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Gerard Hovingh

(Principal Investigator), Prof. MD PhD

 https://orcid.org/0000-0002-8145-1676
20002024

Research activity per year

Search results

  • 2012

    Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

    Scott, R. A., Lagou, V., Welch, R. P., Wheeler, E., Montasser, M. E., Luan, J., Mägi, R., Strawbridge, R. J., Rehnberg, E., Gustafsson, S., Kanoni, S., Rasmussen-Torvik, L. J., Yengo, L., Lecoeur, C., Shungin, D., Hottenga, J. J., Willemsen, G., de Geus, E. J. C., Penninx, B. W. J. H., van Duijn, C. M., & 194 othersBoomsma, D. I., Mohlke, K. L., Balkau, B., Froguel, P., Pouta, A., Jarvelin, M-R., Wareham, N. J., Bouatia-Naji, N., McCarthy, M. I., Franks, P. W., Meigs, J. B., Teslovich, T. M., Florez, J. C., Langenberg, C., Ingelsson, E., Prokopenko, I., Barroso, I., Sanna, S., Sidore, C., Johnson, P. C. D., Jukema, J. W., Johnson, T., Mahajan, A., Verweij, N., Thorleifsson, G., Shah, S., Smith, A. V., Sennblad, B., Gieger, C., Salo, P., Perola, M., Timpson, N. J., Evans, D. M., Pourcain, B. S., Wu, Y., Andrews, J. S., Hui, J., Bielak, L. F., Zhao, W., Horikoshi, M., Navarro, P., Isaacs, A., O'Connell, J. R., Stirrups, K., Vitart, V., Hayward, C., Esko, T., Mihailov, E., Fraser, R. M., Fall, T., Voight, B. F., Raychaudhuri, S., Chen, H., Lindgren, C. M., Morris, A. P., Rayner, N. W., Robertson, N., Rybin, D., Liu, C-T., Beckmann, J. S., Willems, S. M., Chines, P. S., Jackson, A. U., Kang, H. M., Stringham, H. M., Song, K., Tanaka, T., Peden, J. F., Goel, A., Hicks, A. A., An, P., Müller-Nurasyid, M., Franco-Cereceda, A., Folkersen, L., Marullo, L., Jansen, H., Oldehinkel, A. J., Bruinenberg, M., Pankow, J. S., North, K. E., Forouhi, N. G., Loos, R. J. F., Edkins, S., Varga, T. V., Hallmans, G., Oksa, H., Antonella, M., Nagaraja, R., Trompet, S., Ford, I., Bakker, S. J. L., Kong, A., Kumari, M., Gigante, B., Herder, C., Munroe, P. B., Caulfield, M., Antti, J., Mangino, M., Small, K., Miljkovic, I., Liu, Y., Atalay, M., Kiess, W., James, A. L., Rivadeneira, F., Uitterlinden, A. G., Palmer, C. N. A., Doney, A. S. F., Smit, J. H., Campbell, S., Polasek, O., Bonnycastle, L. L., Hercberg, S., Dimitriou, M., Bolton, J. L., Fowkes, G. R., Kovacs, P., Lindström, J., Zemunik, T., Bandinelli, S., Wild, S. H., Basart, H. V., Rathmann, W., Grallert, H., Maerz, W., Kleber, M. E., Boehm, B. O., Peters, A., Pramstaller, P. P., Province, M. A., Borecki, I. B., Hastie, N. D., Rudan, I., Campbell, H., Watkins, H., Farrall, M., Stumvoll, M., Ferrucci, L., Waterworth, D. M., Bergman, R. N., Collins, F. S., Tuomilehto, J., Watanabe, R. M., Hofman, A., Oostra, B. A., Psaty, B. M., Vollenweider, P., Wilson, J. F., Wright, A. F., Hovingh, G. K., Metspalu, A., Uusitupa, M., Magnusson, P. K. E., Kyvik, K. O., Kaprio, J., Price, J. F., Dedoussis, G. V., Deloukas, P., Meneton, P., Lind, L., Boehnke, M., Shuldiner, A. R., Morris, A. D., Toenjes, A., Peyser, P. A., Beilby, J. P., Körner, A., Kuusisto, J., Laakso, M., Bornstein, S. R., Schwarz, P. E. H., Lakka, T. A., Rauramaa, R., Adair, L. S., Smith, G. D., Spector, T. D., Illig, T., de Faire, U., Hamsten, A., Gudnason, V., Kivimaki, M., Hingorani, A., Keinanen-Kiukaanniemi, S. M., Saaristo, T. E., Stefansson, K., van der Harst, P., Dupuis, J., Pedersen, N. L., Sattar, N., Harris, T. B., Cucca, F., Ripatti, S. & Salomaa, V., 2012, In: Nature Genetics. 44, 9, p. 991-1005

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    660 Citations (Scopus)

  • Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

    Morris, A. P., Voight, B. F., Teslovich, T. M., Ferreira, T., Segrè, A. V., Steinthorsdottir, V., Strawbridge, R. J., Khan, H., Grallert, H., Mahajan, A., Prokopenko, I., Kang, H. M., Dina, C., Esko, T., Fraser, R. M., Kanoni, S., Kumar, A., Lagou, V., Langenberg, C., Luan, J., & 184 othersLindgren, C. M., Müller-Nurasyid, M., Pechlivanis, S., Rayner, N. W., Scott, L. J., Wiltshire, S., Yengo, L., Kinnunen, L., Rossin, E. J., Raychaudhuri, S., Johnson, A. D., Dimas, A. S., Loos, R. J. F., Vedantam, S., Chen, H., Florez, J. C., Fox, C., Liu, C-T., Rybin, D., Couper, D. J., Kao, W. H. L., Li, M., Cornelis, M. C., Kraft, P., Sun, Q., van Dam, R. M., Stringham, H. M., Chines, P. S., Fischer, K., Fontanillas, P., Holmen, O. L., Hunt, S. E., Jackson, A. U., Kong, A., Lawrence, R., Meyer, J., Perry, J. R. B., Platou, C. G. P., Potter, S., Rehnberg, E., Robertson, N., Sivapalaratnam, S., Stančáková, A., Stirrups, K., Thorleifsson, G., Tikkanen, E., Wood, A. R., Almgren, P., Atalay, M., Benediktsson, R., Bonnycastle, L. L., Burtt, N., Carey, J., Charpentier, G., Crenshaw, A. T., Doney, A. S. F., Dorkhan, M., Edkins, S., Emilsson, V., Eury, E., Forsen, T., Gertow, K., Gigante, B., Grant, G. B., Groves, C. J., Guiducci, C., Herder, C., Hreidarsson, A. B., Hui, J., James, A., Jonsson, A., Rathmann, W., Klopp, N., Kravic, J., Krjutškov, K., Langford, C., Leander, K., Lindholm, E., Lobbens, S., Männistö, S., Mirza, G., Mühleisen, T. W., Musk, B., Parkin, M., Rallidis, L., Saramies, J., Sennblad, B., Shah, S., Sigurðsson, G., Silveira, A., Steinbach, G., Thorand, B., Trakalo, J., Veglia, F., Wennauer, R., Winckler, W., Zabaneh, D., Campbell, H., van Duijn, C., Uitterlinden, A. G., Hofman, A., Sijbrands, E., Abecasis, G. R., Owen, K. R., Zeggini, E., Trip, M. D., Forouhi, N. G., Syvänen, A-C., Eriksson, J. G., Peltonen, L., Nöthen, M. M., Balkau, B., Palmer, C. N. A., Lyssenko, V., Tuomi, T., Isomaa, B., Hunter, D. J., Qi, L., Shuldiner, A. R., Roden, M., Barroso, I., Wilsgaard, T., Beilby, J., Hovingh, K., Price, J. F., Wilson, J. F., Rauramaa, R., Lakka, T. A., Lind, L., Dedoussis, G., Njølstad, I., Pedersen, N. L., Khaw, K-T., Wareham, N. J., Keinanen-Kiukaanniemi, S. M., Saaristo, T. E., Korpi-Hyövälti, E., Saltevo, J., Laakso, M., Kuusisto, J., Metspalu, A., Collins, F. S., Mohlke, K. L., Bergman, R. N., Tuomilehto, J., Boehm, B. O., Gieger, C., Hveem, K., Cauchi, S., Froguel, P., Baldassarre, D., Tremoli, E., Humphries, S. E., Saleheen, D., Danesh, J., Ingelsson, E., Ripatti, S., Salomaa, V., Erbel, R., Jöckel, K-H., Moebus, S., Peters, A., Illig, T., de Faire, U., Hamsten, A., Morris, A. D., Donnelly, P. J., Frayling, T. M., Hattersley, A. T., Boerwinkle, E., Melander, O., Kathiresan, S., Nilsson, P. M., Deloukas, P., Thorsteinsdottir, U., Groop, L. C., Stefansson, K., Hu, F., Pankow, J. S., Dupuis, J., Meigs, J. B., Altshuler, D., Boehnke, M. & McCarthy, M. I., 2012, In: Nature Genetics. 44, 9, p. 981-+

