E.S. van Haastert

2016

Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer's disease pathology

Rosenberger, A. F. N., Morrema, T. H. J., Gerritsen, W. H., van Haastert, E. S., Snkhchyan, H., Hilhorst, R., Rozemuller, A. J. M., Scheltens, P., van der Vies, S. M. & Hoozemans, J. J. M., 6 Jan 2016, In: Journal of neuroinflammation. 13, 4.

Research output: Contribution to journal › Article › Academic › peer-review

50 Citations (Scopus)

Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease

Hondius, D. C., van Nierop, P., Li, K. W., Hoozemans, J. J. M., van der Schors, R. C., van Haastert, E. S., van der Vies, S. M., Rozemuller, A. J. M. & Smit, A. B., Jun 2016, In: Alzheimers & Dementia. 12, 6, p. 654-668 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

115 Citations (Scopus)

2014

Increased IRAK-4 Kinase Activity in Alzheimer's Disease; IRAK-1/4 Inhibitor I Prevents Pro-inflammatory Cytokine Secretion but not the Uptake of Amyloid Beta by Primary Human Glia

Hoozemans, J. J. M., van Haastert, E. S., Mulder, S. D., Nielsen, H. M., Veerhuis, R., Ruijtenbeek, R., Rozemuller, A. J. M., Hilhorst, R. & van der Vies, S. M., 2014, In: Journal of Clinical & Cellular Immunology. 5, 4, 243.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition

Marlatt, M. W., Bauer, J., Aronica, E., van Haastert, E. S., Hoozemans, J. J. M., Joels, M. & Lucassen, P. J., 2014, In: Neural plasticity. 2014, p. 693851 12 p., 693851.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

64 Citations (Scopus)

The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress

van der Harg, J. M., Nölle, A., Zwart, R., Boerema, A. S., van Haastert, E. S., Strijkstra, A. M., Hoozemans, J. J. M. & Scheper, W., 2014, In: Cell Death & Disease. 28, 5, p. e1393 e1393.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

71 Citations (Scopus)

2013

Immunohistochemical characterization of novel monoclonal antibodies against the N-terminus of amyloid beta-peptide

Verwey, N. A., Hoozemans, J. J. M., Korth, C., van Royen, M. R., Prikulis, I., Wouters, D., Twaalfhoven, H. A. M., van Haastert, E. S., Schenk, D., Scheltens, P., Rozemuller, A. J. M., Blankenstein, M. A. & Veerhuis, R., 2013, In: Amyloid. 20, 3, p. 179-187

Research output: Contribution to journal › Article › Academic › peer-review

12 Citations (Scopus)

Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome: Convergence of aging and Aβ pathology at the lysosome

de Kimpe, L., van Haastert, E. S., Kaminari, A., Zwart, R., Rutjes, H., Hoozemans, J. J. M. & Scheper, W., Jun 2013, In: Age (Dordrecht, Netherlands). 35, 3, p. 673-687

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

46 Citations (Scopus)

Ubiquilin 2 is not associated with tau pathology

Nolle, A., van Haastert, E. S., Zwart, R., Hoozemans, J. J. M., Scheper, W. & Nölle, A., 26 Sept 2013, In: PLOS ONE. 8, 9, p. e76598 e76598.

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Unfolded protein response activates glycogen synthase kinase-3 via selective lysosomal degradation

Nijholt, D. A. T., Nolle, A., van Haastert, E. S., Edelijn, H., Toonen, R. F. G., Hoozemans, J. J. M., Scheper, W. & Nölle, A., 2013, In: Neurobiology of aging. 34, 7, p. 1759-1771

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

38 Citations (Scopus)

2012

Activation of the Unfolded Protein Response Is an Early Event in Alzheimer's and Parkinson's Disease

Hoozemans, J. J. M., van Haastert, E. S., Nijholt, D. A. T., Rozemuller, A. J. M. & Scheper, W., Apr 2012, In: NEURODEGENERATIVE DISEASES. 10, 1-4, p. 212-215

Research output: Contribution to journal › Article › Academic › peer-review

152 Citations (Scopus)

Disturbed Ca2+ Homeostasis Increases Glutaminyl Cyclase Expression; Connecting Two Early Pathogenic Events in Alzheimer's Disease In Vitro

de Kimpe, L., Bennis, A., Zwart, R., van Haastert, E. S., Hoozemans, J. J. M. & Scheper, W., 7 Sept 2012, In: PLoS ONE. 7, 9, p. e44674 e44674.

