Gerard Hovingh

Article

Open-label therapy with alirocumab in patients with heterozygous familial hypercholesterolemia: Results from three years of treatment

Dufour, R., Bergeron, J., Gaudet, D., Weiss, R., Hovingh, G. K., Qing, Z., Yang, F., Andisik, M., Torri, A., Pordy, R. & Gipe, D. A., 2017, In: International journal of cardiology. 228, p. 754-760

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Vallejo-Vaz, A. J., Marco, M. D., Stevens, C. A. T., Akram, A., Freiberger, T., Hovingh, G. K., Kastelein, J. J. P., Mata, P., Raal, F. J., Santos, R. D., Soran, H., Watts, G. F., Abifadel, M., Aguilar-Salinas, C. A., Al-Khnifsawi, M., Alkindi, F. A., Alnouri, F., Alonso, R., Al-Rasadi, K., Al-Sarraf, A., & 331 othersAshavaid, T. F., Binder, C. J., Bogsrud, M. P., Bourbon, M., Bruckert, E., Chlebus, K., Corral, P., Descamps, O., Durst, R., Ezhov, M., Fras, Z., Genest, J., Groselj, U., Harada-Shiba, M., Kayikcioglu, M., Lalic, K., Lam, C. S. P., Latkovskis, G., Laufs, U., Liberopoulos, E., Lin, J., Maher, V., Majano, N., Marais, A. D., März, W., Mirrakhimov, E., Miserez, A. R., Mitchenko, O., Nawawi, H. M., Nordestgaard, B. R. G., Paragh, G., Petrulioniene, Z., Pojskic, B., Postadzhiyan, A., Reda, A., Reiner, Ž., Sadoh, W. E., Sahebkar, A., Shehab, A., Shek, A. B., Stoll, M., Su, T-C., Subramaniam, T., Susekov, A. V., Symeonides, P., Tilney, M., Tomlinson, B., Truong, T-H., Tselepis, A. D., Tybjærg-Hansen, A., Vázquez-Cárdenas, A., Viigimaa, M., Vohnout, B., Widén, E., Yamashita, S., Banach, M., Gaita, D., Jiang, L., Nilsson, L., Santos, L. E., Schunkert, H., Tokgözoğlu, L., Car, J., Catapano, A. L., Ray, K. K., Akram, A., Car, J., Marco, M. D., Ray, K. K., Stevens, C. A. T., Vallejo-Vaz, A. J., Corral, P., Schreier, L., Watts, G. F., Pang, J., Binder, C. J., Dieplinger, H., Hanauer-Mader, G., Descamps, O., Desutter, J., Langlois, M., Mertens, A., Rietzschel, E., Wallemacq, C., Pojskic, B., Isakovic, D., Dzankovic, A. M., Obralija, J., Pojskic, L., Sisic, I., Stimjanin, E., Torlak, V. A., Santos, R. D., Jannes, C. E., Krieger, J. E., Pereira, A. C., Postadzhiyan, A., Genest, J., Ruel, I., Alonso, R., Asenjo, S., Cuevas, A., Lin, J., Jiang, L., Reiner, Ž., Pećin, I., Symeonides, P., Miltiadous, G., Panayiotou, A. G., Freiberger, T., Vrablik, M., Nordestgaard, B. R. G., Tybjærg-Hansen, A., Benn, M., Reda, A., Viigimaa, M., Heinsar, S., Widén, E., Bruckert, E., Béliard, S., Laufs, U., März, W., Schunkert, H., Gouni-Berthold, I., Hengstenberg, W., Julius, U., Kassner, U., Klose, G., König, C., König, W., Otte, B., Parhofer, K., Schatz, U., Schmidt, N., Steinhagen-Thiessen, E., Vogt, A., Liberopoulos, E., Tselepis, A. D., Antza, C., Athyros, V., Bilianou, E., Boufidou, A., Chrousos, G., Elisaf, M., Garoufi, A., Katsiki, N., Kolovou, G., Kotsis, V., Rallidis, L., Rizos, C., Skalidis, E., Skoumas, I., Tziomalos, K., Tomlinson, B., Paragh, G., Ashavaid, T. F., Shawney, J. P. S., Sahebkar, A., Abbaszadegan, M. R., Aminzadeh, M., Hosseini, S., Mobini, M., Vakili, R., Zaeri, H., Al-Khnifsawi, M., Maher, V., Agar, R., Boran, G., Colwell, N., Crowley, V., Durkin, M., Griffin, D., Kelly, M., Rakovac-Tisdall, A., Durst, R., Bitzur, R., Cohen, H., Eliav, O., Ellis, A., Gavish, D., Harats, D., Henkin, Y., Knobler, H., Leavit, L., Leitersdorf, E., Rubinstein, A., Schurr, D., Shpitzen, S., Szalat, A., Catapano, A. L., Arca, M., Averna, M., Bertolini, S., Calandra, S., Tarugi, P., Harada-Shiba, M., Yamashita, S., Al-Sarraf, A., Mirrakhimov, E., Latkovskis, G., Erglis, A., Gilis, D., Nesterovics, G., Saripo, V., Upena-Roze, A., Abifadel, M., Elbitar, S., Jambart, S. L., Khoury, P. E., Petrulioniene, Z., Gargalskaite, U., Kutkiene, S., Nawawi, H. M., Al-Khateeb, A., An, C. Y., Ismail, Z., Kasim, S., Ibrahim, K. S., Radzi, A. B. M., Kasim, N. A., Nor, N. S. M., Ramli, A. S., Razak, S. A., Muid, S., Rosman, A., Sanusi, A. R., Razman, A. Z., Nazli, S. A., Kek, T. L., Tilney, M., Azzopardi, C., Aguilar Salinas, C. A., Vázquez-Cárdenas, N. A., Galán, G., Magaña-Torres, M. T., Martagon, A., Mehta, R., Hovingh, G. K., Kastelein, J. J. P., Wittekoek, M. E., Sadoh, W. E., Isara, A. R., Obaseki, D. E., Ohenhen, O. A., Bogsrud, M. P., Holven, K. B., Al-Rasadi, K., Santos, L. E., Banach, M., Chlebus, K., Gruchała, M., Baranowska, M., Borowiec-Wolny, J., Gilis-Malinowska, N., Michalska-Grzonkowska, A., Pajkowski, M., Parczewska, A., Romanowska-Kocejko, M., Stróżyk, A., Żarczyńska-Buchowiecka, M., Kleinschmidt, M., Bourbon, M., Alves, A. C., Medeiros, A. M., Alkindi, F. A., Gaita, D., Ezhov, M., Susekov, A. V., Ershova, A., Korneva, V., Kuznetsova, T., Malyshev, P., Meshkov, A., Rozhkova, T., Alnouri, F., Lalic, K., Rajkovic, N., Popovic, L., Lukac, S. S., Stosic, L., Rasulic, I., Lalic, N. M., Subramaniam, T., Lam, C. S. P., Chua, T. S. J., Ting, S. P. L., Vohnout, B., Raslova, K., Fras, Z., Groselj, U., Battelino, T., Cevc, M., Jug, B., Kovac, J., Podkrajsek, K. T., Sustar, U., Trontelj, K. J., Marais, D., Raal, F. J., Mata, P., Isla, L. P. D., Nilsson, L., Miserez, A. R., Martin, F. J., Su, T-C., Charng, M-J., Chen, P-L., Kayikçioglu, M., Tokgözoğlu, L., Mitchenko, O., Shehab, A., Soran, H., Stoll, M., Dell’oca, N., Fernández, G., Ressia, A., Reyes, X., Zelarayan, M., Shek, A. B., Alieva, R. B., Hoshimov, S. U., Kurbanov, R. D., Nizamov, U. I., Majano, N., Lima-Martínez, M. M., Truong, T-H., Nguyen, M-N. T., Do, D-L., Kim, N-T., le, H-A. & le, T-T., 2018, In: Atherosclerosis. 277, p. 234-255