    Research output: Contribution to journal › Article › Academic › peer-review

    1510 Citations (Scopus)

  • Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci

    AUTHOR GROUP, Appelman, J. E. A., Meijs, M. E., Volcik, K. A., Zhang, L., Bailey, K. R., Bailey, K. M., Bauer, F., Boer, J. M. A., Braund, P. S., Burt, A., Burton, P. R., Buxbaum, S. G., Cooper-DeHoff, R. M., Cupples, L. A., deJong, J. S., Delles, C., Duggan, D., Fornage, M., Furlong, C. E., & 37 othersGlazer, N., Gums, J. G., Hastie, C., Holmes, M. V., Illig, T., Kirkland, S. A., Kivimaki, M., Klein, R., Klein, B. E., Kooperberg, C., Kottke-Marchant, K., Kumari, M., LaCroix, A. Z., Mallela, L., Murugesan, G., Ordovas, J., Ouwehand, W. H., Post, W. S., Saxena, R., Scharnagl, H., Schreiner, P. J., Shah, T., Shields, D. C., Shimbo, D., Srinivasan, S. R., Stolk, R. P., Swerdlow, D. I., Taylor, H. A., Topo, E. J., Toskala, E., van Pelt, J. L., van Setten, J., Yusuf, S., Whittaker, J. C., Anand, S. S., Balmforth, A. J. & Berenson, G. S., 2012, In: American journal of human genetics. 91, 5, p. 823-838

    Research output: Contribution to journal › Article › Academic › peer-review

    209 Citations (Scopus)

  • Lipid Oxidation in Carriers of Lecithin: Cholesterol Acyltransferase Gene Mutations

    Holleboom, A. G., Daniil, G., Fu, X., Zhang, R., Hovingh, G. K., Schimmel, A. W., Kastelein, J. J. P., Stroes, E. S. G., Witztum, J. L., Hutten, B. A., Tsimikas, S., Hazen, S. L., Chroni, A. & Kuivenhoven, J. A., 2012, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 32, 12, p. 3066-+

    Research output: Contribution to journal › Article › Academic › peer-review

    26 Citations (Scopus)

  • Lipoprotein(a) and Risk of Coronary, Cerebrovascular, and Peripheral Artery Disease The EPIC-Norfolk Prospective Population Study

    Gurdasani, D., Sjouke, B., Tsimikas, S., Hovingh, G. K., Luben, R. N., Wainwright, N. W. J., Pomilla, C., Wareham, N. J., Khaw, K-T., Boekholdt, S. M. & Sandhu, M. S., 2012, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 32, 12, p. 3058-3065

    Research output: Contribution to journal › Article › Academic › peer-review

    139 Citations (Scopus)

  • Monocyte Gene Expression Signature of Patients with Early Onset Coronary Artery Disease

    Sivapalaratnam, S., Basart, H., Watkins, N. A., Maiwald, S., Rendon, A., Krishnan, U., Sondermeijer, B. M., Creemers, E. E., Pinto-Sietsma, S. J., Hovingh, K., Ouwehand, W. H., Kastelein, J. J. P., Goodall, A. H. & Trip, M. D., 2012, In: PLOS ONE. 7, 2, p. e32166

    Research output: Contribution to journal › Article › Academic › peer-review

    29 Citations (Scopus)

  • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

    AUTHOR GROUP, Willems van Dijk, K., Chen, I., Viikari, J., Kähönen, M., Pramstaller, P. P., Evans, D. M., St Pourcain, B., Sattar, N., Wood, A. R., Bandinelli, S., Carlson, O. D., Egan, J. M., Böhringer, S., van Heemst, D., Kedenko, L., Kristiansson, K., Nuotio, M. L., Loo, B. M., Harris, T., & 57 othersGarcia, M., Kanaya, A., Haun, M., Klopp, N., Wichmann, H. E., Deloukas, P., Katsareli, E., Couper, D. J., Duncan, B. B., Kloppenburg, M., Adair, L. S., Borja, J. B., Hottenga, J. J., de Geus, E. J. C., Willemsen, G., Boomsma, D. I., Wilson, J. G., Musani, G., Guo, X., Johnson, T., Semple, R., Teslovich, T. M., Allison, M. A., Redline, S., Buxbaum, S. G., Mohlke, K. L., Meulenbelt, I., Ballantyne, C. M., Dedoussis, G. V., Hu, F. B., Liu, Y., Paulweber, B., Spector, T. D., Slagboom, P. E., Ferrucci, L., Jula, A., Perola, M., Raitakari, O., Florez, J. C., Salomaa, V., Eriksson, J. G., Frayling, T. M., Hicks, A. A., Lehtimäki, T., Smith, G. D., Siscovick, D. S., Kronenberg, F., van Duijn, C. M., Loos, R. J., Waterworth, D., Meigs, J. B., Dupuis, J., Richards, J. B., Posthuma, D., Penninx, B. W. J. H., Vogelzangs, N. & Kathiresan, S., 2012, In: PLoS genetics. 8, 3, p. e1002607 e1002607.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    380 Citations (Scopus)

  • Patients with low HDL-cholesterol caused by mutations in LCAT have increased arterial stiffness

    van den Bogaard, B., Holleboom, A. G., Duivenvoorden, R., Hutten, B. A., Kastelein, J. J. P., Hovingh, G. K., Kuivenhoven, J. A., Stroes, E. S. G. & van den Born, B-J. H., 2012, In: Atherosclerosis. 225, 2, p. 481-485

    Research output: Contribution to journal › Article › Academic › peer-review

    31 Citations (Scopus)

  • Segregation of LIPG, CETP, and GALNT2 Mutations in Caucasian Families with Extremely High HDL Cholesterol

    Tietjen, I., Hovingh, G. K., Singaraja, R. R., Radomski, C., Barhdadi, A., McEwen, J., Chan, E., Mattice, M., Legendre, A., Franchini, P. L., Dubé, M-P., Kastelein, J. J. P. & Hayden, M. R., 2012, In: PLOS ONE. 7, 8, p. e37437

    Research output: Contribution to journal › Article › Academic › peer-review

    29 Citations (Scopus)

  • The 719Arg Variant of KIF6 and Cardiovascular Outcomes in Statin-Treated, Stable Coronary Patients of the Treating to New Targets and Incremental Decrease in End Points Through Aggressive Lipid-Lowering Prospective Studies

    Arsenault, B. J., Boekholdt, S. M., Hovingh, G. K., Hyde, C. L., Demicco, D. A., Chatterjee, A., Barter, P., Deedwania, P., Waters, D. D., LaRosa, J. C., Pedersen, T. R. & Kastelein, J. J. P., 2012, In: Circulation. Cardiovascular genetics. 5, 1, p. 51-57

    Research output: Contribution to journal › Article › Academic › peer-review

    24 Citations (Scopus)

  • The cholesterol content of the erythrocyte membrane is an important determinant of phosphatidylserine exposure

    van Zwieten, R., Bochem, A. E., Hilarius, P. M., van Bruggen, R., Bergkamp, F., Hovingh, G. K. & Verhoeven, A. J., 2012, In: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 1821, 12, p. 1493-1500

    Research output: Contribution to journal › Article › Academic › peer-review

    30 Citations (Scopus)

  • The PCSK9 decade

    Lambert, G., Sjouke, B., Choque, B., Kastelein, J. J. P. & Hovingh, G. K., 2012, In: Journal of Lipid Research. 53, 12, p. 2515-2524

    Research output: Contribution to journal › Review article › Academic › peer-review

    364 Citations (Scopus)
  • 2013

    ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden

    Bochem, A. E., van Wijk, D. F., Holleboom, A. G., Duivenvoorden, R., Motazacker, M. M., Dallinga-Thie, G. M., de Groot, E., Kastelein, J. J. P., Nederveen, A. J., Hovingh, G. K. & Stroes, E. S. G., 2013, In: European Heart journal. 34, 4, p. 286-291

    Research output: Contribution to journal › Article › Academic › peer-review

    62 Citations (Scopus)

  • Antisense oligonucleotides in the treatment of lipid disorders: pitfalls and promises

