Brigitte Boeser - Nunnink

Research output

Research output per year 1992 2003 2005 2007 2010 2011 2016 2024

• 41 Article
• 4 Comment/Letter to the editor

Research output per year

Research output per year

Search results

• 2024

  Autophagy-enhancing ATG16L1 polymorphism is associated with improved clinical outcome and T-cell immunity in chronic HIV-1 infection

  Schreurs, R. R. C. E., Koulis, A., Booiman, T., Boeser-Nunnink, B., Cloherty, A. P. M., Rader, A. G., Patel, K. S., Kootstra, N. A. & Ribeiro, C. M. S., 1 Dec 2024, In: Nature communications. 15, 1, 2465.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2023

  A genetic variation in fucosyltransferase 8 accelerates HIV-1 disease progression indicating a role for N-glycan fucosylation

  van Pul, L., Maurer, I., Boeser-Nunnink, B. D. M., Harskamp, A. M., van Dort, K. A. & Kootstra, N. A., 1 Nov 2023, In: AIDS (London, England). 37, 13, p. 1959-1969 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Virological and immunological correlates of HIV posttreatment control after temporal antiretroviral therapy during acute HIV infection

  van Paassen, P. M., van Pul, L., van der Straten, K., Buchholtz, N. V. J. E., Grobben, M., van Nuenen, A. C., van Dort, K. A., Boeser-Nunnink, B. D., van den Essenburg, M. D., Burger, J. A., van Luin, M., Jurriaans, S., Sanders, R. W., Swelsen, W. T., Symons, J., Klouwens, M. J., Nijhuis, M., van Gils, M. J., Prins, J. M., de Bree, G. J., & 1 othersKootstra, N. A., 1 Dec 2023, In: AIDS (London, England). 37, 15, p. 2297-2304 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2022

  A single mRNA vaccine dose in COVID-19 patients boosts neutralizing antibodies against SARS-CoV-2 and variants of concern

  RECoVERED Study Group, 18 Jan 2022, In: Cell Reports Medicine. 3, 1, 100486.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  13 Citations (Scopus)
• 2020

  Genetic variations in the host dependency factors ALCAM and TPST2 impact HIV-1 disease progression

  Kruize, Z., Maurer, I., Boeser-Nunnink, B. D. M., Booiman, T. & Kootstra, N. A., 15 Jul 2020, In: AIDS (London, England). 34, 9, p. 1303-1312 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)
• 2018

  Patterns of co-occurring comorbidities in people living with HIV

  Pharmacokinetic and Clinical Observations in PeoPle Over fiftY (POPPY) study and the AGEhIV Cohort Study, Study collaborative & Pharmacokinetic and Clinical Observations in PeoPle Over fiftY (POPPY) study, 1 Nov 2018, In: Open forum infectious diseases. 5, 11, p. ofy272

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  36 Citations (Scopus)

• Structural Brain Abnormalities in Successfully Treated HIV Infection: Associations With Disease and Cerebrospinal Fluid Biomarkers

  AUTHOR GROUP, 2018, In: Journal of infectious diseases. 217, 1, p. 69-81

  Research output: Contribution to journal › Article › Academic › peer-review
  40 Citations (Scopus)
• 2017

  High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid

  AUTHOR GROUP, 2017, In: Open forum infectious diseases. 4, 3, p. ofx108

  Research output: Contribution to journal › Article › Academic › peer-review
  17 Citations (Scopus)
• 2016

  Cigarette Smoking and Inflammation, Monocyte Activation, and Coagulation in HIV-Infected Individuals Receiving Antiretroviral Therapy, Compared With Uninfected Individuals

  AUTHOR GROUP, 2016, In: Journal of infectious diseases. 214, 12, p. 1817-1821

  Research output: Contribution to journal › Article › Academic › peer-review
  20 Citations (Scopus)

• Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset

  Ploquin, M. J., Madec, Y., Casrouge, A., Huot, N., Passaes, C., Lécuroux, C., Essat, A., Boufassa, F., Jacquelin, B., Jochems, S. P., Petitjean, G., Angin, M., Gärtner, K., Garcia-Tellez, T., Noël, N., Booiman, T., Boeser-Nunnink, B. D., Roques, P., Saez-Cirion, A., Vaslin, B., & 10 othersDereudre-Bosquet, N., Barré-Sinoussi, F., Ghislain, M., Rouzioux, C., Lambotte, O., Albert, M. L., Goujard, C., Kootstra, N., Meyer, L. & Müller-Trutwin, M. C., 2016, In: PLoS pathogens. 12, 8, p. e1005774