Research output: Contribution to journal › Article › Academic › peer-review

168 Citations (Scopus)

Paediatric patients with heterozygous familial hypercholesterolaemia treated with evolocumab for 80 weeks (HAUSER-OLE): a single-arm, multicentre, open-label extension of HAUSER-RCT

Santos, R. D., Ruzza, A., Hovingh, G. K., Stefanutti, C., Mach, F., Descamps, O. S., Bergeron, J., Wang, B., Bartuli, A., Buonuomo, P. S., Greber-Platzer, S., Luirink, I., Bhatia, A. K., Raal, F. J., Kastelein, J. J. P., Wiegman, A. & Gaudet, D., 1 Oct 2022, In: The Lancet Diabetes and Endocrinology. 10, 10, p. 732-740 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

Patients with low HDL-cholesterol caused by mutations in LCAT have increased arterial stiffness

van den Bogaard, B., Holleboom, A. G., Duivenvoorden, R., Hutten, B. A., Kastelein, J. J. P., Hovingh, G. K., Kuivenhoven, J. A., Stroes, E. S. G. & van den Born, B-J. H., 2012, In: Atherosclerosis. 225, 2, p. 481-485

Research output: Contribution to journal › Article › Academic › peer-review

31 Citations (Scopus)

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study: a mendelian randomisation study

Schmidt, A. F., Swerdlow, D. I., Holmes, M. V., Patel, R. S., Fairhurst-Hunter, Z., Lyall, D. M., Hartwig, F. P., Horta, B. L., Hyppönen, E., Power, C., Moldovan, M., van Iperen, E., Hovingh, G. K., Demuth, I., Norman, K., Steinhagen-Thiessen, E., Demuth, J., Bertram, L., Liu, T., Coassin, S., & 113 othersWilleit, J., Kiechl, S., Willeit, K., Mason, D., Wright, J., Morris, R., Wanamethee, G., Whincup, P., Ben-Shlomo, Y., McLachlan, S., Price, J. F., Kivimaki, M., Welch, C., Sanchez-Galvez, A., Marques-Vidal, P., Nicolaides, A., Panayiotou, A. G., Onland-Moret, N. C., van der Schouw, Y. T., Matullo, G., Fiorito, G., Guarrera, S., Sacerdote, C., Wareham, N. J., Langenberg, C., Scott, R., Luan, J., Bobak, M., Malyutina, S., Pająk, A., Kubinova, R., Tamosiunas, A., Pikhart, H., Husemoen, L. L. N., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Simonsen, K. S., Cooper, J., Humphries, S. E., Brilliant, M., Kitchner, T., Hakonarson, H., Carrell, D. S., McCarty, C. A., Kirchner, H. L., Larson, E. B., Crosslin, D. R., de Andrade, M., Roden, D. M., Denny, J. C., Carty, C., Hancock, S., Attia, J., Holliday, E., O'Donnell, M., Yusuf, S., Chong, M., Pare, G., van der Harst, P., Said, M. A., Eppinga, R. N., Verweij, N., Snieder, H., Christen, T., Mook-Kanamori, D. O., Gustafsson, S., Lind, L., Ingelsson, E., Pazoki, R., Franco, O., Hofman, A., Uitterlinden, A., Dehghan, A., Teumer, A., Baumeister, S., Dörr, M., Lerch, M. M., Völker, U., Völzke, H., Ward, J., Pell, J. P., Smith, D. J., Meade, T., Maitland-van der Zee, A. H., Baranova, E. V., Young, R., Ford, I., Campbell, A., Padmanabhan, S., Bots, M. L., Grobbee, D. E., Froguel, P., Thuillier, D., Balkau, B., Bonnefond, A., Cariou, B., Smart, M., Bao, Y., Kumari, M., Mahajan, A., Ridker, P. M., Chasman, D. I., Reiner, A. P., Lange, L. A., Ritchie, M. D., Asselbergs, F. W., Casas, J-P., Keating, B. J., Preiss, D., Hingorani, A. D. & Sattar, N., Feb 2017, In: Lancet. Diabetes and endocrinology. 5, 2, p. 97-105 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

278 Citations (Scopus)

PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial

AUTHOR GROUP, 2015, In: Lancet. 385, 9965, p. 331-340

Research output: Contribution to journal › Article › Academic › peer-review

636 Citations (Scopus)

PCSK9 inhibition with orally administered NNC0385-0434 in hypercholesterolaemia: a randomised, double-blind, placebo-controlled and active-controlled phase 2 trial

Koren, M. J., Descamps, O., Hata, Y., Hengeveld, E. M., Hovingh, G. K., Ikonomidis, I., Radu Juul Jensen, M. D., Langbakke, I. H., Martens, F. M. A. C., Søndergaard, A. L., Witkowski, A. & Koenig, W., 1 Mar 2024, In: The Lancet Diabetes and Endocrinology. 12, 3, p. 174-183 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

PCSK9 inhibitors: Novel therapeutic agents for the treatment of hypercholesterolemia

Verbeek, R., Stoekenbroek, R. M. & Hovingh, G. K., 2015, In: European journal of pharmacology. 763, Part A, p. 38-47

Research output: Contribution to journal › Article › Academic › peer-review

34 Citations (Scopus)

PCSK9 inhibitors in clinical practice: Delivering on the promise?

