Tytgat Institute for Liver and Intestinal Research

Research output

Research output per year 1980 2002 2006 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

• 993 Article
• 144 Review article
• 35 Comment/Letter to the editor
• 30 Editorial
• 59 More
  • 27 Phd-Thesis - Research and graduation internal
  • 18 Chapter
  • 4 Erratum/Corrigendum
  • 3 Book editing
  • 2 Poster
  • 2 Letter
  • 2 Short survey
  • 1 Abstract

Research output per year

Research output per year

Search results

• 2012

  Systematic review: acute liver failure - one disease, more than 40 definitions

  Wlodzimirow, K. A., Eslami, S., Abu-Hanna, A., Nieuwoudt, M. & Chamuleau, R. A. F. M., 2012, In: Alimentary pharmacology & therapeutics. 35, 11, p. 1245-1256

  Research output: Contribution to journal › Review article › Academic › peer-review
  87 Citations (Scopus)

• The biliary HCO3- umbrella: experimental evidence revisited

  Beuers, U., Maroni, L. & Elferink, R. O., 2012, In: Current opinion in gastroenterology. 28, 3, p. 253-257

  Research output: Contribution to journal › Review article › Academic › peer-review
  46 Citations (Scopus)

• The challenge of cholestatic pruritus

  Bolier, A. R., Peri, S., Oude Elferink, R. P. J. & Beuers, U., 2012, In: Acta gastro-enterologica belgica. 75, 4, p. 399-404

  Research output: Contribution to journal › Review article › Academic › peer-review

  12 Citations (Scopus)

• Transcriptional control of innate lymphoid cells

  Mjösberg, J., Bernink, J., Peters, C. & Spits, H., 2012, In: European journal of immunology. 42, 8, p. 1916-1923

  Research output: Contribution to journal › Review article › Academic › peer-review
  53 Citations (Scopus)

• What an endoscopist should know about immunoglobulin-G4-associated disease of the pancreas and biliary tree

  Maillette De Buy Wenniger, L., Rauws, E. A. & Beuers, U., 2012, In: Endoscopy. 44, 1, p. 66-73 8 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  31 Citations (Scopus)
• 2011

  Mammalian clock output mechanisms

  Kalsbeek, A., Yi, C-X., Cailotto, C., la Fleur, S. E., Fliers, E. & Buijs, R. M., 2011, In: Essays in biochemistry. 49, 1, p. 137-151

  Research output: Contribution to journal › Review article › Academic › peer-review
  52 Citations (Scopus)

• Pathophysiology and current management of pruritus in liver disease

  Kremer, A. E., Oude Elferink, R. P. J. & Beuers, U., 2011, In: Clinics and research in hepatology and gastroenterology. 35, 2, p. 89-97

  Research output: Contribution to journal › Review article › Academic › peer-review
  90 Citations (Scopus)

• Targeting the ABCB4 gene to control cholesterol homeostasis

  Oude Elferink, R. P. & Beuers, U., 2011, In: Expert Opinion on Therapeutic Targets. 15, 10, p. 1173-1182

  Research output: Contribution to journal › Review article › Academic › peer-review
  17 Citations (Scopus)

• The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

  Spits, H. & Di Santo, J. P., 2011, In: Nature immunology. 12, 1, p. 21-27

  Research output: Contribution to journal › Review article › Academic › peer-review
  689 Citations (Scopus)
• 2010

  Biochemical and cellular functions of P4 ATPases

  van der Velden, L. M., van de Graaf, S. F. J. & Klomp, L. W. J., 2010, In: Biochemical journal. 431, 1, p. 1-11

  Research output: Contribution to journal › Review article › Academic › peer-review
  16 Citations (Scopus)

• Neurogenic regulation of dendritic cells in the intestine

  Nijhuis, L. E. J., Olivier, B. J. & de Jonge, W. J., 2010, In: Biochemical Pharmacology. 80, 12, p. 2002-2008

  Research output: Contribution to journal › Review article › Academic › peer-review
  34 Citations (Scopus)

• P4 ATPases - The physiological relevance of lipid flipping transporters

  Paulusma, C. C. & Oude Elferink, R. P. J., 2010, In: FEBS letters. 584, 13, p. 2708-2716

  Research output: Contribution to journal › Review article › Academic › peer-review
  40 Citations (Scopus)

• Progressive Familial Intrahepatic Cholestasis Type 1

  Paulusma, C. C., Oude Elferink, R. P. J. & Jansen, P. L. M., 2010, In: Seminars in liver disease. 30, 2, p. 117-124

  Research output: Contribution to journal › Review article › Academic › peer-review
  44 Citations (Scopus)

• The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies.