Research output: Contribution to journal › Article › Academic › peer-review

23 Citations (Scopus)

Neuroinflammation and common mechanism in Alzheimer's disease and prion amyloidosis: amyloid-associated proteins, neuroinflammation and neurofibrillary degeneration

Rozemuller, A. J. M., Jansen, C., Carrano, A., van Haastert, E. S., Hondius, D., van der Vies, S. M. & Hoozemans, J. J. M., 2012, In: NEURODEGENERATIVE DISEASES. 10, 1-4, p. 301-304

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies

Nijholt, D. A. T., van Haastert, E. S., Rozemuller, A. J. M., Scheper, W. & Hoozemans, J. J. M., Apr 2012, In: Journal of pathology. 226, 5, p. 693-702

Research output: Contribution to journal › Article › Academic › peer-review

147 Citations (Scopus)

2011

Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis

Wilhelmus, M. M. M., Bol, J. G. J. M., van Haastert, E. S., Rozemuller, J. M., Bu, G., Drukarch, B. & Hoozemans, J. J. M., 2011, In: The American Journal of Pathology. 179, 5, p. 2152-2156

Research output: Contribution to journal › Article › Academic › peer-review

31 Citations (Scopus)

Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease: Implications for Alzheimer's disease

Nijholt, D. A. T., Graaf, T. R., van Haastert, E. S., Oliveira, A., Berkers, C. R., Zwart, R., Ovaa, H., Baas, F., Hoozemans, J. J. M., Scheper, R. J. & Scheper, W., Jun 2011, In: Cell death and differentiation. 18, 6, p. 1071-1081

Research output: Contribution to journal › Article › Academic › peer-review

108 Citations (Scopus)

Neuroinflammation in Alzheimer's disease wanes with age

Hoozemans, J. J. M., Rozemuller, A. J. M., van Haastert, E. S., Eikelenboom, P. & van Gool, W. A., 2011, In: Journal of neuroinflammation. 8, 1, p. 171

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

81 Citations (Scopus)

2010

Characteristics of Dyshoric Capillary Cerebral Amyloid Angiopathy

Richard, E., Carrano, A., Hoozemans, J. J., van Horssen, J., van Haastert, E. S., Eurelings, L. S., de Vries, H. E., Thal, D. R., Eikelenboom, P., van Gool, W. A. & Rozemuller, A. J. M., 2010, In: Journal of Neuropathology and Experimental Neurology. 69, 11, p. 1158-1167

Research output: Contribution to journal › Article › Academic › peer-review

61 Citations (Scopus)

Morphometric Changes in the Cortical Microvascular Network in Alzheimer's Disease

Richard, E., van Gool, W. A., Hoozemans, J. J. M., An Haastert, E. S. V., Eikelenboom, P., Rozemuller, A. J. M. & van de Berg, W. D. J., 2010, In: Journal of Alzheimer s disease. 22, 3, p. 811-818

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

2009

The unfolded protein response is activated in pretangle neurons in alzheimer's disease hippocampus

Hoozemans, J. J. M., Van Haastert, E. S., Nijholt, D. A. T., Rozemuller, A. J. M., Eikelenboom, P. & Scheper, W., 2009, In: American journal of pathology. 174, 4, p. 1241-1251

Research output: Contribution to journal › Article › Academic › peer-review

482 Citations (Scopus)

2008

CC chemokine receptor 5 gene promoter activation by the cyclic AMP response element binding transcription factor

Kuipers, H. F., Biesta, P. J., Montagne, L. J., van Haastert, E. S., van der Valk, P. & van den Elsen, P. J., 2008, In: Blood. 112, 5, p. 1610-1619