Stoekenbroek, R. M., Hartgers, M. L., Rutte, R., de Wijer, D. D., Stroes, E. S. G. & Hovingh, G. K., 2018, In: Atherosclerosis. 270, March, p. 205-210

Research output: Contribution to journal › Article › Academic › peer-review

41 Citations (Scopus)

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

AUTHOR GROUP, 2014, In: Nature communications. 5, p. 5068

Research output: Contribution to journal › Article › Academic › peer-review

197 Citations (Scopus)

Phenotype diversity among patients with homozygous familial hypercholesterolemia: A cohort study

Raal, F. J., Sjouke, B., Hovingh, G. K. & Isaac, B. F., 2016, In: Atherosclerosis. 248, p. 238-244

Research output: Contribution to journal › Article › Academic › peer-review

47 Citations (Scopus)

Plasma amyloid-β in patients with Tangier disease

Shahim, P., Bochem, A. E., Mattsson, N., Lautner, R., Blennow, K., Hovingh, G. K., Motazacker, M. M. & Zetterberg, H., 2013, In: Journal of Alzheimer s disease. 35, 2, p. 307-312

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: a prospective case-control analysis nested in the EPIC-Norfolk population study

Holleboom, A. G., Kuivenhoven, J. A., Vergeer, M., Hovingh, G. K., van Miert, J. N., Wareham, N. J., Kastelein, J. J. P., Khaw, K-T. & Boekholdt, S. M., 2010, In: Journal of Lipid Research. 51, 2, p. 416-421

Research output: Contribution to journal › Article › Academic › peer-review

58 Citations (Scopus)

Plasma lipoprotein(a) levels in patients with homozygous autosomal dominant hypercholesterolemia

Sjouke, B., Yahya, R., Tanck, M. W. T., Defesche, J. C., de Graaf, J., Wiegman, A., Kastelein, J. J. P., Mulder, M. T., Hovingh, G. K. & Roeters van Lennep, J. E., 2017, In: Journal of clinical lipidology. 11, 2, p. 507-514

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

Polygenic Background Modifies Risk of Coronary Artery Disease Among Individuals With Heterozygous Familial Hypercholesterolemia

Reeskamp, L. F., Shim, I., Dron, J. S., Ibrahim, S., Tromp, T. R., Fahed, A. C., Patel, A. P., Hutten, B. A., Stroes, E. S. G., Hovingh, G. K. & Khera, A. V., Nov 2023, In: JACC: Advances. 2, 9, 100662.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

1 Citation (Scopus)

Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and design of the global EAS Familial Hypercholesterolaemia Studies Collaboration

Vallejo-Vaz, A. J., Akram, A., Kondapally Seshasai, S. R., Cole, D., Watts, G. F., Hovingh, G. K., Kastelein, J. J. P., Mata, P., Raal, F. J., Santos, R. D., Soran, H., Freiberger, T., Abifadel, M., Aguilar-Salinas, C. A., Alnouri, F., Alonso, R., Al-Rasadi, K., Banach, M., Bogsrud, M. P., Bourbon, M., & 52 othersBruckert, E., Car, J., Ceska, R., Corral, P., Descamps, O., Dieplinger, H., Do, C. T., Durst, R., Ezhov, M. V., Fras, Z., Gaita, D., Gaspar, I. M., Genest, J., Harada-Shiba, M., Jiang, L., Kayikcioglu, M., Lam, C. S. P., Latkovskis, G., Laufs, U., Liberopoulos, E., Lin, J., Lin, N., Maher, V., Majano, N., Marais, A. D., März, W., Mirrakhimov, E., Miserez, A. R., Mitchenko, O., Nawawi, H., Nilsson, L., Nordestgaard, B. G., Paragh, G., Petrulioniene, Z., Pojskic, B., Reiner, Ž., Sahebkar, A., Santos, L. E., Schunkert, H., Shehab, A., Slimane, M. N., Stoll, M., Su, T-C., Susekov, A., Tilney, M., Tomlinson, B., Tselepis, A. D., Vohnout, B., Widén, E., Yamashita, S., Catapano, A. L. & Ray, K. K., 2016, In: Atherosclerosis. Supplements. 22, p. 1-32

Research output: Contribution to journal › Article › Academic › peer-review

92 Citations (Scopus)

Population and assay thresholds for the predictive value of lipoprotein (a) for coronary artery disease: the EPIC-Norfolk Prospective Population Study

Verbeek, R., Boekholdt, S. M., Stoekenbroek, R. M., Hovingh, G. K., Witztum, J. L., Wareham, N. J., Sandhu, M. S., Khaw, K-T. & Tsimikas, S., 2016, In: Journal of Lipid Research. 57, 4, p. 697-705

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

Prevalence and management of familial hypercholesterolaemia in coronary patients: An analysis of EUROASPIRE IV, a study of the European Society of Cardiology

de Backer, G., Besseling, J., Chapman, J., Hovingh, G. K., Kastelein, J. J. P., Kotseva, K., Ray, K., Reiner, Ž., Wood, D. & de Bacquer, D., 2015, In: Atherosclerosis. 241, 1, p. 169-175

Research output: Contribution to journal › Article › Academic › peer-review

131 Citations (Scopus)

Proprotein convertase subtilisin/kexin type 9 inhibition as the next statin?

Rakipovski, G. N., Hovingh, G. K. & Nyberg, M., 1 Dec 2020, In: Current opinion in lipidology. 31, 6, p. 340-346 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Proprotein Convertase Subtilisin Kexin Type 9 Inhibition for Autosomal Recessive Hypercholesterolemia-Brief Report

Thedrez, A., Sjouke, B., Passard, M., Prampart-Fauvet, S., Guédon, A., Croyal, M., Dallinga-Thie, G., Peter, J., Blom, D., Ciccarese, M., Cefalù, A. B., Pisciotta, L., Santos, R. D., Averna, M., Raal, F., Pintus, P., Cossu, M., Hovingh, K. & Lambert, G., 2016, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 8, p. 1647-1650

