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Gerard Hovingh

(Principal Investigator), Prof. MD PhD

 https://orcid.org/0000-0002-8145-1676
20002024

Research activity per year

Search results

  • 2014

    HDL does not influence the polarization of human monocytes toward an alternative phenotype

    Colin, S., Fanchon, M., Belloy, L., Bochem, A. E., Copin, C., Derudas, B., Stroes, E. S. G., Hovingh, G. K., Kuivenhoven, J. A., Dallinga-Thie, G. M., Staels, B. & Chinetti-Gbaguidi, G., 2014, In: International journal of cardiology. 172, 1, p. 179-184

    Research output: Contribution to journal › Article › Academic › peer-review

    21 Citations (Scopus)

  • Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

    AUTHOR GROUP, 2014, In: European Heart journal. 35, 32, p. 2146-2157

    Research output: Contribution to journal › Review article › Academic › peer-review

    831 Citations (Scopus)

  • Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans

    Singaraja, R. R., Tietjen, I., Hovingh, G. K., Franchini, P. L., Radomski, C., Wong, K., vanHeek, M., Stylianou, I. M., Lin, L., Wang, L., Mitnaul, L., Hubbard, B., Winther, M., Mattice, M., Legendre, A., Sherrington, R., Kastelein, J. J., Akinsanya, K., Plump, A. & Hayden, M. R., 2014, In: Journal of Lipid Research. 55, 8, p. 1693-1701

    Research output: Contribution to journal › Article › Academic › peer-review

    23 Citations (Scopus)

  • Inactivating mutations in NPC1L1 and protection from coronary heart disease

    Stitziel, N. O., Won, H-H., Morrison, A. C., Peloso, G. M., Do, R., Lange, L. A., Fontanillas, P., Gupta, N., Duga, S., Goel, A., Farrall, M., Saleheen, D., Ferrario, P., König, I., Asselta, R., Merlini, P. A., Marziliano, N., Notarangelo, M. F., Schick, U., Auer, P., & 57 othersAssimes, T. L., Reilly, M., Wilensky, R., Rader, D. J., Hovingh, G. K., Meitinger, T., Kessler, T., Kastrati, A., Laugwitz, K-L., Siscovick, D., Rotter, J. I., Hazen, S. L., Tracy, R., Cresci, S., Spertus, J., Jackson, R., Schwartz, S. M., Natarajan, P., Crosby, J., Muzny, D., Ballantyne, C., Rich, S. S., O'Donnell, C. J., Abecasis, G., Sunyaev, S., Nickerson, D. A., Buring, J. E., Ridker, P. M., Chasman, D. I., Austin, E., Ye, Z., Kullo, I. J., Weeke, P. E., Shaffer, C. M., Bastarache, L. A., Denny, J. C., Roden, D. M., Palmer, C., Deloukas, P., Lin, D-Y., Tang, Z., Erdmann, J., Schunkert, H., Danesh, J., Marrugat, J., Elosua, R., Ardissino, D., McPherson, R., Watkins, H., Reiner, A. P., Wilson, J. G., Altshuler, D., Gibbs, R. A., Lander, E. S., Boerwinkle, E., Gabriel, S. & Kathiresan, S., 2014, In: New England journal of medicine. 371, 22, p. 2072-2082

    Research output: Contribution to journal › Article › Academic › peer-review

    369 Citations (Scopus)

  • Lysosomal acid lipase deficiency--an under-recognized cause of dyslipidaemia and liver dysfunction

    Reiner, Ž., Guardamagna, O., Nair, D., Soran, H., Hovingh, K., Bertolini, S., Jones, S., Ćorić, M., Calandra, S., Hamilton, J., Eagleton, T. & Ros, E., 2014, In: Atherosclerosis. 235, 1, p. 21-30

    Research output: Contribution to journal › Review article › Academic › peer-review

    223 Citations (Scopus)

  • Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis

    Maiwald, S., Sivapalaratnam, S., Motazacker, M. M., van Capelleveen, J. C., Bot, I., de Jager, S. C., van Eck, M., Jolley, J., Kuiper, J., Stephens, J., Albers, C. A., Vosmeer, C. R., Kruize, H., Geerke, D. P., van der Wal, A. C., van der Loos, C. M., Kastelein, J. J. P., Trip, M. D., Ouwehand, W. H., Dallinga-Thie, G. M., & 1 othersHovingh, G. K., 30 May 2014, In: PLOS ONE. 9, 5, p. e98289

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    7 Citations (Scopus)

  • Mutations in STAP1 are associated with autosomal dominant hypercholesterolemia

    Fouchier, S. W., Dallinga-Thie, G. M., Meijers, J. C. M., Zelcer, N., Kastelein, J. J. P., Defesche, J. C. & Hovingh, G. K., 2014, In: Circulation Research. 115, 6, p. 552-555

    Research output: Contribution to journal › Article › Academic › peer-review

    138 Citations (Scopus)

  • Nonpharmacological lipoprotein apheresis reduces arterial inflammation in familial hypercholesterolemia

    van Wijk, D. F., Sjouke, B., Figueroa, A., Emami, H., van der Valk, F. M., MacNabb, M. H., Hemphill, L. C., Schulte, D. M., Koopman, M. G., Lobatto, M. E., Verberne, H. J., Fayad, Z. A., Kastelein, J. J. P., Mulder, W. J. M., Hovingh, G. K., Tawakol, A. & Stroes, E. S. G., 2014, In: Journal of the American College of Cardiology. 64, 14, p. 1418-1426

    Research output: Contribution to journal › Article › Academic › peer-review

    87 Citations (Scopus)

  • Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index

    AUTHOR GROUP, Hottenga, J. J., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H., Uitterlinden, A. G., van Duijn, C. M., Visscher, P. M., Rousson, V., Hirschhorn, J. N., Rivolta, C., Loos, R. J. F. & Kutali, Z., 2014, In: PLoS genetics. 10, 7, p. e1004508 12 p., e1004508.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    46 Citations (Scopus)

  • Novel Therapies Focused on the High-Density Lipoprotein Particle

    van Capelleveen, J. C., Brewer, H. B., Kastelein, J. J. P. & Hovingh, G. K., 2014, In: Circulation Research. 114, 1, p. 193-204

    Research output: Contribution to journal › Review article › Academic › peer-review

    32 Citations (Scopus)

  • Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

    AUTHOR GROUP, 2014, In: Nature communications. 5, p. 5068

    Research output: Contribution to journal › Article › Academic › peer-review

    196 Citations (Scopus)

  • Quality control and conduct of genome-wide association meta-analyses

    AUTHOR GROUP, Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Willemsen, G., Penninx, B. W. J. H. & Smit, J. H., 2014, In: Nature protocols. 9, 5, p. 1192-1212 21 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    292 Citations (Scopus)

  • Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: a study of a cohort of 14,000 mutation carriers

    Besseling, J., Kindt, I., Hof, M., Kastelein, J. J. P., Hutten, B. A. & Hovingh, G. K., 2014, In: Atherosclerosis. 233, 1, p. 219-223

    Research output: Contribution to journal › Article › Academic › peer-review

    174 Citations (Scopus)

  • Statin and the risk of renal-related serious adverse events: Analysis from the IDEAL, TNT, CARDS, ASPEN, SPARCL, and other placebo-controlled trials