  Beuers, U., Hohenester, S., de Buy Wenniger, L. J. M., Kremer, A. E., Jansen, P. L. M. & Elferink, R. P. J. O., Oct 2010, In: Hepatology (Baltimore, Md.). 52, 4, p. 1489-1496 8 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  291 Citations (Scopus)
• 2009

  Immune-mediated liver diseases: programmed cell death ligands and circulating apoptotic markers

  Kremer, A. E., Rust, C., Eichhorn, P., Beuers, U. & Holdenrieder, S., 2009, In: Expert review of molecular diagnostics. 9, 2, p. 139-156

  Research output: Contribution to journal › Review article › Academic › peer-review
  16 Citations (Scopus)

• P4 ATPases - lipid flippases and their role in disease

  Folmer, D. E., Elferink, R. P. J. O. & Paulusma, C. C., 2009, In: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 1791, 7, p. 628-635

  Research output: Contribution to journal › Review article › Academic › peer-review
  109 Citations (Scopus)

• Towards Liver-Directed Gene Therapy for Crigler-Najjar Syndrome

  Miranda, P. S. M. & Bosma, P. J., 2009, In: Current Gene Therapy. 9, 2, p. 72-82

  Research output: Contribution to journal › Review article › Academic › peer-review

  29 Citations (Scopus)
• 2008

  Pathogenesis and Treatment of Pruritus in Cholestasis

  Kremer, A. E., Beuers, U., Oude-Elferink, R. P. J. & Pusl, T., 2008, In: Drugs. 68, 15, p. 2163-2182

  Research output: Contribution to journal › Review article › Academic › peer-review
  106 Citations (Scopus)
• 2007

  Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein)

  Oude Elferink, R. P. J. & Paulusma, C. C., 2007, In: Pflugers Archiv. 453, 5, p. 601-610

  Research output: Contribution to journal › Review article › Academic › peer-review
  243 Citations (Scopus)

• Physiology of epithelial Ca2+ and Mg2+ transport

  van de Graaf, S. F. J., Bindels, R. J. M. & Hoenderop, J. G. J., 2007, In: Reviews of physiology, biochemistry and pharmacology. 158, p. 77-160

  Research output: Contribution to journal › Review article › Academic › peer-review
  70 Citations (Scopus)

• Transporters in the intestine limiting drug and toxin absorption

  Elferink, R. P. J. O. & de Waart, R., 2007, In: Journal of physiology and biochemistry. 63, 1, p. 75-81

  Research output: Contribution to journal › Review article › Academic › peer-review

  18 Citations (Scopus)
• 2006

  Diseases of intramembranous lipid transport

  Paulusma, C. C. & Oude Elferink, R. P. J., 2006, In: FEBS letters. 580, 23, p. 5500-5509

  Research output: Contribution to journal › Review article › Academic › peer-review
  14 Citations (Scopus)

• Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis

  Beuers, U., 2006, In: Nature clinical practice. Gastroenterology & hepatology. 3, 6, p. 318-328

  Research output: Contribution to journal › Review article › Academic › peer-review
  351 Citations (Scopus)

• Gallbladder stones - a change in the interdisciplinary approach?

  Pusl, T., Huettl, T. P. & Beuers, U., 2006, In: CHIRURGISCHE GASTROENTEROLOGIE. 22, 1, p. 48-52

  Research output: Contribution to journal › Review article › Academic › peer-review

• Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases

  Oude Elferink, R. P. J., Paulusma, C. C. & Groen, A. K., 2006, In: Gastroenterology. 130, 3, p. 908-925

  Research output: Contribution to journal › Review article › Academic › peer-review
  144 Citations (Scopus)

• Regulation of TRPV5 and TRPV6 by associated proteins

  van de Graaf, S. F. J., Hoenderop, J. G. J. & Bindels, R. J. M., 2006, In: American Journal of Physiology. Renal Physiology. 290, 6, p. F1295-F1302

  Research output: Contribution to journal › Review article › Academic › peer-review
  89 Citations (Scopus)

• The hypothalamic clock and its control of glucose homeostasis

  Kalsbeek, A., Ruiter, M., La Fleur, S. E., Cailotto, C., Kreier, F. & Buijs, R. M., 2006, In: Progress in brain research. 153, p. 283-307

  Research output: Contribution to journal › Review article › Academic › peer-review
  30 Citations (Scopus)

• Ursodeoxycholic acid treatment of vanishing bile duct syndromes

  Pusl, T. & Beuers, U., 2006, In: World journal of gastroenterology. 12, 22, p. 3487-3495

  Research output: Contribution to journal › Review article › Academic › peer-review
  61 Citations (Scopus)
• 2005

  Extrahepatic manifestations of cholestatic liver diseases: pathogenesis and therapy

  Pusl, T. & Beuers, U., 2005, In: Clinical reviews in allergy & immunology. 28, 2, p. 147-157