Research output: Contribution to journal › Article › Academic › peer-review

20 Citations (Scopus)

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T., & 380 othersFeitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Boeing, H., Hammerschlag, A. R., Polderman, T. J., Boerwinkle, E., Böger, C. A., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Brumat, M., Burt, A. A., Butterworth, A. S., Campbell, P. T., Cappellani, S., Carey, D. J., Catamo, E., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. I., Chowdhury, R., Christensen, C., Chu, A. Y., Cocca, M., Collins, F. S., Cook, J. P., Corley, J., Corominas Galbany, J., Cox, A. J., Crosslin, D. S., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, P. I. W., Groot, M. C. H., Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., Heijer, M., Hollander, A. I., Ruijter, H. M., Dennis, J. G., Denny, J. C., Angelantonio, E., Drenos, F., Du, M., Dubé, M-P., Dunning, A. M., Easton, D. F., Edwards, T. L., Ellinghaus, D., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A-E., Farooqi, I. S., Faul, J. D., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franco, O. H., Franke, A., Franks, P. W., Friedrich, N., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, A. P., Gordon-Larsen, P., Gorski, M., Grabe, H-J., Grant, S. F. A., Grarup, N., Griffiths, H. L., Grove, M. L., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Have, C. T., Hayward, C., He, L., Heard-Costa, N. L., Heath, A. C., Heid, I. M., Helgeland, Ø., Hernesniemi, J., Hewitt, A. W., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hu, Y., Huang, P. L., Huffman, J. E., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J-H., Jarvik, G. P., Jensen, G. B., Jia, Y., Johansson, S., Jørgensen, M. E., Jørgensen, T., Jukema, J. W., Kahali, B., Kahn, R. S., Kähönen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, L. A., Kim, E., Kitajima, H., Komulainen, P., Kooner, J. S., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T. A., Lamparter, D., Lange, E. M., Lange, L. A., Langenberg, C., Larson, E. B., Lee, N. R., Lehtimäki, T., Lewis, C. E., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K-H., Lin, L-A., Lin, X., Lind, L., Lindström, J., Linneberg, A., Liu, C-T., Liu, D. J., Liu, Y., Lo, K. S., Lophatananon, A., Lotery, A. J., Loukola, A., Luan, J., Lubitz, S. A., Lyytikäinen, L-P., Männistö, S., Marenne, G., Mazul, A. L., McCarthy, M. I., McKean-Cowdin, R., Medland, S. E., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, K. L., Moilanen, L., Moitry, M., Montgomery, G. W., Mook-Kanamori, D. O., Moore, C., Mori, T. A., Morris, A. D., Morris, A. P., Müller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Narisu, N., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njølstad, P. R., Nordestgaard, B. G., Nyholt, D. R., O'Connel, J. R., O'Donoghue, M. L., Olde Loohuis, L. M., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Pers, T. H., Person, T. N., Peters, A., Petersen, E. R. B., Peyser, P. A., Pirie, A., Polasek, O., Puolijoki, H., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Renström, F., Rheinberger, M., Ridker, P. M., Rioux, J. D., Rivas, M. A., Roberts, D. J., Robertson, N. R., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sapkota, Y., Sattar, N., Schoen, R. E., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S. H., Sheu, W. H-H., Sim, X., Slater, A. J., Small, K. S., Smith, A. V., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stefansson, K., Steinthorsdottir, V., Stirrups, K. E., Strauch, K., Stringham, H. M., Stumvoll, M., Sun, L., Surendran, P., Swift, A. J., Tada, H., Tansey, K. E., Tardif, J-C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, B. H., Tönjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Uusitupa, M., Laan, S. W., Duijn, C. M., Leeuwen, N., van Setten, J., Vanhala, M., Varbo, A., Varga, T. V., Varma, R., Velez Edwards, D. R., Vermeulen, S. H., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, T. F., Völker, U., Vuckovic, D., Wagenknecht, L. E., Walker, M., Wallentin, L., Wang, F., Wang, C. A., Wang, S., Wang, Y., Ware, E. B., Wareham, N. J., Warren, H. R., Waterworth, D. M., Wessel, J., White, H. D., Willer, C. J., Wilson, J. G., Witte, D. R., Wood, A. R., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zhou, W., Zondervan, K. T., Rotter, J. I., Pospisilik, J. A., Rivadeneira, F., Borecki, I. B., Deloukas, P., Frayling, T. M., Lettre, G., North, K. E., Lindgren, C. M., Hirschhorn, J. N. & Loos, R. J. F., Jan 2018, In: Nature Genetics. 50, 1, p. 26-41 22 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

237 Citations (Scopus)

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (vol 50, pg 26, 2018)

Turcot, V., Lu, Y., Highland, HM., Schurmann, C., Justice, AE., Fine, RS., Bradfield, JP., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, AE., Karaderi, T., Lempradl, A., Locke, AE., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, KL., Alfred, T., & 381 othersFeitosa, MF., Masca, NGD., Manning, AK., Medina-Gomez, C., Mudgal, P., Ng, MCY., Reiner, AP., Vedantam, S., Willems, SM., Winkler, TW., Abecasis, G., Aben, KK., Alam, DS., Alharthi, SE., Allison, M., Amouyel, P., Asselbergs, FW., Auer, PL., Balkau, B., Bang, LE., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, LF., Bluher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Boger, CA., Bork-Jensen, J., Bots, ML., Bottinger, EP., Bowden, DW., Brandslund, I., Breen, G., Brilliant, MH., Broer, L., Brumat, M., Burt, AA., Butterworth, AS., Campbell, PT., Cappellani, S., Carey, DJ., Catamo, E., Caulfield, MJ., Chambers, JC., Chasman, DI., Chen, Y-DI., Chowdhury, R., Christensen, C., Chu, AY., Cocca, M., Collins, FS., Cook, JP., Corley, J., Galbany, JC., Cox, AJ., Crosslin, DS., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, PIW., Groot, MCH., Mutsert, R., Deary, IJ., Dedoussis, G., Demerath, EW., Heijer, M., Hollander, AI., Ruijter, HM., Dennis, JG., Denny, JC., Di Angelantonio, E., Drenos, F., Du, M., Dube, M-P., Dunning, AM., Easton, DF., Edwards, TL., Ellinghaus, D., Ellinor, PT., Elliott, P., Evangelou, E., Farmaki, A-E., Farooqi, IS., Faul, JD., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, JC., Ford, I., Fornage, M., Franco, OH., Franke, A., Franks, PW., Friedrich, N., Frikke-Schmidt, R., Galesloot, TE., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, AP., Gordon-Larsen, P., Gorski, M., Grabe, H-J., Grant, SFA., Grarup, N., Griffiths, HL., Grove, ML., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, AR., Hansen, T., Harris, KM., Harris, TB., Hattersley, AT., Have, CT., Hayward, C., He, L., Heard-Costa, NL., Heath, AC., Heid, IM., Helgeland, O., Hernesniemi, J., Hewitt, AW., Holmen, OL., Hovingh, GK., Howson, JMM., Hu, Y., Huang, PL., Huffman, JE., Ikram, MA., Ingelsson, E., Jackson, AU., Jansson, J-H., Jarvik, GP., Jensen, GB., Jia, Y., Johansson, S., Jorgensen, ME., Jorgensen, T., Jukema, JW., Kahali, B., Kahn, RS., Kahonen, M., Kamstrup, PR., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, SLR., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, LA., Kim, E., Kitajima, H., Komulainen, P., Kooner, JS., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, TA., Lamparter, D., Lange, EM., Lange, LA., Langenberg, C., Larson, EB., Lee, NR., Lehtimaki, T., Lewis, CE., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K-H., Lin, L-A., Lin, X., Lind, L., Lindstrom, J., Linneberg, A., Liu, C-T., Liu, DJ., Liu, Y., Lo, KS., Lophatananon, A., Lotery, AJ., Loukola, A., Luan, J., Lubitz, SA., Lyytikainen, L-P., Mannisto, S., Marenne, G., Mazul, AL., McCarthy, MI., McKean-Cowdin, R., Medland, SE., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, KL., Moilanen, L., Moitry, M., Montgomery, GW., Mook-Kanamori, DO., Moore, C., Mori, TA., Morris, AD., Morris, AP., Mueller-Nurasyid, M., Munroe, PB., Nalls, MA., Narisu, N., Nelson, CP., Neville, M., Nielsen, SF., Nikus, K., Njolstad, PR., Nordestgaard, BG., Nyholt, DR., O'Connel, JR., O'Donoghue, ML., Loohuis, LMO., Ophoff, RA., Owen, KR., Packard, CJ., Padmanabhan, S., Palmer, CNA., Palmer, ND., Pasterkamp, G., Patel, AP., Pattie, A., Pedersen, O., Peissig, PL., Peloso, GM., Pennell, CE., Perola, M., Perry, JA., Perry, JRB., Pers, TH., Person, TN., Peters, A., Petersen, ERB., Peyser, PA., Pirie, A., Polasek, O., Polderman, TJ., Puolijoki, H., Raitakari, OT., Rasheed, A., Rauramaa, R., Reilly, DF., Renstrom, F., Rheinberger, M., Ridker, PM., Rioux, JD., Rivas, MA., Roberts, DJ., Robertson, NR., Robino, A., Rolandsson, O., Rudan, I., Ruth, KS., Saleheen, D., Salomaa, V., Samani, NJ., Sapkota, Y., Sattar, N., Schoen, RE., Schreiner, PJ., Schulze, MB., Scott, RA., Segura-Lepe, MP., Shah, SH., Sheu, WH-H., Sim, X., Slater, AJ., Small, KS., Smith, AV., Southam, L., Spector, TD., Speliotes, EK., Starr, JM., Stefansson, K., Steinthorsdottir, V., Stirrups, KE., Strauch, K., Stringham, HM., Stumvoll, M., Sun, L., Surendran, P., Swift, AJ., Tada, H., Tansey, KE., Tardif, J-C., Taylor, KD., Teumer, A., Thompson, DJ., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, BH., Tonjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, JP., Uher, R., Uitterlinden, AG., Uusitupa, M., Laan, SW., Duijn, CM., Leeuwen, N., van Setten, J., Vanhala, M., Varbo, A., Varga, TV., Varma, R., Edwards, DRV., Vermeulen, SH., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, TF., Volker, U., Vuckovic, D., Wagenknecht, LE., Walker, M., Wallentin, L., Wang, F., Wang, CA., Wang, S., Wang, Y., Ware, EB., Wareham, NJ., Warren, HR., Waterworth, DM., Wessel, J., White, HD., Willer, CJ., Wilson, JG., Witte, DR., Wood, AR., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, LM., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, JH., Zhao, W., Zhou, W., Zondervan, KT., Consortium, GG., Rotter, JI., Pospisilik, JA., Rivadeneira, F., Borecki, IB., Deloukas, P., Frayling, TM., Lettre, G., North, KE., Lindgren, CM., Hirschhorn, JN. & Loos, RJF., 16 Mar 2018, In: Nature Genetics. 50, 5, p. 766-767 2 p.