    Bangalore, S., Fayyad, R., Hovingh, G. K., Laskey, R., Vogt, L., Demicco, D. A. & Waters, D. D., 2014, In: American Journal of Cardiology. 113, 12, p. 2018-2020

    Research output: Contribution to journal › Article › Academic › peer-review

    38 Citations (Scopus)

  • The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management

    Hegele, R. A., Ginsberg, H. N., Chapman, M. J., Nordestgaard, B. G., Kuivenhoven, J. A., Averna, M., Borén, J., Bruckert, E., Catapano, A. L., Descamps, O. S., Hovingh, G. K., Humphries, S. E., Kovanen, P. T., Masana, L., Pajukanta, P., Parhofer, K. G., Raal, F. J., Ray, K. K., Santos, R. D., Stalenhoef, A. F. H., & 5 othersStroes, E., Taskinen, M-R., Tybjærg-Hansen, A., Watts, G. F. & Wiklund, O., 2014, In: Lancet. Diabetes and endocrinology. 2, 8, p. 655-666

    Research output: Contribution to journal › Review article › Academic › peer-review

    458 Citations (Scopus)

  • The value of screening for carotid plaque in patients referred for echocardiography

    Duivenvoorden, R., Stroes, E. S. G. & Hovingh, G. K., 2014, In: Canadian Journal of Cardiology. 30, 10, p. 1148-1149

    Research output: Contribution to journal › Editorial › Academic › peer-review

    1 Citation (Scopus)

  • Towards network analysis to understand the genetic architecture of blood lipids: Do the inclusion of age-dependency helps to identify seven novel loci?

    Dallinga-Thie, G. M. & Hovingh, G. K., 2014, In: Atherosclerosis. 235, 2, p. 642-643

    Research output: Contribution to journal › Editorial › Academic › peer-review

  • Treatment of low HDL-C subjects with the CETP modulator dalcetrapib increases plasma campesterol only in those without ABCA1 and/or ApoA1 mutations

    Niesor, E. J., Kallend, D., Bentley, D., Kastelein, J. J. P., Kees Hovingh, G. & Stroes, E. S. G., 2014, In: Lipids. 49, 12, p. 1245-1249

    Research output: Contribution to journal › Article › Academic › peer-review

    5 Citations (Scopus)

  • Two novel mutations in apolipoprotein C3 underlie atheroprotective lipid profiles in families

    Bochem, A. E., van Capelleveen, J. C., Dallinga-Thie, G. M., Schimmel, A. W. M., Motazacker, M. M., Tietjen, I., Singaraja, R. R., Hayden, M. R., Kastelein, J. J. P., Stroes, E. S. G. & Hovingh, G. K., 2014, In: Clinical genetics. 85, 5, p. 433-440

    Research output: Contribution to journal › Article › Academic › peer-review

    24 Citations (Scopus)

  • Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials

    Boekholdt, S. M., Hovingh, G. K., Mora, S., Arsenault, B. J., Amarenco, P., Pedersen, T. R., LaRosa, J. C., Waters, D. D., Demicco, D. A., Simes, R. J., Keech, A. C., Colquhoun, D., Hitman, G. A., Betteridge, D. J., Clearfield, M. B., Downs, J. R., Colhoun, H. M., Gotto, A. M., Ridker, P. M., Grundy, S. M., & 1 othersKastelein, J. J. P., 2014, In: Journal of the American College of Cardiology. 64, 5, p. 485-494

    Research output: Contribution to journal › Article › Academic › peer-review

    497 Citations (Scopus)
  • 2013

    ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden

    Bochem, A. E., van Wijk, D. F., Holleboom, A. G., Duivenvoorden, R., Motazacker, M. M., Dallinga-Thie, G. M., de Groot, E., Kastelein, J. J. P., Nederveen, A. J., Hovingh, G. K. & Stroes, E. S. G., 2013, In: European Heart journal. 34, 4, p. 286-291

    Research output: Contribution to journal › Article › Academic › peer-review

    62 Citations (Scopus)

  • Antisense oligonucleotides in the treatment of lipid disorders: pitfalls and promises

    Besseling, J., Hovingh, G. K. & Stroes, E. S. G., 2013, In: Netherlands journal of medicine. 71, 3, p. 118-122

    Research output: Contribution to journal › Review article › Academic › peer-review

    8 Citations (Scopus)

  • Common variants associated with plasma triglycerides and risk for coronary artery disease

    Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H-Y., Demirkan, A., den Hertog, H. M., Donnelly, L. A., Ehret, G. B., Esko, T., & 246 othersFeitosa, M. F., Ferreira, T., Fischer, K., Fontanillas, P., Fraser, R. M., Freitag, D. F., Gurdasani, D., Heikkilä, K., Hyppönen, E., Isaacs, A., Jackson, A. U., Johansson, A., Johnson, T., Kaakinen, M., Kettunen, J., Kleber, M. E., Li, X., Luan, J., Lyytikäinen, L-P., Magnusson, P. K. E., Mangino, M., Mihailov, E., Montasser, M. E., Müller-Nurasyid, M., Nolte, I. M., O'Connell, J. R., Palmer, C. D., Perola, M., Petersen, A-K., Sanna, S., Saxena, R., Service, S. K., Shah, S., Shungin, D., Sidore, C., Song, C., Strawbridge, R. J., Surakka, I., Tanaka, T., Teslovich, T. M., Thorleifsson, G., van den Herik, E. G., Voight, B. F., Volcik, K. A., Waite, L. L., Wong, A., Wu, Y., Zhang, W., Absher, D., Asiki, G., Barroso, I., Been, L. F., Bolton, J. L., Bonnycastle, L. L., Brambilla, P., Burnett, M. S., Cesana, G., Dimitriou, M., Doney, A. S. F., Döring, A., Elliott, P., Epstein, S. E., Eyjolfsson, G. I., Gigante, B., Goodarzi, M. O., Grallert, H., Gravito, M. L., Groves, C. J., Hallmans, G., Hartikainen, A-L., Hayward, C., Hernandez, D., Hicks, A. A., Holm, H., Hung, Y-J., Illig, T., Jones, M. R., Kaleebu, P., Kastelein, J. J. P., Khaw, K-T., Kim, E., Klopp, N., Komulainen, P., Kumari, M., Langenberg, C., Lehtimäki, T., Lin, S-Y., Lindström, J., Loos, R. J. F., Mach, F., McArdle, W. L., Meisinger, C., Mitchell, B. D., Müller, G., Nagaraja, R., Narisu, N., Nieminen, T. V. M., Nsubuga, R. N., Olafsson, I., Ong, K. K., Palotie, A., Papamarkou, T., Pomilla, C., Pouta, A., Rader, D. J., Reilly, M. P., Ridker, P. M., Rivadeneira, F., Rudan, I., Ruokonen, A., Samani, N., Scharnagl, H., Seeley, J., Silander, K., Stančáková, A., Stirrups, K., Swift, A. J., Tiret, L., Uitterlinden, A. G., van Pelt, L. J., Vedantam, S., Wainwright, N., Wijmenga, C., Wild, S. H., Willemsen, G., Wilsgaard, T., Wilson, J. F., Young, E. H., Zhao, J. H., Adair, L. S., Arveiler, D., Assimes, T. L., Bandinelli, S., Bennett, F., Bochud, M., Boehm, B. O., Boomsma, D. I., Borecki, I. B., Bornstein, S. R., Bovet, P., Burnier, M., Campbell, H., Chakravarti, A., Chambers, J. C., Chen, Y-D. I., Collins, F. S., Cooper, R. S., Danesh, J., Dedoussis, G., de Faire, U., Feranil, A. B., Ferrières, J., Ferrucci, L., Freimer, N. B., Gieger, C., Groop, L. C., Gudnason, V., Gyllensten, U., Hamsten, A., Harris, T. B., Hingorani, A., Hirschhorn, J. N., Hofman, A., Hovingh, G. K., Hsiung, C. A., Humphries, S. E., Hunt, S. C., Hveem, K., Iribarren, C., Järvelin, M-R., Jula, A., Kähönen, M., Kaprio, J., Kesäniemi, A., Kivimaki, M., Kooner, J. S., Koudstaal, P. J., Krauss, R. M., Kuh, D., Kuusisto, J., Kyvik, K. O., Laakso, M., Lakka, T. A., Lind, L., Lindgren, C. M., Martin, N. G., März, W., McCarthy, M. I., McKenzie, C. A., Meneton, P., Metspalu, A., Moilanen, L., Morris, A. D., Munroe, P. B., Njølstad, I., Pedersen, N. L., Power, C., Pramstaller, P. P., Price, J. F., Psaty, B. M., Quertermous, T., Rauramaa, R., Saleheen, D., Salomaa, V., Sanghera, D. K., Saramies, J., Schwarz, P. E. H., Sheu, W. H-H., Shuldiner, A. R., Siegbahn, A., Spector, T. D., Stefansson, K., Strachan, D. P., Tayo, B. O., Tremoli, E., Tuomilehto, J., Uusitupa, M., van Duijn, C. M., Vollenweider, P., Wallentin, L., Wareham, N. J., Whitfield, J. B., Wolffenbuttel, B. H. R., Altshuler, D., Ordovas, J. M., Boerwinkle, E., Palmer, C. N. A., Thorsteinsdottir, U., Chasman, D. I., Rotter, J. I., Franks, P. W., Ripatti, S., Cupples, L. A., Sandhu, M. S., Rich, S. S., Boehnke, M., Deloukas, P., Mohlke, K. L., Ingelsson, E., Abecasis, G. R., Daly, M. J., Neale, B. M., Kathiresan, S., Stancakova, A., Hovingh, K. G. & Njolstad, I., 2013, In: Nature Genetics. 45, 11, p. 1345-1352