    Besseling, J., Hovingh, G. K. & Stroes, E. S. G., 2013, In: Netherlands journal of medicine. 71, 3, p. 118-122

    Research output: Contribution to journal › Review article › Academic › peer-review

    8 Citations (Scopus)

  • Common variants associated with plasma triglycerides and risk for coronary artery disease

    Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H-Y., Demirkan, A., den Hertog, H. M., Donnelly, L. A., Ehret, G. B., Esko, T., & 246 othersFeitosa, M. F., Ferreira, T., Fischer, K., Fontanillas, P., Fraser, R. M., Freitag, D. F., Gurdasani, D., Heikkilä, K., Hyppönen, E., Isaacs, A., Jackson, A. U., Johansson, A., Johnson, T., Kaakinen, M., Kettunen, J., Kleber, M. E., Li, X., Luan, J., Lyytikäinen, L-P., Magnusson, P. K. E., Mangino, M., Mihailov, E., Montasser, M. E., Müller-Nurasyid, M., Nolte, I. M., O'Connell, J. R., Palmer, C. D., Perola, M., Petersen, A-K., Sanna, S., Saxena, R., Service, S. K., Shah, S., Shungin, D., Sidore, C., Song, C., Strawbridge, R. J., Surakka, I., Tanaka, T., Teslovich, T. M., Thorleifsson, G., van den Herik, E. G., Voight, B. F., Volcik, K. A., Waite, L. L., Wong, A., Wu, Y., Zhang, W., Absher, D., Asiki, G., Barroso, I., Been, L. F., Bolton, J. L., Bonnycastle, L. L., Brambilla, P., Burnett, M. S., Cesana, G., Dimitriou, M., Doney, A. S. F., Döring, A., Elliott, P., Epstein, S. E., Eyjolfsson, G. I., Gigante, B., Goodarzi, M. O., Grallert, H., Gravito, M. L., Groves, C. J., Hallmans, G., Hartikainen, A-L., Hayward, C., Hernandez, D., Hicks, A. A., Holm, H., Hung, Y-J., Illig, T., Jones, M. R., Kaleebu, P., Kastelein, J. J. P., Khaw, K-T., Kim, E., Klopp, N., Komulainen, P., Kumari, M., Langenberg, C., Lehtimäki, T., Lin, S-Y., Lindström, J., Loos, R. J. F., Mach, F., McArdle, W. L., Meisinger, C., Mitchell, B. D., Müller, G., Nagaraja, R., Narisu, N., Nieminen, T. V. M., Nsubuga, R. N., Olafsson, I., Ong, K. K., Palotie, A., Papamarkou, T., Pomilla, C., Pouta, A., Rader, D. J., Reilly, M. P., Ridker, P. M., Rivadeneira, F., Rudan, I., Ruokonen, A., Samani, N., Scharnagl, H., Seeley, J., Silander, K., Stančáková, A., Stirrups, K., Swift, A. J., Tiret, L., Uitterlinden, A. G., van Pelt, L. J., Vedantam, S., Wainwright, N., Wijmenga, C., Wild, S. H., Willemsen, G., Wilsgaard, T., Wilson, J. F., Young, E. H., Zhao, J. H., Adair, L. S., Arveiler, D., Assimes, T. L., Bandinelli, S., Bennett, F., Bochud, M., Boehm, B. O., Boomsma, D. I., Borecki, I. B., Bornstein, S. R., Bovet, P., Burnier, M., Campbell, H., Chakravarti, A., Chambers, J. C., Chen, Y-D. I., Collins, F. S., Cooper, R. S., Danesh, J., Dedoussis, G., de Faire, U., Feranil, A. B., Ferrières, J., Ferrucci, L., Freimer, N. B., Gieger, C., Groop, L. C., Gudnason, V., Gyllensten, U., Hamsten, A., Harris, T. B., Hingorani, A., Hirschhorn, J. N., Hofman, A., Hovingh, G. K., Hsiung, C. A., Humphries, S. E., Hunt, S. C., Hveem, K., Iribarren, C., Järvelin, M-R., Jula, A., Kähönen, M., Kaprio, J., Kesäniemi, A., Kivimaki, M., Kooner, J. S., Koudstaal, P. J., Krauss, R. M., Kuh, D., Kuusisto, J., Kyvik, K. O., Laakso, M., Lakka, T. A., Lind, L., Lindgren, C. M., Martin, N. G., März, W., McCarthy, M. I., McKenzie, C. A., Meneton, P., Metspalu, A., Moilanen, L., Morris, A. D., Munroe, P. B., Njølstad, I., Pedersen, N. L., Power, C., Pramstaller, P. P., Price, J. F., Psaty, B. M., Quertermous, T., Rauramaa, R., Saleheen, D., Salomaa, V., Sanghera, D. K., Saramies, J., Schwarz, P. E. H., Sheu, W. H-H., Shuldiner, A. R., Siegbahn, A., Spector, T. D., Stefansson, K., Strachan, D. P., Tayo, B. O., Tremoli, E., Tuomilehto, J., Uusitupa, M., van Duijn, C. M., Vollenweider, P., Wallentin, L., Wareham, N. J., Whitfield, J. B., Wolffenbuttel, B. H. R., Altshuler, D., Ordovas, J. M., Boerwinkle, E., Palmer, C. N. A., Thorsteinsdottir, U., Chasman, D. I., Rotter, J. I., Franks, P. W., Ripatti, S., Cupples, L. A., Sandhu, M. S., Rich, S. S., Boehnke, M., Deloukas, P., Mohlke, K. L., Ingelsson, E., Abecasis, G. R., Daly, M. J., Neale, B. M., Kathiresan, S., Stancakova, A., Hovingh, K. G. & Njolstad, I., 2013, In: Nature Genetics. 45, 11, p. 1345-1352

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    673 Citations (Scopus)

  • Diagnosis and treatment of familial hypercholesterolaemia

    Hovingh, G. K., Davidson, M. H., Kastelein, J. J. P. & O'Connor, A. M., 2013, In: European Heart journal. 34, 13, p. 962-971

    Research output: Contribution to journal › Review article › Academic › peer-review