Research output: Contribution to journal › Article › Academic › peer-review

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (vol 50, pg 765, 2017)

Turcot, V., Lu, Y., Highland, HM., Schurmann, C., Justice, AE., Fine, RS., Bradfield, JP., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, AE., Karaderi, T., Lempradl, A., Locke, AE., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, KL., Alfred, T., & 380 othersFeitosa, MF., Masca, NGD., Manning, AK., Medina-Gomez, C., Mudgal, P., Ng, MCY., Reiner, AP., Vedantam, S., Willems, SM., Winkler, TW., Abecasis, G., Aben, KK., Alam, DS., Alharthi, SE., Allison, M., Amouyel, P., Asselbergs, FW., Auer, PL., Balkau, B., Bang, LE., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, LF., Bluher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Boger, CA., Bork-Jensen, J., Bots, ML., Bottinger, EP., Bowden, DW., Brandslund, I., Breen, G., Brilliant, MH., Broer, L., Brumat, M., Burt, AA., Butterworth, AS., Campbell, PT., Cappellani, S., Carey, DJ., Catamo, E., Caulfield, MJ., Chambers, JC., Chasman, DI., Chen, Y-DI., Chowdhury, R., Christensen, C., Chu, AY., Cocca, M., Collins, FS., Cook, JP., Corley, J., Galbany, JC., Cox, AJ., Crosslin, DS., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, PIW., Groot, MCH., Mutsert, R., Deary, IJ., Dedoussis, G., Demerath, EW., Heijer, M., Hollander, AI., Ruijter, HM., Dennis, JG., Denny, JC., Angelantonio, E., Drenos, F., Du, M., Dube, M-P., Dunning, AM., Easton, DF., Edwards, TL., Ellinghaus, D., Ellinor, PT., Elliott, P., Evangelou, E., Farmaki, A-E., Farooqi, IS., Faul, JD., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, JC., Ford, I., Fornage, M., Franco, OH., Franke, A., Franks, PW., Friedrich, N., Frikke-Schmidt, R., Galesloot, TE., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, AP., Gordon-Larsen, P., Gorski, M., Grabe, H-J., Grant, SFA., Grarup, N., Griffiths, HL., Grove, ML., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, AR., Hansen, T., Harris, KM., Harris, TB., Hattersley, AT., Have, CT., Hayward, C., He, L., Heard-Costa, NL., Heath, AC., Heid, IM., Helgeland, O., Hernesniemi, J., Hewitt, AW., Holmen, OL., Hovingh, GK., Howson, JMM., Hu, Y., Huang, PL., Huffman, JE., Ikram, MA., Ingelsson, E., Jackson, AU., Jansson, J-H., Jarvik, GP., Jensen, GB., Jia, Y., Johansson, S., Jorgensen, ME., Jorgensen, T., Jukema, JW., Kahali, B., Kahn, RS., Kahonen, M., Kamstrup, PR., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, SLR., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, LA., Kim, E., Kitajima, H., Komulainen, P., Kooner, JS., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, TA., Lamparter, D., Lange, EM., Lange, LA., Langenberg, C., Larson, EB., Lee, NR., Lehtimaki, T., Lewis, CE., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K-H., Lin, L-A., Lin, X., Lind, L., Lindstrom, J., Linneberg, A., Liu, C-T., Liu, DJ., Liu, Y., Lo, KS., Lophatananon, A., Lotery, AJ., Loukola, A., Luan, J., Lubitz, SA., Lyytikainen, L-P., Mannisto, S., Marenne, G., Mazul, AL., McCarthy, MI., McKean-Cowdin, R., Medland, SE., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, KL., Moilanen, L., Moitry, M., Montgomery, GW., Mook-Kanamori, DO., Moore, C., Mori, TA., Morris, AD., Morris, AP., Mueller-Nurasyid, M., Munroe, PB., Nalls, MA., Narisu, N., Nelson, CP., Neville, M., Nielsen, SF., Nikus, K., Njolstad, PR., Nordestgaard, BG., Nyholt, DR., O'Connel, JR., O'Donoghue, ML., Loohuis, LMO., Ophoff, RA., Owen, KR., Packard, CJ., Padmanabhan, S., Palmer, CNA., Palmer, ND., Pasterkamp, G., Patel, AP., Pattie, A., Pedersen, O., Peissig, PL., Peloso, GM., Pennell, CE., Perola, M., Perry, JA., Perry, JRB., Pers, TH., Person, TN., Peters, A., Petersen, ERB., Peyser, PA., Pirie, A., Polasek, O., Polderman, TJ., Puolijoki, H., Raitakari, OT., Rasheed, A., Rauramaa, R., Reilly, DF., Renstrom, F., Rheinberger, M., Ridker, PM., Rioux, JD., Rivas, MA., Roberts, DJ., Robertson, NR., Robino, A., Rolandsson, O., Rudan, I., Ruth, KS., Saleheen, D., Salomaa, V., Samani, NJ., Sapkota, Y., Sattar, N., Schoen, RE., Schreiner, PJ., Schulze, MB., Scott, RA., Segura-Lepe, MP., Shah, SH., Sheu, WH-H., Sim, X., Slater, AJ., Small, KS., Smith, AV., Southam, L., Spector, TD., Speliotes, EK., Starr, JM., Stefansson, K., Steinthorsdottir, V., Stirrups, KE., Strauch, K., Stringham, HM., Stumvoll, M., Sun, L., Surendran, P., Swift, AJ., Tada, H., Tansey, KE., Tardif, J-C., Taylor, KD., Teumer, A., Thompson, DJ., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, BH., Tonjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, JP., Uher, R., Uitterlinden, AG., Uusitupa, M., Laan, SW., Duijn, CM., Leeuwen, N., van Setten, J., Vanhala, M., Varbo, A., Varga, TV., Varma, R., Edwards, DRV., Vermeulen, SH., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, TF., Volker, U., Vuckovic, D., Wagenknecht, LE., Walker, M., Wallentin, L., Wang, F., Wang, CA., Wang, S., Wang, Y., Ware, EB., Wareham, NJ., Warren, HR., Waterworth, DM., Wessel, J., White, HD., Willer, CJ., Wilson, JG., Witte, DR., Wood, AR., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, LM., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, JH., Zhao, W., Zhou, W., Zondervan, KT., Rotter, JI., Pospisilik, JA., Rivadeneira, F., Borecki, IB., Deloukas, P., Frayling, TM., Lettre, G., North, KE., Lindgren, CM., Hirschhorn, JN. & Loos, RJF., 16 Mar 2018, In: Nature Genetics. 50, 5, p. 765-766 2 p.

