., Muntner, P., Mosteoru, S., García-García, H. M., Hovingh, G. K., Kastelein, J. J. P. & Serruys, P. W., 2015, In: BMC medicine. 13, 1, p. 229

Research output: Contribution to journal › Article › Academic › peer-review

172 Citations (Scopus)

Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial

AUTHOR GROUP, 2015, In: Lancet. 385, 9965, p. 341-350

Research output: Contribution to journal › Article › Academic › peer-review

608 Citations (Scopus)

Is Cholesteryl Ester Transfer Protein Inhibition an Effective Strategy to Reduce Cardiovascular Risk? CETP as a Target to Lower CVD Risk: Suspension of Disbelief?

Hovingh, G. K., Ray, K. K. & Boekholdt, S. M., 2015, In: Circulation. 132, 5, p. 433-440

Research output: Contribution to journal › Article › Academic › peer-review

25 Citations (Scopus)

Lipoprotein profiles in human heterozygote carriers of a functional mutation P297S in scavenger receptor class B1

Ljunggren, S. A., Levels, J. H. M., Hovingh, K., Holleboom, A. G., Vergeer, M., Argyri, L., Gkolfinopoulou, C., Chroni, A., Sierts, J. A., Kastelein, J. J., Kuivenhoven, J. A., Lindahl, M. & Karlsson, H., 2015, In: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 1851, 12, p. 1587-1595