    211 Citations (Scopus)

  • Discovery and refinement of loci associated with lipid levels

    Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H-Y., Demirkan, A., den Hertog, H. M., Do, R., Donnelly, L. A., Ehret, G. B., Esko, T., Feitosa, M. F., & 242 othersFerreira, T., Fischer, K., Fontanillas, P., Fraser, R. M., Freitag, D. F., Gurdasani, D., Heikkilä, K., Hyppönen, E., Isaacs, A., Jackson, A. U., Johansson, A., Johnson, T., Kaakinen, M., Kettunen, J., Kleber, M. E., Li, X., Luan, J., Lyytikäinen, L-P., Magnusson, P. K. E., Mangino, M., Mihailov, E., Montasser, M. E., Müller-Nurasyid, M., Nolte, I. M., O'Connell, J. R., Palmer, C. D., Perola, M., Petersen, A-K., Sanna, S., Saxena, R., Service, S. K., Shah, S., Shungin, D., Sidore, C., Song, C., Strawbridge, R. J., Surakka, I., Tanaka, T., Teslovich, T. M., Thorleifsson, G., van den Herik, E. G., Voight, B. F., Volcik, K. A., Waite, L. L., Wong, A., Wu, Y., Zhang, W., Absher, D., Asiki, G., Barroso, I., Been, L. F., Bolton, J. L., Bonnycastle, L. L., Brambilla, P., Burnett, M. S., Cesana, G., Dimitriou, M., Doney, A. S. F., Döring, A., Elliott, P., Epstein, S. E., Eyjolfsson, G. I., Gigante, B., Goodarzi, M. O., Grallert, H., Gravito, M. L., Groves, C. J., Hallmans, G., Hartikainen, A-L., Hayward, C., Hernandez, D., Hicks, A. A., Holm, H., Hung, Y-J., Illig, T., Jones, M. R., Kaleebu, P., Kastelein, J. J. P., Khaw, K-T., Kim, E., Klopp, N., Komulainen, P., Kumari, M., Langenberg, C., Lehtimäki, T., Lin, S-Y., Lindström, J., Loos, R. J. F., Mach, F., McArdle, W. L., Meisinger, C., Mitchell, B. D., Müller, G., Nagaraja, R., Narisu, N., Nieminen, T. V. M., Nsubuga, R. N., Olafsson, I., Ong, K. K., Palotie, A., Papamarkou, T., Pomilla, C., Pouta, A., Rader, D. J., Reilly, M. P., Ridker, P. M., Rivadeneira, F., Rudan, I., Ruokonen, A., Samani, N., Scharnagl, H., Seeley, J., Silander, K., Stancáková, A., Stirrups, K., Swift, A. J., Tiret, L., Uitterlinden, A. G., van Pelt, L. J., Vedantam, S., Wainwright, N., Wijmenga, C., Wild, S. H., Willemsen, G., Wilsgaard, T., Wilson, J. F., Young, E. H., Zhao, J. H., Adair, L. S., Arveiler, D., Assimes, T. L., Bandinelli, S., Bennett, F., Bochud, M., Boehm, B. O., Boomsma, D. I., Borecki, I. B., Bornstein, S. R., Bovet, P., Burnier, M., Campbell, H., Chakravarti, A., Chambers, J. C., Chen, Y-D. I., Collins, F. S., Cooper, R. S., Danesh, J., Dedoussis, G., de Faire, U., Feranil, A. B., Ferrières, J., Ferrucci, L., Freimer, N. B., Gieger, C., Groop, L. C., Gudnason, V., Gyllensten, U., Hamsten, A., Harris, T. B., Hingorani, A., Hirschhorn, J. N., Hofman, A., Hovingh, G. K., Hsiung, C. A., Humphries, S. E., Hunt, S. C., Hveem, K., Iribarren, C., Järvelin, M-R., Jula, A., Kähönen, M., Kaprio, J., Kesäniemi, A., Kivimaki, M., Kooner, J. S., Koudstaal, P. J., Krauss, R. M., Kuh, D., Kuusisto, J., Kyvik, K. O., Laakso, M., Lakka, T. A., Lind, L., Lindgren, C. M., Martin, N. G., März, W., McCarthy, M. I., McKenzie, C. A., Meneton, P., Metspalu, A., Moilanen, L., Morris, A. D., Munroe, P. B., Njølstad, I., Pedersen, N. L., Power, C., Pramstaller, P. P., Price, J. F., Psaty, B. M., Quertermous, T., Rauramaa, R., Saleheen, D., Salomaa, V., Sanghera, D. K., Saramies, J., Schwarz, P. E. H., Sheu, W. H-H., Shuldiner, A. R., Siegbahn, A., Spector, T. D., Stefansson, K., Strachan, D. P., Tayo, B. O., Tremoli, E., Tuomilehto, J., Uusitupa, M., van Duijn, C. M., Vollenweider, P., Wallentin, L., Wareham, N. J., Whitfield, J. B., Wolffenbuttel, B. H. R., Ordovas, J. M., Boerwinkle, E., Palmer, C. N. A., Thorsteinsdottir, U., Chasman, D. I., Rotter, J. I., Franks, P. W., Ripatti, S., Cupples, L. A., Sandhu, M. S., Rich, S. S., Boehnke, M., Deloukas, P., Kathiresan, S., Mohlke, K. L., Ingelsson, E., Abecasis, G. R., Thorleifson, G., Hovingh, K. G. & Njolstad, I., 2013, In: Nature Genetics. 45, 11, p. 1274-1283

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    2169 Citations (Scopus)

  • Efficacy and safety of mipomersen sodium (Kynamro)

    Hovingh, K., Besseling, J. & Kastelein, J., 2013, In: Expert opinion on drug safety. 12, 4, p. 569-579

    Research output: Contribution to journal › Review article › Academic › peer-review

    26 Citations (Scopus)

  • Evidence of a polygenic origin of extreme high-density lipoprotein cholesterol levels

    Motazacker, M. M., Peter, J., Treskes, M., Shoulders, C. C., Kuivenhoven, J. A. & Hovingh, G. K., 2013, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 7, p. 1521-1528

    Research output: Contribution to journal › Article › Academic › peer-review

    49 Citations (Scopus)

  • Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia

    Stitziel, N. O., Fouchier, S. W., Sjouke, B., Peloso, G. M., Moscoso, A. M., Auer, P. L., Goel, A., Gigante, B., Barnes, T. A., Melander, O., Orho-Melander, M., Duga, S., Sivapalaratnam, S., Nikpay, M., Martinelli, N., Girelli, D., Jackson, R. D., Kooperberg, C., Lange, L. A., Ardissino, D., & 17 othersMcPherson, R., Farrall, M., Watkins, H., Reilly, M. P., Rader, D. J., de Faire, U., Schunkert, H., Erdmann, J., Samani, N. J., Charnas, L., Altshuler, D., Gabriel, S., Kastelein, J. J. P., Defesche, J. C., Nederveen, A. J., Kathiresan, S. & Hovingh, G. K., 2013, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 12, p. 2909-2914

    Research output: Contribution to journal › Article › Academic › peer-review

    77 Citations (Scopus)

  • Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society

    Nordestgaard, B. G., Chapman, M. J., Humphries, S. E., Ginsberg, H. N., Masana, L., Descamps, O. S., Wiklund, O., Hegele, R. A., Raal, F. J., Defesche, J. C., Wiegman, A., Santos, R. D., Watts, G. F., Parhofer, K. G., Hovingh, G. K., Kovanen, P. T., Boileau, C., Averna, M., Borén, J., Bruckert, E., & 8 othersCatapano, A. L., Kuivenhoven, J. A., Pajukanta, P., Ray, K., Stalenhoef, A. F. H., Stroes, E., Taskinen, M-R. & Tybjærg-Hansen, A., 2013, In: European Heart journal. 34, 45, p. 3478-390a

    Research output: Contribution to journal › Article › Academic › peer-review

    2077 Citations (Scopus)

  • Familial LCAT deficiency: from renal replacement to enzyme replacement

    Stoekenbroek, R. M., van den Bergh Weerman, M. A., Hovingh, G. K., Potter van Loon, B. J., Siegert, C. E. H. & Holleboom, A. G., 2013, In: Netherlands journal of medicine. 71, 1, p. 29-31

    Research output: Contribution to journal › Article › Academic › peer-review

    12 Citations (Scopus)

  • Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals

    AUTHOR GROUP, 2013, In: Human Molecular Genetics. 22, 1, p. 184-201

    Research output: Contribution to journal › Article › Academic › peer-review

    70 Citations (Scopus)

  • Genetics of HDL-C: a causal link to atherosclerosis?

    van Capelleveen, J. C., Bochem, A. E., Motazacker, M. M., Hovingh, G. K. & Kastelein, J. J. P., 2013, In: Current Atherosclerosis Reports. 15, 6, p. 326