Research output: Contribution to journal › Article › Academic › peer-review

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

CHD Exome+ Consortium, 1 Mar 2019, In: Nature Genetics. 51, 3, p. 452–469 18 p.

Research output: Contribution to journal › Article › Academic › peer-review

71 Citations (Scopus)

Proteinuria in early childhood due to familial LCAT deficiency caused by loss of a disulfide bond in lecithin:cholesterol acyl transferase

Holleboom, A. G., Kuivenhoven, J. A., van Olden, C. C., Peter, J., Schimmel, A. W., Levels, J. H., Valentijn, R. M., Vos, P., Defesche, J. C., Kastelein, J. J. P., Hovingh, G. K., Stroes, E. S. G. & Hollak, C. E. M., 2011, In: Atherosclerosis. 216, 1, p. 161-165

Research output: Contribution to journal › Article › Academic › peer-review

25 Citations (Scopus)

Quality control and conduct of genome-wide association meta-analyses

AUTHOR GROUP, Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Willemsen, G., Penninx, B. W. J. H. & Smit, J. H., 2014, In: Nature protocols. 9, 5, p. 1192-1212 21 p.

Research output: Contribution to journal › Article › Academic › peer-review

293 Citations (Scopus)

Quality of life and coping in Dutch homozygous familial hypercholesterolemia patients: A qualitative study

Mulder, J. W. C. M., Kranenburg, L. W., Treling, W. J., Hovingh, G. K., Rutten, J. H. W., Busschbach, J. J. & Roeters van Lennep, J. E., May 2022, In: Atherosclerosis. 348, p. 75-81 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

5 Citations (Scopus)

Rare and low-frequency coding variants alter human adult height

EPIC-InterAct Consortium, Böger, C. A., Bonnycastle, L. L., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Burt, A. A., Butterworth, A. S., Carey, D. J., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y-D. I., Chowdhury, R., Christensen, C., & 299 othersChu, A. Y., Cocca, M., Collins, F. S., Cook, J. P., Corley, J., Galbany, J. C., Cox, A. J., Cuellar-Partida, G., Danesh, J., Davies, G., de Bakker, P. I. W., de Borst, G. J., de Denus, S., de Groot, M. C. H., de Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., den Hollander, A. I., Dennis, J. G., Di Angelantonio, E., Drenos, F., Du, M., Dunning, A. M., Easton, D. F., Ebeling, T., Edwards, T. L., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A-E., Faul, J. D., Feitosa, M. F., Feng, S., Ferrannini, E., Ferrario, M. M., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franks, P. W., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Giedraitis, V., Giri, A., Girotto, G., Gordon, S. D., Gordon-Larsen, P., Gorski, M., Grarup, N., Grove, M. L., Gudnason, V., Gustafsson, S., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Hayward, C., He, L., Heid, I. M., Heikkilä, K., Helgeland, Ø., Hernesniemi, J., Hewitt, A. W., Hocking, L. J., Hollensted, M., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hoyng, C. B., Huang, P. L., Hveem, K., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J-H., Jarvik, G. P., Jensen, G. B., Jhun, M. A., Jia, Y., Jiang, X., Johansson, S., Jørgensen, M. E., Jørgensen, T., Jousilahti, P., Jukema, J. W., Kahali, B., Kahn, R. S., Kähönen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kee, F., Keeman, R., Kiemeney, L. A., Kitajima, H., Kluivers, K. B., Kocher, T., Komulainen, P., Kontto, J., Kooner, J. S., Kooperberg, C., Kovacs, P., Kriebel, J., Kuivaniemi, H., Küry, S., Kuusisto, J., La Bianca, M., Laakso, M., Lakka, T. A., Lange, E. M., Lange, L. A., Langefeld, C. D., Langenberg, C., Larson, E. B., Lee, I. -T., Lehtimäki, T., Lewis, C. E., Li-Gao, R., Lin, H., Lin, L-A., Lin, X., Lind, L., Lindström, J., Linneberg, A., Liu, Y., Liu, Y., Lophatananon, A., Luan, J., Lubitz, S. A., Lyytikäinen, L-P., Mackey, D. A., Madden, P. A. F., Manning, A. K., Männistö, S., Marenne, G., Marten, J., Martin, N. G., Mazul, A. L., Meidtner, K., Metspalu, A., Mitchell, P., Mohlke, K. L., Mook-Kanamori, D. O., Morgan, A., Morris, A. D., Morris, A. P., Müller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Nauck, M., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njølstad, P. R., Nordestgaard, B. G., Ntalla, I., O'Connel, J. R., Oksa, H., Loohuis, L. M. O., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Person, T. N., Pirie, A., Polasek, O., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Reiner, A. P., Renström, F., Ridker, P. M., Rioux, J. D., Robertson, N., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sandow, K., Sapkota, Y., Sattar, N., Schmidt, M. K., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S., Sim, X., Sivapalaratnam, S., Small, K. S., Smith, A. V., Smith, J. A., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Steinthorsdottir, V., Stringham, H. M., Stumvoll, M., Surendran, P., 't Hart, L. M., Tansey, K. E., Tardif, J-C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorsteinsdottir, U., Thuesen, B. H., Tönjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Ulivi, S., van der Laan, S. W., van der Leij, A. R., van Duijn, C. M., van Setten, J., Varbo, A., Varga, T. V., Varma, R., Edwards, D. R. V., Vermeulen, S. H., Vestergaard, H., Vitart, V., Vogt, T. F., Vozzi, D., Walker, M., Wang, F., Wang, C. A., Wang, S., Wang, Y., Wareham, N. J., Warren, H. R., Wessel, J., Willems, S. M., Wilson, J. G., Witte, D. R., Woods, M. O., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zheng, H., Zhou, W., Rotter, J. I., Boehnke, M., Kathiresan, S., McCarthy, M. I., Willer, C. J., Stefansson, K., Borecki, I. B., Liu, D. J., North, K. E., Heard-Costa, N. L., Pers, T. H., Lindgren, C. M., Oxvig, C., Kutalik, Z., Rivadeneira, F., Loos, R. J. F., Frayling, T. M., Hirschhorn, J. N., Deloukas, P. & Lettre, G., 9 Feb 2017, In: NATURE. 542, 7640, p. 186-190 5 p.