  Research output: Contribution to journal › Article › Academic › peer-review
  50 Citations (Scopus)

• HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bonds

  van den Kerkhof, T. L. G. M., de Taeye, S. W., Boeser-Nunnink, B. D., Burton, D. R., Kootstra, N. A., Schuitemaker, H., Sanders, R. W. & van Gils, M. J., 2016, In: Retrovirology. 13, 1, p. 48

  Research output: Contribution to journal › Article › Academic › peer-review
  18 Citations (Scopus)

• Probability of N332 glycan occupancy on HIV-1 gp120 modulates sensitivity to broadly neutralizing antibodies

  van den Kerkhof, T. L. G. M., van Gils, M. J., Boeser-Nunnink, B. D., Burger, J. A., Schuitemaker, H. & Sanders, R. W., 2016, In: AIDS (London, England). 30, 14, p. 2179-2184

  Research output: Contribution to journal › Article › Academic › peer-review
  3 Citations (Scopus)

• T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment

  AUTHOR GROUP, 2016, In: Journal of infectious diseases. 214, 2, p. 216-225

  Research output: Contribution to journal › Article › Academic › peer-review
  87 Citations (Scopus)

• The Neutralizing Antibody Response in an Individual with Triple HIV-1 Infection Remains Directed at the First Infecting Subtype

  Cornelissen, M., Euler, Z., van den Kerkhof, T. L. G. M., van Gils, M. J., Boeser-Nunnink, B. D. M., Kootstra, N. A., Zorgdrager, F., Schuitemaker, H., Prins, J. M., Sanders, R. W. & van der Kuyl, A. C., 2016, In: AIDS Research and Human Retroviruses. 32, 10-11, p. 1135-1142

  Research output: Contribution to journal › Article › Academic › peer-review
  11 Citations (Scopus)
• 2014

  Early development of broadly reactive HIV-1 neutralizing activity in elite neutralizers

  van den Kerkhof, T. L. G. M., Euler, Z., van Gils, M. J., Boeser-Nunnink, B. D., Schuitemaker, H. & Sanders, R. W., 2014, In: AIDS (London, England). 28, 8, p. 1237-1240

  Research output: Contribution to journal › Article › Academic › peer-review
  18 Citations (Scopus)
• 2013

  Genome-wide association study on the development of cross-reactive neutralizing antibodies in HIV-1 infected individuals

  Euler, Z., van Gils, M. J., Boeser-Nunnink, B. D., Schuitemaker, H. & van Manen, D., 2013, In: PLOS ONE. 8, 1, p. e54684

  Research output: Contribution to journal › Article › Academic › peer-review
  21 Citations (Scopus)

• HIV-1 envelope glycoprotein signatures that correlate with the development of cross-reactive neutralizing activity

  van den Kerkhof, T. L. G. M., Feenstra, K. A., Euler, Z., van Gils, M. J., Rijsdijk, L. W. E., Boeser-Nunnink, B. D., Heringa, J., Schuitemaker, H. & Sanders, R. W., 2013, In: Retrovirology. 10, 1, p. 102 102.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  37 Citations (Scopus)
• 2012

  Single Nucleotide Polymorphism in Gene Encoding Transcription Factor Prep1 Is Associated with HIV-1-Associated Dementia

  Bol, S. M., Booiman, T., van Manen, D., Bunnik, E. M., van Sighem, A. I., Sieberer, M., Boeser-Nunnink, B., de Wolf, F., Schuitemaker, H., Portegies, P., Kootstra, N. A. & van 't Wout, A. B., 2012, In: PLOS ONE. 7, 2, p. e30990

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)

• The evolution of human immunodeficiency virus type-1 (HIV-1) envelope molecular properties and coreceptor use at all stages of infection in an HIV-1 donor-recipient pair

  Edo-Matas, D., Rachinger, A., Setiawan, L. C., Boeser-Nunnink, B. D., van 't Wout, A. B., Lemey, P. & Schuitemaker, H., 2012, In: Virology. 422, 1, p. 70-80