    Research output: Contribution to journal › Article › Academic › peer-review

    30 Citations (Scopus)

  • Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

    Berndt, S. I., Gustafsson, S., Mägi, R., Ganna, A., Wheeler, E., Feitosa, M. F., Justice, A. E., Monda, K. L., Croteau-Chonka, D. C., Day, F. R., Esko, T., Fall, T., Ferreira, T., Gentilini, D., Jackson, A. U., Luan, J., Randall, J. C., Vedantam, S., Willer, C. J., Winkler, T. W., & 309 othersWood, A. R., Workalemahu, T., Hu, Y-J., Lee, S. H., Liang, L., Lin, D-Y., Min, J. L., Neale, B. M., Thorleifsson, G., Yang, J., Albrecht, E., Amin, N., Bragg-Gresham, J. L., Cadby, G., den Heijer, M., Eklund, N., Fischer, K., Goel, A., Hottenga, J-J., Huffman, J. E., Jarick, I., Johansson, A., Johnson, T., Kanoni, S., Kleber, M. E., König, I. R., Kristiansson, K., Kutalik, Z., Lamina, C., Lecoeur, C., Li, G., Mangino, M., McArdle, W. L., Medina-Gomez, C., Müller-Nurasyid, M., Ngwa, J. S., Nolte, I. M., Paternoster, L., Pechlivanis, S., Perola, M., Peters, M. J., Preuss, M., Rose, L. M., Shi, J., Shungin, D., Smith, A. V., Strawbridge, R. J., Surakka, I., Teumer, A., Trip, M. D., Tyrer, J., van Vliet-Ostaptchouk, J. V., Vandenput, L., Waite, L. L., Zhao, J. H., Absher, D., Asselbergs, F. W., Atalay, M., Attwood, A. P., Balmforth, A. J., Basart, H., Beilby, J., Bonnycastle, L. L., Brambilla, P., Bruinenberg, M., Campbell, H., Chasman, D. I., Chines, P. S., Collins, F. S., Connell, J. M., Cookson, W. O., de Faire, U., de Vegt, F., dei, M., Dimitriou, M., Edkins, S., Estrada, K., Evans, D. M., Farrall, M., Ferrario, M. M., Ferrières, J., Franke, L., Frau, F., Gejman, P. V., Grallert, H., Grönberg, H., Gudnason, V., Hall, A. S., Hall, P., Hartikainen, A-L., Hayward, C., Heard-Costa, N. L., Heath, A. C., Hebebrand, J., Homuth, G., Hu, F. B., Hunt, S. E., Hyppönen, E., Iribarren, C., Jacobs, K. B., Jansson, J-O., Jula, A., Kähönen, M., Kathiresan, S., Kee, F., Khaw, K-T., Kivimäki, M., Koenig, W., Kraja, A. T., Kumari, M., Kuulasmaa, K., Kuusisto, J., Laitinen, J. H., Lakka, T. A., Langenberg, C., Launer, L. J., Lind, L., Lindström, J., Liu, J., Liuzzi, A., Lokki, M-L., Lorentzon, M., Madden, P. A., Magnusson, P. K., Manunta, P., Marek, D., März, W., Mateo Leach, I., McKnight, B., Medland, S. E., Mihailov, E., Milani, L., Montgomery, G. W., Mooser, V., Mühleisen, T. W., Munroe, P. B., Musk, A. W., Narisu, N., Navis, G., Nicholson, G., Nohr, E. A., Ong, K. K., Oostra, B. A., Palmer, C. N. A., Palotie, A., Peden, J. F., Pedersen, N., Peters, A., Polasek, O., Pouta, A., Pramstaller, P. P., Prokopenko, I., Pütter, C., Radhakrishnan, A., Raitakari, O., Rendon, A., Rivadeneira, F., Rudan, I., Saaristo, T. E., Sambrook, J. G., Sanders, A. R., Sanna, S., Saramies, J., Schipf, S., Schreiber, S., Schunkert, H., Shin, S-Y., Signorini, S., Sinisalo, J., Skrobek, B., Soranzo, N., Stančáková, A., Stark, K., Stephens, J. C., Stirrups, K., Stolk, R. P., Stumvoll, M., Swift, A. J., Theodoraki, E. V., Thorand, B., Tregouet, D-A., Tremoli, E., van der Klauw, M. M., van Meurs, J. B. J., Vermeulen, S. H., Viikari, J., Virtamo, J., Vitart, V., Waeber, G., Wang, Z., Widén, E., Wild, S. H., Willemsen, G., Winkelmann, B. R., Witteman, J. C. M., Wolffenbuttel, B. H. R., Wong, A., Wright, A. F., Zillikens, M. C., Amouyel, P., Boehm, B. O., Boerwinkle, E., Boomsma, D. I., Caulfield, M. J., Chanock, S. J., Cupples, L. A., Cusi, D., Dedoussis, G. V., Erdmann, J., Eriksson, J. G., Franks, P. W., Froguel, P., Gieger, C., Gyllensten, U., Hamsten, A., Harris, T. B., Hengstenberg, C., Hicks, A. A., Hingorani, A., Hinney, A., Hofman, A., Hovingh, K. G., Hveem, K., Illig, T., Jarvelin, M-R., Jöckel, K-H., Keinanen-Kiukaanniemi, S. M., Kiemeney, L. A., Kuh, D., Laakso, M., Lehtimäki, T., Levinson, D. F., Martin, N. G., Metspalu, A., Morris, A. D., Nieminen, M. S., Njølstad, I., Ohlsson, C., Oldehinkel, A. J., Ouwehand, W. H., Palmer, L. J., Penninx, B., Power, C., Province, M. A., Psaty, B. M., Qi, L., Rauramaa, R., Ridker, P. M., Ripatti, S., Salomaa, V., Samani, N. J., Snieder, H., Sørensen, T. I. A., Spector, T. D., Stefansson, K., Tönjes, A., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., van der Harst, P., Vollenweider, P., Wallaschofski, H., Wareham, N. J., Watkins, H., Wichmann, H. -E., Wilson, J. F., Abecasis, G. R., Assimes, T. L., Barroso, I., Boehnke, M., Borecki, I. B., Deloukas, P., Fox, C. S., Frayling, T., Groop, L. C., Haritunian, T., Heid, I. M., Hunter, D., Kaplan, R. C., Karpe, F., Moffatt, M. F., Mohlke, K. L., O'Connell, J. R., Pawitan, Y., Schadt, E. E., Schlessinger, D., Steinthorsdottir, V., Strachan, D. P., Thorsteinsdottir, U., van Duijn, C. M., Visscher, P. M., Di Blasio, A. M., Hirschhorn, J. N., Lindgren, C. M., Morris, A. P., Meyre, D., Scherag, A., McCarthy, M. I., Speliotes, E. K., North, K. E., Loos, R. J. F., Ingelsson, E., Stancakova, A., Wolfenbuttel, B. H. R., Järvelin, M. R., Keinanen-Kiukaanniemie, S., Njolstad, I., Sorensen, T. I. A. & Moffat, M. F., 2013, In: Nature Genetics. 45, 5, p. 501-512

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    471 Citations (Scopus)

  • High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-C

    Bochem, A. E., Holleboom, A. G., Romijn, J. A., Hoekstra, M., Dallinga-Thie, G. M., Motazacker, M. M., Hovingh, G. K., Kuivenhoven, J. A. & Stroes, E. S. G., 2013, In: Journal of Lipid Research. 54, 6, p. 1698-1704

    Research output: Contribution to journal › Article › Academic › peer-review

    48 Citations (Scopus)

  • Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: studies in mice and FH children

    Tolani, S., Pagler, T. A., Murphy, A. J., Bochem, A. E., Abramowicz, S., Welch, C., Nagareddy, P. R., Holleran, S., Hovingh, G. K., Kuivenhoven, J. A. & Tall, A. R., 2013, In: Atherosclerosis. 229, 1, p. 79-85

    Research output: Contribution to journal › Article › Academic › peer-review

    92 Citations (Scopus)

  • Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein

    Sorrentino, V., Fouchier, S. W., Motazacker, M. M., Nelson, J. K., Defesche, J. C., Dallinga-Thie, G. M., Kastelein, J. J. P., Kees Hovingh, G. & Zelcer, N., 2013, In: European Heart journal. 34, 17, p. 1292-1297

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    48 Citations (Scopus)

  • In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1

    Holleboom, A. G., Jakulj, L., Franssen, R., Decaris, J., Vergeer, M., Koetsveld, J., Luchoomun, J., Glass, A., Hellerstein, M. K., Kastelein, J. J. P., Hovingh, G. K., Kuivenhoven, J. A., Groen, A. K., Turner, S. M. & Stroes, E. S. G., 2013, In: Journal of Lipid Research. 54, 7, p. 1964-1971

    Research output: Contribution to journal › Article › Academic › peer-review

    23 Citations (Scopus)

  • Large-scale association analysis identifies new risk loci for coronary artery disease

    Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., Thompson, J. R., Ingelsson, E., Saleheen, D., Erdmann, J., Goldstein, B. A., Stirrups, K., König, I. R., Cazier, J-B., Johansson, A., Hall, A. S., Lee, J-Y., Willer, C. J., Chambers, J. C., Esko, T., Folkersen, L., & 163 othersGoel, A., Grundberg, E., Havulinna, A. S., Ho, W. K., Hopewell, J. C., Eriksson, N., Kleber, M. E., Kristiansson, K., Lundmark, P., Lyytikäinen, L-P., Rafelt, S., Shungin, D., Strawbridge, R. J., Thorleifsson, G., Tikkanen, E., van Zuydam, N., Voight, B. F., Waite, L. L., Zhang, W., Ziegler, A., Absher, D., Altshuler, D., Balmforth, A. J., Barroso, I., Braund, P. S., Burgdorf, C., Claudi-Boehm, S., Cox, D., Dimitriou, M., Do, R., Doney, A. S. F., El Mokhtari, N., Eriksson, P., Fischer, K., Fontanillas, P., Franco-Cereceda, A., Gigante, B., Groop, L., Gustafsson, S., Hager, J., Hallmans, G., Han, B-G., Hunt, S. E., Kang, H. M., Illig, T., Kessler, T., Knowles, J. W., Kolovou, G., Kuusisto, J., Langenberg, C., Langford, C., Leander, K., Lokki, M-L., Lundmark, A., McCarthy, M. I., Meisinger, C., Melander, O., Mihailov, E., Maouche, S., Morris, A. D., Müller-Nurasyid, M., Nikus, K., Peden, J. F., Rayner, N. W., Rasheed, A., Rosinger, S., Rubin, D., Rumpf, M. P., Schäfer, A., Sivananthan, M., Song, C., Stewart, A. F. R., Tan, S-T., Thorgeirsson, G., van der Schoot, C. E., Wagner, P. J., Wells, G. A., Wild, P. S., Yang, T-P., Amouyel, P., Arveiler, D., Basart, H., Boehnke, M., Boerwinkle, E., Brambilla, P., Cambien, F., Cupples, A. L., de Faire, U., Dehghan, A., Diemert, P., Epstein, S. E., Evans, A., Ferrario, M. M., Ferrières, J., Gauguier, D., Go, A. S., Goodall, A. H., Gudnason, V., Hazen, S. L., Holm, H., Iribarren, C., Jang, Y., Kähönen, M., Kee, F., Kim, H-S., Klopp, N., Koenig, W., Kratzer, W., Kuulasmaa, K., Laakso, M., Laaksonen, R., Lee, J-Y., Lind, L., Ouwehand, W. H., Parish, S., Park, J. E., Pedersen, N. L., Peters, A., Quertermous, T., Rader, D. J., Salomaa, V., Schadt, E., Shah, S. H., Sinisalo, J., Stark, K., Stefansson, K., Trégouët, D-A., Virtamo, J., Wallentin, L., Wareham, N., Zimmermann, M. E., Nieminen, M. S., Hengstenberg, C., Sandhu, M. S., Pastinen, T., Syvänen, A-C., Hovingh, G. K., Dedoussis, G., Franks, P. W., Lehtimäki, T., Metspalu, A., Zalloua, P. A., Siegbahn, A., Schreiber, S., Ripatti, S., Blankenberg, S. S., Perola, M., Clarke, R., Boehm, B. O., O'Donnell, C., Reilly, M. P., März, W., Collins, R., Kathiresan, S., Hamsten, A., Kooner, J. S., Thorsteinsdottir, U., Danesh, J., Palmer, C. N. A., Roberts, R., Watkins, H., Schunkert, H. & Samani, N. J., 2013, In: Nature Genetics. 45, 1, p. 25-33

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    1315 Citations (Scopus)

  • LDL cholesterol goals in high-risk patients: how low do we go and how do we get there?

    Besseling, J., van Capelleveen, J., Kastelein, J. J. P. & Hovingh, G. K., 2013, In: Drugs. 73, 4, p. 293-301

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    19 Citations (Scopus)

  • Levels and changes of HDL cholesterol and apolipoprotein A-I in relation to risk of cardiovascular events among statin-treated patients: a meta-analysis

    Boekholdt, S. M., Arsenault, B. J., Hovingh, G. K., Mora, S., Pedersen, T. R., LaRosa, J. C., Welch, K. M. A., Amarenco, P., Demicco, D. A., Tonkin, A. M., Sullivan, D. R., Kirby, A., Colhoun, H. M., Hitman, G. A., Betteridge, D. J., Durrington, P. N., Clearfield, M. B., Downs, J. R., Gotto, A. M., Ridker, P. M., & 1 othersKastelein, J. J. P., 2013, In: Circulation. 128, 14, p. 1504-1512

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    158 Citations (Scopus)

  • Loci influencing blood pressure identified using a cardiovascular gene-centric array

    Ganesh, S. K., Tragante, V., Guo, W., Guo, Y. R., Lanktree, M. B., Smith, E. N., Johnson, T., Castillo, B. A., Barnard, J., Baumert, J., Chang, Y. P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Franceschini, N., Gaunt, T. R., Gho, J. M. I. H., Gieger, C., Gong, Y., Isaacs, A., & 117 othersKleber, M. E., Leach, I. M., McDonough, C. W., Meijs, M. F. L., Mellander, O., Molony, C. M., Nolte, I. M., Padmanabhan, S., Price, T. S., Rajagopalan, R., Shaffer, J., Shah, S., Shen, H. Q., Soranzo, N., van der Most, P. J., van Iperen, E. P. A., Van Setten, J. A., Vonk, J. M., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Boer, J. M. A., Boerwinkle, E., Burkley, B., Burt, A., Chakravarti, A., Chen, W., Cooper-DeHoff, R. M., Curtis, S. P., Dreisbach, A., Duggan, D., Ehret, G. B., Fabsitz, R. R., Fornage, M., Fox, E., Furlong, C. E., Gansevoort, R. T., Hofker, M. H., Hovingh, G. K., Kirkland, S. A., Kottke-Marchant, K., Kutlar, A., LaCroix, A. Z., Langaee, T. Y., Li, Y. R., Lin, H. H., Liu, K., Maiwald, S., Malik, R., Murugesan, G., Newton-Cheh, C., OConnell, J. R., Onland-Moret, N. C., Ouwehand, W. H., Palmas, W., Penninx, B. W. J. H., Pepine, C. J., Pettinger, M., Polak, J. F., Ramachandran, V. S., Ranchalis, J., Redline, S., Ridker, P. M., Rose, L. M., Scharnag, H., Schork, N. J., Shimbo, D., Shuldiner, A. R., Srinivasan, S. R., Stolk, R. P., Taylor, H. A., Thorand, B., Trip, M. D., van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Winkelmann, B. R., Wyatt, S., Keating, B. J., Asselbergs, F. W., O'Connell, J. R., Young, J. H., Boehm, B. O., Caulfield, M. J., Chasman, D. I., Davidson, K. W., Doevendans, P. A., FitzGerald, G. A., Gums, J. G., Hakonarson, H., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J. P., Koenig, W., März, W., Mitchell, B. D., Murray, S. S., Oldehinkel, A. J., Rader, D. J., Reilly, M. P., Reiner, A. P., Schadt, E. E., Silverstein, R. L., Snieder, H., Stanton, A. V., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Samani, N. J., Johnson, A. D., Munroe, P. B., de Bakker, P. I. W., Zhu, X. & Levy, D., 2013, In: Human Molecular Genetics. 22, 8, p. 1663-1678

    Research output: Contribution to journal › Article › Academic › peer-review

    109 Citations (Scopus)

  • Loci influencing blood pressure identified using a cardiovascular gene-centric array

    Ganesh, S. K., Tragante, V., Guo, W., Guo, Y., Lanktree, M. B., Smith, E. N., Johnson, T., Castillo, B. A., Barnard, J., Baumert, J., Chang, Y-P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Gaunt, N. F., H. Gho, J. M. I., Gieger, C., Gong, Y., Isaacs, A., Kleber, M. E., & 116 othersLeach, I. M., McDonough, C. W., Meijs, M. F. L., Mellander, O., Molony, C. M., Nolte, I. M., Price, S. P., Rajagopalan, R., Shaffer, J., Shah, S., Shen, H., Soranzo, N., van der Most, P. J., van Iperen, E. P. A., van Setten, J., Vonk, J. M., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Boer, J. M. A., Boerwinkle, E., Burkley, B., Burt, A., Chakravarti, A., Chen, W., Cooper-DeHoff, R. M., Curtis, S. P., Dreisbach, A., Duggan, D., Ehret, G. B., Fabsitz, R. R., Fornage, M., Fox, E., Furlong, C. E., Gansevoort, R. T., Hofker, M. H., Hovingh, G. K., Kirkland, S. A., Kottke-Marchant, K., Kutlar, A., LaCroix, A. Z., Langaee, T. Y., Li, Y. R., Lin, H., Liu, K., Maiwald, S., Malik, R., Metastroke, C., Murugesan, G., Newton-Cheh, C., O'Connell, J. R., Onland-Moret, N. C., Ouwehand, W. H., Palmas, W., Penninx, B. W., Pepine, C. J., Pettinger, M., Polak, J. F., Ramachandran, V. S., Ranchalis, J., Redline, S., Ridker, P. M., Rose, L. M., Scharnag, H., Schork, N. J., Shimbo, D., Shuldiner, A. R., Srinivasan, S. R., Stolk, R. P., Taylor, H. A., Thorand, B., Trip, M. D., van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Winkelmann, B. R., Wyatt, S., Young, J. H., Boehm, B. O., Caulfield, M. J., Chasman, D. I., Davidson, K. W., Doevendans, P. A., FitzGerald, G. A., Gums, J. G., Hakonarson, H., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J. P., Koenig, W., Study, L. C., rz, W. M., Mitchell, B. D., Murray, S. S., Oldehinkel, A. J., Rader, D. J., Reilly, M. P., Reiner, A. P., Schadt, E. E., Silverstein, R. L., Snieder, H., Stanton, A. V., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Samani, N. J., Johnson, A. D., Munroe, P. B., de Bakker, P. I. W., Zhu, X., Levy, D., Keating, B. J. & Asselbergs, F. W., Aug 2013, In: Human Molecular Genetics. 22, 16, p. 3394-3395