Research output: Contribution to journal › Article › Academic › peer-review

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414 Citations (Scopus)

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

AUTHOR GROUP, Craen, A. J. M., Rader, D. J., Willemsen, G. & Boomsma, D. I., 2016, In: Science. 351, 6278, p. 1166-1171

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424 Citations (Scopus)

Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia

Harchaoui, K. E., Franssen, R., Hovingh, G. K., Bisoendial, R. J., Stellaard, F., Kuipers, F., Kastelein, J. J. P., Kuivenhoven, J. A., Stroes, E. S. G. & Groen, A. K., 2009, In: Atherosclerosis. 207, 2, p. 614-616

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Regional Variations in Alirocumab Dosing Patterns in Patients with Heterozygous Familial Hypercholesterolemia During an Open-Label Extension Study

Langslet, G., Hovingh, G. K., Guyton, J. R., Baccara-Dinet, M. T., Letierce, A., Manvelian, G. & Farnier, M., 1 Aug 2020, In: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. 34, 4, p. 515-523 9 p.

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Open Access

2 Citations (Scopus)

Relationship of lipoprotein-associated apolipoprotein C-III with lipid variables and coronary artery disease risk: The EPIC-Norfolk prospective population study

van Capelleveen, J. C., Lee, S-R., Verbeek, R., Kastelein, J. J. P., Wareham, N. J., Stroes, E. S. G., Hovingh, G. K., Khaw, K-T., Boekholdt, S. M., Witztum, J. L. & Tsimikas, S., 2018, In: Journal of clinical lipidology. 12, 6, p. 1493-1501.e11

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7 Citations (Scopus)

Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein

Bisoendial, R. J., Hovingh, G. K., Levels, J. H. M., Lerch, P. G., Andresen, I., Hayden, M. R., Kastelein, J. J. P. & Stroes, E. S. G., 2003, In: Circulation. 107, 23, p. 2944-2948

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284 Citations (Scopus)

Retrospective analysis of cohort database: Phenotypic variability in a large dataset of patients confirmed to have homozygous familial hypercholesterolemia

Raal, F. J., Sjouke, B., Hovingh, G. K. & Isaac, B. F., 2016, In: Data in brief. 7, p. 1458-1462

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1 Citation (Scopus)

Safety and efficacy of granulocyte colony-stimulating factor in kidney and liver transplant recipients

Turgeon, N., Hovingh, G. K., Fishman, J. A., Basgoz, N., Tolkoff-Rubin, N. E., Doran, M., Cosimi, A. B. & Rubin, R. H., 2000, In: Transplant infectious disease. 2, 1, p. 15-21

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48 Citations (Scopus)

Safety and efficacy of LY3015014, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9): a randomized, placebo-controlled Phase 2 study

Kastelein, J. J. P., Nissen, S. E., Rader, D. J., Hovingh, G. K., Wang, M-D., Shen, T. & Krueger, K. A., 2016, In: European Heart journal. 37, 17, p. 1360-1369

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68 Citations (Scopus)

Secretory Phospholipase A2-IIA and Cardiovascular Disease: A Mendelian Randomization Study

Holmes, M. V., Simon, T., Exeter, H. J., Folkersen, L., Asselbergs, F. W., Guardiola, M., Cooper, J. A., Palmen, J., Hubacek, J. A., Carruthers, K. F., Horne, B. D., Brunisholz, K. D., Mega, J. L., van Iperen, E. P. A., Li, M., Leusink, M., Trompet, S., Verschuren, J. J. W., Hovingh, G. K., Dehghan, A., & 93 othersNelson, C. P., Kotti, S., Danchin, N., Scholz, M., Haase, C. L., Rothenbacher, D., Swerdlow, D. I., Kuchenbaecker, K. B., Staines-Urias, E., Goel, A., van 't Hooft, F., Gertow, K., de Faire, U., Panayiotou, A. G., Tremoli, E., Baldassarre, D., Veglia, F., Holdt, L. M., Beutner, F., Gansevoort, R. T., Navis, G. J., Mateo Leach, I., Breitling, L. P., Brenner, H., Thiery, J., Dallmeier, D., Franco-Cereceda, A., Boer, J. M. A., Stephens, J. W., Hofker, M. H., Tedgui, A., Hofman, A., Uitterlinden, A. G., Adamkova, V., Pitha, J., Onland-Moret, N. C., Cramer, M. J., Nathoe, H. M., Spiering, W., Klungel, O. H., Kumari, M., Whincup, P. H., Morrow, D. A., Braund, P. S., Hall, A. S., Olsson, A. G., Doevendans, P. A., Trip, M. D., Tobin, M. D., Hamsten, A., Watkins, H., Koenig, W., Nicolaides, A. N., Teupser, D., Day, I. N. M., Carlquist, J. F., Gaunt, T. R., Ford, I., Sattar, N., Tsimikas, S., Schwartz, G. G., Lawlor, D. A., Morris, R. W., Sandhu, M. S., Poledne, R., Maitland-van der Zee, A. H., Khaw, K-T., Keating, B. J., van der Harst, P., Price, J. F., Mehta, S. R., Yusuf, S., Witteman, J. C. M., Franco, O. H., Jukema, J. W., de Knijff, P., Tybjaerg-Hansen, A., Rader, D. J., Farrall, M., Samani, N. J., Kivimaki, M., Fox, K. A. A., Humphries, S. E., Anderson, J. L., Boekholdt, S. M., Palmer, T. M., Eriksson, P., Paré, G., Hingorani, A. D., Sabatine, M. S., Mallat, Z., Casas, J. P. & Talmud, P. J., 2013, In: Journal of the American College of Cardiology. 62, 21, p. 1966-1976

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100 Citations (Scopus)

Segregation of LIPG, CETP, and GALNT2 Mutations in Caucasian Families with Extremely High HDL Cholesterol

Tietjen, I., Hovingh, G. K., Singaraja, R. R., Radomski, C., Barhdadi, A., McEwen, J., Chan, E., Mattice, M., Legendre, A., Franchini, P. L., Dubé, M-P., Kastelein, J. J. P. & Hayden, M. R., 2012, In: PLOS ONE. 7, 8, p. e37437

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29 Citations (Scopus)

Selection of individuals for genetic testing for familial hypercholesterolaemia: development and external validation of a prediction model for the presence of a mutation causing familial hypercholesterolaemia