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

New genetic loci link adipose and insulin biology to body fat distribution

AUTHOR GROUP, Lockes, A. E., Maegi, R., Kristiansson, K., Mangino, M., Leach, I. M., Medina-Gomez, C., Palmer, C. D., Pasko, D., Pechlivaniss, S., Peters, MJ., Prokopenko, I., Stancakova, A., Sung, Y. J., Tanakam, T., Teumer, A., van Vliet-Ostaptchouk, J. V., Yengo, L., Zhang, W., Albrecht, E., & 343 othersArnlov, J., Arscott, G. M., Bandinelli, S., Barrett, A., Bellis, C., Bennett, A. J., Berne, C., Blueher, M., Buhringer, S., Bonnet, F., Boettcher, Y., Bruinenberg, M., Carba, D. B., Caspersen, I. H., Clarke, R., Daw, E. W., Deelen, J., Deelman, E., Delgado, G., Doney, A. S. F., Eklund, N., Erdos, M. R., Estrada, K., Eury, E., Friedrichs, N., Garcia, M. E., Giedraitis, V., Gigante, B., Go, A. S., Golay, A., Grallert, H., Grammer, T. B., Graessler, J., Grewal, J., Groves, C. J., Haller, T., Hallmans, G., Hartman, C. A., Hassinen, M., Hayward, C., Heikkila, K., Herzig, K., Helmer, Q., Hillege, H. L., Holmen, O., Hunt, S. C., Isaacs, A., Ittermann, T., James, A. L., Johansson, I., Juliusdottir, T., Kalafati, I., Kinnunen, L., Koenig, W., Kooner, I. K., Kratzer, W., Lamina, C., Leander, K., Lee, N. R., Lichtner, P., Lind, L., Lindstrom, J., Lobbens, S., Lorentzon, M., Mach, F., Magnusson, P. K. E., Mahajan, A., McArdle, W. L., Menni, C., Merger, S., Mihailov, E., Milani, L., Mills, R., Moayyeri, A., Monda, K. L., Mooijaart, S. P., Muehleisen, T. W., Mulas, A., Mueller, G., Mueller-Nurasyid, M., Nagaraja, R., Nalls, M. A., Narisu, N., Glorioso, N., Nolte, I. M., Olden, M., Rayner, N. W., Renstrom, F., Ried, J. S., Robertson, N. R., Rose, L. M., Sanna, S., Scharnagl, H., Scholtens, S., Sennblad, B., Seufferlein, T., Sitlani, C. M., Smith, A. V., Stirrups, K., Stringham, H. M., Sundstrom, J., Swertz, M. A., Swift, A. J., Syvanen, A., Tayo, B. O., Thorand, B., Thorleifsson, G., Tomaschitz, A., Troffa, C., van Oort, F. V. A., Verweij, N., Vonk, J. M., Waite, L. L., Wennauer, R., Wilsgaard, T., Wojczynski, M. K., Wong, A., Zhang, Q., Zhao, J. H., Brennan, E. P., Choi, M., Eriksson, P., Folkersen, L., Franco-Cereceda, A., Gharavi, A. G., Hedman, A. K., Hivert, M., Huang, J., Kanoni, S., Karpe, F., Keildson, S., Kiryluk, K., Liang, L., Lifton, R. P., Ma, B., McKnight, A. J., McPherson, R., Metspalu, A., Min, J. L., Moffatt, M. F., Montgomery, G. W., Murabito, J. M., Nicholson, G., Nyholt, DR., Olsson, C., Perry, J. R. B., Reinmaa, E., Salem, R. M., Sandholm, N., Schadt, E. E., Scott, R. A., Stolk, L., Vallejo, E. E., Westra, H., Zondervan, K. T., Amouyel, P., Arveiler, D., Bakker, S. J. L., Beilby, J., Bergman, R. N., Blangero, J., Brown, M. J., Burnier, M., Campbell, H., Chakravarti, A., Chiness, P. S., Claudi-Boehmi, S., Collins, F. S., Crawford, D. C., Danesh, J., de Faire, U., de Geus, E. J. C., Doerr, M., Erbel, R., Eriksson, J. G., Farrall, M., Ferrannini, E., Ferrieres, J., Forouhi, N. G., Forrester, T., Franco, O. H., Gansevoort, R. T., Gieger, C., Gudnason, V., Haiman, C. A., Harris, T. B., Hattersley, A. T., Heliovaara, M., Hicks, A. A., Hingorani, A. D., Hoffmann, W., Hofman, A., Homuth, G., Humphries, S. E., Hyppoenen, E., Illig, T., Jarvelin, M., Johansen, B., Jousilahti, P., Jula, A. M., Kaprio, J., Kee, F., Keinanen-Kiukaanniemi, S. M., Kooner, J. S., Kooperberg, C., Kovacs, P., Kraja, A. T., Kumari, M., Kuulasmaa, K., Kuusisto, J., Lakka, T. A., Langenberg, C., Le Marchand, L., Lehtimaki, T., Lyssenko, V., Mannisto, S., Marette, A., Matise, T. C., McKenzie, C. A., McKnight, B., Musk, A. W., Mohlenkamp, S., Morris, A. D., Nelis, M., Ohlsson, C., Oldehinkel, A. J., Ong, K. K., Palmer, L. J., Penninx, B. W. J. H., Peters, A., Pramstaller, P. P., Raitakari, O. T., Rankinen, T., Rao, D. C., Rice, T. K., Ridker, P. M., Ritchie, M. D., Rudan, I., Salomaa, V., Samani, N. J., Saramies, J., Sarzynski, M. A., Schwarz, P. E. H., Shuldiner, A. R., Staessen, J. A., Steinthorsdottir, V., Stolk, R. P., Strauch, K., Toenjes, A., Tremblay, A., Tremoli, E., Vohl, M., Voelker, U., Vollenweider, P., Wilson, J. F., Witteman, J. C., Adair, L. S., Bochud, M., Boehm, B. O., Bornstein, S. R., Bouchard, C., Cauchi, S., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Cooper, R. S., Dedoussis, G., Ferrucci, L., Froguel, P., Grabe, H., Hamsten, A., Hui, J., Hveem, K., Joeckel, K., Kivimaki, M., Kuh, D., Laakso, M., Liu, Y., Maerz, W., Munroe, P. B., Njolstad, I., Oostra, B. A., Palmer, C. N. A., Pedersen, N. L., Perola, M., Perusse, L., Peters, U., Power, C., Quertermous, T., Rauramaa, R., Rivadeneira, F., Saaristo, T. E., Saleheen, D., Sinisalo, J., Slagboom, P. E., Snieder, H., Spector, T. D., Thorsteinsdottir, U. R., Stumvoll, M., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., van der Harst, P., Veronesi, G., Walker, M., Wareham, N. J., Watkins, H., Wichmann, H., Abecasis, G. R., Assimes, T. L., Berndt, S. I., Boehnkes, M., Borecki, I. B., Deloukas, P., Franke, L., Frayling, T. M., Groop, L. C., Hunter, D. J., Kaplan, R. C., O'Connell, J. R., Qi, L., Schlessinger, D., Strachan, D. P., Stefansson, K., van Dujin, C. M., Willer, C. J., Visscher, P. M., Yang, J., Hirschhorn, J. N., Zillikens, M. C., McCarthy, M. I., Speliotes, E. K., North, K. E., Fox, C. S., Barroso, I., Franks, P. W., Ingelsson, E., Heid, I. M., Loos, R. J. F., Cupples, L. A., Morris, A. P., Lindgren, C. M. & Mohlke, K. L., 2015, In: NATURE. 518, 7538, p. 187-U378