  Research output: Contribution to journal › Review article › Academic › peer-review
  22 Citations (Scopus)

• Medical treatment of primary biliary cirrhosis and primary sclerosing cholangitis

  Rust, C. & Beuers, U., 2005, In: Clinical reviews in allergy & immunology. 28, 2, p. 135-145

  Research output: Contribution to journal › Review article › Academic › peer-review
  21 Citations (Scopus)

• Outcome of regional and local ablative therapies for hepatocellular carcinoma: a collective review

  Jansen, M. C., van Hillegersberg, R., Chamuleau, R. A. F. M., van Delden, O. M., Gouma, D. J. & van Gulik, T. M., 2005, In: European Journal of Surgical Oncology. 31, 4, p. 331-347

  Research output: Contribution to journal › Review article › Academic › peer-review
  126 Citations (Scopus)

• Overlap syndromes

  Beuers, U. & Rust, C., 2005, In: Seminars in liver disease. 25, 3, p. 311-320

  Research output: Contribution to journal › Review article › Academic › peer-review
  97 Citations (Scopus)

• The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease

  Paulusma, C. C. & Oude Elferink, R. P. J., 2005, In: Biochimica et Biophysica Acta-Molecular Basis of Disease. 1741, 1-2, p. 11-24

  Research output: Contribution to journal › Review article › Academic › peer-review
  89 Citations (Scopus)

• Treatment modalities for hepatocellular carcinoma

  Groen, A. K. & Oude Elferink, R. P. J., 2005, In: Current cancer drug targets. 5, 2, p. 131-138

  Research output: Contribution to journal › Review article › Academic › peer-review
  8 Citations (Scopus)
• 2004

  Clinical application of bioartificial liver support systems

  van de Kerkhove, M. P., Hoekstra, R., Chamuleau, R. A. F. M. & van Gulik, T. M., 2004, In: Annals of surgery. 240, 2, p. 216-230

  Research output: Contribution to journal › Review article › Academic › peer-review
  151 Citations (Scopus)

• Large animal models of fulminant hepatic failure in artificial and bioartificial liver support research

  van de Kerkhove, M-P., Hoekstra, R., van Gulik, T. M. & Chamuleau, R. A. F. M., 2004, In: Biomaterials. 25, 9, p. 1613-1625

  Research output: Contribution to journal › Review article › Academic › peer-review
  46 Citations (Scopus)

• The ins and outs of reverse cholesterol transport

  Groen, A. K., Oude Elferink, R. P. J., Verkade, H. J. & Kuipers, F., 2004, In: Annals of Medicine. 36, 2, p. 135-145

  Research output: Contribution to journal › Review article › Academic › peer-review
  55 Citations (Scopus)
• 2003

  Systematic review: ursodeoxycholic acid--adverse effects and drug interactions

  Hempfling, W., Dilger, K. & Beuers, U., 2003, In: Alimentary pharmacology & therapeutics. 18, 10, p. 963-972

  Research output: Contribution to journal › Review article › Academic › peer-review
  97 Citations (Scopus)
• 2002

  Cardiac septation: a late contribution of the embryonic primary myocardium to heart morphogenesis

  Lamers, W. H. & Moorman, A. F. M., 2002, In: Circulation Research. 91, 2, p. 93-103

  Research output: Contribution to journal › Review article › Academic › peer-review
  111 Citations (Scopus)

• Development of alphabeta T cells in the human thymus

  Spits, H., 2002, In: Nature Reviews. Immunology. 2, 10, p. 760-772

  Research output: Contribution to journal › Review article › Academic › peer-review
  206 Citations (Scopus)

• Extrahepatic manifestations of cholestasis

  Glasova, H. & Beuers, U., 2002, In: Journal of gastroenterology and hepatology. 17, 9, p. 938-948

  Research output: Contribution to journal › Review article › Academic › peer-review
  34 Citations (Scopus)

• Genetic defects in hepatobiliary transport

  Elferink, R. O. & Groen, A. K., 2002, In: Biochimica et Biophysica Acta-Molecular Basis of Disease. 1586, 2, p. 129-145

  Research output: Contribution to journal › Review article › Academic › peer-review

  118 Citations (Scopus)

• Recent developments on human cell lines for the bioartificial liver

  Hoekstra, R. & Chamuleau, R. A. F. M., 2002, In: International Journal of Artificial Organs. 25, 3, p. 182-191

  Research output: Contribution to journal › Review article › Academic › peer-review

  47 Citations (Scopus)

• Reduced arginine availability and nitric oxide production

  Hallemeesch, M. M., Lamers, W. H. & Deutz, N. E. P., 2002, In: Clinical nutrition (Edinburgh, Scotland). 21, 4, p. 273-279

  Research output: Contribution to journal › Review article › Academic › peer-review
  67 Citations (Scopus)