    Research output: Contribution to journal › Erratum/Corrigendum › Academic

    10 Citations (Scopus)

  • Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics

    AUTHOR GROUP, Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H. & van Duijn, C. M., 2013, In: American journal of human genetics. 93, 2, p. 236-248

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    49 Citations (Scopus)

  • Plasma amyloid-β in patients with Tangier disease

    Shahim, P., Bochem, A. E., Mattsson, N., Lautner, R., Blennow, K., Hovingh, G. K., Motazacker, M. M. & Zetterberg, H., 2013, In: Journal of Alzheimer s disease. 35, 2, p. 307-312

    Research output: Contribution to journal › Article › Academic › peer-review

    3 Citations (Scopus)

  • Recent failures in antiatherosclerotic drug development: examples from the thyroxin receptor agonist, the secretory phospholipase A2 antagonist, and the acyl coenzyme A: cholesterol acyltransferase inhibitor programs

    Stoekenbroek, R. M., Kastelein, J. J. P. & Hovingh, G. K., 2013, In: Current opinion in lipidology. 24, 6, p. 459-466

    Research output: Contribution to journal › Review article › Academic › peer-review

    6 Citations (Scopus)

  • Secretory Phospholipase A2-IIA and Cardiovascular Disease: A Mendelian Randomization Study

    Holmes, M. V., Simon, T., Exeter, H. J., Folkersen, L., Asselbergs, F. W., Guardiola, M., Cooper, J. A., Palmen, J., Hubacek, J. A., Carruthers, K. F., Horne, B. D., Brunisholz, K. D., Mega, J. L., van Iperen, E. P. A., Li, M., Leusink, M., Trompet, S., Verschuren, J. J. W., Hovingh, G. K., Dehghan, A., & 93 othersNelson, C. P., Kotti, S., Danchin, N., Scholz, M., Haase, C. L., Rothenbacher, D., Swerdlow, D. I., Kuchenbaecker, K. B., Staines-Urias, E., Goel, A., van 't Hooft, F., Gertow, K., de Faire, U., Panayiotou, A. G., Tremoli, E., Baldassarre, D., Veglia, F., Holdt, L. M., Beutner, F., Gansevoort, R. T., Navis, G. J., Mateo Leach, I., Breitling, L. P., Brenner, H., Thiery, J., Dallmeier, D., Franco-Cereceda, A., Boer, J. M. A., Stephens, J. W., Hofker, M. H., Tedgui, A., Hofman, A., Uitterlinden, A. G., Adamkova, V., Pitha, J., Onland-Moret, N. C., Cramer, M. J., Nathoe, H. M., Spiering, W., Klungel, O. H., Kumari, M., Whincup, P. H., Morrow, D. A., Braund, P. S., Hall, A. S., Olsson, A. G., Doevendans, P. A., Trip, M. D., Tobin, M. D., Hamsten, A., Watkins, H., Koenig, W., Nicolaides, A. N., Teupser, D., Day, I. N. M., Carlquist, J. F., Gaunt, T. R., Ford, I., Sattar, N., Tsimikas, S., Schwartz, G. G., Lawlor, D. A., Morris, R. W., Sandhu, M. S., Poledne, R., Maitland-van der Zee, A. H., Khaw, K-T., Keating, B. J., van der Harst, P., Price, J. F., Mehta, S. R., Yusuf, S., Witteman, J. C. M., Franco, O. H., Jukema, J. W., de Knijff, P., Tybjaerg-Hansen, A., Rader, D. J., Farrall, M., Samani, N. J., Kivimaki, M., Fox, K. A. A., Humphries, S. E., Anderson, J. L., Boekholdt, S. M., Palmer, T. M., Eriksson, P., Paré, G., Hingorani, A. D., Sabatine, M. S., Mallat, Z., Casas, J. P. & Talmud, P. J., 2013, In: Journal of the American College of Cardiology. 62, 21, p. 1966-1976

    Research output: Contribution to journal › Article › Academic › peer-review

    100 Citations (Scopus)

  • Sex-stratified Genome-wide Association Studies Including 270000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

    Randall, J. C., Winkler, T. W., Kutalik, Z., Berndt, S. I., Jackson, A. U., Monda, K. L., Kilpeläinen, T. O., Esko, T., Mägi, R., Li, S., Workalemahu, T., Feitosa, M. F., Croteau-Chonka, D. C., Day, F. R., Fall, T., Ferreira, T., Gustafsson, S., Locke, A. E., Mathieson, I., Scherag, A., & 247 othersVedantam, S., Wood, A. R., Liang, L., Steinthorsdottir, V., Thorleifsson, G., Dermitzakis, E. T., Dimas, A. S., Karpe, F., Min, J. L., Nicholson, G., Clegg, D. J., Person, T., Krohn, J. P., Bauer, S., Buechler, C., Eisinger, K., Bonnefond, A., Froguel, P., Hottenga, J. J., Prokopenko, I., Waite, L. L., Harris, T. B., Smith, A. V., Shuldiner, A. R., McArdle, W. L., Caulfield, M. J., Munroe, P. B., Grönberg, H., Chen, Y. D., Li, G., Beckmann, J. S., Johnson, T., Thorsteinsdottir, U., Teder-Laving, M., Khaw, K. T., Wareham, N. J., Zhao, J. H., Amin, N., Oostra, B. A., Kraja, A. T., Province, M. A., Cupples, L. A., Heard-Costa, N. L., Kaprio, J., Ripatti, S., Surakka, I., Collins, F. S., Saramies, J., Tuomilehto, J., Jula, A., Salomaa, V., Erdmann, J., Hengstenberg, C., Loley, C., Schunkert, H., Lamina, C., Wichmann, H. E., Albrecht, E., Gieger, C., Hicks, A. A., Johansson, A., Pramstaller, P. P., Kathiresan, S., Speliotes, E. K., Penninx, B. W. J. H., Hartikainen, A. L., Järvelin, M. R., Gyllensten, U., Boomsma, D. I., Campbell, H., Wilson, J. F., Chanock, S. J., Farrall, M., Goel, A., Medina-Gomez, C., Rivadeneira, F., Estrada, K., Uitterlinden, A. G., Hofman, A., Zillikens, M. C., den Heijer, M., Kiemeney, L. A., Maschio, A., Hall, P., Tyrer, J., Teumer, A., Völzke, H., Kovacs, P., Tönjes, A., Mangino, M., Spector, T. D., Hayward, C., Rudan, I., Hall, A. S., Samani, N. J., Attwood, A. P., Sambrook, J. G., Hung, J., Palmer, L. J., Lokki, M. L., Sinisalo, J., Boucher, G., Huikuri, H. V., Lorentzon, M., Ohlsson, C., Eklund, N., Eriksson, J. G., Barlassina, C., Rivolta, C., Nolte, I. M., Snieder, H., van der Klauw, M. M., van Vliet-Ostaptchouk, J. V., Gejman, P. V., Shi, J., Jacobs, K. B., Wang, Z., Bakker, S. J., Mateo Leach, I., Navis, G., van der Harst, P., Martin, N. G., Medland, S. E., Montgomery, G. W., Yang, J., Chasman, D. I., Ridker, P. M., Rose, L. M., Lehtimäki, T., Raitakari, O., Absher, D., Iribarren, C., Basart, H., Hovingh, K. G., Hyppönen, E., Power, C., Anderson, D., Beilby, J. P., Hui, J., Jolley, J., Sager, H., Bornstein, S. R., Schwarz, P. E., Kristiansson, K., Perola, M., Lindström, J., Swift, A. J., Uusitupa, M., Atalay, M., Lakka, T. A., Rauramaa, R., Bolton, J. L., Fowkes, G., Fraser, R. M., Price, J. F., Fischer, K., Krjuta Kov, K., Metspalu, A., Mihailov, E., Langenberg, C., Luan, J., Ong, K. K., Chines, P. S., Keinanen-Kiukaanniemie, S., Saaristo, T. E., Edkins, S., Franks, P. W., Hallmans, G., Shungin, D., Morris, A. D., Palmer, C. N. A., Erbel, R., Moebus, S., Nöthen, M. M., Pechlivanis, S., Hveem, K., Narisu, N., Hamsten, A., Humphries, S. E., Strawbridge, R. J., Tremoli, E., Grallert, H., Thorand, B., Illig, T., Koenig, W., Müller-Nurasyid, M., Peters, A., Boehm, B. O., Kleber, M. E., März, W., Winkelmann, B. R., Kuusisto, J., Laakso, M., Arveiler, D., Cesana, G., Kuulasmaa, K., Virtamo, J., Yarnell, J. W., Kuh, D., Wong, A., Lind, L., de Faire, U., Gigante, B., Magnusson, P. K. E., Pedersen, N. L., Dedoussis, G., Dimitriou, M., Kolovou, G., Kanoni, S., Stirrups, K., Bonnycastle, L. L., Njolstad, I., Wilsgaard, T., Ganna, A., Rehnberg, E., Hingorani, A. D., Kivimaki, M., Kumari, M., Assimes, T. L., Barroso, I., Boehnke, M., Borecki, I. B., Deloukas, P., Fox, C. S., Frayling, T. M., Groop, L. C., Haritunians, T., Hunter, D., Ingelsson, E., Kaplan, R., Mohlke, K. L., O'Connell, J. R., Schlessinger, D., Strachan, D. P., Stefansson, K., van Duijn, C. M., Abecasis, G. R., McCarthy, M. I., Hirschhorn, J. N., Qi, L., Loos, R. J., Lindgren, C. M., North, K. E., Heid, I. M., Jarvelin, M-R., Keinanen-Kiukaanniemi, S. M. & Njølstad, I., 2013, In: PLoS genetics. 9, 6, p. e1003500 e1003500.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    306 Citations (Scopus)