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1097 Citations (Scopus)

ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia

Kastelein, J. J. P., Ginsberg, H. N., Langslet, G., Hovingh, G. K., Ceska, R., Dufour, R., Blom, D., Civeira, F., Krempf, M., Lorenzato, C., Zhao, J., Pordy, R., Baccara-Dinet, M. T., Gipe, D. A., Geiger, M. J. & Farnier, M., 2015, In: European Heart journal. 36, 43, p. 2996-3003

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476 Citations (Scopus)

PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial

AUTHOR GROUP, 2015, In: Lancet. 385, 9965, p. 331-340

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633 Citations (Scopus)

PCSK9 inhibitors: Novel therapeutic agents for the treatment of hypercholesterolemia

Verbeek, R., Stoekenbroek, R. M. & Hovingh, G. K., 2015, In: European journal of pharmacology. 763, Part A, p. 38-47

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34 Citations (Scopus)

Prevalence and management of familial hypercholesterolaemia in coronary patients: An analysis of EUROASPIRE IV, a study of the European Society of Cardiology

de Backer, G., Besseling, J., Chapman, J., Hovingh, G. K., Kastelein, J. J. P., Kotseva, K., Ray, K., Reiner, Ž., Wood, D. & de Bacquer, D., 2015, In: Atherosclerosis. 241, 1, p. 169-175

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131 Citations (Scopus)

Statin intolerance - an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Banach, M., Rizzo, M., Toth, P. P., Farnier, M., Davidson, M. H., Al-Rasadi, K., Aronow, W. S., Athyros, V., Djuric, D. M., Ezhov, M. V., Greenfield, R. S., Hovingh, G. K., Kostner, K., Serban, C., Lighezan, D., Fras, Z., Moriarty, P. M., Muntner, P., Goudev, A., Ceska, R., & 11 othersNicholls, S. J., Broncel, M., Nikolic, D., Pella, D., Puri, R., Rysz, J., Wong, N. D., Bajnok, L., Jones, S. R., Ray, K. K. & Mikhailidis, D. P., 2015, In: Archives of medical science. 11, 1, p. 1-23

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323 Citations (Scopus)

The effect of an apolipoprotein A-I-containing high-density lipoprotein-mimetic particle (CER-001) on carotid artery wall thickness in patients with homozygous familial hypercholesterolemia: The Modifying Orphan Disease Evaluation (MODE) study

Hovingh, G. K., Smits, L. P., Stefanutti, C., Soran, H., Kwok, S., de Graaf, J., Gaudet, D., Keyserling, C. H., Klepp, H., Frick, J., Paolini, J. F., Dasseux, J-L., Kastelein, J. J. P. & Stroes, E. S., 2015, In: American Heart Journal. 169, 5, p. 736-742.e1

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61 Citations (Scopus)

The impact of LDLR function on fibroblast growth factor 21 levels

Besseling, J., Ong, K. L., Huijgen, R., Rye, K-A., Hovingh, G. K., Hutten, B. A. & Lambert, G., 2015, In: Atherosclerosis. 241, 2, p. 322-325