  Research output: Contribution to journal › Article › Academic › peer-review
  11 Citations (Scopus)
• 2011

  Activity of broadly neutralizing antibodies, including PG9, PG16, and VRC01, against recently transmitted subtype B HIV-1 variants from early and late in the epidemic

  Euler, Z., Bunnik, E. M., Burger, J. A., Boeser-Nunnink, B. D. M., Grijsen, M. L., Prins, J. M. & Schuitemaker, H., 2011, In: Journal of Virology. 85, 14, p. 7236-7245

  Research output: Contribution to journal › Article › Academic › peer-review
  47 Citations (Scopus)

• Genome-wide association scan in HIV-1-infected individuals identifying variants influencing disease course

  van Manen, D., Delaneau, O., Kootstra, N. A., Boeser-Nunnink, B. D., Limou, S., Bol, S. M., Burger, J. A., Zwinderman, A. H., Moerland, P. D., van 't Slot, R., Zagury, J-F., van 't Wout, A. B. & Schuitemaker, H., 2011, In: PLOS ONE. 6, 7, p. e22208

  Research output: Contribution to journal › Article › Academic › peer-review
  36 Citations (Scopus)

• Longer V1V2 region with increased number of potential N-linked glycosylation sites in the HIV-1 envelope glycoprotein protects against HIV-specific neutralizing antibodies

  van Gils, M. J., Bunnik, E. M., Boeser-Nunnink, B. D., Burger, J. A., Terlouw-Klein, M., Verwer, N. & Schuitemaker, H., 2011, In: Journal of Virology. 85, 14, p. 6986-6995

  Research output: Contribution to journal › Article › Academic › peer-review
  76 Citations (Scopus)

• Loss of HIV-1-derived cytotoxic T lymphocyte epitopes restricted by protective HLA-B alleles during the HIV-1 epidemic

  Schellens, I. M. M., Navis, M., van Deutekom, H. W. M., Boeser-Nunnink, B., Berkhout, B., Kootstra, N., Miedema, F., Keşmir, C., Schuitemaker, H., van Baarle, D. & Borghans, J. A. M., 2011, In: AIDS (London, England). 25, 14, p. 1691-1700

  Research output: Contribution to journal › Article › Academic › peer-review
  21 Citations (Scopus)

• Rising HIV-1 viral load set point at a population level coincides with a fading impact of host genetic factors on HIV-1 control

  van Manen, D., Gras, L., Boeser-Nunnink, B. D., van Sighem, A. I., Maurer, I., Mangas Ruiz, M. M., Harskamp, A. M., Steingrover, R., Prins, J. M., de Wolf, F., van 't Wout, A. B. & Schuitemaker, H., 2011, In: AIDS (London, England). 25, 18, p. 2217-2226

  Research output: Contribution to journal › Article › Academic › peer-review
  12 Citations (Scopus)
• 2010

  Adaptation of HIV-1 envelope gp120 to humoral immunity at a population level

  Bunnik, E. M., Euler, Z., Welkers, M. R. A., Boeser-Nunnink, B. D. M., Grijsen, M. L., Prins, J. M. & Schuitemaker, H., 2010, In: Nature medicine. 16, 9, p. 995-997

  Research output: Contribution to journal › Article › Academic › peer-review
  91 Citations (Scopus)

• Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection (vol 23, pg 19, 2009)

  van Manen, D., Kootstra, N. A., Boeser-Nunnink, B., Handulle, M. A. M., van 't Wout, A. B. & Schuitemaker, H., 2010, In: AIDS (London, England). 24, 6, p. 939

  Research output: Contribution to journal › Comment/Letter to the editor › Academic

• Genetic composition of replication competent clonal HIV-1 variants isolated from peripheral blood mononuclear cells (PBMC), HIV-1 proviral DNA from PBMC and HIV-1 RNA in serum in the course of HIV-1 infection

  Edo-Matas, D., van Gils, M. J., Bowles, E. J., Navis, M., Rachinger, A., Boeser-Nunnink, B., Stewart-Jones, G. B., Kootstra, N. A., Wout, A. B. V. . & Schuitemaker, H., 2010, In: Virology. 405, 2, p. 492-504