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    673 Citations (Scopus)

  • Diagnosis and treatment of familial hypercholesterolaemia

    Hovingh, G. K., Davidson, M. H., Kastelein, J. J. P. & O'Connor, A. M., 2013, In: European Heart journal. 34, 13, p. 962-971

    Research output: Contribution to journal › Review article › Academic › peer-review

    211 Citations (Scopus)

  • Discovery and refinement of loci associated with lipid levels

    Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H-Y., Demirkan, A., den Hertog, H. M., Do, R., Donnelly, L. A., Ehret, G. B., Esko, T., Feitosa, M. F., & 242 othersFerreira, T., Fischer, K., Fontanillas, P., Fraser, R. M., Freitag, D. F., Gurdasani, D., Heikkilä, K., Hyppönen, E., Isaacs, A., Jackson, A. U., Johansson, A., Johnson, T., Kaakinen, M., Kettunen, J., Kleber, M. E., Li, X., Luan, J., Lyytikäinen, L-P., Magnusson, P. K. E., Mangino, M., Mihailov, E., Montasser, M. E., Müller-Nurasyid, M., Nolte, I. M., O'Connell, J. R., Palmer, C. D., Perola, M., Petersen, A-K., Sanna, S., Saxena, R., Service, S. K., Shah, S., Shungin, D., Sidore, C., Song, C., Strawbridge, R. J., Surakka, I., Tanaka, T., Teslovich, T. M., Thorleifsson, G., van den Herik, E. G., Voight, B. F., Volcik, K. A., Waite, L. L., Wong, A., Wu, Y., Zhang, W., Absher, D., Asiki, G., Barroso, I., Been, L. F., Bolton, J. L., Bonnycastle, L. L., Brambilla, P., Burnett, M. S., Cesana, G., Dimitriou, M., Doney, A. S. F., Döring, A., Elliott, P., Epstein, S. E., Eyjolfsson, G. I., Gigante, B., Goodarzi, M. O., Grallert, H., Gravito, M. L., Groves, C. J., Hallmans, G., Hartikainen, A-L., Hayward, C., Hernandez, D., Hicks, A. A., Holm, H., Hung, Y-J., Illig, T., Jones, M. R., Kaleebu, P., Kastelein, J. J. P., Khaw, K-T., Kim, E., Klopp, N., Komulainen, P., Kumari, M., Langenberg, C., Lehtimäki, T., Lin, S-Y., Lindström, J., Loos, R. J. F., Mach, F., McArdle, W. L., Meisinger, C., Mitchell, B. D., Müller, G., Nagaraja, R., Narisu, N., Nieminen, T. V. M., Nsubuga, R. N., Olafsson, I., Ong, K. K., Palotie, A., Papamarkou, T., Pomilla, C., Pouta, A., Rader, D. J., Reilly, M. P., Ridker, P. M., Rivadeneira, F., Rudan, I., Ruokonen, A., Samani, N., Scharnagl, H., Seeley, J., Silander, K., Stancáková, A., Stirrups, K., Swift, A. J., Tiret, L., Uitterlinden, A. G., van Pelt, L. J., Vedantam, S., Wainwright, N., Wijmenga, C., Wild, S. H., Willemsen, G., Wilsgaard, T., Wilson, J. F., Young, E. H., Zhao, J. H., Adair, L. S., Arveiler, D., Assimes, T. L., Bandinelli, S., Bennett, F., Bochud, M., Boehm, B. O., Boomsma, D. I., Borecki, I. B., Bornstein, S. R., Bovet, P., Burnier, M., Campbell, H., Chakravarti, A., Chambers, J. C., Chen, Y-D. I., Collins, F. S., Cooper, R. S., Danesh, J., Dedoussis, G., de Faire, U., Feranil, A. B., Ferrières, J., Ferrucci, L., Freimer, N. B., Gieger, C., Groop, L. C., Gudnason, V., Gyllensten, U., Hamsten, A., Harris, T. B., Hingorani, A., Hirschhorn, J. N., Hofman, A., Hovingh, G. K., Hsiung, C. A., Humphries, S. E., Hunt, S. C., Hveem, K., Iribarren, C., Järvelin, M-R., Jula, A., Kähönen, M., Kaprio, J., Kesäniemi, A., Kivimaki, M., Kooner, J. S., Koudstaal, P. J., Krauss, R. M., Kuh, D., Kuusisto, J., Kyvik, K. O., Laakso, M., Lakka, T. A., Lind, L., Lindgren, C. M., Martin, N. G., März, W., McCarthy, M. I., McKenzie, C. A., Meneton, P., Metspalu, A., Moilanen, L., Morris, A. D., Munroe, P. B., Njølstad, I., Pedersen, N. L., Power, C., Pramstaller, P. P., Price, J. F., Psaty, B. M., Quertermous, T., Rauramaa, R., Saleheen, D., Salomaa, V., Sanghera, D. K., Saramies, J., Schwarz, P. E. H., Sheu, W. H-H., Shuldiner, A. R., Siegbahn, A., Spector, T. D., Stefansson, K., Strachan, D. P., Tayo, B. O., Tremoli, E., Tuomilehto, J., Uusitupa, M., van Duijn, C. M., Vollenweider, P., Wallentin, L., Wareham, N. J., Whitfield, J. B., Wolffenbuttel, B. H. R., Ordovas, J. M., Boerwinkle, E., Palmer, C. N. A., Thorsteinsdottir, U., Chasman, D. I., Rotter, J. I., Franks, P. W., Ripatti, S., Cupples, L. A., Sandhu, M. S., Rich, S. S., Boehnke, M., Deloukas, P., Kathiresan, S., Mohlke, K. L., Ingelsson, E., Abecasis, G. R., Thorleifson, G., Hovingh, K. G. & Njolstad, I., 2013, In: Nature Genetics. 45, 11, p. 1274-1283