Research output: Contribution to journal › Article › Academic › peer-review

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler, T. W., Justice, A. E., Graff, M., Barata, L., Feitosa, M. F., Chu, S., Czajkowski, J., Esko, T., Fall, T., Kilpelainen, T. O., Lu, Y., Magi, R., Mihailov, E., Pers, T. H., Rueeger, S., Teumer, A., Ehret, G. B., Ferreira, T., Heard-Costa, N. L., Karjalainen, J., & 442 othersLagou, V., Mahajan, A., Neinast, M. D., Prokopenko, I., Simino, J., Teslovich, T. M., Jansen, R., Westra, H., White, C. C., Absher, D., Ahluwalia, T. S., Ahmad, S., Albrecht, E., Alves, A. C., Bragg-Gresham, J. L., Craen, A. J. M., Bis, J. C., Bonnefond, A., Boucher, G., Cadby, G., Cheng, Y., Chiang, C. W. K., Delgado, G., Demirkan, A., Dueker, N., Eklund, N., Eiriksdottir, G., Eriksson, J., Feenstra, B., Fischer, K., Frau, F., Galesloot, T. E., Geller, F., Goel, A., Gorski, M., Grammer, T. B., Gustafsson, S., Haitjema, S., Hottenga, J. J., Huffman, J. E., Jackson, A. U., Jacobs, K. B., Johansson, A., Kaakinen, M., Kleber, M. E., Lahti, J., Leach, I. M., Lehne, B., Lo, K. S., Lorentzon, M., Luan, J., Madden, P. A. F., Mangino, M., McKnight, B., Medina-Gomez, C., Monda, K. L., Montasser, M. E., Mueller, G., Mueller-Nurasyid, M., Nolte, I. M., Panoutsopoulou, K., Pascoe, L., Paternoster, L., Rayner, N. W., Renstrom, F., Rizzi, F., Rose, L. M., Ryan, K. A., Salo, P., Sanna, S., Scharnagl, H., Shi, J., Smith, A. V., Southam, L., Stancakova, A., Steinthorsdottir, V., Strawbridge, R. J., Sung, Y. J., Tachmazidou, I., Tanaka, T., Thorleifsson, G., Trompet, S., Pervjakova, N., Tyrer, J. P., Vandenput, L., van der Laan, S. W., van der Velde, N., van Setten, J., van Vliet-Ostaptchouk, J. V., Verweij, N., Vlachopoulou, E., Waite, L. L., Wang, S. R., Wang, Z., Wild, S. H., Willenborg, C., Wilson, J. F., Wong, A., Yang, J., Yengo, L., Yerges-Armstrong, L. M., Yu, L., Zhang, W., Zhao, J. H., Andersson, E. A., Bakker, S. J. L., Baldassarre, D., Banasik, K., Barcella, M., Barlassina, C., Bellis, C., Benaglio, P., Blangero, J., Blueher, M., Bonnet, F., Bonnycastle, L. L., Boyd, H. A., Bruinenberg, M., Buchman, A. S., Campbell, H., Chen, Y. I., Chines, P. S., Claudi-Boehm, S., Cole, J., Collins, F. S., de Geus, E. J. C., de Groot, L. C. P. G. M., Dimitriou, M., Duan, J., Enroth, S., Eury, E., Farmaki, A., Forouhi, N. G., Friedrich, N., Gejman, P. V., Gigante, B., Glorioso, N., Go, A. S., Gottesman, O., Graessler, J., Grallert, H., Grarup, N., Gu, Y., Broer, L., van der Ham, A. C., Hansen, T., Harris, T. B., Hartman, C. A., Hassinen, M., Hastie, N., Hattersley, A. T., Heath, A. C., Henders, A. K., Hernandez, D., Hillege, H., Holmen, O., Hovingh, K. G., Hui, J., Husemoen, L. L., Hutri-Kahonen, N., Hysi, P. G., Illig, T., de Jager, P. L., Jalilzadeh, S., Jorgensen, T., Jukema, J. W., Juonala, M., Kanoni, S., Karaleftheri, M., Khaw, K. T., Kinnunen, L., Kittner, S. J., Koenig, W., Kolcic, I., Kovacs, P., Krarup, N. T., Kratzer, W., Krueger, J., Kuh, D., Kumari, M., Kyriakou, T., Langenberg, C., Lannfelt, L., Lanzani, C., Lotay, V., Launer, L. J., Leander, K., Lindstrom, J., Linneberg, A., Liu, Y., Lobbens, S., Luben, R., Lyssenko, V., Mannisto, S., Magnusson, P. K., McArdle, W. L., Menni, C., Merger, S., Milani, L., Montgomery, G. W., Morris, A. P., Narisu, N., Nelis, M., Ong, K. K., Palotie, A., Perusse, L., Pichler, I., Pilia, M. G., Pouta, A., Rheinberger, M., Ribel-Madsen, R., Richards, M., Rice, K. M., Rice, T. K., Rivolta, C., Salomaa, V., Sanders, A. R., Sarzynski, M. A., Scholtens, S., Scott, R. A., Scott, W. R., Sebert, S., Sengupta, S., Sennblad, B., Seufferlein, T., Silveira, A., Slagboom, P. E., Smit, J. H., Sparso, T. H., Stirrups, K., Stolk, R. P., Stringham, H. M., Swertz, M. A., Swift, A. J., Syvanen, A., Tan, S., Thorand, B., Toenjes, A., Tremblay, A., Tsafantakis, E., van