  Research output: Contribution to journal › Article › Academic › peer-review
  19 Citations (Scopus)
• 2009

  Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection

  van Manen, D., Kootstra, N. A., Boeser-Nunnink, B., Handulle, M. A., Vanʼt Wout, A. B. & Schuitemaker, H., 2009, In: AIDS (London, England). 23, 1, p. 19-28

  Research output: Contribution to journal › Article › Academic › peer-review
  77 Citations (Scopus)
• 2007

  Escape of human immunodeficiency virus type 1 from broadly neutralizing antibodies is not associated with a reduction of viral replicative capacity in vitro

  Quakkelaar, E. D., Bunnik, E. M., van Alphen, F. P. J., Boeser-Nunnink, B. D. M., van Nuenen, A. C. & Schuitemaker, H., 2007, In: Virology. 363, 2, p. 447-453

  Research output: Contribution to journal › Article › Academic › peer-review
  24 Citations (Scopus)

• Increased neutralization sensitivity of recently emerged CXCR4-using human immunodeficiency virus type 1 strains compared to coexisting CCR5-using variants from the same patient

  Bunnik, E. M., Quakkelaar, E. D., van Nuenen, A. C., Boeser-Nunnink, B. & Schuitemaker, H., 2007, In: Journal of Virology. 81, 2, p. 525-531

  Research output: Contribution to journal › Article › Academic › peer-review
  45 Citations (Scopus)

• Susceptibility of recently transmitted subtype B human immunodeficiency virus type 1 variants to broadly neutralizing antibodies

  Quakkelaar, E. D., van Alphen, F. P. J., Boeser-Nunnink, B. D. M., van Nuenen, A. C., Pantophlet, R. & Schuitemaker, H., 2007, In: Journal of Virology. 81, 16, p. 8533-8542

  Research output: Contribution to journal › Article › Academic › peer-review
  25 Citations (Scopus)

• T cell line passage can select for pre-existing neutralization-sensitive variants from the quasispecies of primary human immunodeficiency virus type-1 isolates

  Quakkelaar, E. D., Beaumont, T., van Nuenen, A. C., van Alphen, F. P. J., Boeser-Nunnink, B. D. M., van 't Wout, A. B. & Schuitemaker, H., 2007, In: Virology. 359, 1, p. 92-104

  Research output: Contribution to journal › Article › Academic › peer-review
  7 Citations (Scopus)
• 2005

  GB virus C coinfection and HIV-1 disease progression: The Amsterdam Cohort Study

  van der Bij, A. K., Kloosterboer, N., Prins, M., Boeser-Nunnink, B., Geskus, R. B., Lange, J. M. A., Coutinho, R. A. & Schuitemaker, H., 2005, In: The Journal of Infectious Diseases. 191, 5, p. 678-685

  Research output: Contribution to journal › Article › Academic › peer-review
  80 Citations (Scopus)

• GB virus C infection and survival in the Amsterdam Cohort Study [4] (multiple letters)

  Stapleton, J. T., Chaloner, K., Williams, C. F., Van Der Bij, A. K., Kloosterboer, N., Prins, M., Boeser-Nunnink, B., Geskus, R. B., Lange, J. M. A., Coutinho, R. A. & Schuitemaker, H., 15 Jun 2005, In: Journal of infectious diseases. 191, 12, p. 2157-2160 4 p.

  Research output: Contribution to journal › Comment/Letter to the editor › Academic

  Open Access
  7 Citations (Scopus)

• GB virus C infection and survival in the Amsterdam Cohort study - Reply to George and to Stapleton et al

  van der Bij, A. K., Kloosterboer, N., Prins, M., Boeser-Nunnink, B., Geskus, R. B., Lange, J. M. A., Coutinho, R. A. & Schuitemaker, H., 2005, In: Journal of infectious diseases. 191, 12, p. 2158-2160

  Research output: Contribution to journal › Comment/Letter to the editor › Academic
• 2004

  In vivo evolution of X4 human immunodeficiency virus type 1 variants in the natural course of infection coincides with decreasing sensitivity to CXCR4 antagonists

  Stalmeijer, E. H. B., van Rij, R. P., Boeser-Nunnink, B., Visser, J. A., Naarding, M. A., Schols, D. & Schuitemaker, H., 2004, In: Journal of Virology. 78, 6, p. 2722-2728