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    2157 Citations (Scopus)

  • Efficacy and safety of mipomersen sodium (Kynamro)

    Hovingh, K., Besseling, J. & Kastelein, J., 2013, In: Expert opinion on drug safety. 12, 4, p. 569-579

    Research output: Contribution to journal › Review article › Academic › peer-review

    26 Citations (Scopus)

  • Evidence of a polygenic origin of extreme high-density lipoprotein cholesterol levels

    Motazacker, M. M., Peter, J., Treskes, M., Shoulders, C. C., Kuivenhoven, J. A. & Hovingh, G. K., 2013, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 7, p. 1521-1528

    Research output: Contribution to journal › Article › Academic › peer-review

    49 Citations (Scopus)

  • Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia

    Stitziel, N. O., Fouchier, S. W., Sjouke, B., Peloso, G. M., Moscoso, A. M., Auer, P. L., Goel, A., Gigante, B., Barnes, T. A., Melander, O., Orho-Melander, M., Duga, S., Sivapalaratnam, S., Nikpay, M., Martinelli, N., Girelli, D., Jackson, R. D., Kooperberg, C., Lange, L. A., Ardissino, D., & 17 othersMcPherson, R., Farrall, M., Watkins, H., Reilly, M. P., Rader, D. J., de Faire, U., Schunkert, H., Erdmann, J., Samani, N. J., Charnas, L., Altshuler, D., Gabriel, S., Kastelein, J. J. P., Defesche, J. C., Nederveen, A. J., Kathiresan, S. & Hovingh, G. K., 2013, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 12, p. 2909-2914

    Research output: Contribution to journal › Article › Academic › peer-review

    76 Citations (Scopus)

  • Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society

    Nordestgaard, B. G., Chapman, M. J., Humphries, S. E., Ginsberg, H. N., Masana, L., Descamps, O. S., Wiklund, O., Hegele, R. A., Raal, F. J., Defesche, J. C., Wiegman, A., Santos, R. D., Watts, G. F., Parhofer, K. G., Hovingh, G. K., Kovanen, P. T., Boileau, C., Averna, M., Borén, J., Bruckert, E., & 8 othersCatapano, A. L., Kuivenhoven, J. A., Pajukanta, P., Ray, K., Stalenhoef, A. F. H., Stroes, E., Taskinen, M-R. & Tybjærg-Hansen, A., 2013, In: European Heart journal. 34, 45, p. 3478-390a

    Research output: Contribution to journal › Article › Academic › peer-review

    2065 Citations (Scopus)

  • Familial LCAT deficiency: from renal replacement to enzyme replacement

    Stoekenbroek, R. M., van den Bergh Weerman, M. A., Hovingh, G. K., Potter van Loon, B. J., Siegert, C. E. H. & Holleboom, A. G., 2013, In: Netherlands journal of medicine. 71, 1, p. 29-31

    Research output: Contribution to journal › Article › Academic › peer-review

    12 Citations (Scopus)

  • Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals

    AUTHOR GROUP, 2013, In: Human Molecular Genetics. 22, 1, p. 184-201

    Research output: Contribution to journal › Article › Academic › peer-review

    70 Citations (Scopus)

  • Genetics of HDL-C: a causal link to atherosclerosis?

    van Capelleveen, J. C., Bochem, A. E., Motazacker, M. M., Hovingh, G. K. & Kastelein, J. J. P., 2013, In: Current Atherosclerosis Reports. 15, 6, p. 326