Besseling, J., Reitsma, J. B., Gaudet, D., Brisson, D., Kastelein, J. J. P., Hovingh, G. K. & Hutten, B. A., 2017, In: European Heart journal. 38, 8, p. 565-573

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46 Citations (Scopus)

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes

Lincoff, A. M., Brown‑Frandsen, K., Colhoun, H. M., Deanfield, J., Emerson, S. S., Esbjerg, S., Hardt‑Lindberg, S. R., Hovingh, G. K., Kahn, S. E., Kushner, R. F., Lingvay, I., Oral, T. K., Michelsen, M. M., Plutzky, J., Tornøe, C. W. & SELECT Trial Investigators*, 14 Dec 2023, In: New England journal of medicine. 389, 24, p. 2221-2232

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173 Citations (Scopus)

Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) rationale and design

Ryan, D. H., Lingvay, I., Colhoun, H. M., Deanfield, J., Emerson, S. S., Kahn, S. E., Kushner, R. F., Marso, S., Plutzky, J., Brown-Frandsen, K., Gronning, M. O. L., Hovingh, G. K., Holst, A. G., Ravn, H. & Lincoff, A. M., 1 Nov 2020, In: American Heart Journal. 229, p. 61-69 9 p.

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Open Access

131 Citations (Scopus)

Semaglutide for cardiovascular event reduction in people with overweight or obesity: SELECT study baseline characteristics

the SELECT Study Group, 1 Jan 2023, In: Obesity. 31, 1, p. 111-122 12 p.

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Open Access

34 Citations (Scopus)

Semaglutide in HFpEF across obesity class and by body weight reduction: a prespecified analysis of the STEP-HFpEF trial

Borlaug, B. A., Kitzman, D. W., Davies, M. J., Rasmussen, S. R., Barros, E., Butler, J., Einfeldt, M. N., Hovingh, G. K., Møller, D. V., Petrie, M. C., Shah, S. J., Verma, S., Abhayaratna, W., Ahmed, F. Z., Chopra, V., Ezekowitz, J., Fu, M., Ito, H., Lelonek, M., Melenovsky, V., & 8 othersNúñez, J., Perna, E., Schou, M., Senni, M., van der Meer, P., von Lewinski, D., Wolf, D. & Kosiborod, M. N., 1 Sept 2023, In: Nature medicine. 29, 9, p. 2358-2365 8 p.

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26 Citations (Scopus)

Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity.

Kosiborod, M. N., Abildstrøm, S. Z., Borlaug, B. A., Butler, J., Rasmussen, S. R., Davies, M., Hovingh, G. K., Kitzman, D. W., Lindegaard, M. L., Møller, D. V., Shah, S. J., Treppendahl, M. B., Verma, S., Abhayaratna, W., Ahmed, F. Z., Chopra, V., Ezekowitz, J., Fu, M., Ito, H., Lelonek, M., & 11 othersMelenovsky, V., Merkely, B., Núñez, J., Perna, E., Schou, M., Senni, M., Sharma, K., van der Meer, P., von Lewinski, D., Wolf, D. & Petrie, M. C., 2023, In: New England journal of medicine. 389, 12, p. 1069-1084 16 p.

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172 Citations (Scopus)

Semaglutide in Patients with Obesity-Related Heart Failure and Type 2 Diabetes

Kosiborod, M. N., Petrie, M. C., Borlaug, B. A., Butler, J., Davies, M. J., Hovingh, G. K., Kitzman, D. W., Møller, D. V., Treppendahl, M. B., Verma, S., Jensen, T. J., Liisberg, K., Lindegaard, M. L., Abhayaratna, W., Ahmed, F. Z., Ben-Gal, T., Chopra, V., Ezekowitz, J. A., Fu, M., Ito, H., & 12 othersLelonek, M., Melenovský, V., Merkely, B., Núñez, J., Perna, E., Schou, M., Senni, M., Sharma, K., van der Meer, P., von Lewinski, D., Wolf, D. & STEP-HFpEF DM Trial Committees and Investigators, 18 Apr 2024, In: New England journal of medicine. 390, 15, p. 1394-1407

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2 Citations (Scopus)

Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials

Butler, J., Shah, S. J., Petrie, M. C., Borlaug, B. A., Abildstrøm, S. Z., Davies, M. J., Hovingh, G. K., Kitzman, D. W., Møller, D. V., Verma, S., Einfeldt, M. N., Lindegaard, M. L., Rasmussen, S. R., Abhayaratna, W., Ahmed, F. Z., Ben-Gal, T., Chopra, V., Ezekowitz, J. A., Fu, M., Ito, H., & 12 othersLelonek, M., Melenovský, V., Merkely, B., Núñez, J., Perna, E., Schou, M., Senni, M., Sharma, K., van der Meer, P., von Lewinski, D., Wolf, D. & STEP-HFpEF Trial Committees and Investigators, 27 Apr 2024, In: The Lancet. 403, 10437, p. 1635-1648

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1 Citation (Scopus)

Sequencing for LIPA mutations in patients with a clinical diagnosis of familial hypercholesterolemia

Sjouke, B., Defesche, J. C., de Randamie, J. S. E., Wiegman, A., Fouchier, S. W. & Hovingh, G. K., 2016, In: Atherosclerosis. 251, p. 263-265

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28 Citations (Scopus)

Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: a study of a cohort of 14,000 mutation carriers

Besseling, J., Kindt, I., Hof, M., Kastelein, J. J. P., Hutten, B. A. & Hovingh, G. K., 2014, In: Atherosclerosis. 233, 1, p. 219-223

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175 Citations (Scopus)

Sex Differences in Diagnosis, Treatment, and Cardiovascular Outcomes in Homozygous Familial Hypercholesterolemia

Mulder, J. W. C. M., Tromp, T. R., Al-Khnifsawi, M., Blom, D. J., Chlebus, K., Cuchel, M., D'Erasmo, L., Gallo, A., Hovingh, G. K., Kim, N. T., Long, J., Raal, F. J., Schonck, W. A. M., Soran, H., Truong, T-H., Boersma, E., Roeters van Lennep, J. E., Alareedh, M. D., Alieva, R., Allevi, M., & 30 othersAltunkeser, B. B., Al-Waili, K., Al-Zamili, A. F., Arca, M., Atzori, L., Averna, M., Ayesh, M. H., Azar, S. T., Banderali, G., Baratta, F., Bartuli, A., Béliard, S., Bianconi, V., Bini, S., Thani, K. B., Bitar, F. F., Blaha, V., Bonomo, K., Bourbon, M., Branchi, A., Brothers, J. A., Bruckert, E., Brunham, L. R., Defesche, J. C., Hartgers, M. L., Pavanello, C., Reijman, M. D., Stroes, E. S. G., Wiegman, A. & the Homozygous Familial Hypercholesterolemia International Clinical Collaborators, 10 Apr 2024, In: JAMA Cardiology. 9, 4, p. 313-322 10 p.

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Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) & MAGIC Collaboration, 1 Dec 2021, In: Nature communications. 12, 1, p. 1-18 18 p., 24.

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78 Citations (Scopus)

Gerard Hovingh

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