  Research output: Contribution to journal › Article › Academic › peer-review
  36 Citations (Scopus)
• 2003

  Association between an interleukin-4 promoter polymorphism and the acquisition of CXCR4 using HIV-1 variants

  Kwa, D., van Rij, R. P., Boeser-Nunnink, B., Vingerhoed, J. & Schuitemaker, H., 2003, In: AIDS (London, England). 17, 7, p. 981-985

  Research output: Contribution to journal › Article › Academic › peer-review
  23 Citations (Scopus)

• Decreasing sensitivity to RANTES (regulated on activation, normally T cell-expressed and -secreted) neutralization of CC chemokine receptor 5-using, non-syncytium-inducing virus variants in the course of human immunodeficiency virus type 1 infection

  Koning, F. A., Kwa, D., Boeser-Nunnink, B., Dekker, J., Vingerhoed, J., Hiemstra, H. & Schuitemaker, H., 2003, In: The Journal of Infectious Diseases. 188, 6, p. 864-872

  Research output: Contribution to journal › Article › Academic › peer-review
  77 Citations (Scopus)

• Increased in vitro cytopathicity of CC chemokine receptor 5-restricted human immunodeficiency virus type 1 primary isolates correlates with a progressive clinical course of infection

  Kwa, D., Vingerhoed, J., Boeser-Nunnink, B. & Schuitemaker, H., 2003, In: The Journal of Infectious Diseases. 187, 9, p. 1397-1403

  Research output: Contribution to journal › Article › Academic › peer-review
  55 Citations (Scopus)

• Lack of evidence for an association between a polymorphism in CX3CR1 and the clinical course of HIV infection or virus phenotype evolution

  Kwa, D., Boeser-Nunnink, B. & Schuitemaker, H., 2003, In: AIDS (London, England). 17, 5, p. 759-761

  Research output: Contribution to journal › Article › Academic › peer-review
  17 Citations (Scopus)
• 2001

  Cytopathic effects of non-syncytium-inducing and syncytium-inducing human immunodeficiency virus type 1 variants on different CD4(+)-T-cell subsets are determined only by coreceptor expression

  Kwa, D., Vingerhoed, J., Boeser-Nunnink, B., Broersen, S. & Schuitemaker, H., 2001, In: Journal of Virology. 75, 21, p. 10455-10459

  Research output: Contribution to journal › Article › Academic › peer-review
  28 Citations (Scopus)
• 1997

  Stability of HIV-1 RNA in blodd during specimen handling and storage prior to amplification by NASBA-QT

  Bruisten, S. M., Oudshoorn, P., van Swieten, P., Boeser-Nunnink, B., van Aarle, P., Tondreau, S. P. & Cuypers, H. T. M., 1997, In: Journal of virological methods. 67, 2, p. 199-207

  Research output: Contribution to journal › Article › Academic › peer-review
  34 Citations (Scopus)
• 1994

  The duration of fixation influences the yield of HCV cDNA-PCR products from formalin-fixed, paraffin-embedded liver tissue

  Bresters, D., Schipper, M. E., Reesink, H. W., Boeser-Nunnink, B. D. & Cuypers, H. T., 1994, In: Journal of virological methods. 48, 2-3, p. 267-272

  Research output: Contribution to journal › Article › Academic › peer-review
  70 Citations (Scopus)
• 1992

  Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer

  Schuuring, E., Verhoeven, E., van Tinteren, H., Peterse, J. L., Nunnink, B., Thunnissen, F. B., Devilee, P., Cornelisse, C. J., van de Vijver, M. J. & Mooi, W. J., 1992, In: Cancer research. 52, 19, p. 5229-5234

  Research output: Contribution to journal › Article › Academic › peer-review

  205 Citations (Scopus)

• Detection of hepatitis C viral RNA sequences in fresh and paraffin-embedded liver biopsy specimens of non-A, non-B hepatitis patients

  Bresters, D., Cuypers, H. T., Reesink, H. W., Chamuleau, R. A., Schipper, M. E., Boeser-Nunnink, B. D., Lelie, P. N. & Jansen, P. L., 1992, In: Journal of Hepatology. 15, 3, p. 391-395

  Research output: Contribution to journal › Comment/Letter to the editor › Academic
  29 Citations (Scopus)