    Research output: Contribution to journal › Article › Academic › peer-review

    30 Citations (Scopus)

  • Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

    Berndt, S. I., Gustafsson, S., Mägi, R., Ganna, A., Wheeler, E., Feitosa, M. F., Justice, A. E., Monda, K. L., Croteau-Chonka, D. C., Day, F. R., Esko, T., Fall, T., Ferreira, T., Gentilini, D., Jackson, A. U., Luan, J., Randall, J. C., Vedantam, S., Willer, C. J., Winkler, T. W., & 309 othersWood, A. R., Workalemahu, T., Hu, Y-J., Lee, S. H., Liang, L., Lin, D-Y., Min, J. L., Neale, B. M., Thorleifsson, G., Yang, J., Albrecht, E., Amin, N., Bragg-Gresham, J. L., Cadby, G., den Heijer, M., Eklund, N., Fischer, K., Goel, A., Hottenga, J-J., Huffman, J. E., Jarick, I., Johansson, A., Johnson, T., Kanoni, S., Kleber, M. E., König, I. R., Kristiansson, K., Kutalik, Z., Lamina, C., Lecoeur, C., Li, G., Mangino, M., McArdle, W. L., Medina-Gomez, C., Müller-Nurasyid, M., Ngwa, J. S., Nolte, I. M., Paternoster, L., Pechlivanis, S., Perola, M., Peters, M. J., Preuss, M., Rose, L. M., Shi, J., Shungin, D., Smith, A. V., Strawbridge, R. J., Surakka, I., Teumer, A., Trip, M. D., Tyrer, J., van Vliet-Ostaptchouk, J. V., Vandenput, L., Waite, L. L., Zhao, J. H., Absher, D., Asselbergs, F. W., Atalay, M., Attwood, A. P., Balmforth, A. J., Basart, H., Beilby, J., Bonnycastle, L. L., Brambilla, P., Bruinenberg, M., Campbell, H., Chasman, D. I., Chines, P. S., Collins, F. S., Connell, J. M., Cookson, W. O., de Faire, U., de Vegt, F., dei, M., Dimitriou, M., Edkins, S., Estrada, K., Evans, D. M., Farrall, M., Ferrario, M. M., Ferrières, J., Franke, L., Frau, F., Gejman, P. V., Grallert, H., Grönberg, H., Gudnason, V., Hall, A. S., Hall, P., Hartikainen, A-L., Hayward, C., Heard-Costa, N. L., Heath, A. C., Hebebrand, J., Homuth, G., Hu, F. B., Hunt, S. E., Hyppönen, E., Iribarren, C., Jacobs, K. B., Jansson, J-O., Jula, A., Kähönen, M., Kathiresan, S., Kee, F., Khaw, K-T., Kivimäki, M., Koenig, W., Kraja, A. T., Kumari, M., Kuulasmaa, K., Kuusisto, J., Laitinen, J. H., Lakka, T. A., Langenberg, C., Launer, L. J., Lind, L., Lindström, J., Liu, J., Liuzzi, A., Lokki, M-L., Lorentzon, M., Madden, P. A., Magnusson, P. K., Manunta, P., Marek, D., März, W., Mateo Leach, I., McKnight, B., Medland, S. E., Mihailov, E., Milani, L., Montgomery, G. W., Mooser, V., Mühleisen, T. W., Munroe, P. B., Musk, A. W., Narisu, N., Navis, G., Nicholson, G., Nohr, E. A., Ong, K. K., Oostra, B. A., Palmer, C. N. A., Palotie, A., Peden, J. F., Pedersen, N., Peters, A., Polasek, O., Pouta, A., Pramstaller, P. P., Prokopenko, I., Pütter, C., Radhakrishnan, A., Raitakari, O., Rendon, A., Rivadeneira, F., Rudan, I., Saaristo, T. E., Sambrook, J. G., Sanders, A. R., Sanna, S., Saramies, J., Schipf, S., Schreiber, S., Schunkert, H., Shin, S-Y., Signorini, S., Sinisalo, J., Skrobek, B., Soranzo, N., Stančáková, A., Stark, K., Stephens, J. C., Stirrups, K., Stolk, R. P., Stumvoll, M., Swift, A. J., Theodoraki, E. V., Thorand, B., Tregouet, D-A., Tremoli, E., van der Klauw, M. M., van Meurs, J. B. J., Vermeulen, S. H., Viikari, J., Virtamo, J., Vitart, V., Waeber, G., Wang, Z., Widén, E., Wild, S. H., Willemsen, G., Winkelmann, B. R., Witteman, J. C. M., Wolffenbuttel, B. H. R., Wong, A., Wright, A. F., Zillikens, M. C., Amouyel, P., Boehm, B. O., Boerwinkle, E., Boomsma, D. I., Caulfield, M. J., Chanock, S. J., Cupples, L. A., Cusi, D., Dedoussis, G. V., Erdmann, J., Eriksson, J. G., Franks, P. W., Froguel, P., Gieger, C., Gyllensten, U., Hamsten, A., Harris, T. B., Hengstenberg, C., Hicks, A. A., Hingorani, A., Hinney, A., Hofman, A., Hovingh, K. G., Hveem, K., Illig, T., Jarvelin, M-R., Jöckel, K-H., Keinanen-Kiukaanniemi, S. M., Kiemeney, L. A., Kuh, D., Laakso, M., Lehtimäki, T., Levinson, D. F., Martin, N. G., Metspalu, A., Morris, A. D., Nieminen, M. S., Njølstad, I., Ohlsson, C., Oldehinkel, A. J., Ouwehand, W. H., Palmer, L. J., Penninx, B., Power, C., Province, M. A., Psaty, B. M., Qi, L., Rauramaa, R., Ridker, P. M., Ripatti, S., Salomaa, V., Samani, N. J., Snieder, H., Sørensen, T. I. A., Spector, T. D., Stefansson, K., Tönjes, A., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., van der Harst, P., Vollenweider, P., Wallaschofski, H., Wareham, N. J., Watkins, H., Wichmann, H. -E., Wilson, J. F., Abecasis, G. R., Assimes, T. L., Barroso, I., Boehnke, M., Borecki, I. B., Deloukas, P., Fox, C. S., Frayling, T., Groop, L. C., Haritunian, T., Heid, I. M., Hunter, D., Kaplan, R. C., Karpe, F., Moffatt, M. F., Mohlke, K. L., O'Connell, J. R., Pawitan, Y., Schadt, E. E., Schlessinger, D., Steinthorsdottir, V., Strachan, D. P., Thorsteinsdottir, U., van Duijn, C. M., Visscher, P. M., Di Blasio, A. M., Hirschhorn, J. N., Lindgren, C. M., Morris, A. P., Meyre, D., Scherag, A., McCarthy, M. I., Speliotes, E. K., North, K. E., Loos, R. J. F., Ingelsson, E., Stancakova, A., Wolfenbuttel, B. H. R., Järvelin, M. R., Keinanen-Kiukaanniemie, S., Njolstad, I., Sorensen, T. I. A. & Moffat, M. F., 2013, In: Nature Genetics. 45, 5, p. 501-512

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    471 Citations (Scopus)

  • High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-C

    Bochem, A. E., Holleboom, A. G., Romijn, J. A., Hoekstra, M., Dallinga-Thie, G. M., Motazacker, M. M., Hovingh, G. K., Kuivenhoven, J. A. & Stroes, E. S. G., 2013, In: Journal of Lipid Research. 54, 6, p. 1698-1704

    Research output: Contribution to journal › Article › Academic › peer-review

    48 Citations (Scopus)

  • Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: studies in mice and FH children

    Tolani, S., Pagler, T. A., Murphy, A. J., Bochem, A. E., Abramowicz, S., Welch, C., Nagareddy, P. R., Holleran, S., Hovingh, G. K., Kuivenhoven, J. A. & Tall, A. R., 2013, In: Atherosclerosis. 229, 1, p. 79-85

    Research output: Contribution to journal › Article › Academic › peer-review

    92 Citations (Scopus)

  • Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein

    Sorrentino, V., Fouchier, S. W., Motazacker, M. M., Nelson, J. K., Defesche, J. C., Dallinga-Thie, G. M., Kastelein, J. J. P., Kees Hovingh, G. & Zelcer, N., 2013, In: European Heart journal. 34, 17, p. 1292-1297

    Research output: Contribution to journal › Article › Academic › peer-review

    48 Citations (Scopus)

  • In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1

    Holleboom, A. G., Jakulj, L., Franssen, R., Decaris, J., Vergeer, M., Koetsveld, J., Luchoomun, J., Glass, A., Hellerstein, M. K., Kastelein, J. J. P., Hovingh, G. K., Kuivenhoven, J. A., Groen, A. K., Turner, S. M. & Stroes, E. S. G., 2013, In: Journal of Lipid Research. 54, 7, p. 1964-1971

    Research output: Contribution to journal › Article › Academic › peer-review

    23 Citations (Scopus)

  • Large-scale association analysis identifies new risk loci for coronary artery disease

    Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., Thompson, J. R., Ingelsson, E., Saleheen, D., Erdmann, J., Goldstein, B. A., Stirrups, K., König, I. R., Cazier, J-B., Johansson, A., Hall, A. S., Lee, J-Y., Willer, C. J., Chambers, J. C., Esko, T., Folkersen, L., & 163 othersGoel, A., Grundberg, E., Havulinna, A. S., Ho, W. K., Hopewell, J. C., Eriksson, N., Kleber, M. E., Kristiansson, K., Lundmark, P., Lyytikäinen, L-P., Rafelt, S., Shungin, D., Strawbridge, R. J., Thorleifsson, G., Tikkanen, E., van Zuydam, N., Voight, B. F., Waite, L. L., Zhang, W., Ziegler, A., Absher, D., Altshuler, D., Balmforth, A. J., Barroso, I., Braund, P. S., Burgdorf, C., Claudi-Boehm, S., Cox, D., Dimitriou, M., Do, R., Doney, A. S. F., El Mokhtari, N., Eriksson, P., Fischer, K., Fontanillas, P., Franco-Cereceda, A., Gigante, B., Groop, L., Gustafsson, S., Hager, J., Hallmans, G., Han, B-G., Hunt, S. E., Kang, H. M., Illig, T., Kessler, T., Knowles, J. W., Kolovou, G., Kuusisto, J., Langenberg, C., Langford, C., Leander, K., Lokki, M-L., Lundmark, A., McCarthy, M. I., Meisinger, C., Melander, O., Mihailov, E., Maouche, S., Morris, A. D., Müller-Nurasyid, M., Nikus, K., Peden, J. F., Rayner, N. W., Rasheed, A., Rosinger, S., Rubin, D., Rumpf, M. P., Schäfer, A., Sivananthan, M., Song, C., Stewart, A. F. R., Tan, S-T., Thorgeirsson, G., van der Schoot, C. E., Wagner, P. J., Wells, G. A., Wild, P. S., Yang, T-P., Amouyel, P., Arveiler, D., Basart, H., Boehnke, M., Boerwinkle, E., Brambilla, P., Cambien, F., Cupples, A. L., de Faire, U., Dehghan, A., Diemert, P., Epstein, S. E., Evans, A., Ferrario, M. M., Ferrières, J., Gauguier, D., Go, A. S., Goodall, A. H., Gudnason, V., Hazen, S. L., Holm, H., Iribarren, C., Jang, Y., Kähönen, M., Kee, F., Kim, H-S., Klopp, N., Koenig, W., Kratzer, W., Kuulasmaa, K., Laakso, M., Laaksonen, R., Lee, J-Y., Lind, L., Ouwehand, W. H., Parish, S., Park, J. E., Pedersen, N. L., Peters, A., Quertermous, T., Rader, D. J., Salomaa, V., Schadt, E., Shah, S. H., Sinisalo, J., Stark, K., Stefansson, K., Trégouët, D-A., Virtamo, J., Wallentin, L., Wareham, N., Zimmermann, M. E., Nieminen, M. S., Hengstenberg, C., Sandhu, M. S., Pastinen, T., Syvänen, A-C., Hovingh, G. K., Dedoussis, G., Franks, P. W., Lehtimäki, T., Metspalu, A., Zalloua, P. A., Siegbahn, A., Schreiber, S., Ripatti, S., Blankenberg, S. S., Perola, M., Clarke, R., Boehm, B. O., O'Donnell, C., Reilly, M. P., März, W., Collins, R., Kathiresan, S., Hamsten, A., Kooner, J. S., Thorsteinsdottir, U., Danesh, J., Palmer, C. N. A., Roberts, R., Watkins, H., Schunkert, H. & Samani, N. J., 2013, In: Nature Genetics. 45, 1, p. 25-33

    Research output: Contribution to journal › Article › Academic › peer-review

    1313 Citations (Scopus)

  • LDL cholesterol goals in high-risk patients: how low do we go and how do we get there?

    Besseling, J., van Capelleveen, J., Kastelein, J. J. P. & Hovingh, G. K., 2013, In: Drugs. 73, 4, p. 293-301

    Research output: Contribution to journal › Article › Academic › peer-review

    19 Citations (Scopus)

  • Levels and changes of HDL cholesterol and apolipoprotein A-I in relation to risk of cardiovascular events among statin-treated patients: a meta-analysis

    Boekholdt, S. M., Arsenault, B. J., Hovingh, G. K., Mora, S., Pedersen, T. R., LaRosa, J. C., Welch, K. M. A., Amarenco, P., Demicco, D. A., Tonkin, A. M., Sullivan, D. R., Kirby, A., Colhoun, H. M., Hitman, G. A., Betteridge, D. J., Durrington, P. N., Clearfield, M. B., Downs, J. R., Gotto, A. M., Ridker, P. M., & 1 othersKastelein, J. J. P., 2013, In: Circulation. 128, 14, p. 1504-1512

    Research output: Contribution to journal › Article › Academic › peer-review

    157 Citations (Scopus)

  • Loci influencing blood pressure identified using a cardiovascular gene-centric array

    Ganesh, S. K., Tragante, V., Guo, W., Guo, Y. R., Lanktree, M. B., Smith, E. N., Johnson, T., Castillo, B. A., Barnard, J., Baumert, J., Chang, Y. P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Franceschini, N., Gaunt, T. R., Gho, J. M. I. H., Gieger, C., Gong, Y., Isaacs, A., & 117 othersKleber, M. E., Leach, I. M., McDonough, C. W., Meijs, M. F. L., Mellander, O., Molony, C. M., Nolte, I. M., Padmanabhan, S., Price, T. S., Rajagopalan, R., Shaffer, J., Shah, S., Shen, H. Q., Soranzo, N., van der Most, P. J., van Iperen, E. P. A., Van Setten, J. A., Vonk, J. M., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Boer, J. M. A., Boerwinkle, E., Burkley, B., Burt, A., Chakravarti, A., Chen, W., Cooper-DeHoff, R. M., Curtis, S. P., Dreisbach, A., Duggan, D., Ehret, G. B., Fabsitz, R. R., Fornage, M., Fox, E., Furlong, C. E., Gansevoort, R. T., Hofker, M. H., Hovingh, G. K., Kirkland, S. A., Kottke-Marchant, K., Kutlar, A., LaCroix, A. Z., Langaee, T. Y., Li, Y. R., Lin, H. H., Liu, K., Maiwald, S., Malik, R., Murugesan, G., Newton-Cheh, C., OConnell, J. R., Onland-Moret, N. C., Ouwehand, W. H., Palmas, W., Penninx, B. W. J. H., Pepine, C. J., Pettinger, M., Polak, J. F., Ramachandran, V. S., Ranchalis, J., Redline, S., Ridker, P. M., Rose, L. M., Scharnag, H., Schork, N. J., Shimbo, D., Shuldiner, A. R., Srinivasan, S. R., Stolk, R. P., Taylor, H. A., Thorand, B., Trip, M. D., van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Winkelmann, B. R., Wyatt, S., Keating, B. J., Asselbergs, F. W., O'Connell, J. R., Young, J. H., Boehm, B. O., Caulfield, M. J., Chasman, D. I., Davidson, K. W., Doevendans, P. A., FitzGerald, G. A., Gums, J. G., Hakonarson, H., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J. P., Koenig, W., März, W., Mitchell, B. D., Murray, S. S., Oldehinkel, A. J., Rader, D. J., Reilly, M. P., Reiner, A. P., Schadt, E. E., Silverstein, R. L., Snieder, H., Stanton, A. V., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Samani, N. J., Johnson, A. D., Munroe, P. B., de Bakker, P. I. W., Zhu, X. & Levy, D., 2013, In: Human Molecular Genetics. 22, 8, p. 1663-1678