der Most, P. J., Voelker, U., Vohl, M., Vonk, J. M., Waldenberger, M., Walker, R. W., Wennauer, R., Widen, E., Willemsen, G., Wilsgaard, T., Wright, A. F., Zillikens, M. C., van Dijk, S. C., van Schoor, N. M., Asselbergs, F. W., Bakker, P. I. W., Beckmann, J. S., Beilby, J., Bennett, D. A., Bergman, R. N., Bergmann, S., Boeger, C. A., Boehm, B. O., Boerwinkle, E., Boomsma, D. I., Bornstein, S. R., Bottinger, E. P., Bouchard, C., Chambers, J. C., Chanock, S. J., Chasman, D. I., Cucca, F., Cusi, D., Dedoussis, G., Erdmann, J., Eriksson, J. G., Evans, D. A., de Faire, U., Farrall, M., Ferrucci, L., Ford, I., Franke, L., Franks, P. W., Froguel, P., Gansevoort, R. T., Gieger, C., Gronberg, H., Gudnason, V., Gyllensten, U., Hall, P., Hamsten, A., van der Harst, P., Hayward, C., Heliovaara, M., Hengstenberg, C., Hicks, A. A., Hingorani, A., Hofman, A., Hu, F., Huikuri, H. V., Hveem, K., James, A. L., Jordan, J. M., Jula, A., Kaehoenen, M., Kajantie, E., Kathiresan, S., Kiemeney, L. A. L. M., Kivimaki, M., Knekt, P. B., Koistinen, H. A., Kooner, J. S., Koskinen, S., Kuusisto, J., Maerz, W., Martin, N. G., Laakso, M., Lakka, T. A., Lehtimaki, T., Lettre, G., Levinson, D. F., Lind, L., Lokki, M., Mantyselka, P., Melbye, M., Metspalu, A., Mitchell, B. D., Moll, F. L., Murray, J. C., Musk, A. W., Nieminen, M. S., Njolstad, I., Ohlsson, C., Oldehinkel, A. J., Oostra, B. A., Palmer, L. J., Pankow, J. S., Pasterkamp, G., Pedersen, N. L., Pedersen, O., Penninx, B. W. J. H., Perola, M., Peters, A., Polasek, O., Pramstaller, P. P., Psaty, B. M., Qi, L., Quertermous, T., Raitakari, O. T., Rankinen, T., Rauramaa, R., Ridker, P. M., Rioux, J. D., Rivadeneira, F., Rotter, J. I., Rudan, I., den Ruijter, H. M., Saltevo, J., Sattar, N., Schunkert, H., Schwarz, P. E. H., Shuldiner, A. R., Sinisalo, J., Snieder, H., Sorensen, T. I. A., Spector, T. D., Staessen, J. A., Stefania, B., Thorsteinsdottir, U., Stumvoll, M., Tardif, J., Tremoli, E., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., Verbeek, A. L. M., Vermeulen, S. H., Viikari, J. S., Vitart, V., Voelzke, H., Vollenweider, P., Waeber, G., Walker, M., Wallaschofski, H., Wareham, N. J., Watkins, H., Zeggini, E., Chakravarti, A., Clegg, D. J., Cupples, L. A., Gordon-Larsen, P., Jaquish, C. E., Rao, D. C., Abecasis, G. R., Assimes, T. L., Barroso, I., Berndt, S. I., Boehnke, M., Deloukas, P., Fox, C. S., Groop, L. C., Hunter, D. J., Ingelsson, E., Kaplan, R. C., McCarthy, M. I., Mohlke, K. L., O'Connell, J. R., Schlessinger, D., Strachan, D. P., Stefansson, K., van Duijn, C. M., Hirschhorn, J. N., Lindgren, C. M., Heid, I. M., North, K. E., Borecki, I. B., Kutalik, Z., Loos, R. J. F., Kilpeläinen, T. O., Mägi, R., Rüeger, S., Müller, G., Müller-Nurasyid, M., Renström, F., Stančáková, A., Blüher, M., Gräßler, J., Hutri-Kähönen, N., Jørgensen, T., Krüger, J., Lindström, J., Männistö, S., Sparsø, T. H., Syvänen, A-C., Grönberg, H., Heliövaara, M., Kähönen, M., Lehtimäki, T., Mäntyselkä, P., Njølstad, I., Polašek, O. & Sørensen, T. I. A., 2015, In: PLoS genetics. 11, 10, p. e1005378 e1005378.