  • Statin therapy and levels of hemostatic factors in a healthy population: the Multi-Ethnic Study of Atherosclerosis: a rebuttal

    Besseling, J., Hutten, B. A., Meijers, J. C. M., Trip, M. D. & Hovingh, G. K., 2013, In: Journal of thrombosis and haemostasis. 11, 9, p. 1787-1788

    Research output: Contribution to journal › Comment/Letter to the editor › Academic

    2 Citations (Scopus)

  • The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans

    Singaraja, R. R., Sivapalaratnam, S., Hovingh, K., Dubé, M-P., Castro-Perez, J., Collins, H. L., Adelman, S. J., Riwanto, M., Manz, J., Hubbard, B., Tietjen, I., Wong, K., Mitnaul, L. J., van Heek, M., Lin, L., Roddy, T. A., McEwen, J., Dallinge-Thie, G., van Vark-van der Zee, L., Verwoert, G., & 10 othersWinther, M., van Duijn, C., Hofman, A., Trip, M. D., Marais, A. D., Asztalos, B., Landmesser, U., Sijbrands, E., Kastelein, J. J. & Hayden, M. R., 2013, In: Circulation. Cardiovascular genetics. 6, 1, p. 54-62

    Research output: Contribution to journal › Article › Academic › peer-review

    54 Citations (Scopus)
  • 2014

    Abnormal hemostatic parameters in patients with myocardial infarction but angiographically normal coronary arteries

    Maiwald, S., Oey, R. C., Sivapalaratnam, S., Bakhtiari, K., Hovingh, G. K., Basart, D. C. G., Trip, M. D. & Dallinga-Thie, G. M., 2014, In: International journal of cardiology. 174, 3, p. 734-735

    Research output: Contribution to journal › Comment/Letter to the editor › Academic

  • Adrenal Function in females with low plasma HDL-C due to mutations in ABCA1 and LCAT

    Bochem, A. E., Holleboom, A. G., Romijn, J. A., Hoekstra, M., Dallinga, G. M., Motazacker, M. M., Hovingh, G. K., Kuivenhoven, J. A. & Stroes, E. S. G., 2014, In: PLOS ONE. 9, 5, p. e90967

    Research output: Contribution to journal › Article › Academic › peer-review

    12 Citations (Scopus)

  • ApoA-I mutations, L202P and K131del, in HDL from heterozygotes with low HDL-C

    Ljunggren, S., Levels, J. H. M., Turkina, M. V., Sundberg, S., Bochem, A. E., Hovingh, K., Holleboom, A. G., Lindahl, M., Kuivenhoven, J. A. & Karlsson, H., 2014, In: Proteomics. Clinical applications. 8, 3-4, p. 241-250

    Research output: Contribution to journal › Article › Academic › peer-review

    5 Citations (Scopus)

  • Common genetic variants do not associate with CAD in familial hypercholesterolemia

    van Iperen, E. P. A., Sivapalaratnam, S., Boekholdt, S. M., Hovingh, G. K., Maiwald, S., Tanck, M. W., Soranzo, N., Stephens, J. C., Sambrook, J. G., Levi, M., Ouwehand, W. H., Kastelein, J. J., Trip, M. D. & Zwinderman, A. H., 2014, In: European journal of human genetics. 22, 6, p. 809-813

    Research output: Contribution to journal › Article › Academic › peer-review

    4 Citations (Scopus)

  • Defining the role of common variation in the genomic and biological architecture of adult human height

    AUTHOR GROUP, Kleber, M. E., Kristiansson, K., Lim, U., Helmer, Q., Boomsma, D. I., Saleheen, D., Schlessinger, D., Slagboom, P. E., Snieder, H., Spector, T. D., Strauch, K., Stumvoll, M., Tuomilehto, J., Uusitupa, M., van der Harst, P., Völzke, H., Walker, M., Wareham, N. J., Watkins, H., & 39 othersWichmann, H. E., Wilson, J. F., Zanen, P., Deloukas, P., Heid, I. M., Lindgren, C. M., Mohlke, K. L., Speliotes, E. K., Thorsteinsdottir, U., Barroso, I., Fox, C. S., North, K. E., Strachan, D. P., Beckmann, J. S., Berndt, S. I., Boehnke, M., Borecki, I. B., McCarthy, M. I., Metspalu, A., Smit, J. H., Pilz, S., van Schoor, N. M., Stefansson, K., Uitterlinden, A. G., van Duijn, C. M., Franke, L., Willer, C. J., Price, A. L., Lettre, G., Loos, R. J. F., Weedon, M. N., Ingelsson, E., O'Connell, J. R., Abecasis, G. R., Chasman, D. I., Goddard, M. E., Visscher, P. M., Hirschhorn, J. N. & Frayling, T. M., 2014, In: Nature Genetics. 46, 11, p. 1173-1186 14 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    1298 Citations (Scopus)

  • Distribution and medical impact of loss-of-function variants in the Finnish founder population

    Lim, E. T., Würtz, P., Havulinna, A. S., Palta, P., Tukiainen, T., Rehnström, K., Esko, T., Mägi, R., Inouye, M., Lappalainen, T., Chan, Y., Salem, R. M., Lek, M., Flannick, J., Sim, X., Manning, A., Ladenvall, C., Bumpstead, S., Hämäläinen, E., Aalto, K., & 40 othersMaksimow, M., Salmi, M., Blankenberg, S., Ardissino, D., Shah, S., Horne, B., McPherson, R., Hovingh, G. K., Reilly, M. P., Watkins, H., Goel, A., Farrall, M., Girelli, D., Reiner, A. P., Stitziel, N. O., Kathiresan, S., Gabriel, S., Barrett, J. C., Lehtimäki, T., Laakso, M., Groop, L., Kaprio, J., Perola, M., McCarthy, M. I., Boehnke, M., Altshuler, D. M., Lindgren, C. M., Hirschhorn, J. N., Metspalu, A., Freimer, N. B., Zeller, T., Jalkanen, S., Koskinen, S., Raitakari, O., Durbin, R., MacArthur, D. G., Salomaa, V., Ripatti, S., Daly, M. J. & Palotie, A., 2014, In: PLoS genetics. 10, 7, p. e1004494

    Research output: Contribution to journal › Article › Academic › peer-review

    283 Citations (Scopus)

  • eNOS activation by HDL is impaired in genetic CETP deficiency

    Gomaraschi, M., Ossoli, A., Pozzi, S., Nilsson, P., Cefalù, A. B., Averna, M., Kuivenhoven, J. A., Hovingh, G. K., Veglia, F., Franceschini, G. & Calabresi, L., 2014, In: PLOS ONE. 9, 5, p. e95925

    Research output: Contribution to journal › Article › Academic › peer-review

    32 Citations (Scopus)

  • Eprotirome in patients with familial hypercholesterolaemia (the AKKA trial): a randomised, double-blind, placebo-controlled phase 3 study

    Sjouke, B., Langslet, G., Ceska, R., Nicholls, S. J., Nissen, S. E., Öhlander, M., Ladenson, P. W., Olsson, A. G., Hovingh, G. K. & Kastelein, J. J. P., 2014, In: Lancet. Diabetes and endocrinology. 2, 6, p. 455-463

    Research output: Contribution to journal › Article › Academic › peer-review

    86 Citations (Scopus)

  • Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci

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    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    140 Citations (Scopus)