    Research output: Contribution to journal › Article › Academic › peer-review

    109 Citations (Scopus)

  • Loci influencing blood pressure identified using a cardiovascular gene-centric array

    Ganesh, S. K., Tragante, V., Guo, W., Guo, Y., Lanktree, M. B., Smith, E. N., Johnson, T., Castillo, B. A., Barnard, J., Baumert, J., Chang, Y-P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Gaunt, N. F., H. Gho, J. M. I., Gieger, C., Gong, Y., Isaacs, A., Kleber, M. E., & 116 othersLeach, I. M., McDonough, C. W., Meijs, M. F. L., Mellander, O., Molony, C. M., Nolte, I. M., Price, S. P., Rajagopalan, R., Shaffer, J., Shah, S., Shen, H., Soranzo, N., van der Most, P. J., van Iperen, E. P. A., van Setten, J., Vonk, J. M., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Boer, J. M. A., Boerwinkle, E., Burkley, B., Burt, A., Chakravarti, A., Chen, W., Cooper-DeHoff, R. M., Curtis, S. P., Dreisbach, A., Duggan, D., Ehret, G. B., Fabsitz, R. R., Fornage, M., Fox, E., Furlong, C. E., Gansevoort, R. T., Hofker, M. H., Hovingh, G. K., Kirkland, S. A., Kottke-Marchant, K., Kutlar, A., LaCroix, A. Z., Langaee, T. Y., Li, Y. R., Lin, H., Liu, K., Maiwald, S., Malik, R., Metastroke, C., Murugesan, G., Newton-Cheh, C., O'Connell, J. R., Onland-Moret, N. C., Ouwehand, W. H., Palmas, W., Penninx, B. W., Pepine, C. J., Pettinger, M., Polak, J. F., Ramachandran, V. S., Ranchalis, J., Redline, S., Ridker, P. M., Rose, L. M., Scharnag, H., Schork, N. J., Shimbo, D., Shuldiner, A. R., Srinivasan, S. R., Stolk, R. P., Taylor, H. A., Thorand, B., Trip, M. D., van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Winkelmann, B. R., Wyatt, S., Young, J. H., Boehm, B. O., Caulfield, M. J., Chasman, D. I., Davidson, K. W., Doevendans, P. A., FitzGerald, G. A., Gums, J. G., Hakonarson, H., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J. P., Koenig, W., Study, L. C., rz, W. M., Mitchell, B. D., Murray, S. S., Oldehinkel, A. J., Rader, D. J., Reilly, M. P., Reiner, A. P., Schadt, E. E., Silverstein, R. L., Snieder, H., Stanton, A. V., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Samani, N. J., Johnson, A. D., Munroe, P. B., de Bakker, P. I. W., Zhu, X., Levy, D., Keating, B. J. & Asselbergs, F. W., Aug 2013, In: Human Molecular Genetics. 22, 16, p. 3394-3395

    Research output: Contribution to journal › Erratum/Corrigendum › Academic

    10 Citations (Scopus)

  • Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics

    AUTHOR GROUP, Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H. & van Duijn, C. M., 2013, In: American journal of human genetics. 93, 2, p. 236-248

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    49 Citations (Scopus)

  • Plasma amyloid-β in patients with Tangier disease

    Shahim, P., Bochem, A. E., Mattsson, N., Lautner, R., Blennow, K., Hovingh, G. K., Motazacker, M. M. & Zetterberg, H., 2013, In: Journal of Alzheimer s disease. 35, 2, p. 307-312

    Research output: Contribution to journal › Article › Academic › peer-review

    3 Citations (Scopus)

  • Recent failures in antiatherosclerotic drug development: examples from the thyroxin receptor agonist, the secretory phospholipase A2 antagonist, and the acyl coenzyme A: cholesterol acyltransferase inhibitor programs

    Stoekenbroek, R. M., Kastelein, J. J. P. & Hovingh, G. K., 2013, In: Current opinion in lipidology. 24, 6, p. 459-466

    Research output: Contribution to journal › Review article › Academic › peer-review

    6 Citations (Scopus)

  • Secretory Phospholipase A2-IIA and Cardiovascular Disease: A Mendelian Randomization Study

    Holmes, M. V., Simon, T., Exeter, H. J., Folkersen, L., Asselbergs, F. W., Guardiola, M., Cooper, J. A., Palmen, J., Hubacek, J. A., Carruthers, K. F., Horne, B. D., Brunisholz, K. D., Mega, J. L., van Iperen, E. P. A., Li, M., Leusink, M., Trompet, S., Verschuren, J. J. W., Hovingh, G. K., Dehghan, A., & 93 othersNelson, C. P., Kotti, S., Danchin, N., Scholz, M., Haase, C. L., Rothenbacher, D., Swerdlow, D. I., Kuchenbaecker, K. B., Staines-Urias, E., Goel, A., van 't Hooft, F., Gertow, K., de Faire, U., Panayiotou, A. G., Tremoli, E., Baldassarre, D., Veglia, F., Holdt, L. M., Beutner, F., Gansevoort, R. T., Navis, G. J., Mateo Leach, I., Breitling, L. P., Brenner, H., Thiery, J., Dallmeier, D., Franco-Cereceda, A., Boer, J. M. A., Stephens, J. W., Hofker, M. H., Tedgui, A., Hofman, A., Uitterlinden, A. G., Adamkova, V., Pitha, J., Onland-Moret, N. C., Cramer, M. J., Nathoe, H. M., Spiering, W., Klungel, O. H., Kumari, M., Whincup, P. H., Morrow, D. A., Braund, P. S., Hall, A. S., Olsson, A. G., Doevendans, P. A., Trip, M. D., Tobin, M. D., Hamsten, A., Watkins, H., Koenig, W., Nicolaides, A. N., Teupser, D., Day, I. N. M., Carlquist, J. F., Gaunt, T. R., Ford, I., Sattar, N., Tsimikas, S., Schwartz, G. G., Lawlor, D. A., Morris, R. W., Sandhu, M. S., Poledne, R., Maitland-van der Zee, A. H., Khaw, K-T., Keating, B. J., van der Harst, P., Price, J. F., Mehta, S. R., Yusuf, S., Witteman, J. C. M., Franco, O. H., Jukema, J. W., de Knijff, P., Tybjaerg-Hansen, A., Rader, D. J., Farrall, M., Samani, N. J., Kivimaki, M., Fox, K. A. A., Humphries, S. E., Anderson, J. L., Boekholdt, S. M., Palmer, T. M., Eriksson, P., Paré, G., Hingorani, A. D., Sabatine, M. S., Mallat, Z., Casas, J. P. & Talmud, P. J., 2013, In: Journal of the American College of Cardiology. 62, 21, p. 1966-1976

    Research output: Contribution to journal › Article › Academic › peer-review

    100 Citations (Scopus)

  • Sex-stratified Genome-wide Association Studies Including 270000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