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267 Citations (Scopus)

Vascular risk factors, vascular disease, lipids and lipid targets in patients with familial dysbetalipoproteinemia: a European cross-sectional study

Koopal, C., Retterstøl, K., Sjouke, B., Hovingh, G. K., Ros, E., de Graaf, J., Dullaart, R. P. F., Bertolini, S. & Visseren, F. L. J., 2015, In: Atherosclerosis. 240, 1, p. 90-97

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40 Citations (Scopus)

2014

Adrenal Function in females with low plasma HDL-C due to mutations in ABCA1 and LCAT

Bochem, A. E., Holleboom, A. G., Romijn, J. A., Hoekstra, M., Dallinga, G. M., Motazacker, M. M., Hovingh, G. K., Kuivenhoven, J. A. & Stroes, E. S. G., 2014, In: PLOS ONE. 9, 5, p. e90967

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12 Citations (Scopus)

ApoA-I mutations, L202P and K131del, in HDL from heterozygotes with low HDL-C

Ljunggren, S., Levels, J. H. M., Turkina, M. V., Sundberg, S., Bochem, A. E., Hovingh, K., Holleboom, A. G., Lindahl, M., Kuivenhoven, J. A. & Karlsson, H., 2014, In: Proteomics. Clinical applications. 8, 3-4, p. 241-250

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5 Citations (Scopus)

Common genetic variants do not associate with CAD in familial hypercholesterolemia

van Iperen, E. P. A., Sivapalaratnam, S., Boekholdt, S. M., Hovingh, G. K., Maiwald, S., Tanck, M. W., Soranzo, N., Stephens, J. C., Sambrook, J. G., Levi, M., Ouwehand, W. H., Kastelein, J. J., Trip, M. D. & Zwinderman, A. H., 2014, In: European journal of human genetics. 22, 6, p. 809-813

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4 Citations (Scopus)

Defining the role of common variation in the genomic and biological architecture of adult human height

AUTHOR GROUP, Kleber, M. E., Kristiansson, K., Lim, U., Helmer, Q., Boomsma, D. I., Saleheen, D., Schlessinger, D., Slagboom, P. E., Snieder, H., Spector, T. D., Strauch, K., Stumvoll, M., Tuomilehto, J., Uusitupa, M., van der Harst, P., Völzke, H., Walker, M., Wareham, N. J., Watkins, H., & 39 othersWichmann, H. E., Wilson, J. F., Zanen, P., Deloukas, P., Heid, I. M., Lindgren, C. M., Mohlke, K. L., Speliotes, E. K., Thorsteinsdottir, U., Barroso, I., Fox, C. S., North, K. E., Strachan, D. P., Beckmann, J. S., Berndt, S. I., Boehnke, M., Borecki, I. B., McCarthy, M. I., Metspalu, A., Smit, J. H., Pilz, S., van Schoor, N. M., Stefansson, K., Uitterlinden, A. G., van Duijn, C. M., Franke, L., Willer, C. J., Price, A. L., Lettre, G., Loos, R. J. F., Weedon, M. N., Ingelsson, E., O'Connell, J. R., Abecasis, G. R., Chasman, D. I., Goddard, M. E., Visscher, P. M., Hirschhorn, J. N. & Frayling, T. M., 2014, In: Nature Genetics. 46, 11, p. 1173-1186 14 p.

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1295 Citations (Scopus)

Distribution and medical impact of loss-of-function variants in the Finnish founder population