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

Cyclooxygenase-1 and -2 in the different stages of Alzheimer's disease pathology

Hoozemans, J. J. M., Rozemuller, J. M., van Haastert, E. S., Veerhuis, R. & Eikelenboom, P., 2008, In: Current pharmaceutical design. 14, 14, p. 1419-27 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

125 Citations (Scopus)

Increased expression of the oligopeptidase THOP1 is a neuroprotective response to A beta toxicity

Pollio, G., Hoozemans, J. J. M., Andersen, C. A., Roncarati, R., Rosi, M. C., van Haastert, E. S., Seredenina, T., Diamanti, D., Gotta, S., Fiorentini, A., Magnoni, L., Raggiaschi, R., Rozemuller, A. J. M., Casamenti, F., Caricasole, A. & Terstappen, G. C., 2008, In: Neurobiology of Disease. 31, 1, p. 145-158

Research output: Contribution to journal › Article › Academic › peer-review

37 Citations (Scopus)

2007

Activation of the unfolded protein response in Parkinson's disease

Hoozemans, J. J. M., van Haastert, E. S., Eikelenboom, P., de Vos, R. A. I., Rozemuller, J. M. & Scheper, W., 16 Mar 2007, In: Biochemical and Biophysical Research Communications. 354, 3, p. 707-711 5 p.

Research output: Contribution to journal › Article › Academic › peer-review

397 Citations (Scopus)

Microglia activation in sepsis: a case-control study

Lemstra, A. W., in't Woud, J. C. M. G., Hoozemans, J. J. M., van Haastert, E. S., Rozemuller, A. J. M., Eikelenboom, P. & van Gool, W. A., 15 Jan 2007, In: Journal of neuroinflammation. 4, p. 4

Research output: Contribution to journal › Article › Academic › peer-review

171 Citations (Scopus)

2006

DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid

Copani, A., Hoozemans, J. J. M., Caraci, F., Calafiore, M., Van Haastert, E. S., Veerhuis, R., Rozemuller, A. J. M., Aronica, E., Sortino, M. A. & Nicoletti, F., 25 Oct 2006, In: Journal of neuroscience. 26, 43, p. 10949-10957

Research output: Contribution to journal › Article › Academic › peer-review

DNA polymerase-β is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with β-amyloid

Copani, A., Hoozemans, J. J. M., Caraci, F., Calafiore, M., Van Haastert, E. S., Veerhuis, R., Rozemuller, A. J. M., Aronica, E., Sortino, M. A. & Nicoletti, F., 25 Oct 2006, In: Journal of neuroscience. 26, 43, p. 10949-10957 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

73 Citations (Scopus)

Matrix metalloproteinase-19 is highly expressed in active multiple sclerosis lesions

van Horssen, J., Vos, C. M. P., Admiraal, L., van Haastert, E. S., Montagne, L., van der Valk, P. & de Vries, H. E., Dec 2006, In: Neuropathology and applied neurobiology. 32, 6, p. 585-93 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

55 Citations (Scopus)

The unfolded protein response affects neuronal cell cycle protein expression: Implications for Alzheimer's disease pathogenesis

Hoozemans, J. J. M., Stieler, J., van Haastert, E. S., Veerhuis, R., Rozemuller, A. J. M., Baas, F., Eikelenboom, P., Arendt, T. & Scheper, W., Apr 2006, In: Experimental gerontology. 41, 4, p. 380-386 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

48 Citations (Scopus)

2005

Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis

Vos, C. M. P., Geurts, J. J. G., Montagne, L., van Haastert, E. S., Bö, L., van der Valk, P., Barkhof, F. & de Vries, H. E., 2005, In: Neurobiology of Disease. 20, 3, p. 953-960

Research output: Contribution to journal › Article › Academic › peer-review

161 Citations (Scopus)

CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation

Fabriek, B. O., Van Haastert, E. S., Galea, I., Polfliet, M. M. J., Döpp, E. D., Van Den Heuvel, M. M., Van Den Berg, T. K., De Groot, C. J. A., Van Der Valk, P. & Dijkstra, C. D., Sept 2005, In: GLIA. 51, 4, p. 297-305 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

179 Citations (Scopus)