    Randall, J. C., Winkler, T. W., Kutalik, Z., Berndt, S. I., Jackson, A. U., Monda, K. L., Kilpeläinen, T. O., Esko, T., Mägi, R., Li, S., Workalemahu, T., Feitosa, M. F., Croteau-Chonka, D. C., Day, F. R., Fall, T., Ferreira, T., Gustafsson, S., Locke, A. E., Mathieson, I., Scherag, A., & 247 othersVedantam, S., Wood, A. R., Liang, L., Steinthorsdottir, V., Thorleifsson, G., Dermitzakis, E. T., Dimas, A. S., Karpe, F., Min, J. L., Nicholson, G., Clegg, D. J., Person, T., Krohn, J. P., Bauer, S., Buechler, C., Eisinger, K., Bonnefond, A., Froguel, P., Hottenga, J. J., Prokopenko, I., Waite, L. L., Harris, T. B., Smith, A. V., Shuldiner, A. R., McArdle, W. L., Caulfield, M. J., Munroe, P. B., Grönberg, H., Chen, Y. D., Li, G., Beckmann, J. S., Johnson, T., Thorsteinsdottir, U., Teder-Laving, M., Khaw, K. T., Wareham, N. J., Zhao, J. H., Amin, N., Oostra, B. A., Kraja, A. T., Province, M. A., Cupples, L. A., Heard-Costa, N. L., Kaprio, J., Ripatti, S., Surakka, I., Collins, F. S., Saramies, J., Tuomilehto, J., Jula, A., Salomaa, V., Erdmann, J., Hengstenberg, C., Loley, C., Schunkert, H., Lamina, C., Wichmann, H. E., Albrecht, E., Gieger, C., Hicks, A. A., Johansson, A., Pramstaller, P. P., Kathiresan, S., Speliotes, E. K., Penninx, B. W. J. H., Hartikainen, A. L., Järvelin, M. R., Gyllensten, U., Boomsma, D. I., Campbell, H., Wilson, J. F., Chanock, S. J., Farrall, M., Goel, A., Medina-Gomez, C., Rivadeneira, F., Estrada, K., Uitterlinden, A. G., Hofman, A., Zillikens, M. C., den Heijer, M., Kiemeney, L. A., Maschio, A., Hall, P., Tyrer, J., Teumer, A., Völzke, H., Kovacs, P., Tönjes, A., Mangino, M., Spector, T. D., Hayward, C., Rudan, I., Hall, A. S., Samani, N. J., Attwood, A. P., Sambrook, J. G., Hung, J., Palmer, L. J., Lokki, M. L., Sinisalo, J., Boucher, G., Huikuri, H. V., Lorentzon, M., Ohlsson, C., Eklund, N., Eriksson, J. G., Barlassina, C., Rivolta, C., Nolte, I. M., Snieder, H., van der Klauw, M. M., van Vliet-Ostaptchouk, J. V., Gejman, P. V., Shi, J., Jacobs, K. B., Wang, Z., Bakker, S. J., Mateo Leach, I., Navis, G., van der Harst, P., Martin, N. G., Medland, S. E., Montgomery, G. W., Yang, J., Chasman, D. I., Ridker, P. M., Rose, L. M., Lehtimäki, T., Raitakari, O., Absher, D., Iribarren, C., Basart, H., Hovingh, K. G., Hyppönen, E., Power, C., Anderson, D., Beilby, J. P., Hui, J., Jolley, J., Sager, H., Bornstein, S. R., Schwarz, P. E., Kristiansson, K., Perola, M., Lindström, J., Swift, A. J., Uusitupa, M., Atalay, M., Lakka, T. A., Rauramaa, R., Bolton, J. L., Fowkes, G., Fraser, R. M., Price, J. F., Fischer, K., Krjuta Kov, K., Metspalu, A., Mihailov, E., Langenberg, C., Luan, J., Ong, K. K., Chines, P. S., Keinanen-Kiukaanniemie, S., Saaristo, T. E., Edkins, S., Franks, P. W., Hallmans, G., Shungin, D., Morris, A. D., Palmer, C. N. A., Erbel, R., Moebus, S., Nöthen, M. M., Pechlivanis, S., Hveem, K., Narisu, N., Hamsten, A., Humphries, S. E., Strawbridge, R. J., Tremoli, E., Grallert, H., Thorand, B., Illig, T., Koenig, W., Müller-Nurasyid, M., Peters, A., Boehm, B. O., Kleber, M. E., März, W., Winkelmann, B. R., Kuusisto, J., Laakso, M., Arveiler, D., Cesana, G., Kuulasmaa, K., Virtamo, J., Yarnell, J. W., Kuh, D., Wong, A., Lind, L., de Faire, U., Gigante, B., Magnusson, P. K. E., Pedersen, N. L., Dedoussis, G., Dimitriou, M., Kolovou, G., Kanoni, S., Stirrups, K., Bonnycastle, L. L., Njolstad, I., Wilsgaard, T., Ganna, A., Rehnberg, E., Hingorani, A. D., Kivimaki, M., Kumari, M., Assimes, T. L., Barroso, I., Boehnke, M., Borecki, I. B., Deloukas, P., Fox, C. S., Frayling, T. M., Groop, L. C., Haritunians, T., Hunter, D., Ingelsson, E., Kaplan, R., Mohlke, K. L., O'Connell, J. R., Schlessinger, D., Strachan, D. P., Stefansson, K., van Duijn, C. M., Abecasis, G. R., McCarthy, M. I., Hirschhorn, J. N., Qi, L., Loos, R. J., Lindgren, C. M., North, K. E., Heid, I. M., Jarvelin, M-R., Keinanen-Kiukaanniemi, S. M. & Njølstad, I., 2013, In: PLoS genetics. 9, 6, p. e1003500 e1003500.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    306 Citations (Scopus)

  • Statin therapy and levels of hemostatic factors in a healthy population: the Multi-Ethnic Study of Atherosclerosis: a rebuttal

    Besseling, J., Hutten, B. A., Meijers, J. C. M., Trip, M. D. & Hovingh, G. K., 2013, In: Journal of thrombosis and haemostasis. 11, 9, p. 1787-1788

    Research output: Contribution to journal › Comment/Letter to the editor › Academic

    2 Citations (Scopus)

  • The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans

    Singaraja, R. R., Sivapalaratnam, S., Hovingh, K., Dubé, M-P., Castro-Perez, J., Collins, H. L., Adelman, S. J., Riwanto, M., Manz, J., Hubbard, B., Tietjen, I., Wong, K., Mitnaul, L. J., van Heek, M., Lin, L., Roddy, T. A., McEwen, J., Dallinge-Thie, G., van Vark-van der Zee, L., Verwoert, G., & 10 othersWinther, M., van Duijn, C., Hofman, A., Trip, M. D., Marais, A. D., Asztalos, B., Landmesser, U., Sijbrands, E., Kastelein, J. J. & Hayden, M. R., 2013, In: Circulation. Cardiovascular genetics. 6, 1, p. 54-62

    Research output: Contribution to journal › Article › Academic › peer-review

    54 Citations (Scopus)
  • 2012

    Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia

    Motazacker, M. M., Pirruccello, J., Huijgen, R., Do, R., Gabriel, S., Peter, J., Kuivenhoven, J. A., Defesche, J. C., Kastelein, J. J. P., Hovingh, G. K., Zelcer, N., Kathiresan, S. & Fouchier, S. W., 2012, In: European Heart journal. 33, 11, p. 1360-1366

    Research output: Contribution to journal › Article › Academic › peer-review

    70 Citations (Scopus)