Lim, E. T., Würtz, P., Havulinna, A. S., Palta, P., Tukiainen, T., Rehnström, K., Esko, T., Mägi, R., Inouye, M., Lappalainen, T., Chan, Y., Salem, R. M., Lek, M., Flannick, J., Sim, X., Manning, A., Ladenvall, C., Bumpstead, S., Hämäläinen, E., Aalto, K., & 40 othersMaksimow, M., Salmi, M., Blankenberg, S., Ardissino, D., Shah, S., Horne, B., McPherson, R., Hovingh, G. K., Reilly, M. P., Watkins, H., Goel, A., Farrall, M., Girelli, D., Reiner, A. P., Stitziel, N. O., Kathiresan, S., Gabriel, S., Barrett, J. C., Lehtimäki, T., Laakso, M., Groop, L., Kaprio, J., Perola, M., McCarthy, M. I., Boehnke, M., Altshuler, D. M., Lindgren, C. M., Hirschhorn, J. N., Metspalu, A., Freimer, N. B., Zeller, T., Jalkanen, S., Koskinen, S., Raitakari, O., Durbin, R., MacArthur, D. G., Salomaa, V., Ripatti, S., Daly, M. J. & Palotie, A., 2014, In: PLoS genetics. 10, 7, p. e1004494

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283 Citations (Scopus)

eNOS activation by HDL is impaired in genetic CETP deficiency

Gomaraschi, M., Ossoli, A., Pozzi, S., Nilsson, P., Cefalù, A. B., Averna, M., Kuivenhoven, J. A., Hovingh, G. K., Veglia, F., Franceschini, G. & Calabresi, L., 2014, In: PLOS ONE. 9, 5, p. e95925

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32 Citations (Scopus)

Eprotirome in patients with familial hypercholesterolaemia (the AKKA trial): a randomised, double-blind, placebo-controlled phase 3 study

Sjouke, B., Langslet, G., Ceska, R., Nicholls, S. J., Nissen, S. E., Öhlander, M., Ladenson, P. W., Olsson, A. G., Hovingh, G. K. & Kastelein, J. J. P., 2014, In: Lancet. Diabetes and endocrinology. 2, 6, p. 455-463

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85 Citations (Scopus)

Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci

Tragante, V., Barnes, M. R., Ganesh, S. K., Lanktree, M. B., Guo, W., Franceschini, N., Smith, E. N., Johnson, T., Holmes, M. V., Padmanabhan, S., Karczewski, K. J., Almoguera, B., Barnard, J., Baumert, J., Chang, Y. P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Gaunt, T. R., Gho, J. M. I. H., & 116 othersGieger, C., Goel, A., Gong, Y., Isaacs, A., Kleber, M. E., Leach, I. M., McDonough, C. W., Meijs, M. F. L., Melander, O., Nelson, C. P., Nolte, I. M., Pankratz, N., Price, T. S., Shaffer, J., Shah, S., Tomaszewski, M., van der Most, P. J., van Iperen, E. P. A., Vonk, J. M., Witkowska, K., Wong, C. O. L., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Brown, M., Burt, A., Cooper-DeHoff, R. M., Connell, J. M., Cruickshanks, K. J., Curtis, S. P., Davey-Smith, G., Delles, C., Gansevoort, R. T., Guo, X. Q., Haiqing, S., Hastie, C. E., Hofker, M. H., Hovingh, G. K., Kim, D. S., Kirkland, S. A., Klein, B. E., Klein, R., Li, Y. R., Maiwald, S., Newton-Cheh, C., O'Brien, E. T., Onland-Moret, N. C., Palmas, W., Parsa, A., Penninx, B. W., Pettinger, M., Vasan, R. S., Ranchalis, J. E., Ridker, P. M., Rose, L. M., Sever, P., Shimbo, D., Steele, L., Stolk, R. P., Thorand, B., Trip, M. D., van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Wyatt, S., Young, J. H., Zwinderman, A. H., Bezzina, C. R., Boerwinkle, E., Casas, J. P., Caulfield, M. J., Chakravarti, A., Chasman, D. I., Davidson, K. W., Doevendans, P. A., Dominiczak, A. F., FitzGerald, G. A., Gums, J. G., Munroe, P. B., Keating, B. J., Fornage, M., Hakonarson, H., Halder, I., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J. P., Koenig, W., Kumari, M., März, W., Murray, S. S., O'Connell, J. R., Oldehinkel, A. J., Pankow, J. S., Rader, D. J., Redline, S., Reilly, M. P., Schadt, E. E., Kottke-Marchant, K., Snieder, H., Snyder, M., Stanton, A. V., Tobin, M. D., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Samani, N. J., Watkins, H., Johnson, A. D., Reiner, A. P., Zhu, X., de Bakker, P. I. W., Levy, D. & Asselbergs, F. W., 2014, In: American journal of human genetics. 94, 3, p. 349-360

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

140 Citations (Scopus)

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

AUTHOR GROUP, 2014, In: Nature Genetics. 46, 3, p. 234-244

Research output: Contribution to journal › Article › Academic › peer-review

817 Citations (Scopus)

HDL and cardiovascular disease

Rader, D. J. & Hovingh, G. K., 2014, In: Lancet. 384, 9943, p. 618-625

Research output: Contribution to journal › Article › Academic › peer-review

484 Citations (Scopus)

HDL does not influence the polarization of human monocytes toward an alternative phenotype

Colin, S., Fanchon, M., Belloy, L., Bochem, A. E., Copin, C., Derudas, B., Stroes, E. S. G., Hovingh, G. K., Kuivenhoven, J. A., Dallinga-Thie, G. M., Staels, B. & Chinetti-Gbaguidi, G., 2014, In: International journal of cardiology. 172, 1, p. 179-184

Research output: Contribution to journal › Article › Academic › peer-review

21 Citations (Scopus)

Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans

Singaraja, R. R., Tietjen, I., Hovingh, G. K., Franchini, P. L., Radomski, C., Wong, K., vanHeek, M., Stylianou, I. M., Lin, L., Wang, L., Mitnaul, L., Hubbard, B., Winther, M., Mattice, M., Legendre, A., Sherrington, R., Kastelein, J. J., Akinsanya, K., Plump, A. & Hayden, M. R., 2014, In: Journal of Lipid Research. 55, 8, p. 1693-1701

Research output: Contribution to journal › Article › Academic › peer-review

23 Citations (Scopus)

Inactivating mutations in NPC1L1 and protection from coronary heart disease

Stitziel, N. O., Won, H-H., Morrison, A. C., Peloso, G. M., Do, R., Lange, L. A., Fontanillas, P., Gupta, N., Duga, S., Goel, A., Farrall, M., Saleheen, D., Ferrario, P., König, I., Asselta, R., Merlini, P. A., Marziliano, N., Notarangelo, M. F., Schick, U., Auer, P., & 57 othersAssimes, T. L., Reilly, M., Wilensky, R., Rader, D. J., Hovingh, G. K., Meitinger, T., Kessler, T., Kastrati, A., Laugwitz, K-L., Siscovick, D., Rotter, J. I., Hazen, S. L., Tracy, R., Cresci, S., Spertus, J., Jackson, R., Schwartz, S. M., Natarajan, P., Crosby, J., Muzny, D., Ballantyne, C., Rich, S. S., O'Donnell, C. J., Abecasis, G., Sunyaev, S., Nickerson, D. A., Buring, J. E., Ridker, P. M., Chasman, D. I., Austin, E., Ye, Z., Kullo, I. J., Weeke, P. E., Shaffer, C. M., Bastarache, L. A., Denny, J. C., Roden, D. M., Palmer, C., Deloukas, P., Lin, D-Y., Tang, Z., Erdmann, J., Schunkert, H., Danesh, J., Marrugat, J., Elosua, R., Ardissino, D., McPherson, R., Watkins, H., Reiner, A. P., Wilson, J. G., Altshuler, D., Gibbs, R. A., Lander, E. S., Boerwinkle, E., Gabriel, S. & Kathiresan, S., 2014, In: New England journal of medicine. 371, 22, p. 2072-2082

Research output: Contribution to journal › Article › Academic › peer-review

369 Citations (Scopus)

Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis

Maiwald, S., Sivapalaratnam, S., Motazacker, M. M., van Capelleveen, J. C., Bot, I., de Jager, S. C., van Eck, M., Jolley, J., Kuiper, J., Stephens, J., Albers, C. A., Vosmeer, C. R., Kruize, H., Geerke, D. P., van der Wal, A. C., van der Loos, C. M., Kastelein, J. J. P., Trip, M. D., Ouwehand, W. H., Dallinga-Thie, G. M., & 1 othersHovingh, G. K., 30 May 2014, In: PLOS ONE. 9, 5, p. e98289

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

7 Citations (Scopus)

Mutations in STAP1 are associated with autosomal dominant hypercholesterolemia

Fouchier, S. W., Dallinga-Thie, G. M., Meijers, J. C. M., Zelcer, N., Kastelein, J. J. P., Defesche, J. C. & Hovingh, G. K., 2014, In: Circulation Research. 115, 6, p. 552-555

Research output: Contribution to journal › Article › Academic › peer-review

138 Citations (Scopus)

Gerard Hovingh

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